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The map label for this gene is nuoE1 [H]

Identifier: 209548867

GI number: 209548867

Start: 1279954

End: 1281120

Strand: Direct

Name: nuoE1 [H]

Synonym: Rleg2_1264

Alternate gene names: 209548867

Gene position: 1279954-1281120 (Clockwise)

Preceding gene: 209548866

Following gene: 209548868

Centisome position: 28.21

GC content: 64.27

Gene sequence:

>1167_bases
ATGTCCGTTCGTCGATTAGCCGAAGATCAATTTCAGCCTGCCGCATTCGCTTTCAGCGATGAAAATGCGGTCTGGGCGGA
CAAGACGATCCAGAAATACCCCGCCGGCCGCCAGCAGTCGGCGGTCATCCCGCTGTTGATGCGGGCGCAGGAGCAGGACG
GTTGGGTCACGCGCGCGGCGATCGAAAAGATCGCCGACATGCTCGATATGGCCTATATCCGGGTGCTTGAGGTCGCGACC
TTCTATACGCAGTTCCAGCTGCATCCTGTCGGCACCCGCGCCCATGTCCAGGTCTGCGGCACGACGCCCTGCATGCTGCG
CGGCTCGGAAGCGCTGATGTCGGTCTGCAAGAGCAAGATCCACGCCCATGCCTTCGAGCGCAATGCCGAGGGCACGCTGT
CCTGGGAAGAGGTCGAATGTCTTGGCGCCTGCGTCAACGCCCCGATGGTGATGATCGGCAAGGACACCTATGAAGACCTG
ACGCCGGCGCGTCTCGAAGAAATCATCGATACTTTTGCTGCCGGCAATGGCGCGAGTATCAAGCCCGGCACCCAGATCGA
CCGGATTTTCTCCGCCCCTGAAGGCGGCCCGACTTCGCTGACGACGGAAGAGCCGAAGGCAAGGACGCGCGCCAAGAAGG
CCGATGCCGAAAGCATTTCGGCTCCCGTCGACGCCGCTCCGGTTCCGCCCTCCGAGGCTGCCCGCCCGAAGAGCACCGAT
GCCGAAACCAACGCTGCCCTGAAGACGCCGGCAACGGCGCCGAAGGCGGCTGCCAGGAATGCCAAGGCTGCCGAGCAGCA
GCCGGTTTCCGGCACGGCACCTGCCGAACCGGCACCGGTGGCGGCCGCCAAGGCCGAAGCCGCCCGGGCGGCAAAGCCTG
CTCTCACCGACAAGAACCGTCCGGCCGGCATCGAAAAGCCCGCCGCGCCGGATGACCTGAAGATGATCTCCGGCGTCGGC
CCGAAGATCGAGGCGACGCTGAACGAAATCGGCATCTTCACCTTCTCGCAGGTCGCGGGCTGGAAGAAGGCCGAACGCGA
ATGGGTCGACGGCTACCTGAACTTCCGCGGCCGCATCGAGCGCGACGACTGGGTCAAGCAGGCCAAGGCGCTCGCCAAGG
GCGGCGAAGCGGAATATATCAAGGTCTTCGGCAAGAAGCCGCGGTAA

Upstream 100 bases:

>100_bases
GTCGTATTTATGCAGAAAGACCAGTCGGCCTATGCCTGCGAAATGCAGTCTTTGACCGCTTCGCGGTGTGGAACCCTAAA
CTGACAAGGCGTGAGGAAGA

Downstream 100 bases:

>100_bases
GAGGTGAAGCATGTTACAAGATAAAGACCGCATCTTTACCAACATCTACGGCCTCAAGGACAAGTCCCTGAAGGGCGCGA
TGAGCCGCGGCCACTGGGAC

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 1; NDH-1 subunit E 1 [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSVRRLAEDQFQPAAFAFSDENAVWADKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAAIEKIADMLDMAYIRVLEVAT
FYTQFQLHPVGTRAHVQVCGTTPCMLRGSEALMSVCKSKIHAHAFERNAEGTLSWEEVECLGACVNAPMVMIGKDTYEDL
TPARLEEIIDTFAAGNGASIKPGTQIDRIFSAPEGGPTSLTTEEPKARTRAKKADAESISAPVDAAPVPPSEAARPKSTD
AETNAALKTPATAPKAAARNAKAAEQQPVSGTAPAEPAPVAAAKAEAARAAKPALTDKNRPAGIEKPAAPDDLKMISGVG
PKIEATLNEIGIFTFSQVAGWKKAEREWVDGYLNFRGRIERDDWVKQAKALAKGGEAEYIKVFGKKPR

Sequences:

>Translated_388_residues
MSVRRLAEDQFQPAAFAFSDENAVWADKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAAIEKIADMLDMAYIRVLEVAT
FYTQFQLHPVGTRAHVQVCGTTPCMLRGSEALMSVCKSKIHAHAFERNAEGTLSWEEVECLGACVNAPMVMIGKDTYEDL
TPARLEEIIDTFAAGNGASIKPGTQIDRIFSAPEGGPTSLTTEEPKARTRAKKADAESISAPVDAAPVPPSEAARPKSTD
AETNAALKTPATAPKAAARNAKAAEQQPVSGTAPAEPAPVAAAKAEAARAAKPALTDKNRPAGIEKPAAPDDLKMISGVG
PKIEATLNEIGIFTFSQVAGWKKAEREWVDGYLNFRGRIERDDWVKQAKALAKGGEAEYIKVFGKKPR
>Mature_387_residues
SVRRLAEDQFQPAAFAFSDENAVWADKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAAIEKIADMLDMAYIRVLEVATF
YTQFQLHPVGTRAHVQVCGTTPCMLRGSEALMSVCKSKIHAHAFERNAEGTLSWEEVECLGACVNAPMVMIGKDTYEDLT
PARLEEIIDTFAAGNGASIKPGTQIDRIFSAPEGGPTSLTTEEPKARTRAKKADAESISAPVDAAPVPPSEAARPKSTDA
ETNAALKTPATAPKAAARNAKAAEQQPVSGTAPAEPAPVAAAKAEAARAAKPALTDKNRPAGIEKPAAPDDLKMISGVGP
KIEATLNEIGIFTFSQVAGWKKAEREWVDGYLNFRGRIERDDWVKQAKALAKGGEAEYIKVFGKKPR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=192, Percent_Identity=45.3125, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1788621, Length=163, Percent_Identity=30.6748466257669, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17561328, Length=207, Percent_Identity=41.5458937198068, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI18859877, Length=192, Percent_Identity=43.75, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21355353, Length=191, Percent_Identity=32.9842931937173, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 41712; Mature: 41580

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRLAEDQFQPAAFAFSDENAVWADKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAA
CCHHHHHHHCCCCCEEEECCCCCEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHH
IEKIADMLDMAYIRVLEVATFYTQFQLHPVGTRAHVQVCGTTPCMLRGSEALMSVCKSKI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCCEECCCHHHHHHHHHHH
HAHAFERNAEGTLSWEEVECLGACVNAPMVMIGKDTYEDLTPARLEEIIDTFAAGNGASI
HHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHCCHHHHHHHHHHHHCCCCCCC
KPGTQIDRIFSAPEGGPTSLTTEEPKARTRAKKADAESISAPVDAAPVPPSEAARPKSTD
CCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCC
AETNAALKTPATAPKAAARNAKAAEQQPVSGTAPAEPAPVAAAKAEAARAAKPALTDKNR
CCCCCCCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
PAGIEKPAAPDDLKMISGVGPKIEATLNEIGIFTFSQVAGWKKAEREWVDGYLNFRGRIE
CCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
RDDWVKQAKALAKGGEAEYIKVFGKKPR
HHHHHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure 
SVRRLAEDQFQPAAFAFSDENAVWADKTIQKYPAGRQQSAVIPLLMRAQEQDGWVTRAA
CHHHHHHHCCCCCEEEECCCCCEEHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHH
IEKIADMLDMAYIRVLEVATFYTQFQLHPVGTRAHVQVCGTTPCMLRGSEALMSVCKSKI
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEECCCCCCEECCCHHHHHHHHHHH
HAHAFERNAEGTLSWEEVECLGACVNAPMVMIGKDTYEDLTPARLEEIIDTFAAGNGASI
HHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHCCHHHHHHHHHHHHCCCCCCC
KPGTQIDRIFSAPEGGPTSLTTEEPKARTRAKKADAESISAPVDAAPVPPSEAARPKSTD
CCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCC
AETNAALKTPATAPKAAARNAKAAEQQPVSGTAPAEPAPVAAAKAEAARAAKPALTDKNR
CCCCCCCCCCCCCCHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
PAGIEKPAAPDDLKMISGVGPKIEATLNEIGIFTFSQVAGWKKAEREWVDGYLNFRGRIE
CCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
RDDWVKQAKALAKGGEAEYIKVFGKKPR
HHHHHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]