BacMap

Definition	Escherichia coli O157:H7 str. EC4115, complete genome.
Accession	NC_011353
Length	5,572,075

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The map label for this gene is yeaE [H]

Identifier: 209400049

GI number: 209400049

Start: 2372681

End: 2373535

Strand: Reverse

Name: yeaE [H]

Synonym: ECH74115_2505

Alternate gene names: 209400049

Gene position: 2373535-2372681 (Counterclockwise)

Preceding gene: 209400624

Following gene: 209396138

Centisome position: 42.6

GC content: 51.11

Gene sequence:

>855_bases
ATGCAACAAAAAATGATTCAATTTAGTGGCGATGTCTCACTGCCAGCCATAGGGCAGGGAACATGGTATATGGGCGAAGA
TGCCAGTCAGCGCAAAACAGAAGTTGCTGCACTACGCGCGGGCATTGAACTCGGTTTAACCCTCATTGATACCGCCGAAA
TGTATGCCGATGGCGGTGCCGAAAAGGTGGTTGGGGAAGCATTAACCGGTCTGCGAGAGAAGGTCTTTCTCGTCTCTAAA
GTCTATCCGTGGAATGCTGGCGGGCAAAAAGCGATAAATGCATGCGAAGCCAGTTTACGCCGTCTCAATACTGATTATCT
CGATCTCTACTTATTACACTGGTCTGGCAGTTTCGCTTTTGAAGAGACTGTTGCAGTGATGGAAAAATTGATCGCCCAGG
GAAAAATCCGCCGCTGGGGCGTTTCGAACCTTGATTATGCTGATATGCAGGAACTCTGGCAGCTGCCGGGGGGAAATCAG
TGTGCCACTAATCAGGTGCTTTACCATCTCGGTTCACGAGGGATTGAGTACGATCTACTCCCCTGGTGCCAGCAACAGCA
GATGCCGGTGATGGCTTACAGTCCGTTAGCCCAGGCCGGGCGGTTGCGCAATGGACTGTTAAAAAACGCGGTAGTCAACG
AAATTGCACATGCTCACAATATCAGCGCGGCGCAAGTATTGTTGGCGTGGGTAATCAGCCATCAGGGTGTGATGGCGATT
CCAAAAGCGGCCACGATTGCCCATGTCCAACAGAATGCGGCTGTGCTTGAGGTCGAACTTTCGTCAGCGGAATTAGCCAT
GCTGGACAAAGCGTATCCGGCACCAAAAGGAAAAACTGCGCTGGATATGGTGTGA

Upstream 100 bases:

>100_bases
ACAAATTCTGATAATGCATCTTTCCAGGGCATTTTGTGCATAAAAACAGGGCGTCACGCCCTGTTTTGCATTACGGTGGT
GCAATACCTGGGAGGAAACA

Downstream 100 bases:

>100_bases
TGTTGATACGTGCCGGATGCATCGCACCCGGCACACAACATTGACGCAAATTAACGTTTGGCAACGCGAATGGATTGCGC
CAGATGTGCAGGTTTTTCTT

Product: oxidoreductase, aldo/keto reductase family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MQQKMIQFSGDVSLPAIGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSK
VYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAVMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQ
CATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV

Sequences:

>Translated_284_residues
MQQKMIQFSGDVSLPAIGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSK
VYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAVMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQ
CATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
>Mature_284_residues
MQQKMIQFSGDVSLPAIGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGAEKVVGEALTGLREKVFLVSK
VYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAFEETVAVMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQ
CATNQVLYHLGSRGIEYDLLPWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=297, Percent_Identity=29.6296296296296, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI291291012, Length=265, Percent_Identity=30.5660377358491, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=27.2131147540984, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=28.719723183391, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=28.719723183391, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI5174695, Length=302, Percent_Identity=27.4834437086093, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI300116273, Length=288, Percent_Identity=28.4722222222222, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI310109922, Length=275, Percent_Identity=28.7272727272727, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI300116271, Length=281, Percent_Identity=28.1138790035587, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4502049, Length=290, Percent_Identity=30.3448275862069, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI24497585, Length=290, Percent_Identity=28.2758620689655, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310109920, Length=295, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI45446745, Length=295, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI4503285, Length=295, Percent_Identity=27.1186440677966, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI5453543, Length=295, Percent_Identity=26.7796610169492, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI24497583, Length=291, Percent_Identity=26.8041237113402, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI223718702, Length=200, Percent_Identity=31.5, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788081, Length=284, Percent_Identity=99.2957746478873, Blast_Score=581, Evalue=1e-167,
Organism=Escherichia coli, GI1786400, Length=269, Percent_Identity=28.6245353159851, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788070, Length=313, Percent_Identity=27.7955271565495, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI87081735, Length=301, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI87082198, Length=262, Percent_Identity=29.0076335877863, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789199, Length=351, Percent_Identity=29.3447293447293, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789375, Length=323, Percent_Identity=23.8390092879257, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787674, Length=260, Percent_Identity=23.4615384615385, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994888, Length=235, Percent_Identity=31.063829787234, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17561298, Length=280, Percent_Identity=31.7857142857143, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71998625, Length=277, Percent_Identity=30.6859205776173, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17564128, Length=307, Percent_Identity=27.3615635179153, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537077, Length=297, Percent_Identity=29.2929292929293, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17537075, Length=297, Percent_Identity=29.2929292929293, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17561300, Length=293, Percent_Identity=29.0102389078498, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17538386, Length=290, Percent_Identity=29.3103448275862, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17566692, Length=299, Percent_Identity=25.4180602006689, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17550248, Length=297, Percent_Identity=24.5791245791246, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17537079, Length=302, Percent_Identity=21.1920529801325, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324694, Length=293, Percent_Identity=27.9863481228669, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320079, Length=291, Percent_Identity=27.4914089347079, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322556, Length=283, Percent_Identity=26.5017667844523, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323998, Length=305, Percent_Identity=24.5901639344262, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24644950, Length=312, Percent_Identity=32.6923076923077, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221378297, Length=332, Percent_Identity=30.7228915662651, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45553081, Length=290, Percent_Identity=24.8275862068966, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24657054, Length=291, Percent_Identity=26.8041237113402, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24663317, Length=299, Percent_Identity=23.0769230769231, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI20129731, Length=297, Percent_Identity=25.5892255892256, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281366140, Length=252, Percent_Identity=25.7936507936508, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356425, Length=298, Percent_Identity=23.8255033557047, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24662789, Length=313, Percent_Identity=25.8785942492013, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24662781, Length=288, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 31029; Mature: 31029

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQKMIQFSGDVSLPAIGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGA
CCCCEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
EKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAF
HHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHH
EETVAVMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
PWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEC
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
CCHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MQQKMIQFSGDVSLPAIGQGTWYMGEDASQRKTEVAALRAGIELGLTLIDTAEMYADGGA
CCCCEEEECCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
EKVVGEALTGLREKVFLVSKVYPWNAGGQKAINACEASLRRLNTDYLDLYLLHWSGSFAF
HHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHH
EETVAVMEKLIAQGKIRRWGVSNLDYADMQELWQLPGGNQCATNQVLYHLGSRGIEYDLL
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
PWCQQQQMPVMAYSPLAQAGRLRNGLLKNAVVNEIAHAHNISAAQVLLAWVISHQGVMAI
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEC
PKAATIAHVQQNAAVLEVELSSAELAMLDKAYPAPKGKTALDMV
CCHHHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]