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The map label for this gene is ribA

Identifier: 209695264

GI number: 209695264

Start: 1905014

End: 1905613

Strand: Reverse

Name: ribA

Synonym: VSAL_I1787

Alternate gene names: 209695264

Gene position: 1905613-1905014 (Counterclockwise)

Preceding gene: 209695265

Following gene: 209695263

Centisome position: 57.31

GC content: 37.33

Gene sequence:

>600_bases
ATGACAAAGGTAAGAGCTCGTATCGAGTTAAGTGTAGGGCAACACAGTAATATCCCTGCGGAAATGCTTTCATTTGAAGG
GTTAGAAACAGAAAAAGAGCATGTCGCTATTGTTTTTAATCAAGCAGATAAAACACAAAAAACGCCTTTGGTTCGTATGC
ATTCAGAATGCTTAACAGGCGATGTTTTTCACTCTTCACGATGTGATTGTGGTGAGCAGTTAGAAGAAAGTATCAACAAA
ATGGCGATAAGTGGCGGCATTATCTTATATCTTCGTCAAGAAGGCCGTGGTATTGGTTTGTATAATAAGTTAGATGCTTA
TGAGCTTCAAAGTAAAGGCATGAACACGTACGAGGCAAATAACCATTTAGGCTTTGGTGATGATTTACGTGATTTCAAAG
AAGCGGCTCAAATGCTGGGAGCGCTAAACATCAACACAATTAAGCTTGTGACGAACAATCCAAAGAAAATTAAAGACATT
CAAGATTATGGTATTACGCTAGATGAAGTGGTTCATACTCATGCTCATGTAAAAAAAGGCAATGAGAATTATCTCCAATC
AAAAGTAGATCATGGACATCAGTTAGATTTAGATAAATGA

Upstream 100 bases:

>100_bases
TTTTTTGATTCTTGCATTTTTACTAGATATGCTTATGATCTTTTTATCTGATTAAATCGTAGAAGAGTCATCTTCTCATT
GAAAAAGGCAGCAAATCAGC

Downstream 100 bases:

>100_bases
TCAATTGAGTAGTTAGAAAAACGTTGAAGGCTCATTAATTAATGGGGCTTTTTTATATCCAAGTAATAATTGTTAATCTT
AATGATAAATATTTGCATTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTKVRARIELSVGQHSNIPAEMLSFEGLETEKEHVAIVFNQADKTQKTPLVRMHSECLTGDVFHSSRCDCGEQLEESINK
MAISGGIILYLRQEGRGIGLYNKLDAYELQSKGMNTYEANNHLGFGDDLRDFKEAAQMLGALNINTIKLVTNNPKKIKDI
QDYGITLDEVVHTHAHVKKGNENYLQSKVDHGHQLDLDK

Sequences:

>Translated_199_residues
MTKVRARIELSVGQHSNIPAEMLSFEGLETEKEHVAIVFNQADKTQKTPLVRMHSECLTGDVFHSSRCDCGEQLEESINK
MAISGGIILYLRQEGRGIGLYNKLDAYELQSKGMNTYEANNHLGFGDDLRDFKEAAQMLGALNINTIKLVTNNPKKIKDI
QDYGITLDEVVHTHAHVKKGNENYLQSKVDHGHQLDLDK
>Mature_198_residues
TKVRARIELSVGQHSNIPAEMLSFEGLETEKEHVAIVFNQADKTQKTPLVRMHSECLTGDVFHSSRCDCGEQLEESINKM
AISGGIILYLRQEGRGIGLYNKLDAYELQSKGMNTYEANNHLGFGDDLRDFKEAAQMLGALNINTIKLVTNNPKKIKDIQ
DYGITLDEVVHTHAHVKKGNENYLQSKVDHGHQLDLDK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase II family

Homologues:

Organism=Escherichia coli, GI1787533, Length=178, Percent_Identity=48.314606741573, Blast_Score=155, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=169, Percent_Identity=40.8284023668639, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBA_ALISL (B6ENI2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263193.1
- GeneID:   6987370
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1787
- HOGENOM:   HBG735778
- OMA:   TDKEHVA
- ProtClustDB:   PRK00393
- HAMAP:   MF_00179
- InterPro:   IPR000926

Pfam domain/function: PF00925 GTP_cyclohydro2

EC number: =3.5.4.25

Molecular weight: Translated: 22365; Mature: 22233

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: ACT_SITE 128-128 ACT_SITE 130-130 BINDING 73-73 BINDING 116-116 BINDING 151-151 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVRARIELSVGQHSNIPAEMLSFEGLETEKEHVAIVFNQADKTQKTPLVRMHSECLTG
CCCEEEEEEEECCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
DVFHSSRCDCGEQLEESINKMAISGGIILYLRQEGRGIGLYNKLDAYELQSKGMNTYEAN
CCCCCCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCEEECC
NHLGFGDDLRDFKEAAQMLGALNINTIKLVTNNPKKIKDIQDYGITLDEVVHTHAHVKKG
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCC
NENYLQSKVDHGHQLDLDK
CHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKVRARIELSVGQHSNIPAEMLSFEGLETEKEHVAIVFNQADKTQKTPLVRMHSECLTG
CCEEEEEEEECCCCCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
DVFHSSRCDCGEQLEESINKMAISGGIILYLRQEGRGIGLYNKLDAYELQSKGMNTYEAN
CCCCCCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCEEECC
NHLGFGDDLRDFKEAAQMLGALNINTIKLVTNNPKKIKDIQDYGITLDEVVHTHAHVKKG
CCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHCCC
NENYLQSKVDHGHQLDLDK
CHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA