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The map label for this gene is pdxK [H]

Identifier: 209395957

GI number: 209395957

Start: 3364894

End: 3365745

Strand: Reverse

Name: pdxK [H]

Synonym: ECH74115_3649

Alternate gene names: 209395957

Gene position: 3365745-3364894 (Counterclockwise)

Preceding gene: 209397165

Following gene: 209400232

Centisome position: 60.4

GC content: 52.0

Gene sequence:

>852_bases
ATGAGTAGTTTGTTGTTGTTTAACGATAAGAGCAGGGCGCTGCAGGCGGATATCGTCGCCGTGCAGTCGCAGGTGGTTTA
CGGCAGCGTGGGCAACAGCATTGCCGTGCCTGCTATCAAACAGAACGGCCTGAATGTCTTTGCCGTGCCGACGGTATTGC
TGAGCAATACGCCGCATTATGACACTTTCTACGGTGGTGCGATTCCGGATGAATGGTTTAGCGGCTATTTGCGTGCACTT
CAGGAGCGTGATGCGCTGCGCCAACTTCGTGCTGTAACCACGGGCTATATGGGAACGGCATCGCAAATCAAAATCCTTGC
CGAGTGGCTGACTGCGCTACGCAAAGACCATCCTGACCTATTGATCATGGTCGATCCGGTGATTGGCGATATTGACAGCG
GAATTTATGTCAAACCTGACCTTCCCGAAGCGTATCGACAATATTTACTGCCGCTGGCGCAGGGAATTACCCCCAATATC
TTTGAGTTGGAAATCCTGACCGGTAAAAATTGCCGCGATCTCGACAGTGCCATTGCTGCCGCAAAAAGTCTGCTTTCAGA
CACACTAAAATGGGTGGTGATTACCAGCGCCTCCGGTAATGAAGAAAATCAGGAGATGCTGGTTGTGGTGGTCACTGCCG
ACAGCGTGAATGTCATTTCCCATTCAAGGGTAAAAACCGACCTGAAAGGGACTGGCGACCTGTTTTGTGCTCAGCTTATC
AGTGGTTTGCTGAAAGGGAAGGCATTAAACGATGCGGTGCACCGCGCGGGGTTGCGCGTACTGGAAGTGATGCGCTACAC
CCAGCAGCATGAGAGCGATGAATTGATTTTGCCGCCGCTGGCGGAAGCATAA

Upstream 100 bases:

>100_bases
TTACCTTATCCTTGTTTTGTAATAGCCGATTTGACTGCCAGAATCAGGTAAAGTTTCGGTTGGAATACGATGAGGATCAT
CGGCAAGGAGAAAAAATTAA

Downstream 100 bases:

>100_bases
AAAAATGGCGCCGATGGGCGCCATTTTTCACTGCAGCAAGAATTACTTCTTGATGCGGATAACCGGGGTTTCACCCACAG
TCACGCTACCGGACAGTTTG

Product: pyridoxal kinase

Products: NA

Alternate protein names: PN/PL/PM kinase; Pyridoxal kinase; Pyridoxamine kinase; Vitamin B6 kinase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRAL
QERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNI
FELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMLVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLI
SGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA

Sequences:

>Translated_283_residues
MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRAL
QERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNI
FELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMLVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLI
SGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
>Mature_282_residues
SSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHYDTFYGGAIPDEWFSGYLRALQ
ERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDLLIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIF
ELEILTGKNCRDLDSAIAAAKSLLSDTLKWVVITSASGNEENQEMLVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLIS
GLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=241, Percent_Identity=28.6307053941909, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788758, Length=283, Percent_Identity=98.9399293286219, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1787924, Length=268, Percent_Identity=30.2238805970149, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17507759, Length=268, Percent_Identity=29.4776119402985, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17507757, Length=278, Percent_Identity=28.4172661870504, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320806, Length=236, Percent_Identity=26.6949152542373, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324354, Length=239, Percent_Identity=27.1966527196653, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553007, Length=188, Percent_Identity=34.0425531914894, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 30860; Mature: 30729

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHY
CCCEEEECCCCHHHHHHHHHHHHHEEEECCCCCEECCCCCCCCCEEEEEHHHHHCCCCCC
DTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCE
LIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAA
EEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
AKSLLSDTLKWVVITSASGNEENQEMLVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLI
HHHHHHHCEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHH
SGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure 
SSLLLFNDKSRALQADIVAVQSQVVYGSVGNSIAVPAIKQNGLNVFAVPTVLLSNTPHY
CCEEEECCCCHHHHHHHHHHHHHEEEECCCCCEECCCCCCCCCEEEEEHHHHHCCCCCC
DTFYGGAIPDEWFSGYLRALQERDALRQLRAVTTGYMGTASQIKILAEWLTALRKDHPDL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCE
LIMVDPVIGDIDSGIYVKPDLPEAYRQYLLPLAQGITPNIFELEILTGKNCRDLDSAIAA
EEEECCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHH
AKSLLSDTLKWVVITSASGNEENQEMLVVVVTADSVNVISHSRVKTDLKGTGDLFCAQLI
HHHHHHHCEEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHH
SGLLKGKALNDAVHRAGLRVLEVMRYTQQHESDELILPPLAEA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA