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The map label for this gene is bisC [H]

Identifier: 209396486

GI number: 209396486

Start: 4564740

End: 4567073

Strand: Reverse

Name: bisC [H]

Synonym: ECH74115_4926

Alternate gene names: 209396486

Gene position: 4567073-4564740 (Counterclockwise)

Preceding gene: 209396479

Following gene: 209396161

Centisome position: 81.96

GC content: 54.33

Gene sequence:

>2334_bases
TTGACCAACTCATCCTCACGATATTCCGTTCTGACTGCCGCCCATTGGGGGCCCATGCTGGTTGAAACCGACGGCGAAAC
CGTGTTTAGCTCGCGTGGCGCGTTAGCCACAGGAATGGAAAACTCCTTGCAGAGCGCGGTTCGTGACCAGGTTCACAGCA
ATACGCGGGTACGATTTCCAATGGTGCGCAAAGGCTTTCTCGCGTCACCGGAAAACCCGCAAGGCATTCGTGGGCAGGAT
GAATTTGTTCGCGTGAGTTGGGATGAGGCGCTGGATCTTATTCACCAACAACATAAACGCATTCGTGAGGCTTATGGTCC
GGCATCGATTTTTGCTGGTTCCTACGGCTGGCGTTCAAACGGCGTGCTGCATAAGGCCTCGACATTATTACAACGCTATA
TGGCGCTGGCAGGCGGTTATACCGGGCATCTGGGGGATTATTCGACCGGCGCGGCACAGGCGATCATGCCGTATGTCGTG
GGTGGTAGTGAAGTTTATCAACAGCAGACCAGTTGGCCGCTGGTGCTGGAACATAGCGATGTCGTGGTGCTGTGGAGTGC
TAACCCACTCAATACGCTGAAAATTGCGTGGAATGCATCCGATGAGCAGGGGCTTTCTTACTTTTCTGCACTGCGTGACA
GCGGGAAAAAGCTGATCTGCATTGATCCAATGCGATCGGAAACCGTCGATTTCTTTGGCGATAAAATGGAGTGGGTGGCA
CCGCACATGGGCACTGATGTTGCGCTGATGCTGGGGATCGCCCATACGCTGGTGGAAAATGGTTGGCACGACGAAGCGTT
TCTGGCGCGTTGCACCACCGGTTATGCCGTCTTCGCCTCTTATTTGCTGGGCGAGAGTGACGGAATAGCGAAAACCGCCG
AATGGGCAGCAGAGATTTGTGGTGTTAACGCAGAGAAAATCCGCGAGCTGGCGGCTATTTTCCACCAAAATACCACCATG
CTGATGGCTGGCTGGGGAATGCAGCGCCAACAGTTTGGTGAGCAAAAACACTGGATGATCGTCACGCTGGCAGCAATGTT
GGGGCAAATCGGCACACCCGGCGGCGGTTTTGGTCTTTCTTACCATTTTGCCAATGGTGGTAACCCCACGCGGCGCGCTG
CGGTACTCTCTTCCATGCAGGGCAGCTTGCCGGGTGGCTGCGATGCGGTAGATAAAATCCCTGTCGCCCGCATTGTTGAA
GCACTGGAAAACCCCGGTGGCGCATATCAACACAACGGTATGGACCGACATTTCCCGGATATTCGTTTTATCTGGTGGGC
GGGCGGTGCCAACTTTACTCATCATCAGGATACCAATCGCCTGATCCGTGCCTGGCAAAAACCGGAGCTGGTGGTGATCT
CTGAATGCTTCTGGACGGCGGCGGCAAAACACGCGGATATCGTTCTGCCTGCGACTACCTCTTTTGAGCGTAATGATCTC
ACCATGACCGGTGATTACAGTAATCAGCATCTGGTGCCGATGAAGCAAGTGGTGCCGCCACGCTATGAAGCGCGTAATGA
TTTTGATGTTTTTGCCGAGTTAAGTGAACGCTGGGAGAAGGGCGGTTATGCACGTTTTACGGAAGGAAAAAGTGAGCTGC
AATGGCTGGAAACGTTTTATAACGTTGCCCGGCAGCGCGGGGCAAGCCAGCAGGTTGAATTGCCGCCATTTACTGAGTTC
TGGCAAGCCAACCAGTTAATTGAGATGCCGGAAAACCCGGACAGCGAGCGGTTTATTCGCTTCGCTGATTTTTGCCGCGA
TCCGCAGGCGCATCCATTAAAAACCGCCAGCGGTAAGATTGAAATCTTCTCGCAGCGTATTGCCGATTACGCTTATCCGG
ATTGCCCGGGGCATCCAATGTGGCTGGTGCCGGACGAATGGCAGGGCAATGCCGAACCGGAACAGTTACAGGTACTTTCT
GCTCATCCGGCGCATCGTCTGCACAGCCAGCTGAATTACAGTTCTCTGCGCGAATTGTACGCGGTGGCAAACCGTGAGCC
TGTCACCATTCATCCTGACGATGCCCAGGCGCGCGGCATACAAGATGGCGATACTGTTCGGCTGTGGAACGCACGCGGGC
AAATTCTTGCCGGAGCGGTCATTAGCGAGGGAATTAAACCTGGCGTGATTTGCATTCACGAAGGGGCATGGCCGGATCTG
GATTTAACCGCTGACGGTATTTGTAAAAACGGCGCAGTGAACGTGCTGACCAAAGATCTCCCCAGCTCGCGGCTGGGGAA
TGGCTGTGCGGGTAATACGGCGCTGGCATGGCTAGAAAAATACAACGGTCCGGAACTGACACTTACAGCGTTTGAACCAC
CGGCCAGCTCATAA

Upstream 100 bases:

>100_bases
ATTATGCCGCGTGAACATGAAGATTATTCCTGGGAATACTCGGAAATTTGTAAGTAATATTTAACTGCTCAATACATCTA
ACCTTTCAGGAGTCTTCGGT

Downstream 100 bases:

>100_bases
TCCAGGTGGGTAGTTGGGTTTCATCCTGCCATGCGCAATCGACAATGTGAAAACCCTGCGCCTGGTAAAAATCTATCGCC
GGTTGATTTTTTTGATAAAC

Product: biotin sulfoxide reductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MTNSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQD
EFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVV
GGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVA
PHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFHQNTTM
LMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGCDAVDKIPVARIVE
ALENPGGAYQHNGMDRHFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDL
TMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFTEF
WQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLVPDEWQGNAEPEQLQVLS
AHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDL
DLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS

Sequences:

>Translated_777_residues
MTNSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQD
EFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVV
GGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVA
PHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFHQNTTM
LMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGCDAVDKIPVARIVE
ALENPGGAYQHNGMDRHFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDL
TMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFTEF
WQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLVPDEWQGNAEPEQLQVLS
AHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDL
DLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
>Mature_776_residues
TNSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDE
FVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVG
GSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAP
HMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVNAEKIRELAAIFHQNTTML
MAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRAAVLSSMQGSLPGGCDAVDKIPVARIVEA
LENPGGAYQHNGMDRHFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLT
MTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFTEFW
QANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASGKIEIFSQRIADYAYPDCPGHPMWLVPDEWQGNAEPEQLQVLSA
HPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLD
LTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=777, Percent_Identity=98.7129987129987, Blast_Score=1600, Evalue=0.0,
Organism=Escherichia coli, GI87081994, Length=773, Percent_Identity=63.3893919793014, Blast_Score=1056, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=790, Percent_Identity=42.9113924050633, Blast_Score=602, Evalue=1e-173,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=32.4468085106383, Blast_Score=309, Evalue=4e-85,
Organism=Escherichia coli, GI1787870, Length=753, Percent_Identity=30.6772908366534, Blast_Score=294, Evalue=1e-80,
Organism=Escherichia coli, GI171474008, Length=753, Percent_Identity=30.8100929614874, Blast_Score=283, Evalue=3e-77,
Organism=Escherichia coli, GI3868721, Length=474, Percent_Identity=23.8396624472574, Blast_Score=106, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 85953; Mature: 85821

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFP
CCCCCCCEEEEEEECCCCEEEECCCCCEECCCCCCHHCHHHHHHHHHHHHHHCCCEEEEH
MVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSN
HHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCC
GVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSD
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCC
VVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVA
EEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHC
PHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEIC
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
GVNAEKIRELAAIFHQNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLS
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEE
YHFANGGNPTRRAAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMDRHFPD
EEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDL
EEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCC
TMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFY
EEECCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHH
NVARQRGASQQVELPPFTEFWQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASGKI
HHHHHCCCCCCCCCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCH
EIFSQRIADYAYPDCPGHPMWLVPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELY
HHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHH
AVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDL
HHCCCCCEEECCCCHHHCCCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCC
DLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
CCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
TNSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFP
CCCCCCEEEEEEECCCCEEEECCCCCEECCCCCCHHCHHHHHHHHHHHHHHCCCEEEEH
MVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSN
HHHCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHEECCCCCCCC
GVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSD
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEECCHHHHHHCCCCCEEEECCC
VVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVA
EEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCHHHHC
PHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEIC
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
GVNAEKIRELAAIFHQNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLS
CCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCEE
YHFANGGNPTRRAAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMDRHFPD
EEECCCCCHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
IRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDL
EEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHCCCCCEEEECCCCCCCCCC
TMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFY
EEECCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHH
NVARQRGASQQVELPPFTEFWQANQLIEMPENPDSERFIRFADFCRDPQAHPLKTASGKI
HHHHHCCCCCCCCCCCCHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCH
EIFSQRIADYAYPDCPGHPMWLVPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELY
HHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCHHHEEEECCCCHHHHHHHCCHHHHHHHH
AVANREPVTIHPDDAQARGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDL
HHCCCCCEEECCCCHHHCCCCCCCEEEEECCCCCEEEHHHHHCCCCCCEEEEECCCCCCC
DLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS
CCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2180922; 8041620; 9278503 [H]