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The map label for this gene is fhuB [H]

Identifier: 209396292

GI number: 209396292

Start: 175765

End: 177747

Strand: Direct

Name: fhuB [H]

Synonym: ECH74115_0163

Alternate gene names: 209396292

Gene position: 175765-177747 (Clockwise)

Preceding gene: 209400721

Following gene: 209399766

Centisome position: 3.15

GC content: 60.11

Gene sequence:

>1983_bases
GTGAGTAAACGTATTGCGCTTTTCCCGGCATTATTGCTGGCGTTGCTGGTGATTGCCGCTACGGCGCTGACCTGGATGAA
CTTCTCGCAGGCGCTGCCGCGTAGCCAGTGGGCGCAGGCTGCCTGGTCGCCGGATATTGACGTCATCGAGCAGATGATTT
TTCACTACAGCTTGCTGCCGCGTCTGGCGATTTCGCTGCTGGTGGGCGCAGGCCTGGGGCTGGTGGGCGTGCTGTTTCAG
CAAGTGCTGCGTAATCCGCTGGCGGAACCGACGACACTTGGCGTTGCTACAGGCGCGCAACTGGGGATTACCGTCACTAC
GCTCTGGGCGATCCCAGGGGCGATGGCGAGTCAGTTTGCTGCGCTGGCGGGCGCTTGCGTTGTTGGCTTAATCGTCTTTG
GCGTCGCGTGGGGGAAACGGCTTTCGCCGGTAACGCTGATCCTCGCGGGGCTGGTAGTGAGCCTTTATTGTGGGGCAATC
AATCAGTTACTGGTTATCTTCCACCATGACCAACTGCAAAGCATGTTCCTGTGGAGCACCGGAACGCTGACGCAAACCGA
CTGGGGCGGTGTTGAGCGTTTATGGCCGCAGTTGCTGGGCGGTGTGATGCTGACGTTGCTGCTACTTCGTCCGTTAACAC
TGATGGGGCTTGATGATGGCGTGGCGCGCAATCTCGGGCTAGCCTTGTCGCTGGCGCGTCTGGCGGCGCTGTCGCTGGCT
ATTGTCATCAGTGCGCTGCTGGTGAACGCGGTGGGGATTATCGGCTTTATCGGGTTGTTCGCGCCGTTGCTGGCAAAAAT
GCTGGGGGCGCGGCGTCTGCTGCCGCGACTGATGCTGGCGTCGTTGATTGGTGCGCTGATCCTCTGGCTTTCCGATCAAA
TCATCCTCTGGCTGACTCGCGTGTGGATGGAAGTGTCCACCGGTTCGGTCACTGCGTTGATCGGTGCGCCGCTGCTACTG
TGGCTGTTGCCGCGTTTACGCAGCATTAGCGCGCCGGATATGAAGGTCAACGATCGTGTCGCGGCTGAACGCCAACATGT
GCTGGCGTTTGCCCTCGCGGGCGGCGTGCTGCTGTTGATGGCTGTGGTGGTGGCGCTGTCGTTTGGTCGTGATGCGCACG
GCTGGACGTGGGCGAGCGGGGCGTTGCTCGAGGATTTGATGCCCTGGCGCTGGCCGCGAATTATGGCGGCGCTGTTTGCG
GGCGTCATGCTGGCGGTGGCGGGCTGTATTATTCAGCGGCTGACCGGAAACCCGATGGCAAGCCCGGAAGTGCTGGGGAT
TAGCTCTGGCGCGGCGTTTGGCGTGGTACTGATGCTGTTTCTGGTACCGGGTAATGCTTTTGGCTGGCTGTTACCCGCGG
GAAGTATCGGTGCGGCGGTGACGCTGTTGATTATTATGATCGCCGCCGGGCGCGGTGGATTTTCCCCACACCGCATGTTA
CTGGCGGGGATGGCGTTAAGTACCGCATTCACCATGCTTTTAATGATGTTGCAGGCGAGTGGTGACCCGCGAATGGCGCA
AGTGCTGACCTGGATCTCTGGTTCGACCTACAACGCCACCGATGCGCAGGTCTGGCGCACCGGAATTGTGATGGTGATTT
TGCTGGCGATTACCCCGCTGTGCCGCCGCTGGCTGACCATTTTACCGCTGGGTGGTGATACCGCGCGGGCCGTGGGGGTG
GCGTTAACGCCGACGCGAATTGCGCTGCTGCTGTTAGCGGCTTGCCTGACGGCGACCGCGACGATGACCATTGGACCGTT
GAGTTTTGTTGGTTTAATGGCACCGCATATCGCGCGGATGATGGGCTTTCGACGGACGATGCCGCACATCGTGATTTCGG
CGCTGGTGGGTGGTTTACTGCTGGTGTTCGCTGACTGGTGTGGGCGGATGGTGCTGTTTCCGTTCCAGATCCCGGCGGGG
CTGCTGTCGACCTTTATCGGCGCGCCATATTTTATCTATTTGTTGAGAAAGCAGAGCCGTTAA

Upstream 100 bases:

>100_bases
CCGGACGCTTTCAGCGCGTACCCGCAGTCTGGTTTTATGGTGCAACTCTCTCGGCAATGCACTTTGTGCGCGTTCTGGAT
AACGCCATTGGAGGTAAAGC

Downstream 100 bases:

>100_bases
TAAAATGCCTCGCCCGGTGGGCGAGGCAAAATCATCACAACTTCGCAAACACCCGACGTGCAGCATCGATGGTGTTATTG
ATATCTTCCATGCTGTGCGC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MSKRIALFPALLLALLVIAATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAI
NQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLL
WLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWTWASGALLEDLMPWRWPRIMAALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLCRRWLTILPLGGDTARAVGV
ALTPTRIALLLLAACLTATATMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAG
LLSTFIGAPYFIYLLRKQSR

Sequences:

>Translated_660_residues
MSKRIALFPALLLALLVIAATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQ
QVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAI
NQLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLA
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLL
WLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWTWASGALLEDLMPWRWPRIMAALFA
GVMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRML
LAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLCRRWLTILPLGGDTARAVGV
ALTPTRIALLLLAACLTATATMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAG
LLSTFIGAPYFIYLLRKQSR
>Mature_659_residues
SKRIALFPALLLALLVIAATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLPRLAISLLVGAGLGLVGVLFQQ
VLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFAALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAIN
QLLVIFHHDQLQSMFLWSTGTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLAI
VISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTRVWMEVSTGSVTALIGAPLLLW
LLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLMAVVVALSFGRDAHGWTWASGALLEDLMPWRWPRIMAALFAG
VMLAVAGCIIQRLTGNPMASPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRMLL
AGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPLCRRWLTILPLGGDTARAVGVA
LTPTRIALLLLAACLTATATMTIGPLSFVGLMAPHIARMMGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAGL
LSTFIGAPYFIYLLRKQSR

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=660, Percent_Identity=99.3939393939394, Blast_Score=1260, Evalue=0.0,
Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=37.1841155234657, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790741, Length=290, Percent_Identity=35.5172413793103, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786804, Length=278, Percent_Identity=32.3741007194245, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786805, Length=277, Percent_Identity=35.3790613718412, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788004, Length=274, Percent_Identity=31.7518248175182, Blast_Score=94, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 70349; Mature: 70218

Theoretical pI: Translated: 11.36; Mature: 11.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRIALFPALLLALLVIAATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH
RLAISLLVGAGLGLVGVLFQQVLRNPLAEPTTLGVATGAQLGITVTTLWAIPGAMASQFA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHCCHHHHHHHH
ALAGACVVGLIVFGVAWGKRLSPVTLILAGLVVSLYCGAINQLLVIFHHDQLQSMFLWST
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GTLTQTDWGGVERLWPQLLGGVMLTLLLLRPLTLMGLDDGVARNLGLALSLARLAALSLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
IVISALLVNAVGIIGFIGLFAPLLAKMLGARRLLPRLMLASLIGALILWLSDQIILWLTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWMEVSTGSVTALIGAPLLLWLLPRLRSISAPDMKVNDRVAAERQHVLAFALAGGVLLLM
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVVVALSFGRDAHGWTWASGALLEDLMPWRWPRIMAALFAGVMLAVAGCIIQRLTGNPMA
HHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SPEVLGISSGAAFGVVLMLFLVPGNAFGWLLPAGSIGAAVTLLIIMIAAGRGGFSPHRML
CCCEEECCCCHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
LAGMALSTAFTMLLMMLQASGDPRMAQVLTWISGSTYNATDAQVWRTGIVMVILLAITPL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
CRRWLTILPLGGDTARAVGVALTPTRIALLLLAACLTATATMTIGPLSFVGLMAPHIARM
HHHHHHEECCCCCHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGFRRTMPHIVISALVGGLLLVFADWCGRMVLFPFQIPAGLLSTFIGAPYFIYLLRKQSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHCCHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SKRIALFPALLLALLVIAATALTWMNFSQALPRSQWAQAAWSPDIDVIEQMIFHYSLLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHH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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3020380; 8202364; 9278503; 2823072 [H]