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The map label for this gene is hipA [H]

Identifier: 209400663

GI number: 209400663

Start: 2030001

End: 2031056

Strand: Reverse

Name: hipA [H]

Synonym: ECH74115_2121

Alternate gene names: 209400663

Gene position: 2031056-2030001 (Counterclockwise)

Preceding gene: 209400988

Following gene: 209398354

Centisome position: 36.45

GC content: 48.01

Gene sequence:

>1056_bases
TTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGACGAAACCGTAACGCGTCCGATAATGGC
ATGGGAAAAGCTTACTGAAGTCAGACTTGAAGAAGTATTAACGGCTTATAAAGCAGATATCCCGCTAGGCATGATTAGAG
AAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTGCTCAGAATAGGCAATGACTGGTGCATT
CCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGGGAAATCAGGCAGCCCAATGCGACGCTCGATCT
CAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTGGGTTGAATGTCCCGGACGCAGAAATCA
TTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGGAATGCTGAGCGAACGGTTTTACTTCGC
TTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATATGAATCAGATGGAGGCCCAGGCATCGC
GCGGATCATGGCTTTTTTGATGGGGTTCAGCGAGGCGCTTCGCGATCGTTATGATTTTATGAAATTCCAGGTCTTCCAGT
GGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAGGCTGGCGGCAGTTATCGACTCACGCCA
TTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACATCAGCGATCTCAAACTGGCAATGGGGCT
TAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATTTTTTGGCGACAGCAAAGGTGCTGAGAT
TCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCGGCAGCACTGGATAACGTGAAGACTTCA
TTACCGACAGATTTTCCAGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTTGAGGTTGCACGGTCGGTTAAGCCGAGA
ATACGGTATTAAGTAA

Upstream 100 bases:

>100_bases
GGCATGCGGCTTAATATTGCCAACTTCAAAAGGCTTTTAAAGCCTCCCTTTTATCCGCGATCGCGGATATCGCAGCGTTT
ATCCCGTACAGTTTGATTTA

Downstream 100 bases:

>100_bases
GAGTAAGATATGGGGTTTGGTCGTTGTTAATGAGCAGGACAATCATGACCGCCAACGACTAGATTCTCCCTTGGTTTATA
TTGGTGCGCATAATGTATAT

Product: protein HipA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEVRLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTALLRIGNDWCI
PKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRWNAERTVLLR
LPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGFSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRLTP
FYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTS
LPTDFPENVVTAVETNVLRLHGRLSREYGIK

Sequences:

>Translated_351_residues
MSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEVRLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTALLRIGNDWCI
PKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRWNAERTVLLR
LPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGFSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRLTP
FYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTS
LPTDFPENVVTAVETNVLRLHGRLSREYGIK
>Mature_350_residues
SEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEVRLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTALLRIGNDWCIP
KGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRWNAERTVLLRL
PQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGFSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRLTPF
YDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALDNVKTSL
PTDFPENVVTAVETNVLRLHGRLSREYGIK

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=351, Percent_Identity=98.005698005698, Blast_Score=710, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 39187; Mature: 39056

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEVRLEEVLTAYKADIPLGMIREENDFRI
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEE
SVAGAQEKTALLRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLL
EEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHCCCCCCCEECHHCCCCCEEEEEE
AKELGLNVPDAEIIKAGNVRALAVERFDRRWNAERTVLLRLPQEDMCQTFGLPSSVKYES
EHHHCCCCCCHHHEECCCEEEEHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCEEECC
DGGPGIARIMAFLMGFSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRLTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCH
FYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMH
HHHHHHHHHCCCCCCCEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
EILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEVRLEEVLTAYKADIPLGMIREENDFRI
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEE
SVAGAQEKTALLRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLL
EEECCCCCEEEEEECCCCCCCCCCCCCCEEEECCHHHCCCCCCCEECHHCCCCCEEEEEE
AKELGLNVPDAEIIKAGNVRALAVERFDRRWNAERTVLLRLPQEDMCQTFGLPSSVKYES
EHHHCCCCCCHHHEECCCEEEEHHHHHHHHCCCCCEEEEECCHHHHHHHCCCCCCEEECC
DGGPGIARIMAFLMGFSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGSYRLTP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCH
FYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMH
HHHHHHHHHCCCCCCCEEECCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
EILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]