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The map label for this gene is mtlD

Identifier: 209696218

GI number: 209696218

Start: 3048353

End: 3049501

Strand: Direct

Name: mtlD

Synonym: VSAL_I2814

Alternate gene names: 209696218

Gene position: 3048353-3049501 (Clockwise)

Preceding gene: 209696217

Following gene: 209696219

Centisome position: 91.68

GC content: 39.77

Gene sequence:

>1149_bases
ATGAAAGCAGTACATTTTGGCGCAGGTAATATCGGTCGTGGTTTTATTGGTAAAGTTCTTTCTGATTCAAACGTCGCTGT
TACATTCGCAGACGTTGATGCACCGTTAGTTGATCAACTTTGTCATGACCAATCATACAAAGTAAAAGTCGTTGGGTCTA
AATGCCAAATCGACACAGTTACTCATGTAACTGCCGTAAACTCAACCAGTGACGATGTTATTGAGCGTATTGTACACACC
GATTTAGTGACAACCGCCGTTGGCCCTAACGTATTAAATATTATTGCAAAAACCATTGCAAAAGGGTTAACCAAACGTTT
TGAAGCCAACAATGAATCACCACTTAATATCATTGCTTGTGAAAATATGGTTCGAGGTACTACTCACCTTAAAAATGAAG
TGTACTCTCATCTTGACGACTCTTTTCATGCACGTTGTGACGAATTAGTTGGTTTTGTTGATTCTGCGGTTGACCGTATT
GTTCCACCATCAGAAGCGGCCAATGACGATTTACTTGAAGTTACCGTTGAAAGTTTCAGTGAATGGATTGTTGATGAAAA
ACAATTCAAAGGTGGCGTACCTAATATTGCTGGAATGGAAAAAACAGACAACCTAATGGCGTTTGTTGAGCGCAAACTCT
TCACTTTAAATACGGGTCATTGCATTACGGCTTATCTTGGTGCATTAAAAGGCCATGAGACCGTACGTGACGCGATTCAA
GACCCTGAAATTAGAACCGAAGTAAAAGCCGCAATGGAAGAAAGTGGTGAAGTGCTCATTCGTCGCTACGGTTTTGATAA
AGAATTACATGCTGCCTATATCGAAAAAATCTTAGGCCGATTTGCGAATCCGTATTTACGAGATGAGATTGATCGCGTTG
CCCGTCAGCCAATTCGTAAATTAGGTGAAAATGATCGCCTAATCAAACCGTTATTAGGTACAATCGAATACGGAATTGAA
AATAAAACACTATTAAAAGGCATCGCTGCCGCATTTAAATACGTAAATGACACAGATCCACAAGCAGTCGAGCTACAAAC
TCACTTACAGGAATCTGGCTTAAAAGCGACATTAGCGCATTACACCGGATTAAATGAAAACAGTTCAGAAGCGAAAAAGA
TTGAAGCAATCTTTACGACATTAAACTAA

Upstream 100 bases:

>100_bases
TTCAGGCGAACAAGCAGCATAAGTATTTAGTACCAATAAGAAGTCAGCTTTACCCCTATAGGGCTGGCTTCCTCCTAATA
TAAAATTGAAGGTAATTATT

Downstream 100 bases:

>100_bases
TAAGAAACAGTTAGAGAGGCGTAATGCCTCTCTCTTTTATGGCTATTTTATGACAGAAGTAATAAACGAATCTAACATCA
TTGAACGACTAGACGATGCA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKAVHFGAGNIGRGFIGKVLSDSNVAVTFADVDAPLVDQLCHDQSYKVKVVGSKCQIDTVTHVTAVNSTSDDVIERIVHT
DLVTTAVGPNVLNIIAKTIAKGLTKRFEANNESPLNIIACENMVRGTTHLKNEVYSHLDDSFHARCDELVGFVDSAVDRI
VPPSEAANDDLLEVTVESFSEWIVDEKQFKGGVPNIAGMEKTDNLMAFVERKLFTLNTGHCITAYLGALKGHETVRDAIQ
DPEIRTEVKAAMEESGEVLIRRYGFDKELHAAYIEKILGRFANPYLRDEIDRVARQPIRKLGENDRLIKPLLGTIEYGIE
NKTLLKGIAAAFKYVNDTDPQAVELQTHLQESGLKATLAHYTGLNENSSEAKKIEAIFTTLN

Sequences:

>Translated_382_residues
MKAVHFGAGNIGRGFIGKVLSDSNVAVTFADVDAPLVDQLCHDQSYKVKVVGSKCQIDTVTHVTAVNSTSDDVIERIVHT
DLVTTAVGPNVLNIIAKTIAKGLTKRFEANNESPLNIIACENMVRGTTHLKNEVYSHLDDSFHARCDELVGFVDSAVDRI
VPPSEAANDDLLEVTVESFSEWIVDEKQFKGGVPNIAGMEKTDNLMAFVERKLFTLNTGHCITAYLGALKGHETVRDAIQ
DPEIRTEVKAAMEESGEVLIRRYGFDKELHAAYIEKILGRFANPYLRDEIDRVARQPIRKLGENDRLIKPLLGTIEYGIE
NKTLLKGIAAAFKYVNDTDPQAVELQTHLQESGLKATLAHYTGLNENSSEAKKIEAIFTTLN
>Mature_382_residues
MKAVHFGAGNIGRGFIGKVLSDSNVAVTFADVDAPLVDQLCHDQSYKVKVVGSKCQIDTVTHVTAVNSTSDDVIERIVHT
DLVTTAVGPNVLNIIAKTIAKGLTKRFEANNESPLNIIACENMVRGTTHLKNEVYSHLDDSFHARCDELVGFVDSAVDRI
VPPSEAANDDLLEVTVESFSEWIVDEKQFKGGVPNIAGMEKTDNLMAFVERKLFTLNTGHCITAYLGALKGHETVRDAIQ
DPEIRTEVKAAMEESGEVLIRRYGFDKELHAAYIEKILGRFANPYLRDEIDRVARQPIRKLGENDRLIKPLLGTIEYGIE
NKTLLKGIAAAFKYVNDTDPQAVELQTHLQESGLKATLAHYTGLNENSSEAKKIEAIFTTLN

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=368, Percent_Identity=64.6739130434783, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1790779, Length=281, Percent_Identity=27.4021352313167, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788497, Length=289, Percent_Identity=27.681660899654, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324401, Length=249, Percent_Identity=26.1044176706827, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320765, Length=249, Percent_Identity=26.1044176706827, Blast_Score=77, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_ALISL (B6EN80)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002264148.1
- ProteinModelPortal:   B6EN80
- GeneID:   6988854
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2814
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 42107; Mature: 42107

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVHFGAGNIGRGFIGKVLSDSNVAVTFADVDAPLVDQLCHDQSYKVKVVGSKCQIDTV
CCEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCEEEEEE
THVTAVNSTSDDVIERIVHTDLVTTAVGPNVLNIIAKTIAKGLTKRFEANNESPLNIIAC
EEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
ENMVRGTTHLKNEVYSHLDDSFHARCDELVGFVDSAVDRIVPPSEAANDDLLEVTVESFS
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EWIVDEKQFKGGVPNIAGMEKTDNLMAFVERKLFTLNTGHCITAYLGALKGHETVRDAIQ
HHHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHC
DPEIRTEVKAAMEESGEVLIRRYGFDKELHAAYIEKILGRFANPYLRDEIDRVARQPIRK
CCHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGENDRLIKPLLGTIEYGIENKTLLKGIAAAFKYVNDTDPQAVELQTHLQESGLKATLAH
HCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHH
YTGLNENSSEAKKIEAIFTTLN
HCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAVHFGAGNIGRGFIGKVLSDSNVAVTFADVDAPLVDQLCHDQSYKVKVVGSKCQIDTV
CCEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCEEEEECCCEEEEEE
THVTAVNSTSDDVIERIVHTDLVTTAVGPNVLNIIAKTIAKGLTKRFEANNESPLNIIAC
EEEEEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
ENMVRGTTHLKNEVYSHLDDSFHARCDELVGFVDSAVDRIVPPSEAANDDLLEVTVESFS
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
EWIVDEKQFKGGVPNIAGMEKTDNLMAFVERKLFTLNTGHCITAYLGALKGHETVRDAIQ
HHHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHC
DPEIRTEVKAAMEESGEVLIRRYGFDKELHAAYIEKILGRFANPYLRDEIDRVARQPIRK
CCHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LGENDRLIKPLLGTIEYGIENKTLLKGIAAAFKYVNDTDPQAVELQTHLQESGLKATLAH
HCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHH
YTGLNENSSEAKKIEAIFTTLN
HCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA