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The map label for this gene is cytR [H]

Identifier: 209696148

GI number: 209696148

Start: 2967266

End: 2968273

Strand: Reverse

Name: cytR [H]

Synonym: VSAL_I2742

Alternate gene names: 209696148

Gene position: 2968273-2967266 (Counterclockwise)

Preceding gene: 209696149

Following gene: 209696147

Centisome position: 89.27

GC content: 42.86

Gene sequence:

>1008_bases
ATGGCGACAATGAAGGATGTTGCTTTGTCTGCGGGAGTATCAACAGCAACCGTATCACGGGCATTAATGACACCAGAGAA
GGTATCATTAAGCACTCGAAAAAGAGTGGAGGACGCCGTTCTGGAGACGGGTTACTCTCCAACAACATTGACGCGAACCT
TGCGTCGTAACGAATCAAAAACCATCGTAACCATTGTGCCTGATATCTGTGATCCCTATTTCAGTGATATCCTACGTGGT
ATTGAAGATGCAGCCGTAGAGAATGGCTACATCATTTTGGTTGGCGACAGTAGCCAACAAAAGAAACGTGAACAAACTTT
TGTCAATTTAGTCTATACCAAACAAGTTGACGGTATGGTTCTCCTCGGTTCAGATCTTCCATTTAGCGTCAGTCGTCAAG
AACAAAAGAATTTACCCCCATTAGTGATGGCGTGTGAATACGCTCCAGAACTCGAATTACCTACCGTTCACATTGATAAC
CTAACCGCGGCTTATGAAGCGGTGAATTACCTAACAAAACTGGGTCATAAGCGCGTCGCTGAAATTTCAGGTCCTGAAGA
TTCAGCATTATGCCAATTTAGGCATCAAGGTTACCAACAAGCATTACGCCGCGCAGGAATAACAATGAACACCACTTATG
TTCATTATTCTGATTTTTCTTTTCAGGCTGGCGCTAAAGCAATCACAAGCTTACTCTCATTATCATCACCGCCAACGGCT
ATTTTTTGTCATAACGATATAATGGCGATTGGTGCGATTCAAAAAGCAAAGCAAATGGGATTTCGAGTTCCACAAGACAT
TTCAATCATGGGCTTTGATGACATTGAATTTTCACAGTACTGCGATCCGCCACTCACCACCATATCTCAGCCTAGATATG
AGATAGGACGCCAATCGATGTTAATGCTTTTAGATTTATTAAAAGGTCATGATGTGCGTTCAGGCTCTCGACTTTTAGAG
TCATCTTTAGTGGTAAGAGAAAGTACGGCTCCCCCTAAAAACACCTAA

Upstream 100 bases:

>100_bases
AATCTTTATTTTACACATAAAATATCTTCTCAATAAACAAAGCAATCGTTTACTTTACGTATGTTGTTTAACTTTATATA
AATAGTTGGGAGAGGTCTTT

Downstream 100 bases:

>100_bases
TTGAGCCTTTTATTCATAACTTAATTAAGCACACTTTAGTAAAGTCATTATTAAGAACAATAATTTTGTCCAAATAGTGA
CTTTTTGCGTACTTTTTTAC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESKTIVTIVPDICDPYFSDILRG
IEDAAVENGYIILVGDSSQQKKREQTFVNLVYTKQVDGMVLLGSDLPFSVSRQEQKNLPPLVMACEYAPELELPTVHIDN
LTAAYEAVNYLTKLGHKRVAEISGPEDSALCQFRHQGYQQALRRAGITMNTTYVHYSDFSFQAGAKAITSLLSLSSPPTA
IFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPPLTTISQPRYEIGRQSMLMLLDLLKGHDVRSGSRLLE
SSLVVRESTAPPKNT

Sequences:

>Translated_335_residues
MATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESKTIVTIVPDICDPYFSDILRG
IEDAAVENGYIILVGDSSQQKKREQTFVNLVYTKQVDGMVLLGSDLPFSVSRQEQKNLPPLVMACEYAPELELPTVHIDN
LTAAYEAVNYLTKLGHKRVAEISGPEDSALCQFRHQGYQQALRRAGITMNTTYVHYSDFSFQAGAKAITSLLSLSSPPTA
IFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPPLTTISQPRYEIGRQSMLMLLDLLKGHDVRSGSRLLE
SSLVVRESTAPPKNT
>Mature_334_residues
ATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESKTIVTIVPDICDPYFSDILRGI
EDAAVENGYIILVGDSSQQKKREQTFVNLVYTKQVDGMVLLGSDLPFSVSRQEQKNLPPLVMACEYAPELELPTVHIDNL
TAAYEAVNYLTKLGHKRVAEISGPEDSALCQFRHQGYQQALRRAGITMNTTYVHYSDFSFQAGAKAITSLLSLSSPPTAI
FCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPPLTTISQPRYEIGRQSMLMLLDLLKGHDVRSGSRLLES
SLVVRESTAPPKNT

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=61.5853658536585, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1790194, Length=307, Percent_Identity=36.4820846905537, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=32.7327327327327, Blast_Score=194, Evalue=6e-51,
Organism=Escherichia coli, GI1789202, Length=332, Percent_Identity=29.8192771084337, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788474, Length=337, Percent_Identity=30.5637982195846, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789068, Length=339, Percent_Identity=29.4985250737463, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI48994940, Length=311, Percent_Identity=27.6527331189711, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1786540, Length=341, Percent_Identity=30.791788856305, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1790715, Length=312, Percent_Identity=27.2435897435897, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787906, Length=307, Percent_Identity=28.3387622149837, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787580, Length=313, Percent_Identity=26.1980830670927, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789456, Length=325, Percent_Identity=24.6153846153846, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=21.3592233009709, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790192, Length=284, Percent_Identity=24.2957746478873, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790689, Length=319, Percent_Identity=23.8244514106583, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37006; Mature: 36875

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESK
CCCHHHHHHHCCCHHHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVTIVPDICDPYFSDILRGIEDAAVENGYIILVGDSSQQKKREQTFVNLVYTKQVDGMV
EEEEECCHHCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEEEECCCCEE
LLGSDLPFSVSRQEQKNLPPLVMACEYAPELELPTVHIDNLTAAYEAVNYLTKLGHKRVA
EECCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCHHHH
EISGPEDSALCQFRHQGYQQALRRAGITMNTTYVHYSDFSFQAGAKAITSLLSLSSPPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
IFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPPLTTISQPRYEIGRQSM
EEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCHHHHHHHHH
LMLLDLLKGHDVRSGSRLLESSLVVRESTAPPKNT
HHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure 
ATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESK
CCHHHHHHHCCCHHHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVTIVPDICDPYFSDILRGIEDAAVENGYIILVGDSSQQKKREQTFVNLVYTKQVDGMV
EEEEECCHHCCHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHEEEEEEECCCCEE
LLGSDLPFSVSRQEQKNLPPLVMACEYAPELELPTVHIDNLTAAYEAVNYLTKLGHKRVA
EECCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCHHHH
EISGPEDSALCQFRHQGYQQALRRAGITMNTTYVHYSDFSFQAGAKAITSLLSLSSPPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCCCE
IFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPPLTTISQPRYEIGRQSM
EEECCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCHHHHHHHHH
LMLLDLLKGHDVRSGSRLLESSLVVRESTAPPKNT
HHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]