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The map label for this gene is mutL [H]

Identifier: 209548102

GI number: 209548102

Start: 508411

End: 510213

Strand: Reverse

Name: mutL [H]

Synonym: Rleg2_0496

Alternate gene names: 209548102

Gene position: 510213-508411 (Counterclockwise)

Preceding gene: 209548105

Following gene: 209548101

Centisome position: 11.24

GC content: 67.28

Gene sequence:

>1803_bases
ATGGCCATCAGACAGCTTTCCGAAACGCTCATAAACCAGATCGCCGCCGGCGAAGTCATCGAACGGCCGGCGAGCGCTGC
CAAGGAACTGATCGAAAACGCGCTCGATGCGGGCGCGACGCGCATCGAGATCGCCACGGCGGGCGGCGGCAAGGCGTTGC
TGCGGGTCAGCGACAACGGCTCGGGCATGGATGCGGCCGATCTGGAACTGGCGGTCAGGCGCCACTGCACCTCGAAACTA
TCGGAGACGCTGGAGGATATCCGCACGCTCGGTTTCCGCGGCGAGGCGCTGCCGTCGATCGGCTCGGTCGCAAGGCTCAG
CATCGCCAGCCGCAGGCGCGACAGCGCCGGCGGCCACGAGATCGCCGTCAACGCCGGCAAGGTCGCACATTTGCGCCCGG
CCGCCGCCAATCCCGGGACGATCGTCGAAGTGCGCGATCTTTTTTTCGCGACCCCCGCCCGGCTCAAATTCCTGAAGACC
GAGAAGGCCGAGGCCGGCGCCATTACCGAGATCGTCAAGCGCATGGCGATCGCCTTTCCCGCCGTGCGCTTCGTGCTGTC
CGGTTCCGACCGCACGACGCTGGAATTTCCGGCGACCGGCGACGACCATCTGGCGCGCATGGCGCAGGTGCTCGGCAAGG
ACTTCCGCGACAACGCCATCGCCCTCGACGCGGTGCGCGAGGAAATTTCACTCACCGGCTTTGCCGGCGTGCCGACTTTC
AATCGCGGCAACTCCGCCCATCAATACGCCTTCGTCAACGGCCGGCCGGTGCAGGACAAGCTGATCCTGTCGGCGATCCG
CGGCGCCTATGCCGAAACCATCCCGTCAGGCCGTCATCCGGTGGCGGTGCTGTCGATTACCCTCGATCCCGCCCTCGTCG
ACGTCAACGTGCATCCGGCAAAATCCGACGTGCGGTTTCGCGACCCCGGCCTGGTGCGCGGCCTGATCGTCGGCGCCATC
CGCGAGGCCCTGGCGCGCGACGGCAGCCGGGCGGCAACGACCGGGGCAAGCGACATGCTGCGCTCCTTCCGCCCCGGCTT
TCAGCCGCAGGCGCAGCGACCGCAGACGGCATGGTCGGCCGAGACCTCGCCCTTCCGGCCCTACCAGCCGACAACGGGTT
TTTCCGAACGGCCACAGGCCTCCTTCGACGGGCTGTCGATGCCGACGGCGCGGGCCGAGCCGCCGTTTTCGCCGCAGCCG
GCAGCAGCCGACACCACCGCACGCTATCCGCTCGGCGCGGCGCGGGCGCAGATTCACGCCAACTACATCGTCGCCCAGAC
CGAGGACGGGCTTGTCATCGTCGACCAGCATGCCGCCCATGAGCGGCTGGTGTTCGAGGCGATGCGCAAGGCGCTGCATT
CGAAGCGGCTGGCCTCGCAGGTGCTGCTCATCCCGGAGATCGTCGATATTCCAGAAGAGGATTGTGACCGGCTGATGCAG
CATGCGGCGGAACTTGCCGAACTCGGCCTGGCAATCGAGCGTTTCGGCCCCGGGGCGATTGCCGTGCGCGAGACGCCGGC
GATGCTCGGCGAAGTCGACGCGCATGGCCTGATCCGCCAGCTTGCCGACGAGATTGCCGAATGGGACACGGCGTCGGGCC
TGTCGGCCAAGCTCGAATATGTGGCGGCGACGATGGCCTGCCACGGGTCGGTGCGCTCCGGACGGCGGCTGCGGCCGGAG
GAAATGAACGCGCTGCTCAGGGAAATGGAAGTGACGCCCGGCTCCGGCCAGTGCAATCACGGCCGGCCGACCTATATCGA
ATTGAAGCTCAGCGATATCGAGCGGCTCTTCGGCAGAAGCTGA

Upstream 100 bases:

>100_bases
ATGCAGCGGTGATCCCCAAGTTGCGGGAGGCCCGGATCACGCTTTGGGAAAGCCTATCGAACCCTCTTCCCTCCAGCCCG
CGAATCCTCGAAAATAGCCC

Downstream 100 bases:

>100_bases
AAAAGCTGGAAAAGCCGCCTCTGCCGGAGTATGGCAAACGGATGAGAGGCTGCAGGGAACGGAGCGCATGAATTTGTTCG
AAGGGCACGGAAACCGCGAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MAIRQLSETLINQIAAGEVIERPASAAKELIENALDAGATRIEIATAGGGKALLRVSDNGSGMDAADLELAVRRHCTSKL
SETLEDIRTLGFRGEALPSIGSVARLSIASRRRDSAGGHEIAVNAGKVAHLRPAAANPGTIVEVRDLFFATPARLKFLKT
EKAEAGAITEIVKRMAIAFPAVRFVLSGSDRTTLEFPATGDDHLARMAQVLGKDFRDNAIALDAVREEISLTGFAGVPTF
NRGNSAHQYAFVNGRPVQDKLILSAIRGAYAETIPSGRHPVAVLSITLDPALVDVNVHPAKSDVRFRDPGLVRGLIVGAI
REALARDGSRAATTGASDMLRSFRPGFQPQAQRPQTAWSAETSPFRPYQPTTGFSERPQASFDGLSMPTARAEPPFSPQP
AAADTTARYPLGAARAQIHANYIVAQTEDGLVIVDQHAAHERLVFEAMRKALHSKRLASQVLLIPEIVDIPEEDCDRLMQ
HAAELAELGLAIERFGPGAIAVRETPAMLGEVDAHGLIRQLADEIAEWDTASGLSAKLEYVAATMACHGSVRSGRRLRPE
EMNALLREMEVTPGSGQCNHGRPTYIELKLSDIERLFGRS

Sequences:

>Translated_600_residues
MAIRQLSETLINQIAAGEVIERPASAAKELIENALDAGATRIEIATAGGGKALLRVSDNGSGMDAADLELAVRRHCTSKL
SETLEDIRTLGFRGEALPSIGSVARLSIASRRRDSAGGHEIAVNAGKVAHLRPAAANPGTIVEVRDLFFATPARLKFLKT
EKAEAGAITEIVKRMAIAFPAVRFVLSGSDRTTLEFPATGDDHLARMAQVLGKDFRDNAIALDAVREEISLTGFAGVPTF
NRGNSAHQYAFVNGRPVQDKLILSAIRGAYAETIPSGRHPVAVLSITLDPALVDVNVHPAKSDVRFRDPGLVRGLIVGAI
REALARDGSRAATTGASDMLRSFRPGFQPQAQRPQTAWSAETSPFRPYQPTTGFSERPQASFDGLSMPTARAEPPFSPQP
AAADTTARYPLGAARAQIHANYIVAQTEDGLVIVDQHAAHERLVFEAMRKALHSKRLASQVLLIPEIVDIPEEDCDRLMQ
HAAELAELGLAIERFGPGAIAVRETPAMLGEVDAHGLIRQLADEIAEWDTASGLSAKLEYVAATMACHGSVRSGRRLRPE
EMNALLREMEVTPGSGQCNHGRPTYIELKLSDIERLFGRS
>Mature_599_residues
AIRQLSETLINQIAAGEVIERPASAAKELIENALDAGATRIEIATAGGGKALLRVSDNGSGMDAADLELAVRRHCTSKLS
ETLEDIRTLGFRGEALPSIGSVARLSIASRRRDSAGGHEIAVNAGKVAHLRPAAANPGTIVEVRDLFFATPARLKFLKTE
KAEAGAITEIVKRMAIAFPAVRFVLSGSDRTTLEFPATGDDHLARMAQVLGKDFRDNAIALDAVREEISLTGFAGVPTFN
RGNSAHQYAFVNGRPVQDKLILSAIRGAYAETIPSGRHPVAVLSITLDPALVDVNVHPAKSDVRFRDPGLVRGLIVGAIR
EALARDGSRAATTGASDMLRSFRPGFQPQAQRPQTAWSAETSPFRPYQPTTGFSERPQASFDGLSMPTARAEPPFSPQPA
AADTTARYPLGAARAQIHANYIVAQTEDGLVIVDQHAAHERLVFEAMRKALHSKRLASQVLLIPEIVDIPEEDCDRLMQH
AAELAELGLAIERFGPGAIAVRETPAMLGEVDAHGLIRQLADEIAEWDTASGLSAKLEYVAATMACHGSVRSGRRLRPEE
MNALLREMEVTPGSGQCNHGRPTYIELKLSDIERLFGRS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=35.7827476038339, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI4505911, Length=324, Percent_Identity=31.7901234567901, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI189458898, Length=324, Percent_Identity=31.7901234567901, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI4505913, Length=343, Percent_Identity=27.4052478134111, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI310128478, Length=343, Percent_Identity=27.4052478134111, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI189458896, Length=316, Percent_Identity=30.0632911392405, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=28.8990825688073, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=25.4237288135593, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI91992160, Length=361, Percent_Identity=25.207756232687, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI91992162, Length=361, Percent_Identity=25.207756232687, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790612, Length=561, Percent_Identity=33.3333333333333, Blast_Score=238, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=35.0931677018634, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=338, Percent_Identity=26.9230769230769, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=437, Percent_Identity=31.5789473684211, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324247, Length=333, Percent_Identity=28.8288288288288, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=725, Percent_Identity=20.9655172413793, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323063, Length=347, Percent_Identity=26.2247838616715, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17136968, Length=336, Percent_Identity=35.4166666666667, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17136970, Length=347, Percent_Identity=27.0893371757925, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 64497; Mature: 64366

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRQLSETLINQIAAGEVIERPASAAKELIENALDAGATRIEIATAGGGKALLRVSDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCC
SGMDAADLELAVRRHCTSKLSETLEDIRTLGFRGEALPSIGSVARLSIASRRRDSAGGHE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCE
IAVNAGKVAHLRPAAANPGTIVEVRDLFFATPARLKFLKTEKAEAGAITEIVKRMAIAFP
EEEECCCEEEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AVRFVLSGSDRTTLEFPATGDDHLARMAQVLGKDFRDNAIALDAVREEISLTGFAGVPTF
HHHHEECCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCEECCCCCC
NRGNSAHQYAFVNGRPVQDKLILSAIRGAYAETIPSGRHPVAVLSITLDPALVDVNVHPA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEECCCC
KSDVRFRDPGLVRGLIVGAIREALARDGSRAATTGASDMLRSFRPGFQPQAQRPQTAWSA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCCCCCCCCCCCCC
ETSPFRPYQPTTGFSERPQASFDGLSMPTARAEPPFSPQPAAADTTARYPLGAARAQIHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEE
NYIVAQTEDGLVIVDQHAAHERLVFEAMRKALHSKRLASQVLLIPEIVDIPEEDCDRLMQ
EEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HAAELAELGLAIERFGPGAIAVRETPAMLGEVDAHGLIRQLADEIAEWDTASGLSAKLEY
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VAATMACHGSVRSGRRLRPEEMNALLREMEVTPGSGQCNHGRPTYIELKLSDIERLFGRS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
AIRQLSETLINQIAAGEVIERPASAAKELIENALDAGATRIEIATAGGGKALLRVSDNG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCC
SGMDAADLELAVRRHCTSKLSETLEDIRTLGFRGEALPSIGSVARLSIASRRRDSAGGHE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCE
IAVNAGKVAHLRPAAANPGTIVEVRDLFFATPARLKFLKTEKAEAGAITEIVKRMAIAFP
EEEECCCEEEECCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
AVRFVLSGSDRTTLEFPATGDDHLARMAQVLGKDFRDNAIALDAVREEISLTGFAGVPTF
HHHHEECCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEHHHHHHHHCCCEECCCCCC
NRGNSAHQYAFVNGRPVQDKLILSAIRGAYAETIPSGRHPVAVLSITLDPALVDVNVHPA
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEECCCC
KSDVRFRDPGLVRGLIVGAIREALARDGSRAATTGASDMLRSFRPGFQPQAQRPQTAWSA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHCCCCCCCCCCCCCCCCC
ETSPFRPYQPTTGFSERPQASFDGLSMPTARAEPPFSPQPAAADTTARYPLGAARAQIHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHEEE
NYIVAQTEDGLVIVDQHAAHERLVFEAMRKALHSKRLASQVLLIPEIVDIPEEDCDRLMQ
EEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HAAELAELGLAIERFGPGAIAVRETPAMLGEVDAHGLIRQLADEIAEWDTASGLSAKLEY
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VAATMACHGSVRSGRRLRPEEMNALLREMEVTPGSGQCNHGRPTYIELKLSDIERLFGRS
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA