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The map label for this gene is serA [H]

Identifier: 209695962

GI number: 209695962

Start: 2724503

End: 2725732

Strand: Direct

Name: serA [H]

Synonym: VSAL_I2544

Alternate gene names: 209695962

Gene position: 2724503-2725732 (Clockwise)

Preceding gene: 209695961

Following gene: 209695967

Centisome position: 81.94

GC content: 40.89

Gene sequence:

>1230_bases
ATGGCAAAAGTATCTCTGGAAAAAGAAAAAATTAAAATTCTTCTTTTAGAAGGATTGCACCCATCTTGTGTTGAAGTTTT
TCAAGCTGACGGCTATACAAACATTGAATACCATAAAGGTTCATTGTCAGAAGAAGAGCTTCTTGAAGCAGTAAAAGATG
TCCACTTCATAGGTTTACGATCACGAACTCAACTAACCCAAGAAGTGTTTGATGCTGCTAATAAATTAGTTGCCGTTGGT
TGTTTCTGTATTGGTACGAACCAAGTAAACCTAACCGCAGCAGCAAAACGCGGTATTCCTGTCTTTAATGCCCCGTTCTC
TAATACACGTAGTGTGGCTGAACTAGTATTGGGGCAAATCCTATTACTGCTTCGCGGTATTCCAGAAAAGAATGCACAAG
CTCACCGTGGTATCTGGAAAAAAAGTGCTGACTCTTCTTTTGAAGCCAGAGGCAAACGTTTGGGTATCATAGGTTACGGA
CATATCGGCACACAATTGGGGATCTTAGCTGAAAACCTAGGCATGCGTGTTTACTATTATGATATTGAAAATAAATTATC
ATTAGGTAACGCCACTCAAATTCAAACCATGAGTGAACTATTAAACAAGTGTGATGTTATTACCCTTCATGTACCTGAAA
CCGCAGGCACAAAAGACATGATGGGTGCAGAAGAGTTCGCAAGAATGAAACCAGGGGCAATCTTTATCAATGCTGCTCGT
GGTACCGTCGTAAAAATACCCGACTTATGTGCAGCGCTTGAATCTGGCCATCTAGGTGGTGCCGCTATTGACGTATTCCC
AGTAGAACCTAAAACAAATGCAGACCCATTTGAATCACCATTGCAAAAGTTTGATAATGTTATCCTAACACCTCATGTCG
GAGGCTCAACTCAAGAAGCTCAAGAAAACATTGGGGTAGAAGTCGCAGGTAAACTTACAAAATACTCAGATAATGGTTCA
ACACTGTCATCAGTGAACTTCCCAGAAGTCTCTCTACCTCTACATACTGGCACGTCTCGTTTACTTCATATTCATGAGAA
CCGCCCAGGCATTCTGACTAAAATTAACAGTATTTTTGCGGATAAAGGGATTAATATCGCGGCACAATACCTACAAACCT
CATCAGAAATGGGCTATGTCGTTATTGATGTTGAAGCCGCTCGTTCAGAAGAAGCATTAACGAAGCTAAAAGATATTGAA
GGTACTATCCGAGCCCGTATCCTTCACTAA

Upstream 100 bases:

>100_bases
TTTCTTACCCAAACTGGTTATTTTTTGATACTTTATAATCATCAATAAATAATCACTTCCCTAATCATTATTGATTTTGT
TTTTAAGGATAAGAACGACC

Downstream 100 bases:

>100_bases
TAAATCATACGCTAATAACATCGTACAAAAAAAAGGGTTACGCTTAGTAACCCTTTTTATTTCAATGTATTTTTCTAAAC
ACTATTATAGATATAACGTC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLRSRTQLTQEVFDAANKLVAVG
CFCIGTNQVNLTAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNAQAHRGIWKKSADSSFEARGKRLGIIGYG
HIGTQLGILAENLGMRVYYYDIENKLSLGNATQIQTMSELLNKCDVITLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
GTVVKIPDLCAALESGHLGGAAIDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLTKYSDNGS
TLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTKINSIFADKGINIAAQYLQTSSEMGYVVIDVEAARSEEALTKLKDIE
GTIRARILH

Sequences:

>Translated_409_residues
MAKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLRSRTQLTQEVFDAANKLVAVG
CFCIGTNQVNLTAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNAQAHRGIWKKSADSSFEARGKRLGIIGYG
HIGTQLGILAENLGMRVYYYDIENKLSLGNATQIQTMSELLNKCDVITLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
GTVVKIPDLCAALESGHLGGAAIDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLTKYSDNGS
TLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTKINSIFADKGINIAAQYLQTSSEMGYVVIDVEAARSEEALTKLKDIE
GTIRARILH
>Mature_408_residues
AKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLRSRTQLTQEVFDAANKLVAVGC
FCIGTNQVNLTAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNAQAHRGIWKKSADSSFEARGKRLGIIGYGH
IGTQLGILAENLGMRVYYYDIENKLSLGNATQIQTMSELLNKCDVITLHVPETAGTKDMMGAEEFARMKPGAIFINAARG
TVVKIPDLCAALESGHLGGAAIDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLTKYSDNGST
LSSVNFPEVSLPLHTGTSRLLHIHENRPGILTKINSIFADKGINIAAQYLQTSSEMGYVVIDVEAARSEEALTKLKDIEG
TIRARILH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=36.5930599369085, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=29.2, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=29.2, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=28.4615384615385, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=28.4615384615385, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI145580575, Length=278, Percent_Identity=29.4964028776978, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI6912396, Length=276, Percent_Identity=27.536231884058, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=72.992700729927, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=30.4347826086957, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081824, Length=192, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788660, Length=305, Percent_Identity=25.2459016393443, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=33.4365325077399, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147481, Length=284, Percent_Identity=27.4647887323944, Blast_Score=95, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.5845410628019, Blast_Score=397, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=47.3429951690821, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=27.734375, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=284, Percent_Identity=25.7042253521127, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=33.5548172757475, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=29.4339622641509, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571528, Length=293, Percent_Identity=29.0102389078498, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=28.3582089552239, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=28.3582089552239, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=25.7425742574257, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551003, Length=286, Percent_Identity=24.4755244755245, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44401; Mature: 44269

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLR
CCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHEECCC
SRTQLTQEVFDAANKLVAVGCFCIGTNQVNLTAAAKRGIPVFNAPFSNTRSVAELVLGQI
HHHHHHHHHHHHHHHEEEEEEEEEECCEEEEEEHHHCCCCEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNAQAHRGIWKKSADSSFEARGKRLGIIGYGHIGTQLGILAENLGMRVYYY
HHHHCCCCCCCCHHHHCCHHCCCCCCHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQIQTMSELLNKCDVITLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
ECCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHCCHHHHHHCCCCEEEEEECC
GTVVKIPDLCAALESGHLGGAAIDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEA
CCEEECHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCCHHH
QENIGVEVAGKLTKYSDNGSTLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTKINSIFA
HHCCCEEEEEEEEEECCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHH
DKGINIAAQYLQTSSEMGYVVIDVEAARSEEALTKLKDIEGTIRARILH
CCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECC
>Mature Secondary Structure 
AKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLR
CCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHEECCC
SRTQLTQEVFDAANKLVAVGCFCIGTNQVNLTAAAKRGIPVFNAPFSNTRSVAELVLGQI
HHHHHHHHHHHHHHHEEEEEEEEEECCEEEEEEHHHCCCCEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNAQAHRGIWKKSADSSFEARGKRLGIIGYGHIGTQLGILAENLGMRVYYY
HHHHCCCCCCCCHHHHCCHHCCCCCCHHHCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQIQTMSELLNKCDVITLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
ECCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHCCHHHHHHCCCCEEEEEECC
GTVVKIPDLCAALESGHLGGAAIDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEA
CCEEECHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCCHHH
QENIGVEVAGKLTKYSDNGSTLSSVNFPEVSLPLHTGTSRLLHIHENRPGILTKINSIFA
HHCCCEEEEEEEEEECCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHH
DKGINIAAQYLQTSSEMGYVVIDVEAARSEEALTKLKDIEGTIRARILH
CCCCHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]