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The map label for this gene is nagA1 [H]

Identifier: 209399438

GI number: 209399438

Start: 4125115

End: 4126248

Strand: Direct

Name: nagA1 [H]

Synonym: ECH74115_4451

Alternate gene names: 209399438

Gene position: 4125115-4126248 (Clockwise)

Preceding gene: 209399806

Following gene: 209398649

Centisome position: 74.03

GC content: 57.76

Gene sequence:

>1134_bases
ATGACACACGTTCTGCGCGCCAGAAGGCTGCTGACTGAAGAGGGATGGCTCGATGACCATCAGTTGCGTATTGCTGACGG
TGTCATCGCAGCAATCGAACCGATTCCAGTGAGCGTGACTGAACGCGATGCGGAACTGCTCTGCCCCGCTTACATCGACA
CCCATGTACACGGTGGTGCGGGCGTTGATGTAATGGATGACGCGCCGGATGTACTCGACAAGCTGGCAATGCACAAGGCA
CGCGAAGGTGTCGGCAGTTGGTTGCCGACTACCGTAACCGCGCCGCTTAGTACCATTCATGCGGCGCTGAAACGTATTGC
TCAACGTTGCCAACGCGGCGGACCTGGTGCGCAAGTGCTGGGGAGTTATCTCGAAGGACCGTACTTCACGCCGCAGAATA
AAGGCGCGCATCCGCCGGAGTTGTTTCGCGAGCTTGAAATTGCCGAGCTGGATCAATTGATTGCCGTTTCTCAGCACACC
TTACGCGTGGTAGCGCTGGCACCGGAAAAAGAGGGGGCATTGCAGGCCATCCGCCATCTTAAACAGCAAAATGTACGAGT
GATGCTGGGGCATAGCGCGGCGACCTGGCAACAAACTCGCGCCGCGTTTGATGCTGGTGCCGACGGCCTGGTGCATTGCT
ATAACGGGATGACAGGTTTACATCACCGCGAACCGGGAATGGTTGGCGCGGGATTAACGGACAAGCGCGCCTGGCTGGAA
CTGATAGCCGATGGTCATCATGTGCATCCGGCGGCAATGTCGCTGTGTTGTTGCTGTGCGAAAGAGAGAATCGTACTGAT
CACCGACGCGATGCAGGCAGCCGGGATGCCGGATGGTCGCTATACGTTATGTGGCGAAGAAGTGCAGATGCACGGTGGCG
TTGTCCGTACCGCGTCCGGTGGGCTGGCGGGCAGTACGCTGTCTGTTGATGCGGCAGTGCGCAACATGGTCGAGTTGACG
GGCGTAACGCCTGCGGAAGCCATTCATATGGCGTCGCTGCATCCGGCGCGAATGCTGGGTGTTGATGGTGTTCTGGGATC
GCTTAAACCGGGCAAACGCGCCAGCGTCGTTGCGCTGGATAGCGGGCTGCATGTGCAACAAATCTGGATTCAGGGTCAAT
TAGCTTCGTTTTGA

Upstream 100 bases:

>100_bases
AATTCCGTGTACAGGCGCTGGAGTGTGGACATCGTGGGCTGACCAGTCTGGTGGACGAGTTAGGCCGCTGCCATGAAGAA
TGTCCGGTCGAGGAAGGGAT

Downstream 100 bases:

>100_bases
TGGTTTGCTCCATTATTGGGCCTTCACTTCCCCCGTAAGGCCTTTCTTTTTCTTTCGTTTTGATCTGTGCAGCGGTGTCG
GATGCGACGCTAACGCGTCT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: D-Galactosamine 6-Phosphate; Acetate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVSVTERDAELLCPAYIDTHVHGGAGVDVMDDAPDVLDKLAMHKA
REGVGSWLPTTVTAPLSTIHAALKRIAQRCQRGGPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELDQLIAVSQHT
LRVVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTDKRAWLE
LIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHGGVVRTASGGLAGSTLSVDAAVRNMVELT
GVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQIWIQGQLASF

Sequences:

>Translated_377_residues
MTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVSVTERDAELLCPAYIDTHVHGGAGVDVMDDAPDVLDKLAMHKA
REGVGSWLPTTVTAPLSTIHAALKRIAQRCQRGGPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELDQLIAVSQHT
LRVVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTDKRAWLE
LIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHGGVVRTASGGLAGSTLSVDAAVRNMVELT
GVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQIWIQGQLASF
>Mature_376_residues
THVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVSVTERDAELLCPAYIDTHVHGGAGVDVMDDAPDVLDKLAMHKAR
EGVGSWLPTTVTAPLSTIHAALKRIAQRCQRGGPGAQVLGSYLEGPYFTPQNKGAHPPELFRELEIAELDQLIAVSQHTL
RVVALAPEKEGALQAIRHLKQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTDKRAWLEL
IADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHGGVVRTASGGLAGSTLSVDAAVRNMVELTG
VTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALDSGLHVQQIWIQGQLASF

Specific function: N-acetylgalactosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=415, Percent_Identity=33.4939759036145, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI224922791, Length=413, Percent_Identity=33.4140435835351, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1786892, Length=380, Percent_Identity=32.3684210526316, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17553768, Length=387, Percent_Identity=29.7157622739018, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19920392, Length=389, Percent_Identity=30.8483290488432, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281361140, Length=402, Percent_Identity=30.5970149253731, Blast_Score=174, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 40271; Mature: 40140

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVSVTERDAELLCPAYIDTHVHGGA
CCHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCEEEEECCCHHHCCHHHHHCCCCCCC
GVDVMDDAPDVLDKLAMHKAREGVGSWLPTTVTAPLSTIHAALKRIAQRCQRGGPGAQVL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
GSYLEGPYFTPQNKGAHPPELFRELEIAELDQLIAVSQHTLRVVALAPEKEGALQAIRHL
HHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHH
KQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTDKRAWLE
HHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCCCCCEECCCCHHHHHHH
LIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHGGVVRTASG
HHHCCCCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCEEEECCHHHHCCCEEEECCC
GLAGSTLSVDAAVRNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALD
CCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCCCCCEEEEEEC
SGLHVQQIWIQGQLASF
CCCEEEEEEEECCCCCC
>Mature Secondary Structure 
THVLRARRLLTEEGWLDDHQLRIADGVIAAIEPIPVSVTERDAELLCPAYIDTHVHGGA
CHHHHHHHHHHHCCCCCCCEEEEECCEEEEECCCEEEEECCCHHHCCHHHHHCCCCCCC
GVDVMDDAPDVLDKLAMHKAREGVGSWLPTTVTAPLSTIHAALKRIAQRCQRGGPGAQVL
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
GSYLEGPYFTPQNKGAHPPELFRELEIAELDQLIAVSQHTLRVVALAPEKEGALQAIRHL
HHHHCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHHHH
KQQNVRVMLGHSAATWQQTRAAFDAGADGLVHCYNGMTGLHHREPGMVGAGLTDKRAWLE
HHCCCEEEECCCHHHHHHHHHHHHCCCCCCEEHHCCCCCCCCCCCCCEECCCCHHHHHHH
LIADGHHVHPAAMSLCCCCAKERIVLITDAMQAAGMPDGRYTLCGEEVQMHGGVVRTASG
HHHCCCCCCHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCEEEECCHHHHCCCEEEECCC
GLAGSTLSVDAAVRNMVELTGVTPAEAIHMASLHPARMLGVDGVLGSLKPGKRASVVALD
CCCCCEEEHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHCCCHHHCCCCCCCCEEEEEEC
SGLHVQQIWIQGQLASF
CCCEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Acetyl-D-Galactosamine 6-Phosphate; H2O [C]

Specific reaction: N-Acetyl-D-Galactosamine 6-Phosphate + H2O = D-Galactosamine 6-Phosphate + Acetate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8932697 [H]