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The map label for this gene is pheP [H]

Identifier: 209396862

GI number: 209396862

Start: 687727

End: 689139

Strand: Direct

Name: pheP [H]

Synonym: ECH74115_0657

Alternate gene names: 209396862

Gene position: 687727-689139 (Clockwise)

Preceding gene: 209396317

Following gene: 209396640

Centisome position: 12.34

GC content: 53.01

Gene sequence:

>1413_bases
GTGCCCCTCAACAAAAAAGACACACAGGGGAAAGGCGTGAAAAACGCGTCAAACGTATCGGAAGATACTGCGTCGAATCA
AGAGCCGACGCTTCATCGCGGATTACATAACCGTCATATTCAACTGATTGCGCTGGGTGGCGCAATTGGTACTGGTCTGT
TTCTTGGCATTGGCCCGGCGATTCAGATGGCGGGTCCGGCTGTATTGCTGGGCTACGGCGTCGCCGGGATCATCGCTTTC
CTGATTATGCGCCAGCTCGGCGAGATGGTGGTCGAAGAGCCGGTATCCGGTTCATTTGCCCACTTTGCCTATAAATACTG
GGGACCGTTCGCCGGGTTCCTCTCCGGCTGGAACTACTGGGTGATGTTCGTGCTGGTGGGAATGGCAGAGCTGACCGCTG
CGGGCATCTATATGCAGTACTGGTTCCCGGATGTTCCAACGTGGATTTGGGCTGCCGCCTTCTTTATTATCATCAACGCC
GTTAACCTGGTGAACGTGCGCTTATATGGCGAAACCGAGTTCTGGTTTGCGCTGATTAAAGTGCTGGCAATCATCGGTAT
GATCGGCTTTGGCCTGTGGCTGCTGTTTTCTGGTCACGGCGGCGAGAAAGCCAGTATCGACAACCTCTGGCGCTACGGTG
GTTTCTTCGCCACCGGCTGGAATGGGCTGATTTTGTCGCTGGCGGTAATTATGTTCTCCTTCGGCGGTCTGGAGCTGATT
GGGATTACTGCCGCTGAAGCGCGCGATCCGGAAAAAAGCATTCCAAAAGCGGTAAATCAGGTGGTGTATCGCATCCTGCT
GTTTTACATCGGTTCACTGGTGGTTTTACTGGCGCTCTATCCGTGGGTGGAAGTGAAATCCAACAGTAGCCCGTTTGTGA
TGATTTTCCATAATCTCGACAGCAACGTGGTAGCTTCTGCGCTGAACTTCGTCATTCTGGTAGCATCGCTGTCAGTGTAT
AACAGCGGGGTTTACTCTAACAGCCGCATGCTGTTTGGCCTTTCTGTGCAGGGTAATGCGCCGAAGTTCCTTACCCGTGT
TAGCCGTCGCGGCGTGCCGATTAACTCGCTGATGCTTTCCGGAGCGATCACTTCGCTGGTGGTGTTAATCAACTATCTGC
TGCCGCAAAAAGCGTTTGGTCTGCTGATGGCGCTGGTGGTAGCAACGCTGCTGTTGAACTGGATTATGATCTGTCTGGCG
CATCTGCGTTTTCGTGCAGCGATGCGACGTCAGGGGCGTGAAACACAGTTTAAGGCGCTGCTCTATCCGTTCGGCAACTA
TCTTTGCATCGCCTTCCTCGCCATGATTTTGCTGCTGATGTGCACGATGGATGATATGCGCTTGTCAGCGATCCTGCTGC
CGGTGTGGATTGTATTCCTGTTTGTAGCATTTAAAACGCTGCGTCGGAAATAA

Upstream 100 bases:

>100_bases
TGATGTGGCTGCACCGACATCGGGTACGGAAATAAAAGCAGGATACCCGGTTTAACCGTGTGGATTGTGTCTTGCGACGA
TGGGCACTAAATGTTAAAAG

Downstream 100 bases:

>100_bases
GGCATTCACGCTACATCCGACAAAACGATGTCCGCTCTCATCCATTCGATGAGAGCGGTTTTTTTAATTACTGCTTAAAT
GCACCCGCCAGAGAGCGAAT

Product: phenylalanine transporter

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MPLNKKDTQGKGVKNASNVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAF
LIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINA
VNLVNVRLYGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVY
NSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLA
HLRFRAAMRRQGRETQFKALLYPFGNYLCIAFLAMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK

Sequences:

>Translated_470_residues
MPLNKKDTQGKGVKNASNVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAF
LIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINA
VNLVNVRLYGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVY
NSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLA
HLRFRAAMRRQGRETQFKALLYPFGNYLCIAFLAMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK
>Mature_469_residues
PLNKKDTQGKGVKNASNVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFL
IMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAV
NLVNVRLYGETEFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIG
ITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNVVASALNFVILVASLSVYN
SGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAH
LRFRAAMRRQGRETQFKALLYPFGNYLCIAFLAMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=290, Percent_Identity=27.5862068965517, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=405, Percent_Identity=24.1975308641975, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI258645169, Length=441, Percent_Identity=21.7687074829932, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI115648063, Length=460, Percent_Identity=21.9565217391304, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI115648022, Length=460, Percent_Identity=21.9565217391304, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786789, Length=458, Percent_Identity=99.1266375545851, Blast_Score=909, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=434, Percent_Identity=64.2857142857143, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=44.0559440559441, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=45.575221238938, Blast_Score=353, Evalue=1e-98,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=37.9157427937916, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI87081915, Length=425, Percent_Identity=36.4705882352941, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1788480, Length=438, Percent_Identity=37.2146118721461, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.8909512761021, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87081708, Length=418, Percent_Identity=36.1244019138756, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87081869, Length=175, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082023, Length=418, Percent_Identity=22.9665071770335, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI2367353, Length=370, Percent_Identity=21.3513513513514, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=393, Percent_Identity=23.6641221374046, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=391, Percent_Identity=21.9948849104859, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=35.972850678733, Blast_Score=253, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6324061, Length=445, Percent_Identity=35.5056179775281, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6324059, Length=460, Percent_Identity=34.5652173913044, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319824, Length=458, Percent_Identity=31.2227074235808, Blast_Score=219, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6322892, Length=444, Percent_Identity=35.1351351351351, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6324990, Length=441, Percent_Identity=32.4263038548753, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6321629, Length=437, Percent_Identity=31.350114416476, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=448, Percent_Identity=31.25, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=33.4170854271357, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320717, Length=503, Percent_Identity=28.0318091451292, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321053, Length=451, Percent_Identity=32.1507760532151, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6319543, Length=438, Percent_Identity=31.9634703196347, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6320251, Length=501, Percent_Identity=27.3453093812375, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=31.3924050632911, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6319542, Length=480, Percent_Identity=26.6666666666667, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6319608, Length=413, Percent_Identity=29.7820823244552, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6324981, Length=422, Percent_Identity=32.2274881516588, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=27.2177419354839, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI221512776, Length=415, Percent_Identity=22.8915662650602, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666159, Length=415, Percent_Identity=22.8915662650602, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667468, Length=430, Percent_Identity=22.3255813953488, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221331183, Length=351, Percent_Identity=23.3618233618234, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17647653, Length=351, Percent_Identity=23.3618233618234, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24664379, Length=351, Percent_Identity=23.3618233618234, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51940; Mature: 51808

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNKKDTQGKGVKNASNVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPA
CCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHH
IQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
VMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIK
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHH
VLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCEEEE
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLD
EEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCC
SNVVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHH
GAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LYPFGNYLCIAFLAMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLNKKDTQGKGVKNASNVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPA
CCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHH
IQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHH
VMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIK
HHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHH
VLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCEEEE
GITAAEARDPEKSIPKAVNQVVYRILLFYIGSLVVLLALYPWVEVKSNSSPFVMIFHNLD
EEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEEEECCC
SNVVASALNFVILVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSRRGVPINSLMLS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHH
GAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LYPFGNYLCIAFLAMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]