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The map label for this gene is nuoN [H]

Identifier: 209548877

GI number: 209548877

Start: 1291623

End: 1293068

Strand: Direct

Name: nuoN [H]

Synonym: Rleg2_1274

Alternate gene names: 209548877

Gene position: 1291623-1293068 (Clockwise)

Preceding gene: 209548876

Following gene: 209548878

Centisome position: 28.46

GC content: 62.45

Gene sequence:

>1446_bases
ATGACCGCTGAAACAATTCTCCTCAGTCTGCATCTTTCCGCGCCGGAGCTCATCCTCGCGGTCGGCGCCCTTGTCCTGTT
GATGGTCGGCGTCTTCTCAGGCGAGCGGTCTGGCCTCGTCGTCACTGGCCTGGCCATCGTGCTGCTGCTTGCCGCCGGCC
TGTGGCTGCTCTTCGTGCCGGCGGAAGGCCTTGCCTATGGCGGCGTCTACATGGCCGACGGCTTCTCGCGCTTCATGAAG
CTGGTGGCGCTCATCGGTTCGCTGGTCGCCCTGTTCATGACGATGGGTCACGCCCGCGAAAACCAGCTCGACAAGTTCGA
GTTCCCGGTTCTTCTGGTGCTGGCGACCCTCGGCATCCTGCTGATGATCTCGGCCAACGACCTGATCTCGCTCTATCTGG
CGCTGGAACTGCAGTCGCTGGCGCTCTATGTCGTCGCCGCGATCAACCGCGACAGCCTGAAGTCGACCGAAGCCGGCCTG
AAATATTTCGTCCTCGGCGCGCTTTCCTCCGGCATGCTGCTCTACGGTATGTCCCTGGTCTATGGTTTTACCGGCCACAC
CCACTTCTCCGAGATCGCCCAGGCGCTCTCCGTCGAGGGTGCGCGTTCGCTCGGTCTGATCTTCGGCCTGGTCTTCATCC
TCGCCGGCATCGCCTTCAAGATCTCGGCCGTTCCCTTCCATATGTGGACGCCTGACGTCTATGAAGGCGCGCCGACGCCG
GTCACCGCCTTCCTGGCCGCAGCCCCCAAGGTTGCCGCCATGGCAATGATGACCCGCATCGTCATCACCGCCTTCCAGCC
GGTTCTGGCCGACTGGCAGCAGGTGGTCGTCTTCATCTCGATCGCCTCGATGCTGCTCGGCTCCTTTGCCGCGATCGGCC
AGAAGAACATCAAGCGGCTGATGGCCTATTCGTCGATCGGCCACATGGGTTACGCGCTGGTCGGCCTTGCTGCCGGCAAC
CAGACCGGCGTTTCCGGCGTCATGCTTTACATGGTCATCTATATGGTCATGACCCTCGGCACCTTTGCGATCATCATGTC
GATGCGCCGCAAGGACGGCACCGTCGTCGAGGAGGTCAACGATCTCGCCGGCCTCTCCACCACCAACCCGTTCATGGCGG
TGGTGCTGACGGCGCTGATGTTCTCGCTTGCCGGCATTCCGCCGCTCGCCGGCTTCTTCGCCAAGTATTTCGTCTTCGTC
GCCGCCATCGAAGCCAAGCTTTATGCGCTCGCCATCATCGGCGTTCTCGCCTCGGTCGTCGGCGCTTATTATTATCTGCG
CGTCATCAAGCTGATGTGGTTCGATGAGGCGACCGGCGAATTCGCCCGTGTCTCCGGTTCGTTGCGCCTGGTCTTCGGCC
TCTCCGGTCTCTTCGTCACTGCCTATGTCCTGATCGGCGGCCCGATCGGCGGCGCGGCAGAGCTTGCCGCCGCGACGCTC
TTTTGA

Upstream 100 bases:

>100_bases
GGCCGCCTCGGTGGATCTGCTGGTCAACAACTACACGGCCGCCGTGCACGCAGCGCAGAATATTGCGCTGTCTATGAATT
GATGACGGGACTTATCGGAC

Downstream 100 bases:

>100_bases
TGGCTTCCGACGGGCGGCGCCGGATATCGCTCGGCGATTTCAGGCACGAGGCTCTGTCGGAAACGTCGTCCACCAACAGC
GAATGCCTCGCCCGGGCTCG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTAETILLSLHLSAPELILAVGALVLLMVGVFSGERSGLVVTGLAIVLLLAAGLWLLFVPAEGLAYGGVYMADGFSRFMK
LVALIGSLVALFMTMGHARENQLDKFEFPVLLVLATLGILLMISANDLISLYLALELQSLALYVVAAINRDSLKSTEAGL
KYFVLGALSSGMLLYGMSLVYGFTGHTHFSEIAQALSVEGARSLGLIFGLVFILAGIAFKISAVPFHMWTPDVYEGAPTP
VTAFLAAAPKVAAMAMMTRIVITAFQPVLADWQQVVVFISIASMLLGSFAAIGQKNIKRLMAYSSIGHMGYALVGLAAGN
QTGVSGVMLYMVIYMVMTLGTFAIIMSMRRKDGTVVEEVNDLAGLSTTNPFMAVVLTALMFSLAGIPPLAGFFAKYFVFV
AAIEAKLYALAIIGVLASVVGAYYYLRVIKLMWFDEATGEFARVSGSLRLVFGLSGLFVTAYVLIGGPIGGAAELAAATL
F

