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The map label for this gene is lldD [H]

Identifier: 209547680

GI number: 209547680

Start: 68067

End: 69215

Strand: Reverse

Name: lldD [H]

Synonym: Rleg2_0068

Alternate gene names: 209547680

Gene position: 69215-68067 (Counterclockwise)

Preceding gene: 209547681

Following gene: 209547677

Centisome position: 1.53

GC content: 63.71

Gene sequence:

>1149_bases
ATGCGCCTTACAGATTGCTATAATTTTCATGATTTCCGGCGCATGGCCAAACAGCGGCTTCCCGGGCCGATCTTCGATTA
TATCGACGGCGCTGCCGATGACGAGGTGACCTATCGGCGCAATACGGCCGCCTTCGAGGCCTGCGATCTGGTCCCCGACG
TTCTGAGGGGTGTGGCTGAGGTCGACATGTCGGTGACGGTGATGGGGCAGAAGCTGGCGATGCCGGTCTATTGCTCGCCG
ACGGCGCTGCAGCGGCTTTTCCACCACCAGGGCGAGCGGGCGGTCGCGGCGGCGGCGGGAAAATACGGCACGATGTTCGG
CGTCTCCTCGCTCGGCACGATCAGCCTGGAGGAAGCCCGCCAGATCAGCGCCGGGCCGCAGGTCTATCAGTTCTATTTCC
ACAAGGATCGCGGCCTCAACCATGAGATGATGGCGCGGGCAAAAAATGCCGGCGTGCAGGCGATGATGCTGACGGTCGAC
AGCATTACCGGAGGCAACCGCGAGCGCGACAAGCGCACCGGTTTTGCCATTCCCTTCAAGCTTAACCTCGCCGGCATGGC
GCAGTTCGCCATCAAGCCGTCCTGGGCGATCGACTGGCTGACGCATGAGCGCTTCCGGCTGCCGCAGCTCGAAAACCACG
TCAAGATGGATGGCGGCTCGCTGTCGATCAGCCGATATTTCACCGAGATGCTCGACCCCTCCATGTCATGGGACGACGTG
GCGGAGATGGTGCGCGCCTGGGGCGGGCAGTTCTGCCTGAAGGGCATCATGTCGGTCGAAGACGCCAAGCGCGCGGTCGA
GATCGGCTGCACCGGCATCGTGCTTTCCAACCATGGCGGCCGCCAGCTTGACGGTTCGCGCAGCGCTTTCGACCAGTTGG
CCGAGATCGTCGATGCCGTCGGCGACCGGATCGACGTGATGATGGATGGCGGCGTGCAGCGGGGAACCCATGTTCTGAAA
GCGCTGTCGCTGGGGGCGAAGGCCGTCGGGCTCGGCCGCTACTATCTCTTCCCGCTTGCCGCCGCCGGACGGCCGGGCGT
CGAACGGGCGCTGGAGACGATCCGCACCGAGATCGAACGGGACATGAAGCTGATGGGCTGCACCTCGGTCGATCAGCTGA
CACGGCGCAATCTGCGCTTCCGTTCCTGA

Upstream 100 bases:

>100_bases
ATCTCCTCACAAGGGGCCGGAAATCGCCCGATCTAGACTTGGCAAGATTTCGAATCGTGCTTTAGGTTGCGGCCCGAAAC
CAAACGGGTCGAGCAAAAAG

Downstream 100 bases:

>100_bases
GCGGAACAGGATGTCATTTAAGGGCCGCAGCCTTGCATCCGGCTGCGGCCCTCTGACATAGCGGCGTCAGAGCAGGCTAT
AAATCGCCGCCGCCTCCTGC

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MRLTDCYNFHDFRRMAKQRLPGPIFDYIDGAADDEVTYRRNTAAFEACDLVPDVLRGVAEVDMSVTVMGQKLAMPVYCSP
TALQRLFHHQGERAVAAAAGKYGTMFGVSSLGTISLEEARQISAGPQVYQFYFHKDRGLNHEMMARAKNAGVQAMMLTVD
SITGGNRERDKRTGFAIPFKLNLAGMAQFAIKPSWAIDWLTHERFRLPQLENHVKMDGGSLSISRYFTEMLDPSMSWDDV
AEMVRAWGGQFCLKGIMSVEDAKRAVEIGCTGIVLSNHGGRQLDGSRSAFDQLAEIVDAVGDRIDVMMDGGVQRGTHVLK
ALSLGAKAVGLGRYYLFPLAAAGRPGVERALETIRTEIERDMKLMGCTSVDQLTRRNLRFRS

Sequences:

>Translated_382_residues
MRLTDCYNFHDFRRMAKQRLPGPIFDYIDGAADDEVTYRRNTAAFEACDLVPDVLRGVAEVDMSVTVMGQKLAMPVYCSP
TALQRLFHHQGERAVAAAAGKYGTMFGVSSLGTISLEEARQISAGPQVYQFYFHKDRGLNHEMMARAKNAGVQAMMLTVD
SITGGNRERDKRTGFAIPFKLNLAGMAQFAIKPSWAIDWLTHERFRLPQLENHVKMDGGSLSISRYFTEMLDPSMSWDDV
AEMVRAWGGQFCLKGIMSVEDAKRAVEIGCTGIVLSNHGGRQLDGSRSAFDQLAEIVDAVGDRIDVMMDGGVQRGTHVLK
ALSLGAKAVGLGRYYLFPLAAAGRPGVERALETIRTEIERDMKLMGCTSVDQLTRRNLRFRS
>Mature_382_residues
MRLTDCYNFHDFRRMAKQRLPGPIFDYIDGAADDEVTYRRNTAAFEACDLVPDVLRGVAEVDMSVTVMGQKLAMPVYCSP
TALQRLFHHQGERAVAAAAGKYGTMFGVSSLGTISLEEARQISAGPQVYQFYFHKDRGLNHEMMARAKNAGVQAMMLTVD
SITGGNRERDKRTGFAIPFKLNLAGMAQFAIKPSWAIDWLTHERFRLPQLENHVKMDGGSLSISRYFTEMLDPSMSWDDV
AEMVRAWGGQFCLKGIMSVEDAKRAVEIGCTGIVLSNHGGRQLDGSRSAFDQLAEIVDAVGDRIDVMMDGGVQRGTHVLK
ALSLGAKAVGLGRYYLFPLAAAGRPGVERALETIRTEIERDMKLMGCTSVDQLTRRNLRFRS

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=379, Percent_Identity=38.2585751978892, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI54234014, Length=373, Percent_Identity=34.0482573726542, Blast_Score=205, Evalue=5e-53,
Organism=Homo sapiens, GI7705393, Length=373, Percent_Identity=34.0482573726542, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI1790033, Length=369, Percent_Identity=34.6883468834688, Blast_Score=217, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI193208036, Length=367, Percent_Identity=32.1525885558583, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI32566217, Length=278, Percent_Identity=30.2158273381295, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323587, Length=384, Percent_Identity=36.1979166666667, Blast_Score=227, Evalue=3e-60,
Organism=Drosophila melanogaster, GI78707188, Length=369, Percent_Identity=34.4173441734417, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI281363140, Length=369, Percent_Identity=34.4173441734417, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI78707190, Length=369, Percent_Identity=34.4173441734417, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42378; Mature: 42378

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTDCYNFHDFRRMAKQRLPGPIFDYIDGAADDEVTYRRNTAAFEACDLVPDVLRGVAE
CCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
VDMSVTVMGQKLAMPVYCSPTALQRLFHHQGERAVAAAAGKYGTMFGVSSLGTISLEEAR
HCCEEEEECHHHCCCEEECHHHHHHHHHHCCCHHHHHHCCCCHHHHCCCCCCCEEHHHHH
QISAGPQVYQFYFHKDRGLNHEMMARAKNAGVQAMMLTVDSITGGNRERDKRTGFAIPFK
HHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCEEEEEE
LNLAGMAQFAIKPSWAIDWLTHERFRLPQLENHVKMDGGSLSISRYFTEMLDPSMSWDDV
ECHHHHHHHHCCCCCEEEHHHHCCCCCCCHHCCEEECCCCCHHHHHHHHHHCCCCCHHHH
AEMVRAWGGQFCLKGIMSVEDAKRAVEIGCTGIVLSNHGGRQLDGSRSAFDQLAEIVDAV
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GDRIDVMMDGGVQRGTHVLKALSLGAKAVGLGRYYLFPLAAAGRPGVERALETIRTEIER
CCCEEEEECCCHHHHHHHHHHHHCCCHHHCCCHHEEEEECCCCCCHHHHHHHHHHHHHHH
DMKLMGCTSVDQLTRRNLRFRS
HHHHHCCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MRLTDCYNFHDFRRMAKQRLPGPIFDYIDGAADDEVTYRRNTAAFEACDLVPDVLRGVAE
CCCCCCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
VDMSVTVMGQKLAMPVYCSPTALQRLFHHQGERAVAAAAGKYGTMFGVSSLGTISLEEAR
HCCEEEEECHHHCCCEEECHHHHHHHHHHCCCHHHHHHCCCCHHHHCCCCCCCEEHHHHH
QISAGPQVYQFYFHKDRGLNHEMMARAKNAGVQAMMLTVDSITGGNRERDKRTGFAIPFK
HHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCEEEEEE
LNLAGMAQFAIKPSWAIDWLTHERFRLPQLENHVKMDGGSLSISRYFTEMLDPSMSWDDV
ECHHHHHHHHCCCCCEEEHHHHCCCCCCCHHCCEEECCCCCHHHHHHHHHHCCCCCHHHH
AEMVRAWGGQFCLKGIMSVEDAKRAVEIGCTGIVLSNHGGRQLDGSRSAFDQLAEIVDAV
HHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHC
GDRIDVMMDGGVQRGTHVLKALSLGAKAVGLGRYYLFPLAAAGRPGVERALETIRTEIER
CCCEEEEECCCHHHHHHHHHHHHCCCHHHCCCHHEEEEECCCCCCHHHHHHHHHHHHHHH
DMKLMGCTSVDQLTRRNLRFRS
HHHHHCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA