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The map label for this gene is groEL [H]

Identifier: 209548077

GI number: 209548077

Start: 479990

End: 481633

Strand: Reverse

Name: groEL [H]

Synonym: Rleg2_0470

Alternate gene names: 209548077

Gene position: 481633-479990 (Counterclockwise)

Preceding gene: 209548078

Following gene: 209548076

Centisome position: 10.61

GC content: 60.22

Gene sequence:

>1644_bases
ATGGCATCTAAAGAAATCAAGTTTGGTCGTACCGCGCGCGAAAAGATGCTGCGTGGCGTCGACATTCTCGCCGATGCAGT
CAAGGTAACGCTCGGCCCGAAGGGCCGTAACGTCATCATCGACAAGTCCTTCGGCGCTCCGCGCATCACCAAGGACGGCG
TTTCCGTCGCCAAGGAAATCGAACTCGAAGACAAGTTCGAAAACATGGGCGCGCAGATGGTCCGCGAAGTTGCTTCGAAG
ACCAACGACATCGCCGGCGACGGCACCACGACTGCAACCGTTCTGGCCCAGGCGATCGTTCGCGAAGGCAACAAGGCCGT
TGCAGCCGGCATGAACCCGATGGACCTGAAGCGCGGTATCGACCTCGCTGTGGCCGACGTCGTGAAGGATCTCCAGGCCA
AGGCCAAGAAGATCTCCACCTCTGAAGAAGTTGCACAGGTCGGCACGATCTCGGCAAACGGCGACAAGCAGGTCGGTCTC
GACATTGCCGAAGCCATGCAGAAGGTCGGCAACGAAGGCGTCATCACGGTTGAAGAAGCCAAGACCGCCGAAACCGAACT
CGAAGTCGTCGAAGGCATGCAGTTCGACCGCGGCTACCTCAGCCCCTACTTCGTGACCAACCCGGAAAAGATGATTGCCG
ACCTCGAAGACGTCTTCATTCTCCTTCACGAGAAGAAGCTCTCGAACCTGCAGTCGATGCTCCCTGTTCTCGAAGCTGTC
GTCCAGACCGGCAAGCCGCTCCTGATCATCGCTGAAGACGTTGAAGGCGAAGCTCTTGCGACGCTCGTCGTCAACAAGCT
GCGCGGCGGCCTCAAGATCGCTGCTGTCAAGGCGCCTGGCTTCGGCGACCGCCGCAAGGCCATGCTCGAAGACATCGCCA
TCCTGACCGGCGGCACCGTGATCTCCGAAGACCTCGGCATCAAGCTCGAATCCGTCACGCTCGACATGCTCGGCCGTGCG
AAGAAGGTTTCGATCTCCAAGGAAAACACCACGATCGTCGACGGTTCGGGCGCCAAGTCCGACATCGAAGGCCGTGTTGC
CCAGATCAAGGCCCAGATCGAAGAAACCACCTCCGACTACGACCGCGAGAAGCTGCAGGAACGCCTTGCCAAGCTCGCTG
GCGGCGTTGCCGTCATCCGCGTCGGCGGCTCGACGGAAGTCGAAGTGAAGGAAAAGAAGGACCGCATCGACGACGCCCTC
AACGCGACGCGCGCTGCCGTTCAGGAAGGCATCGTCCCCGGCGGCGGTATCGCTCTCCTGCGCTCCTCCACGAAGATCAC
CGTCAAGGGTGCAAACGACGACCAGGAAGCCGGCATCAACATCGTTCGCCGCGCCCTGCAGTCGCTCGTTCGTCAGATCG
CTGAAAACGCAGGCGACGAAGCCTCGATCGTTGTCGGCAAGGTCCTCGACAAGAATGAAGACAACTACGGCTACAACGCC
CAGACGTCCGAATTCGGCGACATGATCGCCATGGGTATCGTCGACCCGCTCAAGGTCGTTCGCACGGCACTGCAGAACGC
TGCTTCTGTTGCATCGCTGCTGATCACCACCGAAGCCATGATCGCCGAACTGCCGAAGAAAGAATCGGCTGGCGGCGGCA
TGCCGGGCGGCATGGGCGGCATGGGCGGAATGGACATGATGTGA

Upstream 100 bases:

>100_bases
GAAGCCGACATTATGGGCATCATCGGCTGATCAGCCGCTGGCCTTTCCGACGTAGCCGACGGGTCCAGAACCCGGACACT
CGAATTGAGGAGTTTCAATC

Downstream 100 bases:

>100_bases
TAGGCGAAAGCCTCCACTGATCACCATTCCGGCATCCGGAATAGGAAGGGCGGCCCTCGGGTCGCCCTTTTCTTTGGCGC
CTAAGCGATTCGGTCCGTTG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MASKEIKFGRTAREKMLRGVDILADAVKVTLGPKGRNVIIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQAIVREGNKAVAAGMNPMDLKRGIDLAVADVVKDLQAKAKKISTSEEVAQVGTISANGDKQVGL
DIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMIADLEDVFILLHEKKLSNLQSMLPVLEAV
VQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGRA
KKVSISKENTTIVDGSGAKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDAL
NATRAAVQEGIVPGGGIALLRSSTKITVKGANDDQEAGINIVRRALQSLVRQIAENAGDEASIVVGKVLDKNEDNYGYNA
QTSEFGDMIAMGIVDPLKVVRTALQNAASVASLLITTEAMIAELPKKESAGGGMPGGMGGMGGMDMM

Sequences:

>Translated_547_residues
MASKEIKFGRTAREKMLRGVDILADAVKVTLGPKGRNVIIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVREVASK
TNDIAGDGTTTATVLAQAIVREGNKAVAAGMNPMDLKRGIDLAVADVVKDLQAKAKKISTSEEVAQVGTISANGDKQVGL
DIAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMIADLEDVFILLHEKKLSNLQSMLPVLEAV
VQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGRA
KKVSISKENTTIVDGSGAKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDAL
NATRAAVQEGIVPGGGIALLRSSTKITVKGANDDQEAGINIVRRALQSLVRQIAENAGDEASIVVGKVLDKNEDNYGYNA
QTSEFGDMIAMGIVDPLKVVRTALQNAASVASLLITTEAMIAELPKKESAGGGMPGGMGGMGGMDMM
>Mature_546_residues
ASKEIKFGRTAREKMLRGVDILADAVKVTLGPKGRNVIIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMVREVASKT
NDIAGDGTTTATVLAQAIVREGNKAVAAGMNPMDLKRGIDLAVADVVKDLQAKAKKISTSEEVAQVGTISANGDKQVGLD
IAEAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFVTNPEKMIADLEDVFILLHEKKLSNLQSMLPVLEAVV
QTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGRAK
KVSISKENTTIVDGSGAKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDALN
ATRAAVQEGIVPGGGIALLRSSTKITVKGANDDQEAGINIVRRALQSLVRQIAENAGDEASIVVGKVLDKNEDNYGYNAQ
TSEFGDMIAMGIVDPLKVVRTALQNAASVASLLITTEAMIAELPKKESAGGGMPGGMGGMGGMDMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=53.4090909090909, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=53.4090909090909, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI5453607, Length=537, Percent_Identity=21.7877094972067, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=68.361581920904, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.6862003780718, Blast_Score=565, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI193210679, Length=240, Percent_Identity=50.4166666666667, Blast_Score=228, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17564182, Length=550, Percent_Identity=23.2727272727273, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.9847908745247, Blast_Score=604, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6322350, Length=557, Percent_Identity=24.2369838420108, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=56.6287878787879, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=56.6287878787879, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=54.1509433962264, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=54.1509433962264, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=54.1509433962264, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI17864606, Length=556, Percent_Identity=46.2230215827338, Blast_Score=474, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24584129, Length=532, Percent_Identity=37.0300751879699, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI19921262, Length=532, Percent_Identity=37.0300751879699, Blast_Score=328, Evalue=5e-90,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57902; Mature: 57771

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKEIKFGRTAREKMLRGVDILADAVKVTLGPKGRNVIIDKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVREGNKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCC
DLAVADVVKDLQAKAKKISTSEEVAQVGTISANGDKQVGLDIAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNPEKMIADLEDVFILLHEKKLSNLQSMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDLGIKLESVTLDMLGRAKKVSISKENTTIVDGSGAKSDIEGRVAQIKAQIEETTSDY
EECCCCCEEEEEHHHHHCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDALNATRAAVQEGIVPGGGIALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RSSTKITVKGANDDQEAGINIVRRALQSLVRQIAENAGDEASIVVGKVLDKNEDNYGYNA
ECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCC
QTSEFGDMIAMGIVDPLKVVRTALQNAASVASLLITTEAMIAELPKKESAGGGMPGGMGG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MGGMDMM
CCCCCCC
>Mature Secondary Structure 
ASKEIKFGRTAREKMLRGVDILADAVKVTLGPKGRNVIIDKSFGAPRITKDGVSVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVREGNKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHCC
DLAVADVVKDLQAKAKKISTSEEVAQVGTISANGDKQVGLDIAEAMQKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFVTNPEKMIADLEDVFILLHEKKLSNLQSMLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEE
ISEDLGIKLESVTLDMLGRAKKVSISKENTTIVDGSGAKSDIEGRVAQIKAQIEETTSDY
EECCCCCEEEEEHHHHHCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRIDDALNATRAAVQEGIVPGGGIALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
RSSTKITVKGANDDQEAGINIVRRALQSLVRQIAENAGDEASIVVGKVLDKNEDNYGYNA
ECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCC
QTSEFGDMIAMGIVDPLKVVRTALQNAASVASLLITTEAMIAELPKKESAGGGMPGGMGG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MGGMDMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA