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The map label for this gene is hutH [H]

Identifier: 209695541

GI number: 209695541

Start: 2247106

End: 2248641

Strand: Reverse

Name: hutH [H]

Synonym: VSAL_I2097

Alternate gene names: 209695541

Gene position: 2248641-2247106 (Counterclockwise)

Preceding gene: 209695542

Following gene: 209695540

Centisome position: 67.62

GC content: 42.32

Gene sequence:

>1536_bases
ATGACAACTAATTCAATTACATTTGGTAAAGGACGTCTGACGATTGAAGACGTTGTTGAGATCGCAAATGGTGCTGATGC
ACAACTTAATAATTCCGATGCATTCACTGCCAAAATTGATCGAGGTGTAGAATTTTTAGAACGTCTTTTACGAGAAGAAG
GCGTTATTTATGGCGTAACAACAGGGTATGGGGATTCTTGTACTGTTGCTATTCCAATGGATTTAGTAGATGAACTGCCA
CTGCATTTAACTCGTTTTCATGGTTGTGGCTTGGGCGAGAACCTTGACGAACAACAATCCCGTGCAGTATTAGCGACACG
TTTGTGTTCATTATCTCAGGGTGTATCCGGCGTAACTCACGATCTATTAAACCAAATTGTGACGCTAATTAATCACGGTA
TTTCACCTCGTATCCCTCAAGAAGGATCGGTGGGTGCAAGCGGTGACTTAACGCCATTATCTTATCTTGCGGCTACTTTA
ATCGGTGAACGTGAAGTTATTTATAAAGGCGAAATCCGTCCAACGGCAGACGTGTTTAAAGCGTTGAATATTACGCCAAT
TAAGCTAAAGCCAAAAGAAGGTTTAGCATTAATGAATGGTACGTCAGTAATGACAGCACTTGCTTGTTTAGCTTACAAAC
GTGCTGAATATTTAGCGCAAATGGCGACTAAAATTACCGCCATGGTGTCTGTGGGTATGCAAGGTAATGACTTCCATTTT
GATGAAGCGTTATTTGCGGTTAAACCGCATCCAGGTCAGCAACAAATTGCGGCATGGTTACGTTCTGATTTGCATAATGA
AACACCACCAAGAAACAGTGATCGTCTGCAAGATCGCTATTCACTGCGTTGTGCTCCTCATGTTATTGGTGTACTTCAAG
ATAGCCTGCCTTTCTTACGTCAAATGATTGAGAATGAGTTAAACAGTGCCAATGATAATCCAATTATCGATGGTGATAAT
GAACGCGTTCTGCATGGTGGACACTTTTACGGCGGTCATATCGCAATGGCGATGGACATGCTAAAAACAGCGGTGGCAAA
CATTGCTGATCTACTGGATCGCCAAATGGCGCAGTTAATGGACTATAAGTTCAATAACGGCTTACCATTTAACTTAACGG
GTGCAACAGGCGCGCGTAAACCGATTAACCACGGGTTTAAAGCCGTACAAATCGGCATTTCAGCGTGGACAGCAGAAGCG
CTTAAGGGCACGATGCCTGCGAGTGTATTCTCACGTTCAACTGAATGTCATAACCAAGATAAAGTAAGCATGGGCACCAT
TGCATCACGCGATTGTTTACGTGTTCTACAGCTGACAGAACAAGTGACCTCAGCGTCATTACTTGCCGCAACTCAAGCAT
TAGTCTTACGTGAAAGACAAGGTGAATTGAGTGATAAAGAACTGAGCGTTGAGTTAAAAACCATGCGTGATGCGGTATTG
TCTGAGTTTGAATTTGTGAATGAAGATCGACCGTTAGAGCATGACTTACGTAACTTTATCGAAAAAATTCAACAACAACA
TTGGACACTTTATTAA

Upstream 100 bases:

>100_bases
GTCGTGCAAAACTATGCTCAACGCTTAGAGCATTTCACACTGAAAGCACCATCACAATGGTATAACTTTTTTAATTTTTG
GCAGTTAACTGGAAAGAAAG

Downstream 100 bases:

>100_bases
TGTCAAACCCTGTGATTAACACGGATGGATCACCAACGTTGAACGTATTGAGTTCAGAGGTGTTGATCACAACGGCTTTT
CAAGATGCAGACCCGATGGG

Product: phenylalanine and histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTTNSITFGKGRLTIEDVVEIANGADAQLNNSDAFTAKIDRGVEFLERLLREEGVIYGVTTGYGDSCTVAIPMDLVDELP
LHLTRFHGCGLGENLDEQQSRAVLATRLCSLSQGVSGVTHDLLNQIVTLINHGISPRIPQEGSVGASGDLTPLSYLAATL
IGEREVIYKGEIRPTADVFKALNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLRQMIENELNSANDNPIIDGDN
ERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLMDYKFNNGLPFNLTGATGARKPINHGFKAVQIGISAWTAEA
LKGTMPASVFSRSTECHNQDKVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLRERQGELSDKELSVELKTMRDAVL
SEFEFVNEDRPLEHDLRNFIEKIQQQHWTLY

Sequences:

>Translated_511_residues
MTTNSITFGKGRLTIEDVVEIANGADAQLNNSDAFTAKIDRGVEFLERLLREEGVIYGVTTGYGDSCTVAIPMDLVDELP
LHLTRFHGCGLGENLDEQQSRAVLATRLCSLSQGVSGVTHDLLNQIVTLINHGISPRIPQEGSVGASGDLTPLSYLAATL
IGEREVIYKGEIRPTADVFKALNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLRQMIENELNSANDNPIIDGDN
ERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLMDYKFNNGLPFNLTGATGARKPINHGFKAVQIGISAWTAEA
LKGTMPASVFSRSTECHNQDKVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLRERQGELSDKELSVELKTMRDAVL
SEFEFVNEDRPLEHDLRNFIEKIQQQHWTLY
>Mature_510_residues
TTNSITFGKGRLTIEDVVEIANGADAQLNNSDAFTAKIDRGVEFLERLLREEGVIYGVTTGYGDSCTVAIPMDLVDELPL
HLTRFHGCGLGENLDEQQSRAVLATRLCSLSQGVSGVTHDLLNQIVTLINHGISPRIPQEGSVGASGDLTPLSYLAATLI
GEREVIYKGEIRPTADVFKALNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHFD
EALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLRQMIENELNSANDNPIIDGDNE
RVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLMDYKFNNGLPFNLTGATGARKPINHGFKAVQIGISAWTAEAL
KGTMPASVFSRSTECHNQDKVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLRERQGELSDKELSVELKTMRDAVLS
EFEFVNEDRPLEHDLRNFIEKIQQQHWTLY

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=451, Percent_Identity=35.6984478935698, Blast_Score=284, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17567831, Length=505, Percent_Identity=35.049504950495, Blast_Score=265, Evalue=5e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56214; Mature: 56083

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNSITFGKGRLTIEDVVEIANGADAQLNNSDAFTAKIDRGVEFLERLLREEGVIYGVT
CCCCCEECCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEE
TGYGDSCTVAIPMDLVDELPLHLTRFHGCGLGENLDEQQSRAVLATRLCSLSQGVSGVTH
CCCCCCEEEEECHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
DLLNQIVTLINHGISPRIPQEGSVGASGDLTPLSYLAATLIGEREVIYKGEIRPTADVFK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHH
ALNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
HCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLR
CCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMIENELNSANDNPIIDGDNERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLM
HHHHHHHCCCCCCCCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYKFNNGLPFNLTGATGARKPINHGFKAVQIGISAWTAEALKGTMPASVFSRSTECHNQD
CCCCCCCCCEEECCCCCCCCCHHCCCEEEEEHHHHHHHHHHHCCCCHHHHHCCHHHCCCC
KVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLRERQGELSDKELSVELKTMRDAVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SEFEFVNEDRPLEHDLRNFIEKIQQQHWTLY
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTNSITFGKGRLTIEDVVEIANGADAQLNNSDAFTAKIDRGVEFLERLLREEGVIYGVT
CCCCEECCCCCEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEE
TGYGDSCTVAIPMDLVDELPLHLTRFHGCGLGENLDEQQSRAVLATRLCSLSQGVSGVTH
CCCCCCEEEEECHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
DLLNQIVTLINHGISPRIPQEGSVGASGDLTPLSYLAATLIGEREVIYKGEIRPTADVFK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCHHHHHH
ALNITPIKLKPKEGLALMNGTSVMTALACLAYKRAEYLAQMATKITAMVSVGMQGNDFHF
HCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DEALFAVKPHPGQQQIAAWLRSDLHNETPPRNSDRLQDRYSLRCAPHVIGVLQDSLPFLR
CCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMIENELNSANDNPIIDGDNERVLHGGHFYGGHIAMAMDMLKTAVANIADLLDRQMAQLM
HHHHHHHCCCCCCCCCCCCCCEEEECCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYKFNNGLPFNLTGATGARKPINHGFKAVQIGISAWTAEALKGTMPASVFSRSTECHNQD
CCCCCCCCCEEECCCCCCCCCHHCCCEEEEEHHHHHHHHHHHCCCCHHHHHCCHHHCCCC
KVSMGTIASRDCLRVLQLTEQVTSASLLAATQALVLRERQGELSDKELSVELKTMRDAVL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
SEFEFVNEDRPLEHDLRNFIEKIQQQHWTLY
HHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA