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The map label for this gene is kefBC [H]

Identifier: 209548090

GI number: 209548090

Start: 496213

End: 498027

Strand: Reverse

Name: kefBC [H]

Synonym: Rleg2_0484

Alternate gene names: 209548090

Gene position: 498027-496213 (Counterclockwise)

Preceding gene: 209548097

Following gene: 209548087

Centisome position: 10.97

GC content: 65.18

Gene sequence:

>1815_bases
ATGTCCGCGTCCAATGCCTTTTTTTCCGAAACGATCCTGCTGCTCGGCGGTGCGGTTGTGGCCGCGCCGATCTTCAAGAA
GCTCGGGCTCGGCACGGTGCTCGGCTATCTCGCCGCCGGCATCGTCATCGGACCGGTTTTCCACGGCATCACCGACGGCG
AACAGATCCTTGCCGTTGCCGAACTCGGCGTCGTCTTCCTGCTTTTCATCATCGGGCTTGAGCTGAAACCCAGCCGCCTC
TGGCAGATGCGCCGCGACATTTTCGGCCTCGGCACGGCGCAGGTGGTGGTGACCGGGCTGGCGCTGACCGCGCTTGCCTG
GTTTTCTGAGGTTCTCGACTGGCGCGGCAGCATCGTCGCCGGCTTCGGCCTGGCGCTGTCTTCGACGGCCTTCGCCATGC
AGATCCTCGAGGGTGACGGCGACGTCAACACGAGGTACGGGCAGCGCTCCTTCTCGATGCTGCTGTTCCAGGACCTGGCG
ATCGTGCCGCTCTTGGCGCTGATCACCGTGCTCGACGGCGGTGGCAAGGGCAGCCCTGCGCCACTCACCGATTTTGCGGT
CGCCGTTGGCGCGGTCGCGGCGATGGTCGTCATGGGGCGCTACCTGCTGACGCCGCTTTTCCAGGTCATCGCCCGCACCG
GTGCGCGCGAAGCGATGATCGCCGCCGCCCTCTTCGTCGTCATGGGATCGGCGAGCCTGATGCAGCTTGCCGGGCTTTCG
ATGGCGATGGGCGCCTTCCTTTCCGGGGTGATGCTGGCCGAATCCTCCTATCGGCACGAGCTGGAGGCCGATATCGAGCC
CTTCCGCGGCGTGCTGCTCGCCATCTTCTTCATCGCCGTCGGCCTGTCGCTGCAGCTCGACGTGCTTGCCGACAACGTGC
TCTTCGTCATCGTCGCGGTGCCGATCATCATGGCGGTCAAGGCGATCATCATCTACGGGCTCTGCCGGATCTCCGGCTCT
CCGCATGATGATGCGATCCGCATCGCCTTCCTGCTGCCGCAGGGCGGCGAATTCGGCTTCGTGCTGTTTACCGCGGCGGC
GACCGTTGGGCTGATGTCGGCGAGCACCGCATCGCTGCTGGTTGCGATCGTCACGCTGTCCATGGCGCTGACGCCGATCG
GCGCGGCGCTTTCGAAGCGTCTGCTCAGCGGCGACGAGCATGAGGAGCTGGACGAGGATTTCGAGGGCGCCGGCGCCGAC
GTGCTGATGGTCGGCTTCTCGCGTTTCGGCCAGATCGCCGCGCAGATTCTGCTTGCCGGCGGGCGCAGCGTCACCGTCAT
CGAATTTTCGGCGGACCGCATCCGCCAGGCCTCCTCTTTCGGCTTCCGCATCTATTTCGGTGACGGCACCCGCAAGGACG
TGCTGCGCTCGGCCGGCATCGACCGGGCAAAGATCGTGCTCGTCTGCACACAGAAGAAGGAAGTCACCGACAAGGTGGTG
GAGCTGGTGCAGGCGGACTATCCGCACACAAGGCTCTATGTGCGCTCCTACGACCGCATCCATTCGATCGAACTGCGCAA
CAAGGGCGTCGATTACGAGCTGCGCGAAACGCTGGAATCCGGCCTGCTCTTTGGGCGGCGGACGCTGGAAGCGCTCGGCG
TTCCCGAGGTCGACGCCTATGAGATCGGCGAGGACATCCGCAAACGCGACGAGGCGCGCCTGGTGCTGCAGGTGTCCGAA
GGGCTGCAGGCCGGGCGCGATATGCTGTTTTCCCACCCTGTCCGCCCCGAACCGCTGGTCAAGCCGAAACGCGCTGCCGA
TCCCTTCGAGGACGATCCGCTGGCGGGAACGGTGGATGCGACGGCAGAGGCATAG

