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The map label for this gene is lspA [H]

Identifier: 209399687

GI number: 209399687

Start: 29619

End: 30113

Strand: Direct

Name: lspA [H]

Synonym: ECH74115_0029

Alternate gene names: 209399687

Gene position: 29619-30113 (Clockwise)

Preceding gene: 209400433

Following gene: 209399254

Centisome position: 0.53

GC content: 53.33

Gene sequence:

>495_bases
ATGAGTCAATCGATCTGTTCAACAGGGCTACGCTGGCTGTGGCTGGTGGTAGTCGTGCTGATTATCGATCTGGGCAGCAA
ATACCTGATCCTCCAGAACTTTGCTCTGGGGGATACGGTCCCGCTGTTCCCGTCGCTTAATCTGCATTATGCGCGTAACT
ATGGCGCGGCGTTTAGTTTCCTTGCCGATAGCGGCGGCTGGCAGCGTTGGTTCTTTGCCGGTATTGCGATTGGTATTAGC
GTTACCCTGGTTGTGATGATGTATCGCTCGAAGGCCACGCAGAAGCTAAACAATATCGCCTACGCGCTGATTATTGGCGG
CGCGCTGGGCAACCTGTTCGACCGCCTGTGGCACGGCTTCGTTGTCGATATGATCGACTTCTACGTCGGCGACTGGCACT
TCGCCACCTTCAACCTCGCCGATACTGCCATCTGTGTTGGTGCGGCACTGATTGTGCTGGAAGGTTTTTTGCCTTCTAAA
GCGAAAAAACAATAA

Upstream 100 bases:

>100_bases
ACTACACCCAGGATGTCGGCAAGGTGGCGGAACACGCAGAAATCTGCGGCCGCTGTGTCAGCAACGTCGCCGGTGACGGT
GAAAAACGTAAGTTTGCCTG

Downstream 100 bases:

>100_bases
TAAACCCTGCCGGATAAGGCCTACAGATTGCTGCGAAATCGTAGGCCGCATCCGGCAAAAATCCTCAAAATATAAGAGCA
AACCTGCATGTCTGAATCTG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGIS
VTLVVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSK
AKKQ

Sequences:

>Translated_164_residues
MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGIS
VTLVVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSK
AKKQ
>Mature_163_residues
SQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSFLADSGGWQRWFFAGIAIGISV
TLVVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSKA
KKQ

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=98.1707317073171, Blast_Score=326, Evalue=4e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 18145; Mature: 18013

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSF
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHH
LADSGGWQRWFFAGIAIGISVTLVVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSKAKKQ
HHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SQSICSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVPLFPSLNLHYARNYGAAFSF
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHCCCHHHHH
LADSGGWQRWFFAGIAIGISVTLVVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVDMIDFYVGDWHFATFNLADTAICVGAALIVLEGFLPSKAKKQ
HHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA