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The map label for this gene is hppA [H]

Identifier: 209548795

GI number: 209548795

Start: 1202001

End: 1204139

Strand: Direct

Name: hppA [H]

Synonym: Rleg2_1192

Alternate gene names: 209548795

Gene position: 1202001-1204139 (Clockwise)

Preceding gene: 209548794

Following gene: 209548797

Centisome position: 26.49

GC content: 64.8

Gene sequence:

>2139_bases
ATGACGATTCTTTTATGCGTAATCGCATGCGGTCTGCTCTCGGTGGTCTATGCCGCCTGGGCAACCCGGTCGGTGCTTGC
CGCCGATCAGGGCAACAGCCGCATGCAGGAGATCGCGGGTTATATCCGCGAAGGCGCTCAGGCCTATCTGACCCGCCAGT
ACAGAACCATTGCCCTTGTCGGCGTCGTTGTTTTCATCGCAGCCTGGCTGCTTCTTTCCGCCACGGCCGCCATCGGCTTC
CTGATCGGCGCCGTGCTTTCCGGTGCTGCCGGCTTCATCGGCATGCATGTCTCCGTCCGCGCCAATGTGCGCACCGCCCA
GGCGGCTTCCACCAGCCTCTCGGCCGGCCTCGACATCGCCTTCAAGTCGGGTGCGATCACCGGCATGCTGGTGGCGGGCC
TCGCACTGCTCGGCGTCTCCATTTACTATACTATTTTGACCTTCGGCCTCGGCCATGAGAGCGGCTCGCGCGAAGTCATC
GATGCGCTGGTGGCGCTCGGCTTCGGTGCTTCGCTGATTTCCATCTTCGCCCGTCTCGGCGGCGGCATCTTCACCAAGGG
CGCCGATGTCGGCGGCGACCTCGTCGGCAAGGTGGAAGCCGGCATTCCGGAGGACGATCCGCGCAACCCGGCAACGATTG
CCGATAACGTCGGCGACAATGTCGGCGATTGCGCCGGCATGGCCGCCGACCTTTTCGAGACTTATGCGGTTTCCGTCGTC
GCCACCATGGTTCTGGCCGCAATCTTCTTTGCCGGCGCGCCGATCCTCCAGTCGGCGATGATCTATCCGCTGGCGATCTG
CGGCGCCTGCATCATCACCTCGATCATCGGCACTTTCTTCGTCAAGCTCGGCTCGAACGGCTCGATCATGGGCGCGCTCT
ACAAGGGGCTCATCGTCACCGGCCTGCTGTCCATCGTCGGTCTCGGCGCCGCCACCTCGCTGACGGTCGGCTGGGGCTCG
CTCGGCACGGTCGCCGGCGCCGACGTCACAGGCACGAACCTGTTCGTCTGCGGCCTTGTCGGCCTCGTCGTCACCGCGCT
GATCGTCGTCATCACCGAATACTACACCGGCACCGGCAAGCGTCCGGTCGTGTCGATCGCCCAGTCGTCGGTGACCGGTC
ACGGCACCAACGTCATCCAGGGCCTGGCGGTCTCGCTGGAATCGACCGCCCTGCCGGCGATCGTCATCGTCGGCGGTATT
CTTGCCACCTACCAGCTCGGCGGCCTTTTCGGCACCGGCATCGCGGTTACCGCCATGCTCGGCCTTGCCGGCATGATTGT
CGCGCTCGACGCCTTCGGCCCGGTCACCGACAATGCCGGCGGCATCGCCGAAATGGCGCATCTGCCGCCTGAGGTGCGCA
AATCGACCGACGCGCTCGACGCCGTCGGCAATACCACCAAGGCGGTCACCAAGGGTTACGCGATCGGCTCGGCGGGTCTC
GGCGCGCTGGTGCTCTTCGCCGCCTACGCCAACGACCTGCGGTATTTCGCAGCCCATGGCGATCAGTACCCCTATTTCGC
CAATATCGGCGAAATCTCGTTCGAGTTGTCGAATCCCTATGTCGTCGCCGGCCTGCTGTTCGGCGGCCTGATCCCCTATC
TCTTCGGCGGCATCGCCATGACCGCCGTCGGCCGCGCCGCCGGTTCGATCGTCGAAGAGGTGCGGCGTCAGTTCAAGGAA
AAGCCCGGCATCATGCAGGGCACCGAGAAGCCGGATTACGGCAAGGCGGTCGACCTTCTGACCAAGGCCGCCATCCGTGA
AATGCTCGTGCCGTCGCTGCTGCCGGTGCTGGCGCCGATCGTCGTCTATTTCGGCGTGCTGCTGATCTCCGGCTCCAAGG
CTTCGGCCTTCGCCGCTCTCGGCGCATCGCTGCTCGGCGTCATCATCAACGGCCTGTTCGTCGCCATCTCGATGACATCG
GGCGGCGGCGCCTGGGACAATGCCAAGAAGAGCTTCGAGGACGGCTTCGTCGACAAGGACGGCGTGCGTCACATGAAGGG
CTCGGATGCGCACAAGGCGTCGGTCACCGGCGATACCGTCGGCGATCCCTACAAGGACACGGCCGGCCCCGCCGTCAACC
CGGCGATCAAGATCACCAACATCGTCGCGCTGCTGCTGCTCGCCGTTCTCGCCGGTTGA

Upstream 100 bases:

>100_bases
CGCACCGCTTAGCTGTGGCATTTCTGTGGAGAGGAAGGCGAGTCGGCGGCATATCTGCCGGAGAAGGAGTGATCTCCGGC
CTATGGGAGGAAAGAGCGAA

Downstream 100 bases:

>100_bases
TAAATCCAGGCATCACGGTTCGCCGTGGTGCCATACCCCGACCATTAAAAAACCCGCCGGAAGGCGGGTTTTTCGTTGAA
AATCTGTTCGATCAGCGCAG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 712; Mature: 711

Protein sequence:

>712_residues
MTILLCVIACGLLSVVYAAWATRSVLAADQGNSRMQEIAGYIREGAQAYLTRQYRTIALVGVVVFIAAWLLLSATAAIGF
LIGAVLSGAAGFIGMHVSVRANVRTAQAASTSLSAGLDIAFKSGAITGMLVAGLALLGVSIYYTILTFGLGHESGSREVI
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
ATMVLAAIFFAGAPILQSAMIYPLAICGACIITSIIGTFFVKLGSNGSIMGALYKGLIVTGLLSIVGLGAATSLTVGWGS
LGTVAGADVTGTNLFVCGLVGLVVTALIVVITEYYTGTGKRPVVSIAQSSVTGHGTNVIQGLAVSLESTALPAIVIVGGI
LATYQLGGLFGTGIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMAHLPPEVRKSTDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYANDLRYFAAHGDQYPYFANIGEISFELSNPYVVAGLLFGGLIPYLFGGIAMTAVGRAAGSIVEEVRRQFKE
KPGIMQGTEKPDYGKAVDLLTKAAIREMLVPSLLPVLAPIVVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTS
GGGAWDNAKKSFEDGFVDKDGVRHMKGSDAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAG

Sequences:

>Translated_712_residues
MTILLCVIACGLLSVVYAAWATRSVLAADQGNSRMQEIAGYIREGAQAYLTRQYRTIALVGVVVFIAAWLLLSATAAIGF
LIGAVLSGAAGFIGMHVSVRANVRTAQAASTSLSAGLDIAFKSGAITGMLVAGLALLGVSIYYTILTFGLGHESGSREVI
DALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
ATMVLAAIFFAGAPILQSAMIYPLAICGACIITSIIGTFFVKLGSNGSIMGALYKGLIVTGLLSIVGLGAATSLTVGWGS
LGTVAGADVTGTNLFVCGLVGLVVTALIVVITEYYTGTGKRPVVSIAQSSVTGHGTNVIQGLAVSLESTALPAIVIVGGI
LATYQLGGLFGTGIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMAHLPPEVRKSTDALDAVGNTTKAVTKGYAIGSAGL
GALVLFAAYANDLRYFAAHGDQYPYFANIGEISFELSNPYVVAGLLFGGLIPYLFGGIAMTAVGRAAGSIVEEVRRQFKE
KPGIMQGTEKPDYGKAVDLLTKAAIREMLVPSLLPVLAPIVVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTS
GGGAWDNAKKSFEDGFVDKDGVRHMKGSDAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAG
>Mature_711_residues
TILLCVIACGLLSVVYAAWATRSVLAADQGNSRMQEIAGYIREGAQAYLTRQYRTIALVGVVVFIAAWLLLSATAAIGFL
IGAVLSGAAGFIGMHVSVRANVRTAQAASTSLSAGLDIAFKSGAITGMLVAGLALLGVSIYYTILTFGLGHESGSREVID
ALVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVVA
TMVLAAIFFAGAPILQSAMIYPLAICGACIITSIIGTFFVKLGSNGSIMGALYKGLIVTGLLSIVGLGAATSLTVGWGSL
GTVAGADVTGTNLFVCGLVGLVVTALIVVITEYYTGTGKRPVVSIAQSSVTGHGTNVIQGLAVSLESTALPAIVIVGGIL
ATYQLGGLFGTGIAVTAMLGLAGMIVALDAFGPVTDNAGGIAEMAHLPPEVRKSTDALDAVGNTTKAVTKGYAIGSAGLG
ALVLFAAYANDLRYFAAHGDQYPYFANIGEISFELSNPYVVAGLLFGGLIPYLFGGIAMTAVGRAAGSIVEEVRRQFKEK
PGIMQGTEKPDYGKAVDLLTKAAIREMLVPSLLPVLAPIVVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTSG
GGAWDNAKKSFEDGFVDKDGVRHMKGSDAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAG

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72270; Mature: 72139

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILLCVIACGLLSVVYAAWATRSVLAADQGNSRMQEIAGYIREGAQAYLTRQYRTIALV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVFIAAWLLLSATAAIGFLIGAVLSGAAGFIGMHVSVRANVRTAQAASTSLSAGLDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEEECCHHHHHHHHHHHCCCEEE
FKSGAITGMLVAGLALLGVSIYYTILTFGLGHESGSREVIDALVALGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAGAPILQSAMIYPLAICGACIITSIIGTFFVKLGSNGSIMGALYKGLIVT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GLLSIVGLGAATSLTVGWGSLGTVAGADVTGTNLFVCGLVGLVVTALIVVITEYYTGTGK
HHHHHHHCCCHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPVVSIAQSSVTGHGTNVIQGLAVSLESTALPAIVIVGGILATYQLGGLFGTGIAVTAML
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMAHLPPEVRKSTDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYANDLRYFAAHGDQYPYFANIGEISFELSNPYVVAGLLFGGLIPYLFGGIAM
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
TAVGRAAGSIVEEVRRQFKEKPGIMQGTEKPDYGKAVDLLTKAAIREMLVPSLLPVLAPI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTSGGGAWDNAKKSFEDGFVDKD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHCCCCCCC
GVRHMKGSDAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAG
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TILLCVIACGLLSVVYAAWATRSVLAADQGNSRMQEIAGYIREGAQAYLTRQYRTIALV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVVFIAAWLLLSATAAIGFLIGAVLSGAAGFIGMHVSVRANVRTAQAASTSLSAGLDIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEEECCHHHHHHHHHHHCCCEEE
FKSGAITGMLVAGLALLGVSIYYTILTFGLGHESGSREVIDALVALGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVSVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAGAPILQSAMIYPLAICGACIITSIIGTFFVKLGSNGSIMGALYKGLIVT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GLLSIVGLGAATSLTVGWGSLGTVAGADVTGTNLFVCGLVGLVVTALIVVITEYYTGTGK
HHHHHHHCCCHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPVVSIAQSSVTGHGTNVIQGLAVSLESTALPAIVIVGGILATYQLGGLFGTGIAVTAML
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
GLAGMIVALDAFGPVTDNAGGIAEMAHLPPEVRKSTDALDAVGNTTKAVTKGYAIGSAGL
HHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHH
GALVLFAAYANDLRYFAAHGDQYPYFANIGEISFELSNPYVVAGLLFGGLIPYLFGGIAM
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHH
TAVGRAAGSIVEEVRRQFKEKPGIMQGTEKPDYGKAVDLLTKAAIREMLVPSLLPVLAPI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVYFGVLLISGSKASAFAALGASLLGVIINGLFVAISMTSGGGAWDNAKKSFEDGFVDKD
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHCCCCCCC
GVRHMKGSDAHKASVTGDTVGDPYKDTAGPAVNPAIKITNIVALLLLAVLAG
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]