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The map label for this gene is mprA [H]

Identifier: 209695438

GI number: 209695438

Start: 2121749

End: 2122408

Strand: Reverse

Name: mprA [H]

Synonym: VSAL_I1979

Alternate gene names: 209695438

Gene position: 2122408-2121749 (Counterclockwise)

Preceding gene: 209695439

Following gene: 209695437

Centisome position: 63.83

GC content: 38.79

Gene sequence:

>660_bases
ATGAAAATTTTAGTTGTTGAAGATGACCAACGCTTAGGTCAACAAATTATTGACGCTCTCGAAGCAAACAACTGGACACC
AGAGCTTTCTCAAGATGGCATTGATGCATTATACCGTGCAACGTCAGAATCTTGGGATGCCATTGTTCTCGATCTAGGTT
TACCTAAATTGGATGGATTGACGGTACTTAAAGGCTTAAGAGATGAATCAGTCAATATTCCTGTCATTATTTTAAGTGCT
CGTGATACGTTAACTCAACGCATTGATGGCCTTAATGCAGGGGCTGACGATTATTTAACGAAACCCTTTGAATTACCAGA
GTTAATCGCCCGCTTACGCGTTCAACTTCGTCGCGCTTCAGGCAGTGCCTCTTCGGTATTAAAAATCGGTAATTTAAGCT
TAGATACGTGTTCTTCTAAAATTGTTTGGTATGGTGAAACTATCGAATTAACCGCATTAGAATATAAAGTCGTTGCTTAC
TTTATGCACAACAAAGAAAAAGTCATTTCTCGAACAGAGTTAGTCGAACATATCTACAAACAAGATTTTGATCGCGATTC
AAATACTATTGAAGTGTTTATTGGGCGAATTCGAAGAAAGTTATCGCCTTCCGTAATAAAAACAGTGCGTGGACTTGGGT
ACCAACTTAATGCCGAATAA

Upstream 100 bases:

>100_bases
ATCTACGAAAATCAGATCATAAAAGTTGAATACAACGCGTCTTCTCTTCAAATGCTAGAGCTTAAAGGCCGTCATCTACA
AAAGGTTATAAAATAATAAT

Downstream 100 bases:

>100_bases
CAAAAGTAATTTCAAGCATTTAAGTTTAAAAAATCGCTTATTGTTAACGACTACCTTATGGTTAAGCCTGATGCTTGTCA
GTGCTGGATTATTGATCCCT

Product: transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKILVVEDDQRLGQQIIDALEANNWTPELSQDGIDALYRATSESWDAIVLDLGLPKLDGLTVLKGLRDESVNIPVIILSA
RDTLTQRIDGLNAGADDYLTKPFELPELIARLRVQLRRASGSASSVLKIGNLSLDTCSSKIVWYGETIELTALEYKVVAY
FMHNKEKVISRTELVEHIYKQDFDRDSNTIEVFIGRIRRKLSPSVIKTVRGLGYQLNAE

Sequences:

>Translated_219_residues
MKILVVEDDQRLGQQIIDALEANNWTPELSQDGIDALYRATSESWDAIVLDLGLPKLDGLTVLKGLRDESVNIPVIILSA
RDTLTQRIDGLNAGADDYLTKPFELPELIARLRVQLRRASGSASSVLKIGNLSLDTCSSKIVWYGETIELTALEYKVVAY
FMHNKEKVISRTELVEHIYKQDFDRDSNTIEVFIGRIRRKLSPSVIKTVRGLGYQLNAE
>Mature_219_residues
MKILVVEDDQRLGQQIIDALEANNWTPELSQDGIDALYRATSESWDAIVLDLGLPKLDGLTVLKGLRDESVNIPVIILSA
RDTLTQRIDGLNAGADDYLTKPFELPELIARLRVQLRRASGSASSVLKIGNLSLDTCSSKIVWYGETIELTALEYKVVAY
FMHNKEKVISRTELVEHIYKQDFDRDSNTIEVFIGRIRRKLSPSVIKTVRGLGYQLNAE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.5454545454545, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=33.9366515837104, Blast_Score=154, Evalue=3e-39,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=41.2844036697248, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=36.9369369369369, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=36.4444444444444, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=35.3211009174312, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=34.8214285714286, Blast_Score=126, Evalue=9e-31,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=34.2222222222222, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=30.9417040358744, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.4801762114537, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=32.3008849557522, Blast_Score=100, Evalue=8e-23,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=30.0884955752212, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.8245614035088, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=25.5411255411255, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=28.9719626168224, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=31.4814814814815, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24604; Mature: 24604

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDDQRLGQQIIDALEANNWTPELSQDGIDALYRATSESWDAIVLDLGLPKLDGL
CEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCH
TVLKGLRDESVNIPVIILSARDTLTQRIDGLNAGADDYLTKPFELPELIARLRVQLRRAS
HHHHCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCC
GSASSVLKIGNLSLDTCSSKIVWYGETIELTALEYKVVAYFMHNKEKVISRTELVEHIYK
CCHHHEEEECCCCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFIGRIRRKLSPSVIKTVRGLGYQLNAE
HCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKILVVEDDQRLGQQIIDALEANNWTPELSQDGIDALYRATSESWDAIVLDLGLPKLDGL
CEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCH
TVLKGLRDESVNIPVIILSARDTLTQRIDGLNAGADDYLTKPFELPELIARLRVQLRRAS
HHHHCCCCCCCCCCEEEEECCHHHHHHHCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCC
GSASSVLKIGNLSLDTCSSKIVWYGETIELTALEYKVVAYFMHNKEKVISRTELVEHIYK
CCHHHEEEECCCCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFIGRIRRKLSPSVIKTVRGLGYQLNAE
HCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA