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The map label for this gene is ggt [H]

Identifier: 209397919

GI number: 209397919

Start: 4405817

End: 4407562

Strand: Reverse

Name: ggt [H]

Synonym: ECH74115_4761

Alternate gene names: 209397919

Gene position: 4407562-4405817 (Counterclockwise)

Preceding gene: 209397176

Following gene: 209400110

Centisome position: 79.1

GC content: 54.52

Gene sequence:

>1746_bases
ATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGTTCACAGGAAGTTGTTTTAGTACGGTAGCCGCGCC
ACCTGCGCCGTCTCCTGTTTCTTACGGCGTGGAGGAAGATGTCTTTCATCCGGTACGCGCGAAACAGGGGATGGTGGCAT
CTGTAGATGCTACTGCCACTCAGGTGGGGGTGGATATCCTCAAGGAGGGCGGGAATGCCGTTGATGCCGCCGTGGCTGTG
GGCTACGCGCTGGCGGTAACGCATCCGCAGGCAGGGAATCTGGGCGGTGGTGGTTTTATGCTGATCCGCTCGAAAAATGG
CAATACCACCGCTATCGATTTCCGCGAAATGGCACCCGCCAAAGCGACCCGCGATATGTTCCTTGATGACCAGGGCAACC
CGGACAGCAAAAAATCACTCACTTCGCATCTGGCTTCCGGCACGCCCGGTACGGTCGCTGGTTTCTCGCTGGCGTTGGAT
AAATACGGCACAATGCCGTTGAACAAAGTGGTGCAGCCAGCGTTTAAACTGGCACGCGATGGTTTTATCGTTAACGACGA
GCTGGCTGACGATCTCAAAACCTACGGGAGCGAAGTGCTGCCGAATCACGAAAACAGCAAGGCTATCTTCTGGAAAGAGG
GCGAGCCGCTGAAAAAGGGCGACAAGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATTGCCGAAAACGGCCCG
GACGAATTCTACAAAGGCACGATAGCGGAACAGATTGCCCAGGAGATGCAGAAAAACGGTGGCCTGATCACTAAAGAAGA
TTTAGCGGCGTATAAAGCGGTCGAACGCACACCGATAAGCGGCGATTATCGCGGGTATCAGGTTTACTCCATGCCACCGC
CATCCTCCGGCGGGATCCATATCGTACAAATCCTCAATATTCTGGAAAACTTCGATATGAAGAAATACGGTTTTGGCAGC
GCCGACGCGATGCAGATCATGGCAGAAGCGGAGAAATATGCCTACGCTGACCGCTCGGAATATCTTGGCGACCCGGATTT
TGTGAAAGTCCCGTGGCAGGCGCTGACCAATAAAGCCTATGCCAAATCTATTGCCGAGCAAATCGATATCAATAAAGCGA
AACCGTCCAGCGAGATTCGCCCCGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTATTCGGTGGTGGATAAA
GACGGTAACGCGGTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGTATTGTCGCGGGCGAGAGCGGTATTTT
GCTCAATAACCAAATGGATGATTTCTCTGCCAAACCGGGCGTACCGAACGTTTACGGGCTGGTGGGCGGTGATGCCAACG
CCGTCGGGCCGAACAAACGCCCGCTGTCATCGATGTCACCAACCATTGTGGTGAAAGACGGTAAAACCTGGCTGGTCACC
GGTAGCCCTGGCGGGAGCCTGATCATCACTACAGTGCTTCAAATGGTGGTGAATAGCATCGATTATGGCATGAACGTCGC
CGAAGCGACCAATGCGCCGCGTTTCCACCATCAGTGGTTGCCGGACGAGCTGCGTGTCGAAAAAGGGTTTAGCCCGGATA
CGCTCAAGCTGCTGGAAGCAAAAGGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGTACACAAAGCATTATGGTTGGG
CCGGACGGTGAGTTGTACTGCGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTACTAA

Upstream 100 bases:

>100_bases
ATATTCTTTAAGTTTACTCCTTTCCTGCAATCATCAGGATTAATTCAGAGTTATATACCAGGCTTAGCTGGGGTTGCCCC
TTAATCTCTGGAGAATAACG

Downstream 100 bases:

>100_bases
GGTTAGCGGCCCTCTTCGTGGGAAGAGGGCTGTTTTCTTGAACAAGATAAATTAGTGTCTGGATTGCTTTTACTATTGCT
CCGTAATATATAATCATAAT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAV
GYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALD
KYGTMPLNKVVQPAFKLARDGFIVNDELADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGP
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGS
ADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIAEQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDK
DGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
GSPGGSLIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVG
PDGELYCASDPRSVDDLTAGY

Sequences:

>Translated_581_residues
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAV
GYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALD
KYGTMPLNKVVQPAFKLARDGFIVNDELADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGP
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGS
ADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIAEQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDK
DGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
GSPGGSLIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVG
PDGELYCASDPRSVDDLTAGY
>Mature_581_residues
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAV
GYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALD
KYGTMPLNKVVQPAFKLARDGFIVNDELADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGP
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGS
ADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIAEQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDK
DGNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
GSPGGSLIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVG
PDGELYCASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.6698656429942, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI113429326, Length=530, Percent_Identity=30.9433962264151, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.511839708561, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI153266901, Length=513, Percent_Identity=29.4346978557505, Blast_Score=176, Evalue=8e-44,
Organism=Homo sapiens, GI153266885, Length=514, Percent_Identity=29.3774319066148, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=27.1897810218978, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=5e-19,
Organism=Escherichia coli, GI1789856, Length=581, Percent_Identity=97.934595524957, Blast_Score=1147, Evalue=0.0,
Organism=Caenorhabditis elegans, GI212646519, Length=574, Percent_Identity=33.7979094076655, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI72000294, Length=574, Percent_Identity=33.7979094076655, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI193208245, Length=561, Percent_Identity=32.7985739750446, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI193208247, Length=561, Percent_Identity=32.7985739750446, Blast_Score=242, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=35.6713426853707, Blast_Score=238, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=30.7001795332136, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.765237020316, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI72001497, Length=232, Percent_Identity=26.2931034482759, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=26.2931034482759, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=503, Percent_Identity=28.4294234592445, Blast_Score=153, Evalue=9e-38,
Organism=Drosophila melanogaster, GI45551474, Length=516, Percent_Identity=32.7519379844961, Blast_Score=249, Evalue=5e-66,
Organism=Drosophila melanogaster, GI161077880, Length=516, Percent_Identity=32.7519379844961, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI161077878, Length=516, Percent_Identity=32.7519379844961, Blast_Score=248, Evalue=8e-66,
Organism=Drosophila melanogaster, GI24642670, Length=516, Percent_Identity=32.7519379844961, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24642666, Length=516, Percent_Identity=32.7519379844961, Blast_Score=248, Evalue=9e-66,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=31.2977099236641, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.6949806949807, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.6751361161525, Blast_Score=193, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62082; Mature: 62082

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATAT
CCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHH
QVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPA
HHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCC
KATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARD
HHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GFIVNDELADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGP
CEEECHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIH
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCH
IVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAY
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHH
AKSIAEQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEE
AGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
ECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEE
GSPGGSLIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEA
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHH
KGQKVALKEAMGSTQSIMVGPDGELYCASDPRSVDDLTAGY
CCCEEEHHHHCCCCCEEEECCCCCEEECCCCCCCCHHCCCC
>Mature Secondary Structure
MIKPTFLRRVAIAALFTGSCFSTVAAPPAPSPVSYGVEEDVFHPVRAKQGMVASVDATAT
CCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHH
QVGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPA
HHHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCC
KATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARD
HHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GFIVNDELADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDKLVQANLAKSLEMIAENGP
CEEECHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
DEFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIH
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCH
IVQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAY
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHH
AKSIAEQIDINKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIV
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEE
AGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVT
ECCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEE
GSPGGSLIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEA
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHH
KGQKVALKEAMGSTQSIMVGPDGELYCASDPRSVDDLTAGY
CCCEEEHHHHCCCCCEEEECCCCCEEECCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]