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The map label for this gene is bioC [H]

Identifier: 209399655

GI number: 209399655

Start: 937253

End: 938008

Strand: Direct

Name: bioC [H]

Synonym: ECH74115_0925

Alternate gene names: 209399655

Gene position: 937253-938008 (Clockwise)

Preceding gene: 209398877

Following gene: 209397953

Centisome position: 16.82

GC content: 56.75

Gene sequence:

>756_bases
ATGGCAACGGTTAATAAACAAGCCATTGCAGCGGCATTTGGTCGGGCAGCCGCGCACTATGAGCAACACGCAGAGTTACA
GCGCCAGAGTGCTGATGTCTTACTGGCAATGCTCCCACAGCGTAAATACCCCCACGTACTGGACGCGGGGTGTGGGCCTG
GCTGGATGAGCCGCCACTGGCGAGAGCGTCACGCGCAGGTGACGGCGTTAGATCTCTCGCCGCCAATGCTTGCGCAAGCC
CGCCAGAAAGATGCTGCAGACCATTATCTGGCGGGAGATATCGAATCCCTGCCGTTAGCGACTGCGACGTTCGATCTTGC
ATGGAGCAATCTCGCGGTGCAGTGGTGCGGTAATTTATCAACGGCACTCCGCGAGCTGTATCGGGTGGTGCGCCCCGGAG
GCGTGGTCGCGTTTACCACGCTGGTGCAGGGATCGTTACCCGAACTGCATCAGGCGTGGCAGGCGGTGGACGAGCGCCCG
CATGCTAATCGCTTTTTACCGCCAGATGAAATCGAACAGTCGCTGAACGGCGTGCATTATCAACATCGTATTCAGCCCAT
CACACTATGGTTTGATGATGCGCTCAGTGCCATGCGTTCGCTGAAAGGCATCGGTGCCACGCATCTTCATGAAGGGCGCG
ACCAGCGAATATTAACGCGTTCACAGTTGCAGCGATTGCAACTGGCCTGGCCGCAACAACAGGGGCGATATCCTCTGACG
TATCATCTTTTTTTGGGAGTGATTGTTCGTGAGTAA

Upstream 100 bases:

>100_bases
ATTCGCCCGCCAACCGTACCCTCTGGTACTGCGCGACTGCGCTTAACGCTAACCGCCGCGCATGAAATGCAGGATATCGA
CCGTCTGCTGGAGGTGCTGC

Downstream 100 bases:

>100_bases
ACGTTATTTTGTCACCGGAACGGATACCGAAGTGGGGAAAACTGTCGCCAGTTGTGCACTTTTACAAGCCGCAAAGGCAG
CAGGCTATCGGACGGCAGGT

Product: biotin biosynthesis protein BioC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MATVNKQAIAAAFGRAAAHYEQHAELQRQSADVLLAMLPQRKYPHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLAQA
RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP
HANRFLPPDEIEQSLNGVHYQHRIQPITLWFDDALSAMRSLKGIGATHLHEGRDQRILTRSQLQRLQLAWPQQQGRYPLT
YHLFLGVIVRE

Sequences:

>Translated_251_residues
MATVNKQAIAAAFGRAAAHYEQHAELQRQSADVLLAMLPQRKYPHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLAQA
RQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERP
HANRFLPPDEIEQSLNGVHYQHRIQPITLWFDDALSAMRSLKGIGATHLHEGRDQRILTRSQLQRLQLAWPQQQGRYPLT
YHLFLGVIVRE
>Mature_250_residues
ATVNKQAIAAAFGRAAAHYEQHAELQRQSADVLLAMLPQRKYPHVLDAGCGPGWMSRHWRERHAQVTALDLSPPMLAQAR
QKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERPH
ANRFLPPDEIEQSLNGVHYQHRIQPITLWFDDALSAMRSLKGIGATHLHEGRDQRILTRSQLQRLQLAWPQQQGRYPLTY
HLFLGVIVRE

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786994, Length=251, Percent_Identity=96.8127490039841, Blast_Score=473, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 28294; Mature: 28162

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVNKQAIAAAFGRAAAHYEQHAELQRQSADVLLAMLPQRKYPHVLDAGCGPGWMSRHW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHH
RERHAQVTALDLSPPMLAQARQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLS
HHHCCEEEEEECCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
TALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERPHANRFLPPDEIEQSLNGVHY
HHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCH
QHRIQPITLWFDDALSAMRSLKGIGATHLHEGRDQRILTRSQLQRLQLAWPQQQGRYPLT
HHCCEEEEEEHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCH
YHLFLGVIVRE
HHHHHHHHHCC
>Mature Secondary Structure 
ATVNKQAIAAAFGRAAAHYEQHAELQRQSADVLLAMLPQRKYPHVLDAGCGPGWMSRHW
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHH
RERHAQVTALDLSPPMLAQARQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLS
HHHCCEEEEEECCCHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
TALRELYRVVRPGGVVAFTTLVQGSLPELHQAWQAVDERPHANRFLPPDEIEQSLNGVHY
HHHHHHHHHHCCCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCH
QHRIQPITLWFDDALSAMRSLKGIGATHLHEGRDQRILTRSQLQRLQLAWPQQQGRYPLT
HHCCEEEEEEHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCH
YHLFLGVIVRE
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3058702; 9278503 [H]