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The map label for this gene is mngR [H]

Identifier: 209397083

GI number: 209397083

Start: 4456870

End: 4457616

Strand: Direct

Name: mngR [H]

Synonym: ECH74115_4822

Alternate gene names: 209397083

Gene position: 4456870-4457616 (Clockwise)

Preceding gene: 209397817

Following gene: 209398767

Centisome position: 79.99

GC content: 41.77

Gene sequence:

>747_bases
ATGAAATCATTAAGTAAGTCGTCACAAATACCGCTCTATCAACAAGTGGTGGAGTGGATAAGAGAAAGTATTTATACCGG
AGATCTGGTGGAAGACGATCGCATTCCTTCGGAATACCAGATTATGGATATGCTGGACGTGAGTCGGGGAACCGTTAAAA
AAGCGGTCGCCCAACTGGTAAAAGAAGGCGTGTTAATACAGGTCCAGGGTAAGGGAACATTTGTCAAAAAAGAGAACGTG
GCATATCCGTTAGGTGAAGGATTATTGTCATTCGCGGAATCGCTGGAAAGCCAGAAAATACATTTTACCACTGAAGTTAT
TACGTCACGGATTGAATCGGCTAATCGTTATGTGGCAGAGAAATTAAGAATAACGCCCGGTCAGGATATTCTTTACCTTG
AACGCTTACGCTCAATTGGTGATGAAAAAGCGATGCTGATAGAGAACCGTATCAATATTGAGCTATGCCCCGGTATTGCT
GAAATCGATTTTAATCAACACAATTTATTTCCAACAATAGAAAGTTTGTCGCAAAGAAAAATTCGTTACTCGGAAAGTCG
CTATGCCGCGCGATTAATTGGTAATGAACGTGGTCATTTTTTAGATATCAGTGAAGACGCACCCGTTTTGCATCTGGAGC
AGTTAGTCTTTTTCTCCCGAGGATTACCCATTGAGTTTGGCAACGTCTGGTTAAAAGGAAATAAATATTATCTTGGCACC
GTACTGCAACGGCGGGAAGTGAGTTAA

Upstream 100 bases:

>100_bases
TGTGAGACGCTTCGATCCTCTTTTTCTCCCGTTCACCTACTATACGCTTGAAGTTGTCCATGATTGTCCATAGACAACTG
TAAATGTTCAGGTGCGCGCC

Downstream 100 bases:

>100_bases
GTACACTTTTTTAAGAGGAATAAAATGCAAGGCATACATTTTCAGGAAAATTATATTCAACGACTTCCGGCAGGGTTAAG
CGTTGAACAGATCATCCGCC

Product: transcriptional regulator, GntR family

Products: NA

Alternate protein names: Fatty acyl-responsive regulator; Protein P30 [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKSLSKSSQIPLYQQVVEWIRESIYTGDLVEDDRIPSEYQIMDMLDVSRGTVKKAVAQLVKEGVLIQVQGKGTFVKKENV
AYPLGEGLLSFAESLESQKIHFTTEVITSRIESANRYVAEKLRITPGQDILYLERLRSIGDEKAMLIENRINIELCPGIA
EIDFNQHNLFPTIESLSQRKIRYSESRYAARLIGNERGHFLDISEDAPVLHLEQLVFFSRGLPIEFGNVWLKGNKYYLGT
VLQRREVS

Sequences:

>Translated_248_residues
MKSLSKSSQIPLYQQVVEWIRESIYTGDLVEDDRIPSEYQIMDMLDVSRGTVKKAVAQLVKEGVLIQVQGKGTFVKKENV
AYPLGEGLLSFAESLESQKIHFTTEVITSRIESANRYVAEKLRITPGQDILYLERLRSIGDEKAMLIENRINIELCPGIA
EIDFNQHNLFPTIESLSQRKIRYSESRYAARLIGNERGHFLDISEDAPVLHLEQLVFFSRGLPIEFGNVWLKGNKYYLGT
VLQRREVS
>Mature_248_residues
MKSLSKSSQIPLYQQVVEWIRESIYTGDLVEDDRIPSEYQIMDMLDVSRGTVKKAVAQLVKEGVLIQVQGKGTFVKKENV
AYPLGEGLLSFAESLESQKIHFTTEVITSRIESANRYVAEKLRITPGQDILYLERLRSIGDEKAMLIENRINIELCPGIA
EIDFNQHNLFPTIESLSQRKIRYSESRYAARLIGNERGHFLDISEDAPVLHLEQLVFFSRGLPIEFGNVWLKGNKYYLGT
VLQRREVS

Specific function: Represses mngA and mngB. Regulates its own expression [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=235, Percent_Identity=28.0851063829787, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790540, Length=184, Percent_Identity=28.2608695652174, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788418, Length=231, Percent_Identity=24.6753246753247, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI87082252, Length=248, Percent_Identity=25, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1790118, Length=144, Percent_Identity=25.6944444444444, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28368; Mature: 28368

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLSKSSQIPLYQQVVEWIRESIYTGDLVEDDRIPSEYQIMDMLDVSRGTVKKAVAQLV
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
KEGVLIQVQGKGTFVKKENVAYPLGEGLLSFAESLESQKIHFTTEVITSRIESANRYVAE
HCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
KLRITPGQDILYLERLRSIGDEKAMLIENRINIELCPGIAEIDFNQHNLFPTIESLSQRK
HHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCEEEECCCCCCCCCCHHHHHHHH
IRYSESRYAARLIGNERGHFLDISEDAPVLHLEQLVFFSRGLPIEFGNVWLKGNKYYLGT
HHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCEEEECCCEEEHH
VLQRREVS
HHHHHCCC
>Mature Secondary Structure
MKSLSKSSQIPLYQQVVEWIRESIYTGDLVEDDRIPSEYQIMDMLDVSRGTVKKAVAQLV
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHH
KEGVLIQVQGKGTFVKKENVAYPLGEGLLSFAESLESQKIHFTTEVITSRIESANRYVAE
HCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHH
KLRITPGQDILYLERLRSIGDEKAMLIENRINIELCPGIAEIDFNQHNLFPTIESLSQRK
HHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCEEECCCEEEECCCCCCCCCCHHHHHHHH
IRYSESRYAARLIGNERGHFLDISEDAPVLHLEQLVFFSRGLPIEFGNVWLKGNKYYLGT
HHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEECCEEEECCCEEEHH
VLQRREVS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548486; 9278503; 9063979; 8905232; 7805834 [H]