Click here to switch to the map view.

The map label for this gene is flhA [H]

Identifier: 209547953

GI number: 209547953

Start: 347753

End: 349840

Strand: Direct

Name: flhA [H]

Synonym: Rleg2_0345

Alternate gene names: 209547953

Gene position: 347753-349840 (Clockwise)

Preceding gene: 209547952

Following gene: 209547954

Centisome position: 7.66

GC content: 61.69

Gene sequence:

>2088_bases
ATGGCGCAACCACCTGCATTACCCCTTCCGAAAGTCGCCCCGAGCCTGCGCGATGTCGGTTTTGCCCTCGGCATCATCGG
CATCATCTGCATTCTCTTTCTGCCGATCCCGCCATTCCTGATTGACATGGGGCTGGCCTTCTCGATCGCCTTCTCGGTGC
TGATCCTGATGGTTGCGCTGTGGATCCAGAAACCGCTCGATTTCTCGTCTTTCCCGACCATTCTACTGATCGCGACGATG
ACCCGGCTGGCGCTGAACATTGCGACGACGCGCGTCATCCTGTCCCACGGCAACGAGGGCCACGACGCGGCCGGCGGCGT
CATCGCCGGTTTCGCAAGCCTGGTGATGTCCGGCGACTTCGTCATCGGTCTGATCGTCTTCCTGATCCTCATCACCATCA
ACTTCATCGTCATCACCAAGGGCGCCACGCGTATCGCCGAAGTCGGCGCGCGATTCACCCTCGATGCCATCCCCGGCAAG
CAGATGTCGATCGACGCCGATCTTTCGGCCGGCATCATCGATGAAAGGGAAGCCCAGCGCCGGCGCAGGGAACTCGAAGA
GGAAAGCTCCTTCTTCGGTGCGATGGACGGTGCGTCGAAATTTGTGCGCGGCGATGCCGTCGCCGGCCTGATCATTACCG
CCATCAATGTCTTCGGCGGCATCATCATCGGCTATTTCCGCCACGGCATGCCGATCGGCGAAGCAGCCGACGTCTTCGTC
AAGCTCTCCGTCGGCGACGGCCTCGTCTCCCAGATGCCGGCCCTCATCGTCTCGCTCGCCGCCGGCCTGCTCGTCTCGCG
CGGCGGCACCACCGGCTCCACCGACCAGGCGGTTGTCAACCAGTTGAGCGGTTACCCCCGCGCGCTCTCGGTCTCGGCCG
TGCTGATGTTCGTTCTGGCGCTGATGCCGGGCCTGCCCTTCGTCCCCTTCGTGATCCTCGGCAGTCTTCTTGCCTTCGGC
GCCTGGTTCATCCCGCGTCAGGTCGAGGCTGAAAACAAGCTTCGCCGCGAGCAGGAGGAAAAGAAGGTCGTCCAGAGCAA
GGAGCTGGAAAAGGATTCAGTCAAGGCGGTACTGCGGACCTCCGAGATCGAGCTTGCGCTCGGCAAGATGGTCTCGACGC
GACTGCTCGGCGCCCACCAGGAGCTCGCGTTCCGCGTCGGCAAGATGCGCAAGAAGTTCGCCACCCAATACGGTTTCGTC
GTGCCCGAGATCAAGGTCACCGACGATATCGCCATCGCCGAGAAGTCCTACCAGATCCGCATCCACGGCACGACGGTCGC
CTCCAACTTGCTACGCGTCGGCGAAGTTCTCGTCGTGACCGGCGCCGGCCGCCGGCCGAGCATCCCCGGCGACGAAATCC
GCGAACCAGCTTTCGGCATGCCGGCGGTCTCGATCCTCGAAAACTTCGCCGACGATCTGAAACGCGAGGGCTTCCAGCCG
ATCGACAACGTCTCCGTCGTGCTCACCCATATGAGCGAGGTCATCCGCAACAACCTGCCGCAGCTTCTGTCCTACAAGGA
CGTCAAGGTGCTGATCGATCGCCTCGATCCCGAATACAAGAAACTCGCCGACGAGATCTGCTCGTCGCACATGTCCTATT
CGGGCCTGCAGGCGGTGCTCAAGCTGCTGCTTGCCGAACGCGTCTCGATCCGCAACCTGCACCTCATTCTCGAAGCGGTG
GCCGAGCTCGCCCCGCATGTCAGGAAGACCGAGCAGATCGTCGAGCATGTCCGCATCCGCATGGCCCAGCAGCTCTGCGG
CGACCTTGCCGACAACGGCGTGCTACGCGTCCTCAGGCTGGGCAGCAAATGGGATCTCGCTTTCCACCAGGCGCTGAAGC
GCGACGCCAAAGGCGAGGTGATCGAATTCGACATCGATCCGCGCAACCTGGAAGAATTCAGCGAGCAGGCCACCAAAGTT
ATCCGTGAGTTCATGGATCGCGGCCTGCCATTCGCACTTGTCACCTCGCCGGAAACACGCTCCTATGTGCGCATGATCAT
CGAACGGCTGTTCGCCACGCTGCCGGTCCTGTCGCATGTCGAACTGGCCAAGGGCATCGAGATAAAGATTTTGGGCTCTA
TTTCATGA

Upstream 100 bases:

>100_bases
TCCGGTTTCTGAGCCACCTTCGCGCAAGCTTCGCCATTTAACTCTCGATCCGAATTGGGCGGACCGAGTCCGCCTCCTCT
CATGAAGAGACGGAACTGTT

Downstream 100 bases:

>100_bases
TAACAGACCCGCAAGGGACCGTTCTCGCGCTGTTTCTGGTTTTCTGCCGGATCGGCGGCTGTGTGCTGGCTCTTCCGGGT
TTTTCCTCGGCGCGCGTGCC

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MAQPPALPLPKVAPSLRDVGFALGIIGIICILFLPIPPFLIDMGLAFSIAFSVLILMVALWIQKPLDFSSFPTILLIATM
TRLALNIATTRVILSHGNEGHDAAGGVIAGFASLVMSGDFVIGLIVFLILITINFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGIIDEREAQRRRRELEEESSFFGAMDGASKFVRGDAVAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
KLSVGDGLVSQMPALIVSLAAGLLVSRGGTTGSTDQAVVNQLSGYPRALSVSAVLMFVLALMPGLPFVPFVILGSLLAFG
AWFIPRQVEAENKLRREQEEKKVVQSKELEKDSVKAVLRTSEIELALGKMVSTRLLGAHQELAFRVGKMRKKFATQYGFV
VPEIKVTDDIAIAEKSYQIRIHGTTVASNLLRVGEVLVVTGAGRRPSIPGDEIREPAFGMPAVSILENFADDLKREGFQP
IDNVSVVLTHMSEVIRNNLPQLLSYKDVKVLIDRLDPEYKKLADEICSSHMSYSGLQAVLKLLLAERVSIRNLHLILEAV
AELAPHVRKTEQIVEHVRIRMAQQLCGDLADNGVLRVLRLGSKWDLAFHQALKRDAKGEVIEFDIDPRNLEEFSEQATKV
IREFMDRGLPFALVTSPETRSYVRMIIERLFATLPVLSHVELAKGIEIKILGSIS

Sequences:

>Translated_695_residues
MAQPPALPLPKVAPSLRDVGFALGIIGIICILFLPIPPFLIDMGLAFSIAFSVLILMVALWIQKPLDFSSFPTILLIATM
TRLALNIATTRVILSHGNEGHDAAGGVIAGFASLVMSGDFVIGLIVFLILITINFIVITKGATRIAEVGARFTLDAIPGK
QMSIDADLSAGIIDEREAQRRRRELEEESSFFGAMDGASKFVRGDAVAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
KLSVGDGLVSQMPALIVSLAAGLLVSRGGTTGSTDQAVVNQLSGYPRALSVSAVLMFVLALMPGLPFVPFVILGSLLAFG
AWFIPRQVEAENKLRREQEEKKVVQSKELEKDSVKAVLRTSEIELALGKMVSTRLLGAHQELAFRVGKMRKKFATQYGFV
VPEIKVTDDIAIAEKSYQIRIHGTTVASNLLRVGEVLVVTGAGRRPSIPGDEIREPAFGMPAVSILENFADDLKREGFQP
IDNVSVVLTHMSEVIRNNLPQLLSYKDVKVLIDRLDPEYKKLADEICSSHMSYSGLQAVLKLLLAERVSIRNLHLILEAV
AELAPHVRKTEQIVEHVRIRMAQQLCGDLADNGVLRVLRLGSKWDLAFHQALKRDAKGEVIEFDIDPRNLEEFSEQATKV
IREFMDRGLPFALVTSPETRSYVRMIIERLFATLPVLSHVELAKGIEIKILGSIS
>Mature_694_residues
AQPPALPLPKVAPSLRDVGFALGIIGIICILFLPIPPFLIDMGLAFSIAFSVLILMVALWIQKPLDFSSFPTILLIATMT
RLALNIATTRVILSHGNEGHDAAGGVIAGFASLVMSGDFVIGLIVFLILITINFIVITKGATRIAEVGARFTLDAIPGKQ
MSIDADLSAGIIDEREAQRRRRELEEESSFFGAMDGASKFVRGDAVAGLIITAINVFGGIIIGYFRHGMPIGEAADVFVK
LSVGDGLVSQMPALIVSLAAGLLVSRGGTTGSTDQAVVNQLSGYPRALSVSAVLMFVLALMPGLPFVPFVILGSLLAFGA
WFIPRQVEAENKLRREQEEKKVVQSKELEKDSVKAVLRTSEIELALGKMVSTRLLGAHQELAFRVGKMRKKFATQYGFVV
PEIKVTDDIAIAEKSYQIRIHGTTVASNLLRVGEVLVVTGAGRRPSIPGDEIREPAFGMPAVSILENFADDLKREGFQPI
DNVSVVLTHMSEVIRNNLPQLLSYKDVKVLIDRLDPEYKKLADEICSSHMSYSGLQAVLKLLLAERVSIRNLHLILEAVA
ELAPHVRKTEQIVEHVRIRMAQQLCGDLADNGVLRVLRLGSKWDLAFHQALKRDAKGEVIEFDIDPRNLEEFSEQATKVI
REFMDRGLPFALVTSPETRSYVRMIIERLFATLPVLSHVELAKGIEIKILGSIS

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=676, Percent_Identity=36.094674556213, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 75905; Mature: 75774

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQPPALPLPKVAPSLRDVGFALGIIGIICILFLPIPPFLIDMGLAFSIAFSVLILMVAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WIQKPLDFSSFPTILLIATMTRLALNIATTRVILSHGNEGHDAAGGVIAGFASLVMSGDF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCH
VIGLIVFLILITINFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGIIDEREAQR
HHHHHHHHHHHHHHHHEEECCHHHHHHHCCCEEEECCCCCCEEECCCCCCCCCCHHHHHH
RRRELEEESSFFGAMDGASKFVRGDAVAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
KLSVGDGLVSQMPALIVSLAAGLLVSRGGTTGSTDQAVVNQLSGYPRALSVSAVLMFVLA
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LMPGLPFVPFVILGSLLAFGAWFIPRQVEAENKLRREQEEKKVVQSKELEKDSVKAVLRT
HHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SEIELALGKMVSTRLLGAHQELAFRVGKMRKKFATQYGFVVPEIKVTDDIAIAEKSYQIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEECCCEEEE
IHGTTVASNLLRVGEVLVVTGAGRRPSIPGDEIREPAFGMPAVSILENFADDLKREGFQP
EECHHHHHHHHHHCCEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
IDNVSVVLTHMSEVIRNNLPQLLSYKDVKVLIDRLDPEYKKLADEICSSHMSYSGLQAVL
CHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHH
KLLLAERVSIRNLHLILEAVAELAPHVRKTEQIVEHVRIRMAQQLCGDLADNGVLRVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GSKWDLAFHQALKRDAKGEVIEFDIDPRNLEEFSEQATKVIREFMDRGLPFALVTSPETR
CCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHH
SYVRMIIERLFATLPVLSHVELAKGIEIKILGSIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
>Mature Secondary Structure 
AQPPALPLPKVAPSLRDVGFALGIIGIICILFLPIPPFLIDMGLAFSIAFSVLILMVAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
WIQKPLDFSSFPTILLIATMTRLALNIATTRVILSHGNEGHDAAGGVIAGFASLVMSGDF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCH
VIGLIVFLILITINFIVITKGATRIAEVGARFTLDAIPGKQMSIDADLSAGIIDEREAQR
HHHHHHHHHHHHHHHHEEECCHHHHHHHCCCEEEECCCCCCEEECCCCCCCCCCHHHHHH
RRRELEEESSFFGAMDGASKFVRGDAVAGLIITAINVFGGIIIGYFRHGMPIGEAADVFV
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
KLSVGDGLVSQMPALIVSLAAGLLVSRGGTTGSTDQAVVNQLSGYPRALSVSAVLMFVLA
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LMPGLPFVPFVILGSLLAFGAWFIPRQVEAENKLRREQEEKKVVQSKELEKDSVKAVLRT
HHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
SEIELALGKMVSTRLLGAHQELAFRVGKMRKKFATQYGFVVPEIKVTDDIAIAEKSYQIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEECCCEEEE
IHGTTVASNLLRVGEVLVVTGAGRRPSIPGDEIREPAFGMPAVSILENFADDLKREGFQP
EECHHHHHHHHHHCCEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
IDNVSVVLTHMSEVIRNNLPQLLSYKDVKVLIDRLDPEYKKLADEICSSHMSYSGLQAVL
CHHHHHHHHHHHHHHHCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHH
KLLLAERVSIRNLHLILEAVAELAPHVRKTEQIVEHVRIRMAQQLCGDLADNGVLRVLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHC
GSKWDLAFHQALKRDAKGEVIEFDIDPRNLEEFSEQATKVIREFMDRGLPFALVTSPETR
CCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHH
SYVRMIIERLFATLPVLSHVELAKGIEIKILGSIS
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]