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The map label for this gene is pepA [H]

Identifier: 209548673

GI number: 209548673

Start: 1089323

End: 1090813

Strand: Direct

Name: pepA [H]

Synonym: Rleg2_1070

Alternate gene names: 209548673

Gene position: 1089323-1090813 (Clockwise)

Preceding gene: 209548665

Following gene: 209548674

Centisome position: 24.0

GC content: 62.71

Gene sequence:

>1491_bases
ATGTCAGCAAAGTTCGAAATCTCATTTTCAAAGTCGGCGAAGCTCACTGGCGGCCTGGCGATCCTGTTGAAGACCACGGA
CGCCGACAGCGCTGCGGGCGCCGAAACAGTCGATCCGGCAGGCGTGATCGCCAAGGCCGCCAGGATCGCCCGATTCTCCG
CGAAATCCATGAGCGCGCTCGATATCGTTGCCCCGGAAGGCGCATCCGTCGAGCGCATTGTCGTCATCGGGCTCGGCAAG
GCCGCCGACCTCACCGCCCATGATTGGCTGAAGGCCGGCGGTACGGCGGCAGCGAGAATCAAGAATACCGACAAGACGGC
CGTCTTCATCGACGTGCCTGGCCGTGAGACGAGCGCGCGGGCCGCCGCCGATTTCGCCCTCGGCATGCTGCTGCGCACCT
ATAGCTTCGATACCTACAAGACGAAGAAGAACGACGACGAGGAAAAGGCGGGTAAATCCGTCAAGGTGACGATCGTCACC
ACCGATCCGGCCGGCGCCAAGAAGGCGTTTTCCGATTCCGAAGCGATAGCCGGCGGCGTCAATCTTGCCCGTGACCTCGT
CAACGAGCCGCCGAACGTGCTCGGCCCGGTCGAGTTCGCGGCCAAGGCGAAGGAACTGGAAAAGCTCGGCATCGAAGTGG
AAATCCTGACCGAGAAGGAAATGCGCCGTTTCGGCATGGGCGCCCTTCTCGGCGTCGCCCAGGGCTCCGTGCGTCCGCCG
CGCCTGGCGGTGATGCAATGGAAGGGCGGCAAAGCCAAGGATCGTCCTGTCGCCTTCATCGGCAAGGGCGTCGTCTTCGA
TACCGGCGGCATTTCGATCAAGCCTGCCGCCGGCATGGAGGACATGAAGGGCGATATGGGCGGCGCGGCAGCCGTCACCG
GCCTCATGCACGTGCTCGCCTCGCGCAAGGCCGCCGTCAACGCCGTCGGCATCATCGGCCTGGTCGAGAACATGCCTGAC
GGCAACGCCCAGCGTCCCGGCGATATCGTCACCTCGATGTCAGGCCAGACGATCGAGGTGATCAATACCGATGCCGAAGG
CCGTCTCGTGCTCTGCGATGCGCTCTGGTATTGCAACGACCGTTTCAAGCCTCAGTTCATGATCAATCTCGCCACGCTGA
CCGGCGCGATCGTCGTGGCGCTCGGCAATGTGCATGCCGGCCTGTTTTCCAATGACGATCAACTTTCCGCTCAGCTGACG
GAAGCCGGCCTTTCCACAAACGAGAAGCTCTGGCGCATGCCCCTCGGCAAGGACTACGACAAGCTGATCGACAGCAAGTT
CGCCGACATGAAGAACACCGGCGGCCGGCAGGCCGGCTCGATTACCGCTGCGCATTTCATCAAGCGCTTCGTACAGGACA
CGCCCTGGGCGCATCTCGATATCGCCGGCACGGCGATGGGCTCGCCGCAGGACGAGATCAACCAGTCCTGGGGTTCCGGT
TTTGGCGTGCGCCTGCTCGACGAGCTCGTTCGCGCCCATTATGAATCCTGA

Upstream 100 bases:

>100_bases
CCGCGGGCGACCATAACAATTGTCGCAAGCCATTGACAGACCCGCCAAACGCGAAATTATCCGCGGCGGACGGATTTCAA
AGAATCCCAGCGGAGAAGAC

Downstream 100 bases:

>100_bases
TGACGGACGTTCTCTTTTATCATCTGACCGAAACCAAGCTGGAAGACGCGCTTCCGCCGCTGATCGACAAAAGCGTCGAG
CGCGGCTGGCGCGTCGCCGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSAKFEISFSKSAKLTGGLAILLKTTDADSAAGAETVDPAGVIAKAARIARFSAKSMSALDIVAPEGASVERIVVIGLGK
AADLTAHDWLKAGGTAAARIKNTDKTAVFIDVPGRETSARAAADFALGMLLRTYSFDTYKTKKNDDEEKAGKSVKVTIVT
TDPAGAKKAFSDSEAIAGGVNLARDLVNEPPNVLGPVEFAAKAKELEKLGIEVEILTEKEMRRFGMGALLGVAQGSVRPP
RLAVMQWKGGKAKDRPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHVLASRKAAVNAVGIIGLVENMPD
GNAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCNDRFKPQFMINLATLTGAIVVALGNVHAGLFSNDDQLSAQLT
EAGLSTNEKLWRMPLGKDYDKLIDSKFADMKNTGGRQAGSITAAHFIKRFVQDTPWAHLDIAGTAMGSPQDEINQSWGSG
FGVRLLDELVRAHYES

Sequences:

>Translated_496_residues
MSAKFEISFSKSAKLTGGLAILLKTTDADSAAGAETVDPAGVIAKAARIARFSAKSMSALDIVAPEGASVERIVVIGLGK
AADLTAHDWLKAGGTAAARIKNTDKTAVFIDVPGRETSARAAADFALGMLLRTYSFDTYKTKKNDDEEKAGKSVKVTIVT
TDPAGAKKAFSDSEAIAGGVNLARDLVNEPPNVLGPVEFAAKAKELEKLGIEVEILTEKEMRRFGMGALLGVAQGSVRPP
RLAVMQWKGGKAKDRPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHVLASRKAAVNAVGIIGLVENMPD
GNAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCNDRFKPQFMINLATLTGAIVVALGNVHAGLFSNDDQLSAQLT
EAGLSTNEKLWRMPLGKDYDKLIDSKFADMKNTGGRQAGSITAAHFIKRFVQDTPWAHLDIAGTAMGSPQDEINQSWGSG
FGVRLLDELVRAHYES
>Mature_495_residues
SAKFEISFSKSAKLTGGLAILLKTTDADSAAGAETVDPAGVIAKAARIARFSAKSMSALDIVAPEGASVERIVVIGLGKA
ADLTAHDWLKAGGTAAARIKNTDKTAVFIDVPGRETSARAAADFALGMLLRTYSFDTYKTKKNDDEEKAGKSVKVTIVTT
DPAGAKKAFSDSEAIAGGVNLARDLVNEPPNVLGPVEFAAKAKELEKLGIEVEILTEKEMRRFGMGALLGVAQGSVRPPR
LAVMQWKGGKAKDRPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHVLASRKAAVNAVGIIGLVENMPDG
NAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCNDRFKPQFMINLATLTGAIVVALGNVHAGLFSNDDQLSAQLTE
AGLSTNEKLWRMPLGKDYDKLIDSKFADMKNTGGRQAGSITAAHFIKRFVQDTPWAHLDIAGTAMGSPQDEINQSWGSGF
GVRLLDELVRAHYES

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=406, Percent_Identity=39.9014778325123, Blast_Score=251, Evalue=9e-67,
Organism=Homo sapiens, GI47155554, Length=365, Percent_Identity=33.1506849315069, Blast_Score=155, Evalue=7e-38,
Organism=Escherichia coli, GI1790710, Length=406, Percent_Identity=41.3793103448276, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI87082123, Length=323, Percent_Identity=37.4613003095975, Blast_Score=196, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=313, Percent_Identity=32.2683706070287, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=297, Percent_Identity=26.2626262626263, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24662227, Length=378, Percent_Identity=32.010582010582, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI20129969, Length=290, Percent_Identity=34.1379310344828, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24661038, Length=315, Percent_Identity=35.5555555555556, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21355725, Length=287, Percent_Identity=36.9337979094077, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161077148, Length=288, Percent_Identity=33.3333333333333, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI20130057, Length=288, Percent_Identity=33.3333333333333, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355645, Length=326, Percent_Identity=31.2883435582822, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662223, Length=326, Percent_Identity=31.2883435582822, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19922386, Length=407, Percent_Identity=29.2383292383292, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129963, Length=288, Percent_Identity=32.6388888888889, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI21357381, Length=324, Percent_Identity=33.9506172839506, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI221379063, Length=324, Percent_Identity=33.9506172839506, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI221379062, Length=324, Percent_Identity=33.9506172839506, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24646701, Length=233, Percent_Identity=28.3261802575107, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24646703, Length=233, Percent_Identity=28.3261802575107, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21358201, Length=233, Percent_Identity=28.3261802575107, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52325; Mature: 52194

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKFEISFSKSAKLTGGLAILLKTTDADSAAGAETVDPAGVIAKAARIARFSAKSMSAL
CCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
DIVAPEGASVERIVVIGLGKAADLTAHDWLKAGGTAAARIKNTDKTAVFIDVPGRETSAR
EEECCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHH
AAADFALGMLLRTYSFDTYKTKKNDDEEKAGKSVKVTIVTTDPAGAKKAFSDSEAIAGGV
HHHHHHHHHHHHHHCCCCEECCCCCCHHHCCCEEEEEEEEECCCCCHHHCCCCHHHHHHH
NLARDLVNEPPNVLGPVEFAAKAKELEKLGIEVEILTEKEMRRFGMGALLGVAQGSVRPP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCCC
RLAVMQWKGGKAKDRPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHVLA
EEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHHH
SRKAAVNAVGIIGLVENMPDGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCND
HHHHHHHHHEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEEEECCCC
RFKPQFMINLATLTGAIVVALGNVHAGLFSNDDQLSAQLTEAGLSTNEKLWRMPLGKDYD
CCCCEEEEEHHHHHHEEEEEECCCEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCHH
KLIDSKFADMKNTGGRQAGSITAAHFIKRFVQDTPWAHLDIAGTAMGSPQDEINQSWGSG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCC
FGVRLLDELVRAHYES
CCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAKFEISFSKSAKLTGGLAILLKTTDADSAAGAETVDPAGVIAKAARIARFSAKSMSAL
CCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
DIVAPEGASVERIVVIGLGKAADLTAHDWLKAGGTAAARIKNTDKTAVFIDVPGRETSAR
EEECCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHH
AAADFALGMLLRTYSFDTYKTKKNDDEEKAGKSVKVTIVTTDPAGAKKAFSDSEAIAGGV
HHHHHHHHHHHHHHCCCCEECCCCCCHHHCCCEEEEEEEEECCCCCHHHCCCCHHHHHHH
NLARDLVNEPPNVLGPVEFAAKAKELEKLGIEVEILTEKEMRRFGMGALLGVAQGSVRPP
HHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHCCCCCCCC
RLAVMQWKGGKAKDRPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHVLA
EEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHHH
SRKAAVNAVGIIGLVENMPDGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCND
HHHHHHHHHEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEEEECCCC
RFKPQFMINLATLTGAIVVALGNVHAGLFSNDDQLSAQLTEAGLSTNEKLWRMPLGKDYD
CCCCEEEEEHHHHHHEEEEEECCCEECCCCCCHHHHHHHHHHCCCCCCCEEECCCCCCHH
KLIDSKFADMKNTGGRQAGSITAAHFIKRFVQDTPWAHLDIAGTAMGSPQDEINQSWGSG
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCC
FGVRLLDELVRAHYES
CCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA