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The map label for this gene is phoP [H]

Identifier: 209395806

GI number: 209395806

Start: 1548176

End: 1548847

Strand: Reverse

Name: phoP [H]

Synonym: ECH74115_1591

Alternate gene names: 209395806

Gene position: 1548847-1548176 (Counterclockwise)

Preceding gene: 209399204

Following gene: 209397549

Centisome position: 27.8

GC content: 47.32

Gene sequence:

>672_bases
ATGCGCGTACTGGTTGTTGAAGACAATGCGTTGTTACGTCACCACCTTAAAGTTCAGATTCAGGATGCTGGTCATCAGGT
CGATGATGCAGAAGATGCCAAAGAAGCCGATTATTATCTCAATGAACATTTACCGGATATTGCGATTGTCGATCTCGGAT
TGCCAGACGAGGACGGTCTGTCACTGATTTGCCGCTGGCGTAGCAATGATGTTTCACTGCCGATTCTGGTATTAACCGCC
CGTGAAAGCTGGCAGGACAAAGTCGAAGTATTAAGTGCCGGTGCTGATGATTACGTGACTAAACCGTTTCATATTGAAGA
GGTGATGGCGCGAATGCAGGCATTAATGCGGCGTAATAGCGGCCTGGCTTCACAGGTCATTTCGCTCCCCCCGTTTCAGG
TTGATCTCTCTCGCCGTGAATTATCTATTAATGACGAAGTGATCAAACTGACCGCGTTCGAATACACCATTATGGAAACG
TTGATACGCAATAATGGCAAAGTGGTCAGCAAAGATTCGTTAATGCTACAACTCTATCCGGATGCGGAGCTGCGGGAAAG
CCATACCATTGATGTACTGATGGGACGTCTGCGCAAAAAAATTCAGGCACAATATCCGCAAGAAGTGATTACTACCGTTC
GCGGCCAGGGCTATTTGTTCGAATTGCGCTGA

Upstream 100 bases:

>100_bases
CACTTTACCTCCCCTCCCCCGCTGGTTTATTTAATGTTTACCCCCATAACCACATAATCGCGTTACACTATTTTAATAAT
TAAGACAGGGAGAAATAAAA

Downstream 100 bases:

>100_bases
TGAAAAAATTACTGCGTCTTTTTTTCCCGCTCTCGCTGCGGGTACGTTTTCTGTTGGCAACGGCAGCGGTAGTACTGGTG
CTTTCGCTTGCCTACGGAAT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLICRWRSNDVSLPILVLTA
RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR

Sequences:

>Translated_223_residues
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLICRWRSNDVSLPILVLTA
RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
>Mature_223_residues
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLICRWRSNDVSLPILVLTA
RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=99.1031390134529, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=34.5454545454545, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=34.8214285714286, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=34.8623853211009, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.8888888888889, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=34.2105263157895, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.0357142857143, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.2465753424658, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=28.6363636363636, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=31.8385650224215, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.0748898678414, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI145693140, Length=241, Percent_Identity=27.3858921161826, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25483; Mature: 25483

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGL
CEEEEEECCHHEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCC
SLICRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNS
EEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
CCHHHHHCCCCCEEECCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGL
CEEEEEECCHHEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCC
SLICRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNS
EEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
CCHHHHHCCCCCEEECCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA