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The map label for this gene is aslA [H]

Identifier: 209399246

GI number: 209399246

Start: 4881089

End: 4882744

Strand: Reverse

Name: aslA [H]

Synonym: ECH74115_5237

Alternate gene names: 209399246

Gene position: 4882744-4881089 (Counterclockwise)

Preceding gene: 209398548

Following gene: 209397506

Centisome position: 87.63

GC content: 52.72

Gene sequence:

>1656_bases
ATGGAATTTTCGTTTTCACCCAAACTTCTTGTTGTTGCTGTCGCCGCCGCTCTTCCTCTCATGGCCAGCGCAGCAGATAC
CCCGTCAACTGCCACCGCGCGCAAAGGCTTTGCCGGATACGATCACCCAAACCAGTATCTGGTTAAACCGGCGACCACTA
TTGCCGACAACATGATGCCAGTAATGCAGCATCCGGCGCAGGATAAAGAACCCCAGCAGAAGCTGGCAGAACTTGAGAAA
AAAACCGGTAAGAAACCGAATGTGGTTGTTTTCTTGCTGGACGATGTGGGCTGGATGGACGTCGGTTTTAACGGTGGCGG
CGTGGCGGTGGGTAACCCTACACCAGATATCGACGCCGTTGCCAGCCAGGGGCTGATTTTAACTTCGGCGTATTCTCAAC
CAAGCTCTTCCCCAACCCGCGCCACCATTCTCACCGGACAATACTCCATCCACCACGGCATTCTGATGCCGCCAATGTAC
GGGCAACCGGGCGGGCTGCAAGGGTTAACCACGCTGCCGCAGTTGCTGCACGATCAGGGCTACGTCACTCAGGCCATCGG
GAAATGGCATATGGGGGAAAACAAAGAGTCGCAGCCGCAGAACGTTGGCTTTGATGATTTCCGTGGCTTTAACTCGGTGT
CTGATATGTACACCGAATGGCGCGACGTTCACGTCAATCCGGAAGTGGCCCTGAGTCCGGACCGTTCTGAATACATCAAG
CAATTACCATTTAGCAAAGATGATGTTCATGCGGTGCGCGGCGGCGAACAACAGGCCATTGCCGACATTACGCCGAAATA
TATGGAAGATCTGGATCAACGCTGGATGGAATATGGCGTTAAGTTCCTCGACAAGATGGCGAAGAGTGATAAGCCTTTCT
TCCTCTATTACGGCACTCGCGGCTGTCACTTCGATAACTACCCGAACGCCAAATATGCGGGTAGCTCTCCGGCACGCACC
TCGTATGGCGACTGCATGGTGGAAATGAACGATGTGTTCGCTAATCTGTATAAAGCACTGGAGAAAAACGGTCAGCTTGA
TAACACGCTGATTGTCTTTACCTCCGATAACGGACCGGAAGCCGAAGTACCGCCGCACGGACGCACACCGTTCCGTGGTG
CGAAAGGATCTACCTGGGAAGGCGGCGTTCGCGTACCGACTTTCGTTTACTGGAAAGGCATGATCCAACCGCGTAAATCT
GACGGTATTGTTGATCTGGCAGATCTCTTCCCAACAGCACTGGATCTGGCGGGGCATCCTGGTGCGAAAGTGGCGAATTT
AGTGCCGAAAACCACCTTTATCGATGGTGTGGACCAGACATCTTTCTTCCTGGGAACAAATGGTCAGTCTAACCGTAAGG
CCGAGCACTACTTCCTCAACGGTAAACTCGCTGCTGTGCGTATGGATGAATTCAAGTATCACGTCCTGATTCAGCAACCT
TACGCTTATACCCAGAGCGGATATCAGGGTGGATTCACCGGCACAGTAATGCAAACAGCCGGATCGTCGGTGTTTAACCT
CTACACCGATCCGCAGGAGAGCGACTCTATCGGCGTGCGCCATATTCCGATGGGTGTACCGCTACAGACCGAAATGCACG
CGTATATGGAGATCCTGAAAAAGTATCCACCACGCGCGCAGATTAAATCTGATTAA

Upstream 100 bases:

>100_bases
TCACTATTATTTATGTAATCATCCTGTCAGGGAGAGGGATCTCAATTATCAATGCTTAATTACGTCATCATTTTGTTGAC
ATGAAACCGGAGCATTTTGC

Downstream 100 bases:

>100_bases
GCCGGCGCTATCGCTGAGATCTGCCTTTGCCGGATGCGATGCTGACGCATCTTATCCAGCCTACAGAACGCTGCAATTTA
TTGAATTTGCACGATCATGT

Product: arylsulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MEFSFSPKLLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKEPQQKLAELEK
KTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMY
GQPGGLQGLTTLPQLLHDQGYVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIK
QLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMEYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPART
SYGDCMVEMNDVFANLYKALEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKS
DGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD

Sequences:

>Translated_551_residues
MEFSFSPKLLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKEPQQKLAELEK
KTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMY
GQPGGLQGLTTLPQLLHDQGYVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIK
QLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMEYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPART
SYGDCMVEMNDVFANLYKALEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKS
DGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD
>Mature_551_residues
MEFSFSPKLLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMPVMQHPAQDKEPQQKLAELEK
KTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAVASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMY
GQPGGLQGLTTLPQLLHDQGYVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIK
QLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMEYGVKFLDKMAKSDKPFFLYYGTRGCHFDNYPNAKYAGSSPART
SYGDCMVEMNDVFANLYKALEKNGQLDNTLIVFTSDNGPEAEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKS
DGIVDLADLFPTALDLAGHPGAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQP
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILKKYPPRAQIKSD

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=409, Percent_Identity=29.3398533007335, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI146229329, Length=409, Percent_Identity=29.3398533007335, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI6005990, Length=409, Percent_Identity=29.3398533007335, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI146229324, Length=409, Percent_Identity=29.3398533007335, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI45430057, Length=480, Percent_Identity=28.3333333333333, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4503899, Length=405, Percent_Identity=28.8888888888889, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI38569407, Length=349, Percent_Identity=30.945558739255, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI38569405, Length=349, Percent_Identity=30.945558739255, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI146229327, Length=318, Percent_Identity=28.3018867924528, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI59797060, Length=347, Percent_Identity=31.4121037463977, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI109389362, Length=365, Percent_Identity=29.3150684931507, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI157266309, Length=449, Percent_Identity=27.8396436525612, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI31742482, Length=519, Percent_Identity=26.5895953757225, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI71852584, Length=520, Percent_Identity=25.9615384615385, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI58743319, Length=502, Percent_Identity=25.0996015936255, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI53831991, Length=273, Percent_Identity=27.8388278388278, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI71852586, Length=150, Percent_Identity=35.3333333333333, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1790233, Length=551, Percent_Identity=99.2740471869328, Blast_Score=1137, Evalue=0.0,
Organism=Escherichia coli, GI87081924, Length=417, Percent_Identity=26.8585131894484, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI115533416, Length=411, Percent_Identity=24.5742092457421, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115533418, Length=403, Percent_Identity=23.8213399503722, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17559078, Length=264, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363223, Length=368, Percent_Identity=30.4347826086957, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24666175, Length=390, Percent_Identity=29.4871794871795, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24666109, Length=424, Percent_Identity=26.1792452830189, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281366397, Length=366, Percent_Identity=28.1420765027322, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281366395, Length=366, Percent_Identity=28.1420765027322, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24666163, Length=366, Percent_Identity=28.1420765027322, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 60655; Mature: 60655

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSFSPKLLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHCCHH
VMQHPAQDKEPQQKLAELEKKTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAV
HHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCEECCCCCCCHHHH
ASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMYGQPGGLQGLTTLPQLLHDQG
HCCCEEEEECCCCCCCCCCEEEEEECCEEECCCEECCCCCCCCCCCCHHHHHHHHHHCCC
YVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIK
CHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHEEECCCCEEECCCHHHHHH
QLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMEYGVKFLDKMAKSDKPFFLYYGTR
HCCCCCCCHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GCHFDNYPNAKYAGSSPARTSYGDCMVEMNDVFANLYKALEKNGQLDNTLIVFTSDNGPE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
AEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKSDGIVDLADLFPTALDLAGHP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHCCCC
GAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQP
CCHHHHHCCCCCEECCCCCCEEEEECCCCCCCCCCEEEECCEEEEEEECCEEEEEEEECC
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILK
CHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
KYPPRAQIKSD
HCCCCCCCCCC
>Mature Secondary Structure
MEFSFSPKLLVVAVAAALPLMASAADTPSTATARKGFAGYDHPNQYLVKPATTIADNMMP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEECCHHHHHHCCHH
VMQHPAQDKEPQQKLAELEKKTGKKPNVVVFLLDDVGWMDVGFNGGGVAVGNPTPDIDAV
HHHCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCCCEECCCCCCCHHHH
ASQGLILTSAYSQPSSSPTRATILTGQYSIHHGILMPPMYGQPGGLQGLTTLPQLLHDQG
HCCCEEEEECCCCCCCCCCEEEEEECCEEECCCEECCCCCCCCCCCCHHHHHHHHHHCCC
YVTQAIGKWHMGENKESQPQNVGFDDFRGFNSVSDMYTEWRDVHVNPEVALSPDRSEYIK
CHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHEEECCCCEEECCCHHHHHH
QLPFSKDDVHAVRGGEQQAIADITPKYMEDLDQRWMEYGVKFLDKMAKSDKPFFLYYGTR
HCCCCCCCHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
GCHFDNYPNAKYAGSSPARTSYGDCMVEMNDVFANLYKALEKNGQLDNTLIVFTSDNGPE
CCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
AEVPPHGRTPFRGAKGSTWEGGVRVPTFVYWKGMIQPRKSDGIVDLADLFPTALDLAGHP
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEHHHHHHHHHHHCCCC
GAKVANLVPKTTFIDGVDQTSFFLGTNGQSNRKAEHYFLNGKLAAVRMDEFKYHVLIQQP
CCHHHHHCCCCCEECCCCCCEEEEECCCCCCCCCCEEEECCEEEEEEECCEEEEEEEECC
YAYTQSGYQGGFTGTVMQTAGSSVFNLYTDPQESDSIGVRHIPMGVPLQTEMHAYMEILK
CHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHH
KYPPRAQIKSD
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]