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The map label for this gene is dxs [H]

Identifier: 209548170

GI number: 209548170

Start: 587109

End: 589025

Strand: Reverse

Name: dxs [H]

Synonym: Rleg2_0564

Alternate gene names: 209548170

Gene position: 589025-587109 (Counterclockwise)

Preceding gene: 209548172

Following gene: 209548167

Centisome position: 12.98

GC content: 65.57

Gene sequence:

>1917_bases
GTGACACAACTGCCGAAGACCCCCCTGCTCGATCAGGTCACCTACCCCGCCGACCTGCGCAAGCTCGAGGATCGCGACCT
GCCGCAGCTGGCCCGCGAAGTCCGGGACGAAATGATCGATGCGGTGTCGCGCACCGGCGGCCATCTCGGCGCCGGTCTCG
GCGTCGTCGAGCTGACGATCGCTATCCACAGCGTCTTCGACACGCCTGACGATCGGCTGATCTTCGATGTCGGCCATCAA
TGTTATCCGCACAAGATCCTCACCGGCCGGCGCGACCGCATCCGCACGCTGCGCCAGGAAGACGGACTTTCCGGCTTCAC
CCGCCGGGCCGAGAGCGAATACGACCCCTTCGGCGCGGCGCACTCCTCGACCTCGATCTCGGCCGGCCTCGGCATGGCAA
TCGCCGCCGATCTCGACAAGAACGACCGGCGCGTCATCGCCGTCATCGGCGACGGGGCGATGTCGGCCGGCATGGCCTAT
GAGGCGCTGAACAATGCCGGCGCGCTCGATGCGCGCCTCATCGTCATTCTCAACGACAACGACATGTCGATCGCGCCGCC
GACAGGCGCCATGAGCGCCTATCTCGCCCGCCTCGCCTCGGGCCGCACCTATATGGGCTTCCGCGACTTCGGCAAGAAGC
TGACGGCCTATCTCGGCAAGAATATCGACCGGGCGATCACCCGCGCCGTCGAGCATGCCCGCGGCTATGTCACCGGCGGC
ACCATGTTCGAGGAGATGGGCTTTTATCATATCGGGCCGATCGACGGGCATTCCTTCGACCATCTGCTGCCGGTGCTGCG
CAACGTGCGCGACAATGCCCGCGGACCGGTGCTGATCCATGTGGTCACCCAGAAGGGCAAGGGTTATCCGCCGGCCGAAG
CCGCCGCCGACAAATATCATGGCGTCAACAAGTTCGACGTCATCACCGGCGCCCAGGCCAGGGTCAAGCCGAATGCGCCG
AGCTATACCAGCGTCTTTGCCGAAGCGCTGGTGCAGGAAGCCACCCTCGACGACAAGATCGTCGGCATCACCGCCGCCAT
GCCGAACGGCACCGGCCTCGACAAGCTCGCCGAAGCCTTTCCGTCGCGCTGTTTCGATGTCGGCATCGCCGAGCAGCATG
CCGTGACCTTCGCCGCCGGCCTTGCAGCTGAGGGATACAAGCCGTTTGCGGCGCTCTATTCCACCTTCCTGCAGCGGGCC
TACGACCAGGTCGTTCACGACGTGGCGATCCAGGGACTGCCGGTGCGTTTTCCGATCGATCGTGCCGGCTTCGTCGGCGC
CGACGGTCCGACGCATGCCGGCTCCTTCGACACCGCCTTCCTCACCACCCTGCCCGGCTTCGTGGTGATGGCGGCGGCCG
ACGAGGCCGAACTCAAGCACATGGTGCGCACCGCCGTCGCCTATGACGCCGGGCCGATCTCGTTCCGTTATCCGCGCGGC
GAAGGTGTCGGCGTCGACATGCCGGTGCGCGGCGAAATCCTGCGGATCGGCAAGGGCCGCATCGTCAAGGAAGGCACCAA
GGTGGCGCTGCTCTCCTTCGGCACCCGGCTTGCCGATTGTCTGCTTGCCGCCGAAGATCTCGATGCCGCCGGCCTTTCGA
CGACGGTTGCCGATGCCCGCTTCGCCAAGCCGCTCGACCACGACCTGATCCGCCAGTTCGCCCGCCACCACGAGATGGTG
ATCACCGTCGAGGAAGGCTCGGTCGGCGGCTTCGGCAGCCAGGTGATGCAATATCTCTCAAGCGAAGGCCTGCTCGACAA
CGGCCTGAAGATCCGCTCACTTGTGATGCCCGATATCTGGATGGAGCAGGCAAAGCCCGAAGCGATGAACGCCCATGCCG
GGCTGGATCGCGCCGGGATTGTTTCGACCGTGTTCCGGGCGCTTGGGCGCGGGGTTGCGGTCGGGGTTGCTGGATAA

Upstream 100 bases:

>100_bases
TGCTCTAAGGTGAAAACCTTCGGTTCCTGAAAATCACTTGTTTTGCCTCGTTCTAATCGAATAAAGCGGTACAAGGAAAA
GTAAGAAAGAGCGCCCGCCC

Downstream 100 bases:

>100_bases
TGATTAGTGAGGGTGTGCCGTGAGGCCCCCTCATCCGCCCTACGGGCACCGACCGGGGTTGAGCCACTGGTCTCAACCCG
TCCTTCGGACCCCCGCAGGG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MTQLPKTPLLDQVTYPADLRKLEDRDLPQLAREVRDEMIDAVSRTGGHLGAGLGVVELTIAIHSVFDTPDDRLIFDVGHQ
CYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAIAADLDKNDRRVIAVIGDGAMSAGMAY
EALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKNIDRAITRAVEHARGYVTGG
TMFEEMGFYHIGPIDGHSFDHLLPVLRNVRDNARGPVLIHVVTQKGKGYPPAEAAADKYHGVNKFDVITGAQARVKPNAP
SYTSVFAEALVQEATLDDKIVGITAAMPNGTGLDKLAEAFPSRCFDVGIAEQHAVTFAAGLAAEGYKPFAALYSTFLQRA
YDQVVHDVAIQGLPVRFPIDRAGFVGADGPTHAGSFDTAFLTTLPGFVVMAAADEAELKHMVRTAVAYDAGPISFRYPRG
EGVGVDMPVRGEILRIGKGRIVKEGTKVALLSFGTRLADCLLAAEDLDAAGLSTTVADARFAKPLDHDLIRQFARHHEMV
ITVEEGSVGGFGSQVMQYLSSEGLLDNGLKIRSLVMPDIWMEQAKPEAMNAHAGLDRAGIVSTVFRALGRGVAVGVAG

Sequences:

>Translated_638_residues
MTQLPKTPLLDQVTYPADLRKLEDRDLPQLAREVRDEMIDAVSRTGGHLGAGLGVVELTIAIHSVFDTPDDRLIFDVGHQ
CYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAIAADLDKNDRRVIAVIGDGAMSAGMAY
EALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKNIDRAITRAVEHARGYVTGG
TMFEEMGFYHIGPIDGHSFDHLLPVLRNVRDNARGPVLIHVVTQKGKGYPPAEAAADKYHGVNKFDVITGAQARVKPNAP
SYTSVFAEALVQEATLDDKIVGITAAMPNGTGLDKLAEAFPSRCFDVGIAEQHAVTFAAGLAAEGYKPFAALYSTFLQRA
YDQVVHDVAIQGLPVRFPIDRAGFVGADGPTHAGSFDTAFLTTLPGFVVMAAADEAELKHMVRTAVAYDAGPISFRYPRG
EGVGVDMPVRGEILRIGKGRIVKEGTKVALLSFGTRLADCLLAAEDLDAAGLSTTVADARFAKPLDHDLIRQFARHHEMV
ITVEEGSVGGFGSQVMQYLSSEGLLDNGLKIRSLVMPDIWMEQAKPEAMNAHAGLDRAGIVSTVFRALGRGVAVGVAG
>Mature_637_residues
TQLPKTPLLDQVTYPADLRKLEDRDLPQLAREVRDEMIDAVSRTGGHLGAGLGVVELTIAIHSVFDTPDDRLIFDVGHQC
YPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDPFGAAHSSTSISAGLGMAIAADLDKNDRRVIAVIGDGAMSAGMAYE
ALNNAGALDARLIVILNDNDMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKNIDRAITRAVEHARGYVTGGT
MFEEMGFYHIGPIDGHSFDHLLPVLRNVRDNARGPVLIHVVTQKGKGYPPAEAAADKYHGVNKFDVITGAQARVKPNAPS
YTSVFAEALVQEATLDDKIVGITAAMPNGTGLDKLAEAFPSRCFDVGIAEQHAVTFAAGLAAEGYKPFAALYSTFLQRAY
DQVVHDVAIQGLPVRFPIDRAGFVGADGPTHAGSFDTAFLTTLPGFVVMAAADEAELKHMVRTAVAYDAGPISFRYPRGE
GVGVDMPVRGEILRIGKGRIVKEGTKVALLSFGTRLADCLLAAEDLDAAGLSTTVADARFAKPLDHDLIRQFARHHEMVI
TVEEGSVGGFGSQVMQYLSSEGLLDNGLKIRSLVMPDIWMEQAKPEAMNAHAGLDRAGIVSTVFRALGRGVAVGVAG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=522, Percent_Identity=25.4789272030651, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI4507521, Length=522, Percent_Identity=25.4789272030651, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI225637461, Length=522, Percent_Identity=23.3716475095785, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI225637459, Length=522, Percent_Identity=23.3716475095785, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI225637463, Length=525, Percent_Identity=23.2380952380952, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=48.6312399355878, Blast_Score=583, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17539652, Length=613, Percent_Identity=24.4698205546493, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551847, Length=641, Percent_Identity=25.2730109204368, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI45550715, Length=641, Percent_Identity=25.2730109204368, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24645119, Length=498, Percent_Identity=25.9036144578313, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24666278, Length=542, Percent_Identity=26.1992619926199, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68417; Mature: 68286

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLPKTPLLDQVTYPADLRKLEDRDLPQLAREVRDEMIDAVSRTGGHLGAGLGVVELTI
CCCCCCCCCHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AIHSVFDTPDDRLIFDVGHQCYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDPFGAA
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
HSSTSISAGLGMAIAADLDKNDRRVIAVIGDGAMSAGMAYEALNNAGALDARLIVILNDN
CCCCCHHCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCC
DMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKNIDRAITRAVEHARGYVTGG
CCEECCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEECC
TMFEEMGFYHIGPIDGHSFDHLLPVLRNVRDNARGPVLIHVVTQKGKGYPPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVNKFDVITGAQARVKPNAPSYTSVFAEALVQEATLDDKIVGITAAMPNGTGLDKLAEAF
CCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
PSRCFDVGIAEQHAVTFAAGLAAEGYKPFAALYSTFLQRAYDQVVHDVAIQGLPVRFPID
HHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
RAGFVGADGPTHAGSFDTAFLTTLPGFVVMAAADEAELKHMVRTAVAYDAGPISFRYPRG
CCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCC
EGVGVDMPVRGEILRIGKGRIVKEGTKVALLSFGTRLADCLLAAEDLDAAGLSTTVADAR
CCCCCCCCCCCCEEEECCCCEEECCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FAKPLDHDLIRQFARHHEMVITVEEGSVGGFGSQVMQYLSSEGLLDNGLKIRSLVMPDIW
HCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEHHHCCHHH
MEQAKPEAMNAHAGLDRAGIVSTVFRALGRGVAVGVAG
HHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure 
TQLPKTPLLDQVTYPADLRKLEDRDLPQLAREVRDEMIDAVSRTGGHLGAGLGVVELTI
CCCCCCCCHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AIHSVFDTPDDRLIFDVGHQCYPHKILTGRRDRIRTLRQEDGLSGFTRRAESEYDPFGAA
HHHHHHCCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
HSSTSISAGLGMAIAADLDKNDRRVIAVIGDGAMSAGMAYEALNNAGALDARLIVILNDN
CCCCCHHCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEEEECCC
DMSIAPPTGAMSAYLARLASGRTYMGFRDFGKKLTAYLGKNIDRAITRAVEHARGYVTGG
CCEECCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEECC
TMFEEMGFYHIGPIDGHSFDHLLPVLRNVRDNARGPVLIHVVTQKGKGYPPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVNKFDVITGAQARVKPNAPSYTSVFAEALVQEATLDDKIVGITAAMPNGTGLDKLAEAF
CCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
PSRCFDVGIAEQHAVTFAAGLAAEGYKPFAALYSTFLQRAYDQVVHDVAIQGLPVRFPID
HHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
RAGFVGADGPTHAGSFDTAFLTTLPGFVVMAAADEAELKHMVRTAVAYDAGPISFRYPRG
CCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCC
EGVGVDMPVRGEILRIGKGRIVKEGTKVALLSFGTRLADCLLAAEDLDAAGLSTTVADAR
CCCCCCCCCCCCEEEECCCCEEECCCEEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FAKPLDHDLIRQFARHHEMVITVEEGSVGGFGSQVMQYLSSEGLLDNGLKIRSLVMPDIW
HCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEHHHCCHHH
MEQAKPEAMNAHAGLDRAGIVSTVFRALGRGVAVGVAG
HHHCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA