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The map label for this gene is ahpC [C]

Identifier: 209695865

GI number: 209695865

Start: 2614720

End: 2615328

Strand: Direct

Name: ahpC [C]

Synonym: VSAL_I2441

Alternate gene names: 209695865

Gene position: 2614720-2615328 (Clockwise)

Preceding gene: 209695861

Following gene: 209695866

Centisome position: 78.63

GC content: 45.16

Gene sequence:

>609_bases
ATGGTACTAGTAGGTCGTCAAGCACCAGACTTTACTGCTGCAGCTGTTCTAGGTAACGGCGAGATCGTTGATAGCTTCAA
CTTCAAAGAATTCACTAAAGGTAAGAAAGCGGTAGTATTTTTCTACCCACTAGACTTCACTTTCGTTTGTCCTTCAGAGC
TAATCGCTTTTGACAACCGTCTAGCTGATTTCCAAGCTAAAGGCGCGGAAGTAATTGGTATCTCAATTGATTCACAATTC
TCTCACAACGCATGGCGTAACACGGCTATCGAAGATGGCGGTATTGGTCAAGTTAAGTACCCACTAGTTGCTGACGTTAA
GCACGAAATCTGTAAAGCATACGACGTTGAGCATCCAGAAGCTGGTGTTGCTTTCCGTGGTTCTTTCCTAATCGATGCTG
ATGGCCTTGTTCGTCATCAAGTAGTTAACGATCTTCCACTAGGTCGTAACATCGACGAAATGCTACGTATGGTAGACGCG
CTAAACTTCCACGAGAAGAATGGTGAAGTTTGTCCAGCACAATGGGAAGAAGGCAAAGCAGGTATGGACGCATCTCCAAA
AGGCGTTGCAGCATTCCTATCTGAACACGCTGACGACCTAAGCAAGTAA

Upstream 100 bases:

>100_bases
ACCTTTTGTACTATAGTTTGTCCTGTTGAAACAATTTATTGTATTGAAAAACAAAGCCAAACACGAAGTTTGGAAAATCT
AACTTTTAGGAGATTCAAAA

Downstream 100 bases:

>100_bases
TTGCTAAGATAGAGTATTTTAAATAAAGTACTCGAATGCACCTACGCTCAACGGTGCATGTGGCTAGAATATTAAAAGCG
TATAAACGCAGTAGCCTAAA

Product: peroxidase/antioxidant

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MVLVGRQAPDFTAAAVLGNGEIVDSFNFKEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRLADFQAKGAEVIGISIDSQF
SHNAWRNTAIEDGGIGQVKYPLVADVKHEICKAYDVEHPEAGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDA
LNFHEKNGEVCPAQWEEGKAGMDASPKGVAAFLSEHADDLSK

Sequences:

>Translated_202_residues
MVLVGRQAPDFTAAAVLGNGEIVDSFNFKEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRLADFQAKGAEVIGISIDSQF
SHNAWRNTAIEDGGIGQVKYPLVADVKHEICKAYDVEHPEAGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDA
LNFHEKNGEVCPAQWEEGKAGMDASPKGVAAFLSEHADDLSK
>Mature_202_residues
MVLVGRQAPDFTAAAVLGNGEIVDSFNFKEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRLADFQAKGAEVIGISIDSQF
SHNAWRNTAIEDGGIGQVKYPLVADVKHEICKAYDVEHPEAGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDA
LNFHEKNGEVCPAQWEEGKAGMDASPKGVAAFLSEHADDLSK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=197, Percent_Identity=46.1928934010152, Blast_Score=189, Evalue=1e-48,
Organism=Homo sapiens, GI4505591, Length=175, Percent_Identity=49.1428571428571, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI32455266, Length=175, Percent_Identity=49.1428571428571, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI32455264, Length=175, Percent_Identity=49.1428571428571, Blast_Score=182, Evalue=2e-46,
Organism=Homo sapiens, GI5453549, Length=189, Percent_Identity=44.973544973545, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI32483377, Length=180, Percent_Identity=45.5555555555556, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI5802974, Length=183, Percent_Identity=44.8087431693989, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI33188454, Length=86, Percent_Identity=54.6511627906977, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=26.8421052631579, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786822, Length=186, Percent_Identity=32.258064516129, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17554494, Length=170, Percent_Identity=48.8235294117647, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=44.8453608247423, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=44.8453608247423, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25153706, Length=185, Percent_Identity=25.4054054054054, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=182, Percent_Identity=43.4065934065934, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=41.8994413407821, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6319407, Length=181, Percent_Identity=28.1767955801105, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17738015, Length=189, Percent_Identity=44.4444444444444, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=43.8144329896907, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=43.8144329896907, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17157991, Length=186, Percent_Identity=46.7741935483871, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24641739, Length=186, Percent_Identity=46.7741935483871, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21357347, Length=188, Percent_Identity=40.4255319148936, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24581278, Length=185, Percent_Identity=29.1891891891892, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22105; Mature: 22105

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVGRQAPDFTAAAVLGNGEIVDSFNFKEFTKGKKAVVFFYPLDFTFVCPSELIAFDNR
CEEECCCCCCCEEEEEECCCCEEECCCCHHHCCCCEEEEEEEECCEEEECHHHHHHHHHH
LADFQAKGAEVIGISIDSQFSHNAWRNTAIEDGGIGQVKYPLVADVKHEICKAYDVEHPE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCC
AGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDALNFHEKNGEVCPAQWEEGKA
CCEEEECEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GMDASPKGVAAFLSEHADDLSK
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLVGRQAPDFTAAAVLGNGEIVDSFNFKEFTKGKKAVVFFYPLDFTFVCPSELIAFDNR
CEEECCCCCCCEEEEEECCCCEEECCCCHHHCCCCEEEEEEEECCEEEECHHHHHHHHHH
LADFQAKGAEVIGISIDSQFSHNAWRNTAIEDGGIGQVKYPLVADVKHEICKAYDVEHPE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCC
AGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDALNFHEKNGEVCPAQWEEGKA
CCEEEECEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GMDASPKGVAAFLSEHADDLSK
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]