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The map label for this gene is clpP [H]

Identifier: 209548850

GI number: 209548850

Start: 1262053

End: 1262682

Strand: Direct

Name: clpP [H]

Synonym: Rleg2_1247

Alternate gene names: 209548850

Gene position: 1262053-1262682 (Clockwise)

Preceding gene: 209548847

Following gene: 209548851

Centisome position: 27.81

GC content: 60.95

Gene sequence:

>630_bases
ATGAGAAACCCAGTCGATACCGCAATGGCCCTCGTGCCGATGGTCGTGGAACAGACCAACCGCGGTGAACGCTCCTACGA
CATCTATTCCCGCCTGTTGAAGGAACGCATCATCTTCCTGACCGGTGCCGTCGAAGACCATATGGCAACGCTCGTCTGCG
CCCAGCTTCTCTTCCTCGAGGCCGAAAACCCGAAGAAGGAAATCGCCCTATACATCAATTCGCCGGGCGGCGTCGTCACC
GCCGGCATGGCGATCTACGATACGATGCAGTTCATCAAGCCGGCGGTTTCGACGCTCTGCATCGGCCAGGCCGCATCCAT
GGGCTCGCTGCTGCTGGCGGCCGGCCACAAGGACATGCGCTTCGCCACGCCGAATTCCCGCATCATGGTGCATCAGCCCT
CGGGCGGCTTCCAGGGCCAGGCCTCGGACATCGAGCGCCATGCCCGCGACATCCTCAAGATGAAGCGCCGCCTGAACGAG
GTCTATGTCAAGCACACCGGCCGCACCTACGAGGAAGTTGAAAAGACGCTCGATCGTGACCATTTCATGGATGCGGACGA
AGCCCAGGGCTGGGGCGTGATCGACAAGGTTCTGACGTCGCGCCTCGAAATGGAAGGCGAACAGGCCTAG

Upstream 100 bases:

>100_bases
ATGCGTGTCTTGAAGAGAAGGGCACGGACACTCTATGTAGGGATAAGACATTTTCTTTGATTCCCGGCGCCGGCCGGCGA
GACGCTGACAAAGGACGCAC

Downstream 100 bases:

>100_bases
TAATTAATTGGGATGGTGTTTTCGTCGCCACAGTTCTATCTCATTTGTGATCGAACAAGGCTTTCAACTGGCGACGAAGA
CGCTAATAGTAGCTATTAAT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGAVEDHMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMRFATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNE
VYVKHTGRTYEEVEKTLDRDHFMDADEAQGWGVIDKVLTSRLEMEGEQA

Sequences:

>Translated_209_residues
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGAVEDHMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMRFATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNE
VYVKHTGRTYEEVEKTLDRDHFMDADEAQGWGVIDKVLTSRLEMEGEQA
>Mature_209_residues
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGAVEDHMATLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMRFATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNE
VYVKHTGRTYEEVEKTLDRDHFMDADEAQGWGVIDKVLTSRLEMEGEQA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=59.375, Blast_Score=248, Evalue=3e-66,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=68.9119170984456, Blast_Score=293, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=61.1702127659574, Blast_Score=242, Evalue=8e-65,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=64.3617021276596, Blast_Score=264, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23346; Mature: 23346

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGAVEDHMATLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTAGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMR
CCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNEVYVKHTGRTYEEVEKTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HFMDADEAQGWGVIDKVLTSRLEMEGEQA
HCCCCCCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRNPVDTAMALVPMVVEQTNRGERSYDIYSRLLKERIIFLTGAVEDHMATLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTAGMAIYDTMQFIKPAVSTLCIGQAASMGSLLLAAGHKDMR
CCCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FATPNSRIMVHQPSGGFQGQASDIERHARDILKMKRRLNEVYVKHTGRTYEEVEKTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HFMDADEAQGWGVIDKVLTSRLEMEGEQA
HCCCCCCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]