Upstream 100 bases:

>100_bases
CTTCCATTTATTGTGCACTCACCCAAGCATCAAGGCCGCCGCCGCCGATTCTTTGTCGGGGCTGCCGGCCTGTTCCCCGC
CGTCGAAAGAAATCGCCCCG

Downstream 100 bases:

>100_bases
TTGAGCTGATTGCTGCGGCCCCGAGGCTGCTGCCGATCGTCCGGCAGCAGCGCGCAGCTATTCCTTTCTCACCACTAGAG
CGGGATGATTTTAGGTGGAA

Product: potassium efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSASNAFFSETILLLGGAVVAAPIFKKLGLGTVLGYLAAGIVIGPVFHGITDGEQILAVAELGVVFLLFIIGLELKPSRL
WQMRRDIFGLGTAQVVVTGLALTALAWFSEVLDWRGSIVAGFGLALSSTAFAMQILEGDGDVNTRYGQRSFSMLLFQDLA
IVPLLALITVLDGGGKGSPAPLTDFAVAVGAVAAMVVMGRYLLTPLFQVIARTGAREAMIAAALFVVMGSASLMQLAGLS
MAMGAFLSGVMLAESSYRHELEADIEPFRGVLLAIFFIAVGLSLQLDVLADNVLFVIVAVPIIMAVKAIIIYGLCRISGS
PHDDAIRIAFLLPQGGEFGFVLFTAAATVGLMSASTASLLVAIVTLSMALTPIGAALSKRLLSGDEHEELDEDFEGAGAD
VLMVGFSRFGQIAAQILLAGGRSVTVIEFSADRIRQASSFGFRIYFGDGTRKDVLRSAGIDRAKIVLVCTQKKEVTDKVV
ELVQADYPHTRLYVRSYDRIHSIELRNKGVDYELRETLESGLLFGRRTLEALGVPEVDAYEIGEDIRKRDEARLVLQVSE
GLQAGRDMLFSHPVRPEPLVKPKRAADPFEDDPLAGTVDATAEA

Sequences:

>Translated_604_residues
MSASNAFFSETILLLGGAVVAAPIFKKLGLGTVLGYLAAGIVIGPVFHGITDGEQILAVAELGVVFLLFIIGLELKPSRL
WQMRRDIFGLGTAQVVVTGLALTALAWFSEVLDWRGSIVAGFGLALSSTAFAMQILEGDGDVNTRYGQRSFSMLLFQDLA
IVPLLALITVLDGGGKGSPAPLTDFAVAVGAVAAMVVMGRYLLTPLFQVIARTGAREAMIAAALFVVMGSASLMQLAGLS
MAMGAFLSGVMLAESSYRHELEADIEPFRGVLLAIFFIAVGLSLQLDVLADNVLFVIVAVPIIMAVKAIIIYGLCRISGS
PHDDAIRIAFLLPQGGEFGFVLFTAAATVGLMSASTASLLVAIVTLSMALTPIGAALSKRLLSGDEHEELDEDFEGAGAD
VLMVGFSRFGQIAAQILLAGGRSVTVIEFSADRIRQASSFGFRIYFGDGTRKDVLRSAGIDRAKIVLVCTQKKEVTDKVV
ELVQADYPHTRLYVRSYDRIHSIELRNKGVDYELRETLESGLLFGRRTLEALGVPEVDAYEIGEDIRKRDEARLVLQVSE
GLQAGRDMLFSHPVRPEPLVKPKRAADPFEDDPLAGTVDATAEA
>Mature_603_residues
SASNAFFSETILLLGGAVVAAPIFKKLGLGTVLGYLAAGIVIGPVFHGITDGEQILAVAELGVVFLLFIIGLELKPSRLW
QMRRDIFGLGTAQVVVTGLALTALAWFSEVLDWRGSIVAGFGLALSSTAFAMQILEGDGDVNTRYGQRSFSMLLFQDLAI
VPLLALITVLDGGGKGSPAPLTDFAVAVGAVAAMVVMGRYLLTPLFQVIARTGAREAMIAAALFVVMGSASLMQLAGLSM
AMGAFLSGVMLAESSYRHELEADIEPFRGVLLAIFFIAVGLSLQLDVLADNVLFVIVAVPIIMAVKAIIIYGLCRISGSP
HDDAIRIAFLLPQGGEFGFVLFTAAATVGLMSASTASLLVAIVTLSMALTPIGAALSKRLLSGDEHEELDEDFEGAGADV
LMVGFSRFGQIAAQILLAGGRSVTVIEFSADRIRQASSFGFRIYFGDGTRKDVLRSAGIDRAKIVLVCTQKKEVTDKVVE
LVQADYPHTRLYVRSYDRIHSIELRNKGVDYELRETLESGLLFGRRTLEALGVPEVDAYEIGEDIRKRDEARLVLQVSEG
LQAGRDMLFSHPVRPEPLVKPKRAADPFEDDPLAGTVDATAEA

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=381, Percent_Identity=26.246719160105, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1789749, Length=594, Percent_Identity=40.5723905723906, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1786232, Length=545, Percent_Identity=40.3669724770642, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1786685, Length=497, Percent_Identity=27.5653923541247, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 64504; Mature: 64373

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASNAFFSETILLLGGAVVAAPIFKKLGLGTVLGYLAAGIVIGPVFHGITDGEQILAVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
ELGVVFLLFIIGLELKPSRLWQMRRDIFGLGTAQVVVTGLALTALAWFSEVLDWRGSIVA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
GFGLALSSTAFAMQILEGDGDVNTRYGQRSFSMLLFQDLAIVPLLALITVLDGGGKGSPA
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLTDFAVAVGAVAAMVVMGRYLLTPLFQVIARTGAREAMIAAALFVVMGSASLMQLAGLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHH
MAMGAFLSGVMLAESSYRHELEADIEPFRGVLLAIFFIAVGLSLQLDVLADNVLFVIVAV
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHH
PIIMAVKAIIIYGLCRISGSPHDDAIRIAFLLPQGGEFGFVLFTAAATVGLMSASTASLL
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VAIVTLSMALTPIGAALSKRLLSGDEHEELDEDFEGAGADVLMVGFSRFGQIAAQILLAG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHCC
GRSVTVIEFSADRIRQASSFGFRIYFGDGTRKDVLRSAGIDRAKIVLVCTQKKEVTDKVV
CCEEEEEEECHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEEEEEECCCHHHHHHHH
ELVQADYPHTRLYVRSYDRIHSIELRNKGVDYELRETLESGLLFGRRTLEALGVPEVDAY
HHHHCCCCCCEEEEEHHHHHHEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EIGEDIRKRDEARLVLQVSEGLQAGRDMLFSHPVRPEPLVKPKRAADPFEDDPLAGTVDA
HHHHHHHCCCHHHEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TAEA
CCCC
>Mature Secondary Structure 
SASNAFFSETILLLGGAVVAAPIFKKLGLGTVLGYLAAGIVIGPVFHGITDGEQILAVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH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CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]