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The map label for this gene is argD

Identifier: 209396810

GI number: 209396810

Start: 4311946

End: 4313166

Strand: Reverse

Name: argD

Synonym: ECH74115_4669

Alternate gene names: 209396810

Gene position: 4313166-4311946 (Counterclockwise)

Preceding gene: 209396064

Following gene: 209396265

Centisome position: 77.41

GC content: 54.22

Gene sequence:

>1221_bases
ATGGCAATTGAACAAACAGCAATTACACGCGCGACTTTCGATGAAGTGATCCTGCCGATTTATGCTCCGGCAGAGTTCAT
TCCGGTAAAAGGTCAGGGCAGCCGAATCTGGGATCAGCAAGGCAAGGAGTATGTCGATTTCGCGGGTGGCATTGCAGTTA
CGGCGTTGGGCCATTGCCATCCTGCGCTGGTGAACGCGTTAAAAACCCAGGGCGAAACTCTGTGGCATATCAGTAACGTT
TTCACCAATGAACCGGCGCTGCGTCTTGGGCGTAAACTGATTGAGGCGACGTTTGCCGAACGCGTGGTGTTTATGAACTC
CGGCACGGAAGCTAACGAAACCGCCTTTAAACTGGCACGCCATTACGCCTGCGTGCGTCATAGCCCGTTCAAAACCAAAA
TTATTGCCTTCCATAACGCTTTTCATGGTCGCTCGCTGTTTACCGTTTCGGTGGGTGGGCAGCCAAAATATTCCGACGGC
TTTGGGCCAAAACCATCAGACATCATCCACGTTCCCTTTAACGATCTCCACGCAGTGAAAGCGGTGATGGATGATCACAC
CTGTGCGGTGGTGGTTGAGCCGATCCAGGGCGAGGGCGGTGTGACGGCAGCGACGCCAGAGTTTTTGCAGGGCTTGCGTG
AGTTGTGCGATCAACATCAGGCATTATTGGTGTTTGATGAAGTACAGTGCGGGATGGGGCGGACTGGCGATTTGTTTGCT
TACATGCACTACGGCGTGACGCCGGATATTCTGACTTCTGCGAAAGCGTTAGGCGGCGGCTTCCCGATTAGCGCCATGCT
GACCACGGCGGAAATTGCTTCTGCGTTTCATCCTGGTTCTCACGGTTCCACCTACGGCGGTAATCCTCTGGCCTGTGCAG
TAGCGGGCGCGGCGTTTGATATCATTAATACCCCTGAAGTGCTGGAAGGCATTCAGGCGAAACGCCAGCGTTTTGTTGAC
CATTTGCAGAAGATCGATCAGCAGTACGATGTGTTTAGCGATATTCGCGGTATGGGGCTGTTAATTGGCGCGGAGCTGAA
ACCACAGTACAAAGGTCAGGCGCGTGATTTCCTGTATGCGGGCGCAGAGGCTGGCGTAATGGTGCTGAATGCCGGACCGG
ATGTGATGCGTTTTGCGCCGTCGCTGGTGGTGGAAGATGCGGATATCGATGAAGGGATGCAACGTTTCGCCCACGCGGTG
GCGAAGGTGGTTGGGGCGTAA

Upstream 100 bases:

>100_bases
TTCCTGCATCGCTGATTTCTGATTGCCATTCAATGATTTTTTATGCATATTTTGTGATTATAATTTCACATTTATTTATG
CATAACAGGGTGATCATGAG

Downstream 100 bases:

>100_bases
ATAAGACGCATCAGGCAAAAGATGTCGGATGCGGCGTGCATGCCTTATCCGATGGTTTAGCCTGCATTACGCCTTCGAAT
CCCGCAACTTGCGACTCAGC

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPSDIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
AKVVGA

Sequences:

>Translated_406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPSDIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
AKVVGA
>Mature_405_residues
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVF
TNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGF
GPKPSDIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAY
MHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDH
LQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVA
KVVGA

Specific function: Involved in both the arginine and lysine biosynthetic pathways

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=378, Percent_Identity=37.037037037037, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI284507298, Length=294, Percent_Identity=38.7755102040816, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=28.9411764705882, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI37574042, Length=401, Percent_Identity=30.4239401496259, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI226442709, Length=374, Percent_Identity=30.7486631016043, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442705, Length=401, Percent_Identity=29.1770573566085, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI24119277, Length=393, Percent_Identity=26.7175572519084, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI188536080, Length=419, Percent_Identity=23.1503579952267, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38679950, Length=419, Percent_Identity=23.1503579952267, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI38679946, Length=419, Percent_Identity=23.1503579952267, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=99.5073891625616, Blast_Score=833, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=397, Percent_Identity=60.2015113350126, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=35.3808353808354, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=33.1683168316832, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI145693181, Length=330, Percent_Identity=36.6666666666667, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=31.5457413249211, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1786991, Length=414, Percent_Identity=29.7101449275362, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=36.2666666666667, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=28.6374133949192, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=37.3076923076923, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=28.3333333333333, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=25.7471264367816, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=32.3170731707317, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=38.1313131313131, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=32.258064516129, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=29.9363057324841, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=24.8275862068966, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21357415, Length=377, Percent_Identity=34.7480106100796, Blast_Score=224, Evalue=8e-59,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=28.169014084507, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI161085790, Length=421, Percent_Identity=28.0285035629454, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=29.9287410926366, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI281366494, Length=434, Percent_Identity=22.3502304147465, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667139, Length=434, Percent_Identity=22.3502304147465, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667143, Length=434, Percent_Identity=22.3502304147465, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_ECO57 (Q8X4S6)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B91155
- PIR:   G86000
- RefSeq:   NP_289907.1
- RefSeq:   NP_312237.1
- ProteinModelPortal:   Q8X4S6
- SMR:   Q8X4S6
- EnsemblBacteria:   EBESCT00000023997
- EnsemblBacteria:   EBESCT00000057902
- GeneID:   915934
- GeneID:   961532
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4720
- KEGG:   ecs:ECs4210
- GeneTree:   EBGT00050000010246
- HOGENOM:   HBG725944
- OMA:   ERTRVIT
- ProtClustDB:   PRK05093
- BioCyc:   ECOL83334:ECS4210-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR03246
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11; =2.6.1.17

Molecular weight: Translated: 43755; Mature: 43624

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 141-141 BINDING 144-144 BINDING 283-283 BINDING 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPSDIIHVPFNDLHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPSDIIHVPFNDLHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCEEE
YMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
EEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGQARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796