Sequences:

>Translated_481_residues
MTAETILLSLHLSAPELILAVGALVLLMVGVFSGERSGLVVTGLAIVLLLAAGLWLLFVPAEGLAYGGVYMADGFSRFMK
LVALIGSLVALFMTMGHARENQLDKFEFPVLLVLATLGILLMISANDLISLYLALELQSLALYVVAAINRDSLKSTEAGL
KYFVLGALSSGMLLYGMSLVYGFTGHTHFSEIAQALSVEGARSLGLIFGLVFILAGIAFKISAVPFHMWTPDVYEGAPTP
VTAFLAAAPKVAAMAMMTRIVITAFQPVLADWQQVVVFISIASMLLGSFAAIGQKNIKRLMAYSSIGHMGYALVGLAAGN
QTGVSGVMLYMVIYMVMTLGTFAIIMSMRRKDGTVVEEVNDLAGLSTTNPFMAVVLTALMFSLAGIPPLAGFFAKYFVFV
AAIEAKLYALAIIGVLASVVGAYYYLRVIKLMWFDEATGEFARVSGSLRLVFGLSGLFVTAYVLIGGPIGGAAELAAATL
F
>Mature_480_residues
TAETILLSLHLSAPELILAVGALVLLMVGVFSGERSGLVVTGLAIVLLLAAGLWLLFVPAEGLAYGGVYMADGFSRFMKL
VALIGSLVALFMTMGHARENQLDKFEFPVLLVLATLGILLMISANDLISLYLALELQSLALYVVAAINRDSLKSTEAGLK
YFVLGALSSGMLLYGMSLVYGFTGHTHFSEIAQALSVEGARSLGLIFGLVFILAGIAFKISAVPFHMWTPDVYEGAPTPV
TAFLAAAPKVAAMAMMTRIVITAFQPVLADWQQVVVFISIASMLLGSFAAIGQKNIKRLMAYSSIGHMGYALVGLAAGNQ
TGVSGVMLYMVIYMVMTLGTFAIIMSMRRKDGTVVEEVNDLAGLSTTNPFMAVVLTALMFSLAGIPPLAGFFAKYFVFVA
AIEAKLYALAIIGVLASVVGAYYYLRVIKLMWFDEATGEFARVSGSLRLVFGLSGLFVTAYVLIGGPIGGAAELAAATLF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=304, Percent_Identity=25, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI145693160, Length=363, Percent_Identity=37.7410468319559, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788831, Length=393, Percent_Identity=27.735368956743, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1788613, Length=413, Percent_Identity=23.4866828087167, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788614, Length=364, Percent_Identity=23.3516483516484, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788829, Length=255, Percent_Identity=26.2745098039216, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788827, Length=294, Percent_Identity=24.8299319727891, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 50986; Mature: 50855

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAETILLSLHLSAPELILAVGALVLLMVGVFSGERSGLVVTGLAIVLLLAAGLWLLFVP
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEC
AEGLAYGGVYMADGFSRFMKLVALIGSLVALFMTMGHARENQLDKFEFPVLLVLATLGIL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHH
LMISANDLISLYLALELQSLALYVVAAINRDSLKSTEAGLKYFVLGALSSGMLLYGMSLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YGFTGHTHFSEIAQALSVEGARSLGLIFGLVFILAGIAFKISAVPFHMWTPDVYEGAPTP
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECEEECCCCHHCCCCCCH
VTAFLAAAPKVAAMAMMTRIVITAFQPVLADWQQVVVFISIASMLLGSFAAIGQKNIKRL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAYSSIGHMGYALVGLAAGNQTGVSGVMLYMVIYMVMTLGTFAIIMSMRRKDGTVVEEVN
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLAGLSTTNPFMAVVLTALMFSLAGIPPLAGFFAKYFVFVAAIEAKLYALAIIGVLASVV
HHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAYYYLRVIKLMWFDEATGEFARVSGSLRLVFGLSGLFVTAYVLIGGPIGGAAELAAATL
HHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHC
F
C
>Mature Secondary Structure 
TAETILLSLHLSAPELILAVGALVLLMVGVFSGERSGLVVTGLAIVLLLAAGLWLLFVP
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEC
AEGLAYGGVYMADGFSRFMKLVALIGSLVALFMTMGHARENQLDKFEFPVLLVLATLGIL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHH
LMISANDLISLYLALELQSLALYVVAAINRDSLKSTEAGLKYFVLGALSSGMLLYGMSLV
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
YGFTGHTHFSEIAQALSVEGARSLGLIFGLVFILAGIAFKISAVPFHMWTPDVYEGAPTP
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECEEECCCCHHCCCCCCH
VTAFLAAAPKVAAMAMMTRIVITAFQPVLADWQQVVVFISIASMLLGSFAAIGQKNIKRL
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAYSSIGHMGYALVGLAAGNQTGVSGVMLYMVIYMVMTLGTFAIIMSMRRKDGTVVEEVN
HHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DLAGLSTTNPFMAVVLTALMFSLAGIPPLAGFFAKYFVFVAAIEAKLYALAIIGVLASVV
HHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAYYYLRVIKLMWFDEATGEFARVSGSLRLVFGLSGLFVTAYVLIGGPIGGAAELAAATL
HHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHC
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA