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The map label for this gene is ubiA

Identifier: 209399362

GI number: 209399362

Start: 5170552

End: 5171424

Strand: Direct

Name: ubiA

Synonym: ECH74115_5521

Alternate gene names: 209399362

Gene position: 5170552-5171424 (Clockwise)

Preceding gene: 209397494

Following gene: 209396567

Centisome position: 92.79

GC content: 51.66

Gene sequence:

>873_bases
ATGGAGTGGAGTCTGACGCAGAATAAGCTGCTGGCGTTTCATCGCTTAATGCGTACGGATAAGCCAATTGGCGCGTTACT
GCTGCTCTGGCCAACATTATGGGCGTTGTGGGTGGCGACACCGGGCGTTCCCCAGCTCTGGATCCTGGCGGTGTTTGTCG
CGGGTGTCTGGCTGATGCGCGCTGCCGGATGTGTGGTGAATGATTATGCTGACCGCAAGTTTGATGGTCATGTTAAGCGC
ACGGCGAACCGACCACTTCCCAGCGGCGCGGTAACAGAGAAAGAGGCGCGCGCGCTGTTTGTAGTGCTGGTACTGATTTC
GTTTTTACTGGTGCTGACGCTGAATACGATGACCATTCTGTTGTCGATTGCCGCGCTAGCGCTGGCGTGGGTGTACCCGT
TTATGAAGCGGTATACCCATCTACCGCAAGTGGTGCTGGGCGCGGCGTTTGGCTGGTCGATTCCAATGGCTTTTGCTGCT
GTGAGTGAGTCGGTGCCATTGAGTTGCTGGTTAATGTTCCTCGCCAATATTCTCTGGGCGGTGGCTTACGACACGCAGTA
TGCGATGGTTGACCGTGATGATGATGTGAAGATTGGCATTAAATCCACCGCAATCCTGTTCGGCCAATACGATAAATTGA
TTATTGGTATTTTGCAGATTGGCGTACTGGCGCTGATGGCGATTATCGGTGAGTTAAATGGCTTAGGCTGGGGATATTAC
TGGTCAATTCTGGTGGCTGGCGCGCTGTTTGTTTATCAACAAAAACTGATTGCCAACCGCGAGCGCGAAGCCTGCTTTAA
AGCATTTATGAATAATAACTATGTTGGTCTGGTACTGTTTTTAGGGCTGGCAATGAGTTACTGGCATTTCTGA

Upstream 100 bases:

>100_bases
ACTGTGGGGGCGACGTTCCCGCTTGCGATTAAGCGGTAAACCGCTGTTGCTAACAGAACTGTTTTTACCGGCGTCACCGT
TGTACTAAGAGGAAAAAAAT

Downstream 100 bases:

>100_bases
TGATGTAAAAAAGCCGGATGATCATCCGGCTTTCTTCTGGGTTGCCTGATGCGCTGCGCTTCTCAGGCCTACACAACAGA
TCGCAATTTATTGAATTTGC

Product: 4-hydroxybenzoate octaprenyltransferase

Products: NA

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
WSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Sequences:

>Translated_290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
WSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
>Mature_290_residues
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKR
TANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAA
VSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
WSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=282, Percent_Identity=34.3971631205674, Blast_Score=174, Evalue=6e-44,
Organism=Escherichia coli, GI1790473, Length=290, Percent_Identity=100, Blast_Score=584, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI32565247, Length=281, Percent_Identity=37.0106761565836, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=36.9718309859155, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17553720, Length=183, Percent_Identity=42.0765027322404, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI32565245, Length=141, Percent_Identity=44.6808510638298, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565243, Length=140, Percent_Identity=44.2857142857143, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6324370, Length=300, Percent_Identity=32, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21355567, Length=276, Percent_Identity=37.3188405797101, Blast_Score=180, Evalue=8e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_ECO24 (A7ZUR2)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001465541.1
- ProteinModelPortal:   A7ZUR2
- STRING:   A7ZUR2
- EnsemblBacteria:   EBESCT00000020355
- GeneID:   5586134
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_4593
- eggNOG:   COG0382
- GeneTree:   EBGT00050000009570
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12848
- BioCyc:   ECOL331111:ECE24377A_4593-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32512; Mature: 32512

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1386ed88)-; HASH(0x1328b2c4)-; HASH(0x11516590)-; HASH(0x12ed51b0)-; HASH(0x138cf858)-; HASH(0x12c56184)-; HASH(0x138b582c)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTIL
HCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMR
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
AAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARALFVVLVLISFLLVLTLNTMTIL
HCCHHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
VAYDTQYAMVDRDDDVKIGIKSTAILFGQYDKLIIGILQIGVLALMAIIGELNGLGWGYY
HHHCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WSILVAGALFVYQQKLIANREREACFKAFMNNNYVGLVLFLGLAMSYWHF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA