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The map label for this gene is serS [H]

Identifier: 209549091

GI number: 209549091

Start: 1521379

End: 1522662

Strand: Direct

Name: serS [H]

Synonym: Rleg2_1490

Alternate gene names: 209549091

Gene position: 1521379-1522662 (Clockwise)

Preceding gene: 209549090

Following gene: 209549092

Centisome position: 33.53

GC content: 62.77

Gene sequence:

>1284_bases
ATGCTCGATATCAAATGGATCCGTGAGAATCCCGAAGCGCTCGATGCCGCCCTCGCCAAGCGCGGTGCGGAGCCTCTGGC
GCAAAATCTCGTTGCCCTCGATGAAAAGCGCCGCTCCGCCGTGCAGAAGGCGCAGGACCTGCTGTCCCGCCGCAACCTCG
CTTCCAAGGAGATCGGCGCGGCGCTATCGCAGAAGAACGGTGAGCTCGCCGAGAAGCTGAAGGTCGAGGTCGCCGAATTG
AAGGCTATGCTGCCGGCGGTCGAGGAAGAGGACCGTCAGCTGACGGCCGAACTCAACGACGCGCTGTCGCGCATCCCGAA
CATTCCTTTCGACGACGTCCCGGTCGGCAAGGACGAGCACGACAATGTCGTCACCCGCACCGTCGGCGAAAAGCCGCGCT
GGAACCACACGCCCAAGGAGCACTTCGAAATCGGCGAGGCGCTCGGCTATATGGATTTCGAGCGCGCCGCCAAGCTCTCC
GGCTCGCGCTTCACGGTTCTCACAGGGCCGCTCGCCAGGCTCGAGCGCGCGCTTGGCCAGTTCATGATCGATCTCCACAC
CCGCGAGCACGGCTATACCGAAGTCAGCTCTCCGCTGATGGTTCGCGCTGAAGCGCTGTTCGGCACCGGCAACCTGCCGA
AGTTCGAAGAGGATCTCTTCAAGACGACGGATGGACGCTATCTCATTCCGACGGCGGAGGTGACGCTGACCAATCTGGTG
CGCGAGGAGATCCTCGACCAGGAAAAGCTGCCGCTCCGCTTCACCGCCTTGACGCCGTCCTTCCGCTCGGAAGCGGGTTC
TGCCGGCCGCGACACCCGTGGCATGCTGCGCCAGCATCAGTTCTGGAAATGTGAGCTCGTCTCGATCACCGATGCCGAGA
GCGCTGTTGCCGAGCATGAACGGATGACCGCCTGCGCCGAAGACGTGCTGAAGCGCCTCGGCCTGCATTTCCGCACGATG
ACGCTTTGCACCGGCGACATGGGGTTCGGCTCGCGCAAGACCTACGATCTCGAAGTCTGGCTGCCGGGACAGAATGCCTT
CCGCGAAATCTCCTCCTGCTCGGTCTGCGGCGATTTCCAGGCCCGCCGGATGAATGCGCGCTACCGCGGCAAGGACGACA
AGAGCAACAGGTTCGTGCACACGCTGAACGGCTCCGGCACCGCCGTCGGCCGGTGCCTCATCGCCGTGCTTGAAAATTAT
TTGAACGAGGATGGCTCGGTCACGATTCCGGACGTTTTGCTGCCTTATATGGGCGGATTGACCAAGATCGAACGGGCGGC
CTGA

Upstream 100 bases:

>100_bases
AGCGGCAATCCGGAAATCCTTTCACGAACGCCGTCTCATCCGGCCGAAGCCCGGTCAGGCTTTGGCCGGGTCATTTCTGT
TGCAACGACCTGGAACGACG

Downstream 100 bases:

>100_bases
GGCGATGCGCATCCTGCTTACGAATGACGACGGCATTCACGCCGAAGGCTTGGCCGCGCTGGAGCGGATCGCCCGCACGC
TGTCCGACGATGTCTGGATC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDIKWIRENPEALDAALAKRGAEPLAQNLVALDEKRRSAVQKAQDLLSRRNLASKEIGAALSQKNGELAEKLKVEVAEL
KAMLPAVEEEDRQLTAELNDALSRIPNIPFDDVPVGKDEHDNVVTRTVGEKPRWNHTPKEHFEIGEALGYMDFERAAKLS
GSRFTVLTGPLARLERALGQFMIDLHTREHGYTEVSSPLMVRAEALFGTGNLPKFEEDLFKTTDGRYLIPTAEVTLTNLV
REEILDQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHERMTACAEDVLKRLGLHFRTM
TLCTGDMGFGSRKTYDLEVWLPGQNAFREISSCSVCGDFQARRMNARYRGKDDKSNRFVHTLNGSGTAVGRCLIAVLENY
LNEDGSVTIPDVLLPYMGGLTKIERAA

Sequences:

>Translated_427_residues
MLDIKWIRENPEALDAALAKRGAEPLAQNLVALDEKRRSAVQKAQDLLSRRNLASKEIGAALSQKNGELAEKLKVEVAEL
KAMLPAVEEEDRQLTAELNDALSRIPNIPFDDVPVGKDEHDNVVTRTVGEKPRWNHTPKEHFEIGEALGYMDFERAAKLS
GSRFTVLTGPLARLERALGQFMIDLHTREHGYTEVSSPLMVRAEALFGTGNLPKFEEDLFKTTDGRYLIPTAEVTLTNLV
REEILDQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHERMTACAEDVLKRLGLHFRTM
TLCTGDMGFGSRKTYDLEVWLPGQNAFREISSCSVCGDFQARRMNARYRGKDDKSNRFVHTLNGSGTAVGRCLIAVLENY
LNEDGSVTIPDVLLPYMGGLTKIERAA
>Mature_427_residues
MLDIKWIRENPEALDAALAKRGAEPLAQNLVALDEKRRSAVQKAQDLLSRRNLASKEIGAALSQKNGELAEKLKVEVAEL
KAMLPAVEEEDRQLTAELNDALSRIPNIPFDDVPVGKDEHDNVVTRTVGEKPRWNHTPKEHFEIGEALGYMDFERAAKLS
GSRFTVLTGPLARLERALGQFMIDLHTREHGYTEVSSPLMVRAEALFGTGNLPKFEEDLFKTTDGRYLIPTAEVTLTNLV
REEILDQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHERMTACAEDVLKRLGLHFRTM
TLCTGDMGFGSRKTYDLEVWLPGQNAFREISSCSVCGDFQARRMNARYRGKDDKSNRFVHTLNGSGTAVGRCLIAVLENY
LNEDGSVTIPDVLLPYMGGLTKIERAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=455, Percent_Identity=31.8681318681319, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI8923421, Length=433, Percent_Identity=29.7921478060046, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI225579074, Length=435, Percent_Identity=28.9655172413793, Blast_Score=176, Evalue=5e-44,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=52.2041763341067, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17539260, Length=469, Percent_Identity=31.1300639658849, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=324, Percent_Identity=28.3950617283951, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=31.7460317460317, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321799, Length=366, Percent_Identity=27.5956284153005, Blast_Score=161, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24581334, Length=467, Percent_Identity=29.9785867237687, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17737985, Length=364, Percent_Identity=32.967032967033, Blast_Score=177, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47676; Mature: 47676

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKWIRENPEALDAALAKRGAEPLAQNLVALDEKRRSAVQKAQDLLSRRNLASKEIGA
CCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ALSQKNGELAEKLKVEVAELKAMLPAVEEEDRQLTAELNDALSRIPNIPFDDVPVGKDEH
HHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVVTRTVGEKPRWNHTPKEHFEIGEALGYMDFERAAKLSGSRFTVLTGPLARLERALGQ
CCHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
FMIDLHTREHGYTEVSSPLMVRAEALFGTGNLPKFEEDLFKTTDGRYLIPTAEVTLTNLV
HHHHHHHCCCCCCHHCCCHHEEEHHHCCCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHH
REEILDQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHE
HHHHHCCCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHH
RMTACAEDVLKRLGLHFRTMTLCTGDMGFGSRKTYDLEVWLPGQNAFREISSCSVCGDFQ
HHHHHHHHHHHHHCCHHEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCCHH
ARRMNARYRGKDDKSNRFVHTLNGSGTAVGRCLIAVLENYLNEDGSVTIPDVLLPYMGGL
HHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCH
TKIERAA
HHHHHCC
>Mature Secondary Structure
MLDIKWIRENPEALDAALAKRGAEPLAQNLVALDEKRRSAVQKAQDLLSRRNLASKEIGA
CCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ALSQKNGELAEKLKVEVAELKAMLPAVEEEDRQLTAELNDALSRIPNIPFDDVPVGKDEH
HHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVVTRTVGEKPRWNHTPKEHFEIGEALGYMDFERAAKLSGSRFTVLTGPLARLERALGQ
CCHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
FMIDLHTREHGYTEVSSPLMVRAEALFGTGNLPKFEEDLFKTTDGRYLIPTAEVTLTNLV
HHHHHHHCCCCCCHHCCCHHEEEHHHCCCCCCCHHHHHHHHCCCCCEEECCHHHHHHHHH
REEILDQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHE
HHHHHCCCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHH
RMTACAEDVLKRLGLHFRTMTLCTGDMGFGSRKTYDLEVWLPGQNAFREISSCSVCGDFQ
HHHHHHHHHHHHHCCHHEEEEEEECCCCCCCCCEEEEEEEECCHHHHHHHHCCCCCCCHH
ARRMNARYRGKDDKSNRFVHTLNGSGTAVGRCLIAVLENYLNEDGSVTIPDVLLPYMGGL
HHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCH
TKIERAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA