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The map label for this gene is dnaE

Identifier: 209398477

GI number: 209398477

Start: 208450

End: 211932

Strand: Direct

Name: dnaE

Synonym: ECH74115_0194

Alternate gene names: 209398477

Gene position: 208450-211932 (Clockwise)

Preceding gene: 209400402

Following gene: 209398883

Centisome position: 3.74

GC content: 54.95

Gene sequence:

>3483_bases
ATGTCTGAACCACGTTTCGTACACCTGCGGGTGCACAGCGACTACTCGATGATCGATGGCCTGGCCAAAACCGCACCGCT
GGTAAAAAAGGCGGCGGCGTTGGGTATGCCAGCACTGGCGATCACCGATTTCACCAACCTTTGCGGTCTGGTGAAGTTCT
ACGGAGCGGGACATGGCGCAGGGATTAAGCCTATCGTCGGGGCAGATTTTAACGTCCAGTGCGACCTGCTGGGTGATGAG
TTAACCCACCTGACGGTACTGGCGGCGAACAATACCGGCTATCAGAATCTGACGTTGCTGATCTCAAAAGCGTATCAGCG
CGGGTACGGTGCCGCCGGGCCGATCATCGATCGCGACTGGCTTATCGAATTAAACGAAGGGTTGATCCTTCTTTCCGGCG
GGCGCATGGGCGACGTCGGACGCAGTCTTTTGCGTGGTAACAGCGCGCTGGTAGATGAGTGTGTCGCGTTTTATGAAGAA
CACTTCCCGGATCGCTATTTTCTCGAGCTGATCCGCACCGGCAGGCCGGATGAAGAAAGCTATCTGCACGCGGCGGTGGA
ACTGGCGGAAGCGCGCGGTTTGCCCGTCGTGGCGACTAACGATGTGCGCTTTATCGACAGCAGCGACTTTGACGCACACG
AAATCCGCGTCGCGATCCACGACGGCTTTACCCTCGACGATCCTAAACGCCCGCGTAACTATTCGCCGCAGCAATATATG
CGTAGCGAAGAGGAGATGTGCGAGCTGTTTGCCGACATCCCAGAAGCCCTTGCCAACACCGTTGAGATCGCCAAACGCTG
TAACGTAACTGTGCGTCTTGGTGAATACTTCCTGCCGCAGTTCCCGACCGGGGACATGAGCACCGAAGATTATCTGGTCA
AGCGTGCAAAAGAGGGCCTGGAAGAGCGTCTGGCCTTTTTATTCCCTGATGAGGAAGAACGTGTTAAGCGCCGCCCGGAA
TATGACGAACGTCTGGAGACTGAACTTCAGGTTATCAACCAGATGGGCTTCCCGGGCTACTTCCTCATCGTTATGGAATT
TATCCAGTGGTCGAAAGATAACGGCGTACCGGTAGGGCCAGGCCGTGGCTCCGGTGCGGGTTCACTGGTGGCCTACGCGC
TGAAAATCACCGACCTCGATCCGCTGGAATTTGACCTGCTGTTCGAACGTTTCCTTAACCCGGAACGTGTCTCCATGCCT
GACTTCGACGTTGACTTCTGTATGGAGAAACGCGATCAGGTTATCGAACACGTAGCGGACATGTACGGTCGTGATGCGGT
ATCGCAGATTATCACCTTCGGTACGATGGCGGCGAAAGCGGTGATCCGCGACGTAGGCCGCGTGCTGGGGCATCCGTACG
GCTTTGTCGATCGTATCTCGAAACTGATCCCGCCCGATCCGGGGATGACGCTGGCGAAAGCGTTTGAAGCCGAGCCGCAG
CTGCCGGAAATCTACGAAGCGGATGAAGAAGTTAAGGCGTTGATCGACATGGCGCGCAAACTGGAAGGGGTCACCCGTAA
CGCCGGTAAGCACGCCGGTGGGGTGGTTATCGCGCCGACCAAAATTACCGATTTTGCGCCGCTTTATTGCGATGAAGAGG
GCAAACATCCGGTCACCCAGTTTGATAAAAGCGACGTTGAATACGCCGGACTGGTGAAGTTCGACTTCCTTGGTTTGCGT
ACGCTCACCATCATCAACTGGGCGCTGGAGATGATCAACAAGCGGCGGGCGAAGAATGGCGAGCCGCCGCTGGATATCGC
CGCGATCCCGCTGGATGACAAGAAAAGCTTCGACATGCTGCAACGCTCGGAAACCACGGCGGTATTCCAGCTTGAATCGC
GCGGCATGAAGGACCTGATCAAGCGTCTGCAACCTGACTGCTTCGAAGATATGATCGCACTGGTGGCACTGTTCCGCCCT
GGTCCGTTGCAATCAGGGATGGTGGATAACTTTATCGACCGTAAACATGGTCGCGAAGAGATCTCCTATCCGGACGTGCA
GTGGCAGCATGAAAGCCTGAAACCGGTACTGGAGCCAACCTACGGCATTATCCTGTATCAGGAACAGGTCATGCAGATTG
CGCAGGTGCTTTCTGGTTATACCCTCGGTGGCGCGGATATGCTGCGTCGTGCGATGGGTAAGAAAAAGCCGGAAGAGATG
GCTAAGCAACGTTCTGTATTTGCTGAAGGTGCAGAAAAGAACGGAATCAACGCCGAACTGGCGATGAAAATCTTCGACCT
GGTGGAGAAATTCGCTGGTTACGGATTTAACAAATCGCACTCTGCGGCCTATGCTTTGGTGTCATATCAAACATTATGGT
TGAAAGCGCACTATCCGGCAGAGTTTATGGCGGCGGTAATGACCGCCGATATGGACAACACCGAGAAGGTGGTGGGCCTG
GTGGATGAGTGCTGGCGGATGGGGCTGAAAATCCTGCCACCAGATATAAACTCCGGTCTTTACCATTTCCACGTCAACGA
CGACGGCGAAATCGTGTATGGTATTGGCGCGATCAAAGGGGTAGGTGAAGGTCCGATTGAGGCGATCATCGAAGCCCGTA
ATAAAGGCGGCTACTTCCGCGAACTGTTTGATCTCTGCGCCCGAACCGACACCAAAAAGTTGAACCGTCGCGTGCTGGAA
AAACTGATCATGTCCGGGGCGTTTGACCGTCTTGGGCCACATCGCGCGGCGCTGATGAACTCGCTGGGCGATGCGTTAAA
AGCGGCAGATCAACACGCGAAAGCGGAAGCTATCGGTCAGGCCGATATGTTCGGCGTGCTGGCCGAAGAGCCGGAACAAA
TTGAACAATCCTATGCCAGCTGCCAACCGTGGCCGGAGCAGGTGGTATTAGATGGGGAACGTGAAACGTTAGGCCTGTAC
CTGACCGGACACCCTATCAACCAGTATTTAAAAGAGATTGAGCGTTATGTCGGAGGCGTAAGGCTGAAAGACATGCACCC
GACAGAACGTGGTAAAGTCATCACGGCTGCGGGGCTCGTTGTTGCCGCGCGGGTTATGGTCACCAAGCGCGGCAATCGTA
TCGGTATCTGCACGCTGGATGACCGTTCCGGGCGGCTGGAAGTGATGTTGTTTACTGACGCCCTGGATAAATACCAGCAT
TTGCTGGAAAAAGACCGCATACTTATCGTCAGCGGACAGGTCAGCTTTGATGACTTCAGCGGTGGGCTTAAAATGACCGC
TCGCGAAGTGATGGATATTGACGAAGCCCGGGAAAAATATGCTCGCGGGCTTGCTATCTCGCTGACGGACAGGCAAATTG
ATGACCAGCTTTTAAACCGACTCCGTCAGTCTCTGGAACCCCACCGCTCTGGGACAATTCCAGTACATCTCTACTATCAG
AGGGCGGATGCACGCGCGCGGTTGCGTTTTGGCGCGACGTGGCGTGTCTCTCCGAGCGATCGTTTATTAAACGATCTCCG
TGGCCTCATTGGTTCGGAGCAGGTGGAACTGGAGTTTGACTAA

Upstream 100 bases:

>100_bases
CGCGACCGAACACCATCGGCGCAGCTTTGGGCCTGTCAAACGCGCACTGGGACTTGCGTCCTGATTCTTGTGTCGAGATT
AAGTAAACCGGAATCTGAAG

Downstream 100 bases:

>100_bases
TACAGGAATACTATGAGTCTGAATTTCCTTGATTTTGAACAGCCGATTGCAGAGCTGGAAGCGAAAATCGATTCTCTGAC
TGCGGTTAGCCGTCAGGATG

Product: DNA polymerase III subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 1160; Mature: 1159

Protein sequence:

>1160_residues
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGAGIKPIVGADFNVQCDLLGDE
LTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEE
HFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM
RSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGLEERLAFLFPDEEERVKRRPE
YDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMP
DFDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQ
LPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAGLVKFDFLGLR
TLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRP
GPLQSGMVDNFIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
AKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGL
VDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLE
KLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLY
LTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALDKYQH
LLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQ
RADARARLRFGATWRVSPSDRLLNDLRGLIGSEQVELEFD

Sequences:

>Translated_1160_residues
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGAGIKPIVGADFNVQCDLLGDE
LTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEE
HFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM
RSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGLEERLAFLFPDEEERVKRRPE
YDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMP
DFDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQ
LPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAGLVKFDFLGLR
TLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRP
GPLQSGMVDNFIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
AKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGL
VDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLE
KLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLY
LTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALDKYQH
LLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQ
RADARARLRFGATWRVSPSDRLLNDLRGLIGSEQVELEFD
>Mature_1159_residues
SEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGAGIKPIVGADFNVQCDLLGDEL
THLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEEH
FPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMR
SEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGLEERLAFLFPDEEERVKRRPEY
DERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPD
FDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQL
PEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAGLVKFDFLGLRT
LTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPG
PLQSGMVDNFIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEMA
KQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGLV
DECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLEK
LIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLYL
TGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALDKYQHL
LEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQR
ADARARLRFGATWRVSPSDRLLNDLRGLIGSEQVELEFD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase

COG id: COG0587

COG function: function code L; DNA polymerase III, alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase type-C family. DnaE subfamily

Homologues:

Organism=Escherichia coli, GI1786381, Length=1160, Percent_Identity=99.8275862068966, Blast_Score=2380, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPO3A_ECO57 (Q8X8X5)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85503
- PIR:   B90652
- RefSeq:   NP_285878.1
- RefSeq:   NP_308213.1
- ProteinModelPortal:   Q8X8X5
- SMR:   Q8X8X5
- EnsemblBacteria:   EBESCT00000026102
- EnsemblBacteria:   EBESCT00000055459
- GeneID:   913906
- GeneID:   956917
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z0196
- KEGG:   ecs:ECs0186
- GeneTree:   EBGT00050000010406
- HOGENOM:   HBG734490
- OMA:   QIVTFGT
- ProtClustDB:   PRK05673
- BioCyc:   ECOL83334:ECS0186-MONOMER
- GO:   GO:0005737
- InterPro:   IPR011708
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR004805
- SMART:   SM00481
- TIGRFAMs:   TIGR00594

Pfam domain/function: PF07733 DNA_pol3_alpha; PF02811 PHP; PF01336 tRNA_anti; SSF89550 PHP-like

EC number: =2.7.7.7

Molecular weight: Translated: 129901; Mature: 129770

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGA
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
GIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDW
CCCCEECCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCE
LIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEEHFPDRYFLELIRTGRPDEES
EEEECCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHH
YLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM
HHHHHHHHHHHCCCCEEEECCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
RSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHH
EERLAFLFPDEEERVKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGP
HHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
GRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVAD
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQ
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCC
LPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQ
CCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCHH
FDKSDVEYAGLVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDML
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHH
QRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREE
HHCCCCEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
ISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
CCCCCCCCCHHHCCHHHCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHH
AKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEEEEECCCH
EFMAAVMTADMDNTEKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCEEEEEECCCC
VGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMN
CCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHH
SLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCCEEEEE
LTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLD
EECCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEHHHHHHHHHHHHEECCCEEEEEEEC
DRSGRLEVMLFTDALDKYQHLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKY
CCCCEEEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQRADARARLRFGATWRVSPSD
HCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCEEEECCHH
RLLNDLRGLIGSEQVELEFD
HHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure 
SEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGA
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
GIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDW
CCCCEECCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCE
LIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEEHFPDRYFLELIRTGRPDEES
EEEECCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHH
YLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYM
HHHHHHHHHHHCCCCEEEECCEEEECCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
RSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHCCCCCCCCCCHHHHHHHHHHHHH
EERLAFLFPDEEERVKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGP
HHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
GRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVAD
CCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQ
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCC
LPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQ
CCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCEECCCCCCCCHH
FDKSDVEYAGLVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDML
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHH
QRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREE
HHCCCCEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCC
ISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEM
CCCCCCCCCHHHCCHHHCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHH
AKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEEEEECCCH
EFMAAVMTADMDNTEKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEECCCCCEEEEEECCCC
VGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMN
CCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHCCHHHHHHHH
SLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLY
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCCEEEEE
LTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLD
EECCCHHHHHHHHHHHHCCEEEECCCCCCCCCEEEHHHHHHHHHHHHEECCCEEEEEEEC
DRSGRLEVMLFTDALDKYQHLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKY
CCCCEEEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQRADARARLRFGATWRVSPSD
HCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCEEEECCHH
RLLNDLRGLIGSEQVELEFD
HHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796