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The map label for this gene is degS [H]

Identifier: 209696076

GI number: 209696076

Start: 2885461

End: 2886525

Strand: Direct

Name: degS [H]

Synonym: VSAL_I2668

Alternate gene names: 209696076

Gene position: 2885461-2886525 (Clockwise)

Preceding gene: 209696075

Following gene: 209696083

Centisome position: 86.78

GC content: 41.31

Gene sequence:

>1065_bases
ATGCTCTCATTTTTACTGCGTTCTGCTGTAATAGGCACAGTAACTGCCGCTGTATTACTTCTTGCTTTTCCTAACCTTCG
CTCAGGTATAACGCCTGAACAAGATACGAACCAACAAACACCTCGAATCAGTAACCAAATTTCATTTAATGATGCGGTAC
GTCGAGCTGCGCCTGCTGTCGTAAATATTTATAGCCGTAAATATAATGATAAAGATCGATTACGACTAGATACAGAAGGC
CTTGGTTCTGGTGTTATTGTTAGCGATAAAGGCTACATCATTACCAATTACCATGTAGTTGCAGAAGCCGATCAAATTAT
TGTTGCCCTTCAAGATGGACGATTGTTTAATTCGCAATTAATTGGGAAAGATAAACGTACCGATCTTGCTGTTCTACAAA
TTAAAGACACCAACCTTCCAGTGATCCCTTTAAATCCGAAATATCAAGCGGATATTGGTGATGTCGTGTTGGCTATTGGT
AATCCTTATAATTTAGGACAGACCACCACATTTGGTATTATTTCAGCAACGGGTCGTGCTGCCTTAAGTTCTGATGGTAC
TCAAGGCCTTATTCAAACAGATGCTGCGATTAACCGCGGTAATTCAGGCGGGGCGCTCGTTAATACTCGAGGAGAATTAG
TCGGTATCAATACCGCCTCTTTTCAACAAGCCACAGAGCTAGAAACCTATGGGATTTCTTTCGCGATTCCTTACGCACTG
GCAGATAAGATAATGCGTCGCTTAATTGCTGATGGTCAAGTTATCCGTGGTTATATAGGTATTGATGGCAGAGACATAAA
TCCAGCAATGGCTCGCTTAATGAATGCCGATAATATCAATGGTATTTTAGTTCTTGGTGTTGCTCCTGATAGCCCGGCTG
AAAAAAGTGGCATTATGACTCAGGATATAATTACCAGTATTGATGGGCAAACAGTCACTAATCGACAAAGTGTCATTGAT
ATTGTGACTGAATTACGTCCAGGAACTAACGTTAATGTCGATGTAATTCGAAAAGGGGTGACTCAAACTATTCCACTAAT
GATCGAAGAAGACCCCGCGGACTAG

Upstream 100 bases:

>100_bases
CATTTCGATGAGCCGAGCCTGCTCTTTCTTCTCTACTTCTTGGCAACATTAATGTTATCCTAACTTCTGGTCATTTATTA
CTTACAAGTTTAGGAAGCCA

Downstream 100 bases:

>100_bases
AACCCCCATAAGCGAAATATCGAAATATCGAAATATCGAAATATCGAAATATCGAAATAAAAAAATAGCGCATTCATCAT
GCGCTATTTTTTATTAACGA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MLSFLLRSAVIGTVTAAVLLLAFPNLRSGITPEQDTNQQTPRISNQISFNDAVRRAAPAVVNIYSRKYNDKDRLRLDTEG
LGSGVIVSDKGYIITNYHVVAEADQIIVALQDGRLFNSQLIGKDKRTDLAVLQIKDTNLPVIPLNPKYQADIGDVVLAIG
NPYNLGQTTTFGIISATGRAALSSDGTQGLIQTDAAINRGNSGGALVNTRGELVGINTASFQQATELETYGISFAIPYAL
ADKIMRRLIADGQVIRGYIGIDGRDINPAMARLMNADNINGILVLGVAPDSPAEKSGIMTQDIITSIDGQTVTNRQSVID
IVTELRPGTNVNVDVIRKGVTQTIPLMIEEDPAD

Sequences:

>Translated_354_residues
MLSFLLRSAVIGTVTAAVLLLAFPNLRSGITPEQDTNQQTPRISNQISFNDAVRRAAPAVVNIYSRKYNDKDRLRLDTEG
LGSGVIVSDKGYIITNYHVVAEADQIIVALQDGRLFNSQLIGKDKRTDLAVLQIKDTNLPVIPLNPKYQADIGDVVLAIG
NPYNLGQTTTFGIISATGRAALSSDGTQGLIQTDAAINRGNSGGALVNTRGELVGINTASFQQATELETYGISFAIPYAL
ADKIMRRLIADGQVIRGYIGIDGRDINPAMARLMNADNINGILVLGVAPDSPAEKSGIMTQDIITSIDGQTVTNRQSVID
IVTELRPGTNVNVDVIRKGVTQTIPLMIEEDPAD
>Mature_354_residues
MLSFLLRSAVIGTVTAAVLLLAFPNLRSGITPEQDTNQQTPRISNQISFNDAVRRAAPAVVNIYSRKYNDKDRLRLDTEG
LGSGVIVSDKGYIITNYHVVAEADQIIVALQDGRLFNSQLIGKDKRTDLAVLQIKDTNLPVIPLNPKYQADIGDVVLAIG
NPYNLGQTTTFGIISATGRAALSSDGTQGLIQTDAAINRGNSGGALVNTRGELVGINTASFQQATELETYGISFAIPYAL
ADKIMRRLIADGQVIRGYIGIDGRDINPAMARLMNADNINGILVLGVAPDSPAEKSGIMTQDIITSIDGQTVTNRQSVID
IVTELRPGTNVNVDVIRKGVTQTIPLMIEEDPAD

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=321, Percent_Identity=35.202492211838, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI22129776, Length=331, Percent_Identity=36.2537764350453, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI24308541, Length=288, Percent_Identity=32.2916666666667, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI7019477, Length=295, Percent_Identity=34.2372881355932, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1789630, Length=358, Percent_Identity=53.6312849162011, Blast_Score=339, Evalue=1e-94,
Organism=Escherichia coli, GI1786356, Length=272, Percent_Identity=42.6470588235294, Blast_Score=207, Evalue=8e-55,
Organism=Escherichia coli, GI1789629, Length=273, Percent_Identity=42.8571428571429, Blast_Score=207, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24646839, Length=375, Percent_Identity=30.4, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 37943; Mature: 37943

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFLLRSAVIGTVTAAVLLLAFPNLRSGITPEQDTNQQTPRISNQISFNDAVRRAAPAV
CHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHH
VNIYSRKYNDKDRLRLDTEGLGSGVIVSDKGYIITNYHVVAEADQIIVALQDGRLFNSQL
EEEHHHCCCCCHHEEEECCCCCCCEEEECCCEEEEEEEEEEECCEEEEEEECCCEECHHH
IGKDKRTDLAVLQIKDTNLPVIPLNPKYQADIGDVVLAIGNPYNLGQTTTFGIISATGRA
CCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCE
ALSSDGTQGLIQTDAAINRGNSGGALVNTRGELVGINTASFQQATELETYGISFAIPYAL
ECCCCCCCCEEEECHHHCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHCCEEEEEHHHH
ADKIMRRLIADGQVIRGYIGIDGRDINPAMARLMNADNINGILVLGVAPDSPAEKSGIMT
HHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHCCCCH
QDIITSIDGQTVTNRQSVIDIVTELRPGTNVNVDVIRKGVTQTIPLMIEEDPAD
HHHHHHCCCCEECCHHHHHHHHHHCCCCCCCCHHHHHCCCCCEECEEEECCCCC
>Mature Secondary Structure
MLSFLLRSAVIGTVTAAVLLLAFPNLRSGITPEQDTNQQTPRISNQISFNDAVRRAAPAV
CHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHH
VNIYSRKYNDKDRLRLDTEGLGSGVIVSDKGYIITNYHVVAEADQIIVALQDGRLFNSQL
EEEHHHCCCCCHHEEEECCCCCCCEEEECCCEEEEEEEEEEECCEEEEEEECCCEECHHH
IGKDKRTDLAVLQIKDTNLPVIPLNPKYQADIGDVVLAIGNPYNLGQTTTFGIISATGRA
CCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCE
ALSSDGTQGLIQTDAAINRGNSGGALVNTRGELVGINTASFQQATELETYGISFAIPYAL
ECCCCCCCCEEEECHHHCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHCCEEEEEHHHH
ADKIMRRLIADGQVIRGYIGIDGRDINPAMARLMNADNINGILVLGVAPDSPAEKSGIMT
HHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCHHCCCCH
QDIITSIDGQTVTNRQSVIDIVTELRPGTNVNVDVIRKGVTQTIPLMIEEDPAD
HHHHHHCCCCEECCHHHHHHHHHHCCCCCCCCHHHHHCCCCCEECEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]