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The map label for this gene is acrE [H]

Identifier: 209399035

GI number: 209399035

Start: 4250590

End: 4251747

Strand: Direct

Name: acrE [H]

Synonym: ECH74115_4582

Alternate gene names: 209399035

Gene position: 4250590-4251747 (Clockwise)

Preceding gene: 209396821

Following gene: 209396069

Centisome position: 76.28

GC content: 52.25

Gene sequence:

>1158_bases
ATGACGAAACATGCCAGGTTTTTCCTCCTGCCCTCCTTTATTCTGATCTCCGCGGCTTTAATCGCCGGTTGTAACGATAA
GGGAGAAGAGAAAGCTCACGTCGGTGAACCGCAGGTTACCGTTCATATTGTAAAAACGGCCCCGTTAGAAGTTAAGACTG
AATTACCAGGCCGCACCAATGCTTATCGTATAGCCGAAGTTCGCCCACAGGTTAGCGGGATCGTACTGAATCGCAATTTC
ACTGAAGGCAGCGATGTGCAAGCAGGCCAGTCCCTGTACCAGATCGATCCCGCGACCTATCAGGCAAATTATGACAGCGC
GAAAGGCGAACTGGCGAAAAGTGAAGCCGCCGCCGCCATCGCGCATTTGACGGTAAAACGTTACGTTCCGCTCGTGGGTA
CGAAATACATCAGCCAGCAGGAGTACGACCAGGCCATTGCTGATGCTCGCCAGGCCGATGCCGCCGTGATTGCCGCAAAA
GCCACAGTCGAAAGCGCTCGCATCAATCTTGCTTATACCAAAGTGACTGCGCCAATTAGCGGACGTATCGGCAAATCGAC
TGTGACCGAAGGCGCTCTTGTCACTAATGGGCAAACGACTGAACTGGCAACTGTCCAGCAGCTCGATCCTATCTATGTTG
ATGTGACCCAATCCAGCAACGATTTTATGAGGCTGAAGCAGTCCGTAGAGCAAGGAAATTTGCATAAGGAAAACGCCACC
AGCAACGTAGAGTTGGTCATGGAAAACGGTCAAACCTATCCCCTGAAAGGTACGCTGCAATTCTCCGATGTGACCGTTGA
TGAAAGCACCGGCTCCATAACCCTACGTGCTGTCTTCCCTAACCCGCAACATACGCTTTTGCCGGGTATGTTTGTGCGTG
CACGGATTGATGAAGGCGTCCAACCTGACGCCATTCTCATCCCGCAACAAGGCGTTAGCCGCACACCGCGTGGTGATGCA
ACCGTGCTGATTGTTAACGATAAAAGTCAGGTGGAAGTGCGCCCTGTCGTTGCCAGTCAGGCGATTGGCGATAAATGGTT
GATTAGCGAAGGTCTGAAATCTGGCGATCAAGTCATTGTCAGCGGCCTGCAAAAAGCGCGTCCGGGAGAGCAGGTTAAAG
CCACTACCGATACCCCCGCAGATACTGCATCGAAGTAA

Upstream 100 bases:

>100_bases
ATGATAATTTGTAGGATAGCGAACTGTATTTTTCTTTCTGCGAGTTAACGCGTTGCCTTTTTGGGTAAATAACGCGCTTT
TGGTTTTTTGAGGAATAGTA

Downstream 100 bases:

>100_bases
GGTAATCTGACATGGCAAACTTTTTTATTCGACGACCGATATTTGCATGGGTGCTGGCCATTATTCTGATGATGGCGGGC
GCACTGGCGATCCTACAATT

Product: acriflavine resistance protein E

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNF
TEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAK
ATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDA
TVLIVNDKSQVEVRPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADTASK

Sequences:

>Translated_385_residues
MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNF
TEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAK
ATVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDA
TVLIVNDKSQVEVRPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADTASK
>Mature_384_residues
TKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTNAYRIAEVRPQVSGIVLNRNFT
EGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAIAHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKA
TVESARINLAYTKVTAPISGRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENATS
NVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGVQPDAILIPQQGVSRTPRGDAT
VLIVNDKSQVEVRPVVASQAIGDKWLISEGLKSGDQVIVSGLQKARPGEQVKATTDTPADTASK

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=385, Percent_Identity=99.7402597402597, Blast_Score=783, Evalue=0.0,
Organism=Escherichia coli, GI1786668, Length=375, Percent_Identity=69.3333333333333, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1789929, Length=382, Percent_Identity=49.4764397905759, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI87082036, Length=320, Percent_Identity=29.0625, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87081796, Length=205, Percent_Identity=27.3170731707317, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41346; Mature: 41215

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTN
CCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCEEEEECCCCCCC
AYRIAEVRPQVSGIVLNRNFTEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAI
CEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHH
AHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPIS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEEEEEEEECCCC
GRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
CCCCCCCCCCCEEEECCCCCEEEHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGV
CCEEEEEECCCEECEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
QPDAILIPQQGVSRTPRGDATVLIVNDKSQVEVRPVVASQAIGDKWLISEGLKSGDQVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHCCCHHHHHHHCCCCHHHHH
SGLQKARPGEQVKATTDTPADTASK
HHHHHCCCCCCEEECCCCCCCCCCC
>Mature Secondary Structure 
TKHARFFLLPSFILISAALIAGCNDKGEEKAHVGEPQVTVHIVKTAPLEVKTELPGRTN
CCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCEEEEECCCCCCC
AYRIAEVRPQVSGIVLNRNFTEGSDVQAGQSLYQIDPATYQANYDSAKGELAKSEAAAAI
CEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEECCCEEECCCCCCCCHHHHHHHHHHH
AHLTVKRYVPLVGTKYISQQEYDQAIADARQADAAVIAAKATVESARINLAYTKVTAPIS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEEEEEEEEEEEEECCCC
GRIGKSTVTEGALVTNGQTTELATVQQLDPIYVDVTQSSNDFMRLKQSVEQGNLHKENAT
CCCCCCCCCCCEEEECCCCCEEEHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCC
SNVELVMENGQTYPLKGTLQFSDVTVDESTGSITLRAVFPNPQHTLLPGMFVRARIDEGV
CCEEEEEECCCEECEEEEEEEEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCC
QPDAILIPQQGVSRTPRGDATVLIVNDKSQVEVRPVVASQAIGDKWLISEGLKSGDQVIV
CCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEEHHHHHCCCHHHHHHHCCCCHHHHH
SGLQKARPGEQVKATTDTPADTASK
HHHHHCCCCCCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]