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The map label for this gene is gne [H]

Identifier: 209696435

GI number: 209696435

Start: 3303337

End: 3304344

Strand: Direct

Name: gne [H]

Synonym: VSAL_I3049

Alternate gene names: 209696435

Gene position: 3303337-3304344 (Clockwise)

Preceding gene: 209696434

Following gene: 209696437

Centisome position: 99.34

GC content: 43.65

Gene sequence:

>1008_bases
ATGAATATTTTAGTCACTGGCGGAATGGGTTACATCGGTAGCCATACCTGCGTACAAATGATTGAAGCGGGCTTAACGCC
GATCATTTTAGACAACTTATACAACAGTAAAGAAGTGGTGCTTGATCGCATTGAAGCTTTGGTTGGTGTAAAACCTAAAT
TTTATGAGGGTGACATTCGTGATCCTCAAATCTTAGCGACTGTCTTTGCTGAAAACCAAATCGATAGTGTGATCCACTTT
GCTGGCTTAAAAGCAGTCGGTGAGTCGGTTGAAAAACCAATCATGTATTACGATAACAATGTATCGGGTACTTTGGTTTT
AGTTGAAGCGATGCGTAAAGCGGGTGTGAACAGCATTGTATTTAGTTCATCAGCGACGGTTTATGGTGATCCGGCGTCTA
CCCCAATTAATGAAAACTTCCCAAAATCAGCAACCAATCCTTATGGTCGCAGTAAGCTGATTGTTGAAGAGTGTCTAACT
GATATTCAAAAAGCACACCCTGAGATGAGTGTGACGCTATTACGTTACTTTAATCCGGTTGGTTCTCATAAATCAGGCAC
CATGGGTGAAGATCCTCAAGGTATTCCAAACAACTTGATGCCGTTTATCTCTCAAGTTGCTGTTGGCCGTCGTGAATTTT
TATCGGTATTTGGTGATGATTATCCTACAGTAGATGGTACGGGTGTTCGTGATTATATCCATGTGGTGGATTTAGCTGAT
GGTCACTTAGCGGCGTTAAAGCACAAAGGCCAACAAGCGGGTTTGCATATTTATAACTTGGGTACTGGTAATGGTAACAG
TGTTCTTCAAATGGTCGCTGCGTTTGAGAAAGCTTCTGGCGCTAAAGTTCCGTATCAAATAGTCCCTCGCCGCCCTGGTG
ATATTGCCGAGTGTTGGGCTGACCCTGCTAAAGCGCGTGAAGAGTTGAAGTGGGAAGCGAAATTGTCTCTTGATGATATG
ACGGCGGATACGTGGCGCTGGCAGTCGAATAATCCGAAAGGATACTAG

Upstream 100 bases:

>100_bases
CAACATGAATGCTTTTGATTTTATAGTTTCTAGAGCGAAGCGTTCTAGTTAGCTCAGCGTATAGGCTCTTATTCAAATAA
ATTAAAAATAGAGAAAAACA

Downstream 100 bases:

>100_bases
AAACTATACGCTTCGCTAACTAGAGACTATAAGATCAAAAGCGAGTATTGCTCTTGTTCTTATAGGAGCGAAGCGGTCTA
GTTTCTAGCTAGCGAAGCGT

Product: uridine diphosphate N-acetylgalactosamine 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNILVTGGMGYIGSHTCVQMIEAGLTPIILDNLYNSKEVVLDRIEALVGVKPKFYEGDIRDPQILATVFAENQIDSVIHF
AGLKAVGESVEKPIMYYDNNVSGTLVLVEAMRKAGVNSIVFSSSATVYGDPASTPINENFPKSATNPYGRSKLIVEECLT
DIQKAHPEMSVTLLRYFNPVGSHKSGTMGEDPQGIPNNLMPFISQVAVGRREFLSVFGDDYPTVDGTGVRDYIHVVDLAD
GHLAALKHKGQQAGLHIYNLGTGNGNSVLQMVAAFEKASGAKVPYQIVPRRPGDIAECWADPAKAREELKWEAKLSLDDM
TADTWRWQSNNPKGY

Sequences:

>Translated_335_residues
MNILVTGGMGYIGSHTCVQMIEAGLTPIILDNLYNSKEVVLDRIEALVGVKPKFYEGDIRDPQILATVFAENQIDSVIHF
AGLKAVGESVEKPIMYYDNNVSGTLVLVEAMRKAGVNSIVFSSSATVYGDPASTPINENFPKSATNPYGRSKLIVEECLT
DIQKAHPEMSVTLLRYFNPVGSHKSGTMGEDPQGIPNNLMPFISQVAVGRREFLSVFGDDYPTVDGTGVRDYIHVVDLAD
GHLAALKHKGQQAGLHIYNLGTGNGNSVLQMVAAFEKASGAKVPYQIVPRRPGDIAECWADPAKAREELKWEAKLSLDDM
TADTWRWQSNNPKGY
>Mature_335_residues
MNILVTGGMGYIGSHTCVQMIEAGLTPIILDNLYNSKEVVLDRIEALVGVKPKFYEGDIRDPQILATVFAENQIDSVIHF
AGLKAVGESVEKPIMYYDNNVSGTLVLVEAMRKAGVNSIVFSSSATVYGDPASTPINENFPKSATNPYGRSKLIVEECLT
DIQKAHPEMSVTLLRYFNPVGSHKSGTMGEDPQGIPNNLMPFISQVAVGRREFLSVFGDDYPTVDGTGVRDYIHVVDLAD
GHLAALKHKGQQAGLHIYNLGTGNGNSVLQMVAAFEKASGAKVPYQIVPRRPGDIAECWADPAKAREELKWEAKLSLDDM
TADTWRWQSNNPKGY

Specific function: Galactose metabolism; third step. [C]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=56.7647058823529, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=56.7647058823529, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=56.7647058823529, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI7657641, Length=280, Percent_Identity=29.6428571428571, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI42516563, Length=324, Percent_Identity=24.0740740740741, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=61.6071428571429, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1788353, Length=365, Percent_Identity=25.7534246575342, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994969, Length=353, Percent_Identity=24.929178470255, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788366, Length=360, Percent_Identity=22.5, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71982038, Length=348, Percent_Identity=50.5747126436782, Blast_Score=352, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI71982035, Length=346, Percent_Identity=50.5780346820809, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17568069, Length=338, Percent_Identity=24.8520710059172, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI115532424, Length=342, Percent_Identity=25.7309941520468, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=342, Percent_Identity=51.1695906432749, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=54.3859649122807, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI21356223, Length=322, Percent_Identity=24.223602484472, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 36576; Mature: 36576

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILVTGGMGYIGSHTCVQMIEAGLTPIILDNLYNSKEVVLDRIEALVGVKPKFYEGDIR
CEEEEECCCCCCCHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
DPQILATVFAENQIDSVIHFAGLKAVGESVEKPIMYYDNNVSGTLVLVEAMRKAGVNSIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCEEE
FSSSATVYGDPASTPINENFPKSATNPYGRSKLIVEECLTDIQKAHPEMSVTLLRYFNPV
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
GSHKSGTMGEDPQGIPNNLMPFISQVAVGRREFLSVFGDDYPTVDGTGVRDYIHVVDLAD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEECCC
GHLAALKHKGQQAGLHIYNLGTGNGNSVLQMVAAFEKASGAKVPYQIVPRRPGDIAECWA
CHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHC
DPAKAREELKWEAKLSLDDMTADTWRWQSNNPKGY
CHHHHHHHCCHHEECCCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MNILVTGGMGYIGSHTCVQMIEAGLTPIILDNLYNSKEVVLDRIEALVGVKPKFYEGDIR
CEEEEECCCCCCCHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCC
DPQILATVFAENQIDSVIHFAGLKAVGESVEKPIMYYDNNVSGTLVLVEAMRKAGVNSIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCEEE
FSSSATVYGDPASTPINENFPKSATNPYGRSKLIVEECLTDIQKAHPEMSVTLLRYFNPV
EECCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
GSHKSGTMGEDPQGIPNNLMPFISQVAVGRREFLSVFGDDYPTVDGTGVRDYIHVVDLAD
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHEEEEECCC
GHLAALKHKGQQAGLHIYNLGTGNGNSVLQMVAAFEKASGAKVPYQIVPRRPGDIAECWA
CHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHC
DPAKAREELKWEAKLSLDDMTADTWRWQSNNPKGY
CHHHHHHHCCHHEECCCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]