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The map label for this gene is hisG [H]

Identifier: 209548073

GI number: 209548073

Start: 476800

End: 477495

Strand: Direct

Name: hisG [H]

Synonym: Rleg2_0466

Alternate gene names: 209548073

Gene position: 476800-477495 (Clockwise)

Preceding gene: 209548072

Following gene: 209548075

Centisome position: 10.51

GC content: 65.23

Gene sequence:

>696_bases
ATGACCATCACCATCGCGCTTCCCTCCAAGGGCCGGATGAAGGACGAAGCTTCGGCGATCTTCGAACGGGCCGGCATGCC
GATCACCGCTGTCGGCAATGACCGCTCCTATCGCGGCCGCGTCGAAGGCTGGGGCGATGTCGAGGTCGCCTTCCTGTCTG
CCTCCGAAATCTCCCGCGAACTCGGCAACGGCACCGTCGATTTCGGCGTCACCGGCGAGGATCTGATGCGGGAAGGTTTT
TCCGAGGTGGATAAGCGCGTCGAATTCTGCGCCCGCCTCGGCTTCGGCCATGCCGACGTCGTCGTCGCCGTGCCGGAGAT
CTGGCTGGATGTCGAAACCATGGCCGATCTCGGCGATGTCGCTGCCGATTTCCGCGCCCGCCACTCCAGGCGCCTGGCCA
TCGCCACAAAATACTGGCGGCTGACCCAGCAGTTCTTTTCGAGCCAGCACGGCATTCAGCTCTATCGCATCGTCGAGAGC
CTCGGCGCTACCGAGGGGGCTCCCGCCTCCGGCTCGGCCGATATCATCGTCGATATCACCTCTACCGGCTCGACGCTGCG
CGCCAACCACCTGAAGGTGCTCCAGGACGGCGTCATCCTGCATTCGCAGGCCTGCCTGGTGCGCGCCCGCAAGGAGAGCC
ACGTCGATGCGCCGGTCGTGCAGGCGATTATCGACGCGGTGCGCGCCGCCCTCTGA

Upstream 100 bases:

>100_bases
GTTTCGATAAACTCCTGACCTTCCTCGGTGCGACGGACCGCATTCCGGCTGTCGGCTTCTCCTTCTGGCTCGACCGCATC
GAAACCGAAAGGGCAGCCGT

Downstream 100 bases:

>100_bases
TCTAGCGATCATTGAATGCATAAGAAAACCCGCCGTCAATTCAATGACGGCGGGTTCTGCATGTCTGGGAGGATGTCTGT
TGGATCAGGCAGCCGCATAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MTITIALPSKGRMKDEASAIFERAGMPITAVGNDRSYRGRVEGWGDVEVAFLSASEISRELGNGTVDFGVTGEDLMREGF
SEVDKRVEFCARLGFGHADVVVAVPEIWLDVETMADLGDVAADFRARHSRRLAIATKYWRLTQQFFSSQHGIQLYRIVES
LGATEGAPASGSADIIVDITSTGSTLRANHLKVLQDGVILHSQACLVRARKESHVDAPVVQAIIDAVRAAL

Sequences:

>Translated_231_residues
MTITIALPSKGRMKDEASAIFERAGMPITAVGNDRSYRGRVEGWGDVEVAFLSASEISRELGNGTVDFGVTGEDLMREGF
SEVDKRVEFCARLGFGHADVVVAVPEIWLDVETMADLGDVAADFRARHSRRLAIATKYWRLTQQFFSSQHGIQLYRIVES
LGATEGAPASGSADIIVDITSTGSTLRANHLKVLQDGVILHSQACLVRARKESHVDAPVVQAIIDAVRAAL
>Mature_230_residues
TITIALPSKGRMKDEASAIFERAGMPITAVGNDRSYRGRVEGWGDVEVAFLSASEISRELGNGTVDFGVTGEDLMREGFS
EVDKRVEFCARLGFGHADVVVAVPEIWLDVETMADLGDVAADFRARHSRRLAIATKYWRLTQQFFSSQHGIQLYRIVESL
GATEGAPASGSADIIVDITSTGSTLRANHLKVLQDGVILHSQACLVRARKESHVDAPVVQAIIDAVRAAL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25042; Mature: 24910

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITIALPSKGRMKDEASAIFERAGMPITAVGNDRSYRGRVEGWGDVEVAFLSASEISRE
CEEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECHHHHHHH
LGNGTVDFGVTGEDLMREGFSEVDKRVEFCARLGFGHADVVVAVPEIWLDVETMADLGDV
HCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHH
AADFRARHSRRLAIATKYWRLTQQFFSSQHGIQLYRIVESLGATEGAPASGSADIIVDIT
HHHHHHHHCCEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEE
STGSTLRANHLKVLQDGVILHSQACLVRARKESHVDAPVVQAIIDAVRAAL
CCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TITIALPSKGRMKDEASAIFERAGMPITAVGNDRSYRGRVEGWGDVEVAFLSASEISRE
EEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECHHHHHHH
LGNGTVDFGVTGEDLMREGFSEVDKRVEFCARLGFGHADVVVAVPEIWLDVETMADLGDV
HCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHH
AADFRARHSRRLAIATKYWRLTQQFFSSQHGIQLYRIVESLGATEGAPASGSADIIVDIT
HHHHHHHHCCEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEE
STGSTLRANHLKVLQDGVILHSQACLVRARKESHVDAPVVQAIIDAVRAAL
CCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA