Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 209694923

GI number: 209694923

Start: 1513835

End: 1515616

Strand: Reverse

Name: moeA [H]

Synonym: VSAL_I1397

Alternate gene names: 209694923

Gene position: 1515616-1513835 (Counterclockwise)

Preceding gene: 209694924

Following gene: 209694919

Centisome position: 45.58

GC content: 41.19

Gene sequence:

>1782_bases
ATGAGCTTAACGACTGCGTCTATTCCATTATTGGGTTTTGTTGCTTATAGCGGTACAGGTAAAACCACCTTATTAGAAAA
GTTATTACCAAAACTGAATGAAATGGGACTAAAAGTCGCAGTCATCAAACATGCTCATCATAATTTTGATATTGACCAAG
AAGGCAAAGACAGCTACCGACTGCGTAAAGCAGGTGCAAGCCAAATGCTGATCAGTTCTCGCTTTCGTCATGCCTTAATT
ACTGAAACACCTGATGAAGAAACAAGCTGTCAGCAACTCATAAATAAACTAGATCAAACCCAACTTGATTTGATCTTAAT
CGAAGGTTTTAAACAACTTCCATACACTAAGATTGAATTGCATCGTGATGATGTCGGTAAGCCATGGATTTTTCCTGAAG
ACAACAACATCATTGCGATCGCGGCAGACTCTAAAGCAAAGTCTGAACTCCCTCAAATGAACATCAATGATACTGATGCT
ATTACTGCATTCATTGTTGAATATGTGAAACAGCATCAGCATAAACAACAAAGCGATTTATCAGCAAATTGTGATGAATT
ATCACCTGCGTTTTTATCTGTTAGTCAAGGTAGAGCTAAGATTCTAGAGGCCATCAAACCATTAGAATCAAACGAAAACG
TGTGTTTAATATCATCAATCAATGCATTAAGTGCACAAGATATCCTGTCACCAATTAACGTACCACAACATAACAATTCA
GCGATGGATGGTTATGTTATTTGTGGTGATGATTTAGAACGGAATAGCTATACTGTCGTTGCCGAGATAATGGCAGGACA
CAGTTACGATCATCCTCTTCAACATGGTGAAGCGGCAAAAATAATGACCGGCGCACCCGTTCCACAAAATGGCAATGCGG
TGATCATGCGCGAACAAGCAACCCAAGAAGGAAATCAAGTACGTTTTGATACTGGAAAGTCAGGTATTCGCAAAGGTCAA
AACGTTCGTCTTGCCGGTGAAGATCTCGCTATCAACCAAGTTTGTGTCGCAAAAGGCACTCGTATTACCGCACCAGAAGT
AGGTATGTTGGCCTCTCTTGGAATAGCCTCAGTTTCTGTTGTTACAAAAACTAAAGTCGCAATTTTCTCTACTGGTGATG
AAGTTCAAGCGCCAGGAGAAGCTCAAAAAGCGAACTCTATTTATGATTCAAACCGTTTCACACTTACAGCCCTATTACAA
AAACTAGGTTGTGAAGTGATTGATTTTGGTATTATTGAAGATAATGAAGCCGCTTTGGAGTCCACGCTTTCTCAAGCATC
GCAGCAAGCGGATATGATTTTATCCTCAGGCGGTGTCTCAGTAGGAGATGCCGACTACATTAAAACCATTTTAGATAAGC
TGGGTGACATTAATTTCTGGCGTATTAATATGCGTCCGGGGCGACCTCTTGCATTTGGTCACATTGGTGATACCCCTTTC
TTTGGTTTACCGGGTAACCCTGTTGCCGTAATGGTCGCGTTCTTACAGTTTGTGGAACCTGCATTGCGTAAACTACAAGG
TGAAGATAATTGGCAGCCAGAAACCTATACCGCCATTGCAAAAGAGTTCATTCGATCTCGCACAGGTCGTACAGAATACA
GCCGTGGTGTTTATTCTATTAACCAAAATGGTCAAATGGAAGTAGTGACAACTGGCAAACAAGGTTCGGGGATTTTACGC
TCTATGAGTGAAGCCAATTGCTTAATTGAAGTGCAGCCTGAAGTCGAATCTGTCAATATTGGTCAGAAGGTAACGGTTAT
ACCTCTGCTCTCGCGAATCTAA

Upstream 100 bases:

>100_bases
ATAAAGAGTGTAATACTGTTTTTGCTGATTTCTCAGATTACCCAAATGCCTTTATCAATTTGAATAGCCCTCAAGAACTT
GAACAATTTGGAACTTTATT

Downstream 100 bases:

>100_bases
TTGATGTACTTAAAGCGCAGCTAAGTGCAAATTATCATTAGTACAACGTCAAACTGATAGCATATTTTTGTTAATGCCGA
ATAGTCCTATTCGGTTTTTA

Product: bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSLTTASIPLLGFVAYSGTGKTTLLEKLLPKLNEMGLKVAVIKHAHHNFDIDQEGKDSYRLRKAGASQMLISSRFRHALI
TETPDEETSCQQLINKLDQTQLDLILIEGFKQLPYTKIELHRDDVGKPWIFPEDNNIIAIAADSKAKSELPQMNINDTDA
ITAFIVEYVKQHQHKQQSDLSANCDELSPAFLSVSQGRAKILEAIKPLESNENVCLISSINALSAQDILSPINVPQHNNS
AMDGYVICGDDLERNSYTVVAEIMAGHSYDHPLQHGEAAKIMTGAPVPQNGNAVIMREQATQEGNQVRFDTGKSGIRKGQ
NVRLAGEDLAINQVCVAKGTRITAPEVGMLASLGIASVSVVTKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQ
KLGCEVIDFGIIEDNEAALESTLSQASQQADMILSSGGVSVGDADYIKTILDKLGDINFWRINMRPGRPLAFGHIGDTPF
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETYTAIAKEFIRSRTGRTEYSRGVYSINQNGQMEVVTTGKQGSGILR
SMSEANCLIEVQPEVESVNIGQKVTVIPLLSRI

Sequences:

>Translated_593_residues
MSLTTASIPLLGFVAYSGTGKTTLLEKLLPKLNEMGLKVAVIKHAHHNFDIDQEGKDSYRLRKAGASQMLISSRFRHALI
TETPDEETSCQQLINKLDQTQLDLILIEGFKQLPYTKIELHRDDVGKPWIFPEDNNIIAIAADSKAKSELPQMNINDTDA
ITAFIVEYVKQHQHKQQSDLSANCDELSPAFLSVSQGRAKILEAIKPLESNENVCLISSINALSAQDILSPINVPQHNNS
AMDGYVICGDDLERNSYTVVAEIMAGHSYDHPLQHGEAAKIMTGAPVPQNGNAVIMREQATQEGNQVRFDTGKSGIRKGQ
NVRLAGEDLAINQVCVAKGTRITAPEVGMLASLGIASVSVVTKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQ
KLGCEVIDFGIIEDNEAALESTLSQASQQADMILSSGGVSVGDADYIKTILDKLGDINFWRINMRPGRPLAFGHIGDTPF
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETYTAIAKEFIRSRTGRTEYSRGVYSINQNGQMEVVTTGKQGSGILR
SMSEANCLIEVQPEVESVNIGQKVTVIPLLSRI
>Mature_592_residues
SLTTASIPLLGFVAYSGTGKTTLLEKLLPKLNEMGLKVAVIKHAHHNFDIDQEGKDSYRLRKAGASQMLISSRFRHALIT
ETPDEETSCQQLINKLDQTQLDLILIEGFKQLPYTKIELHRDDVGKPWIFPEDNNIIAIAADSKAKSELPQMNINDTDAI
TAFIVEYVKQHQHKQQSDLSANCDELSPAFLSVSQGRAKILEAIKPLESNENVCLISSINALSAQDILSPINVPQHNNSA
MDGYVICGDDLERNSYTVVAEIMAGHSYDHPLQHGEAAKIMTGAPVPQNGNAVIMREQATQEGNQVRFDTGKSGIRKGQN
VRLAGEDLAINQVCVAKGTRITAPEVGMLASLGIASVSVVTKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQK
LGCEVIDFGIIEDNEAALESTLSQASQQADMILSSGGVSVGDADYIKTILDKLGDINFWRINMRPGRPLAFGHIGDTPFF
GLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETYTAIAKEFIRSRTGRTEYSRGVYSINQNGQMEVVTTGKQGSGILRS
MSEANCLIEVQPEVESVNIGQKVTVIPLLSRI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=406, Percent_Identity=32.0197044334975, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI66932975, Length=406, Percent_Identity=32.0197044334975, Blast_Score=182, Evalue=8e-46,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=42.159383033419, Blast_Score=322, Evalue=3e-89,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=48.1927710843374, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=304, Percent_Identity=31.25, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=356, Percent_Identity=24.1573033707865, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136978, Length=352, Percent_Identity=31.8181818181818, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24638841, Length=352, Percent_Identity=31.8181818181818, Blast_Score=149, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 64649; Mature: 64518

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTTASIPLLGFVAYSGTGKTTLLEKLLPKLNEMGLKVAVIKHAHHNFDIDQEGKDSYR
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHH
LRKAGASQMLISSRFRHALITETPDEETSCQQLINKLDQTQLDLILIEGFKQLPYTKIEL
HHHCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCHHHEEEEEEECHHHCCCEEEEE
HRDDVGKPWIFPEDNNIIAIAADSKAKSELPQMNINDTDAITAFIVEYVKQHQHKQQSDL
ECCCCCCCCEEECCCCEEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SANCDELSPAFLSVSQGRAKILEAIKPLESNENVCLISSINALSAQDILSPINVPQHNNS
CCCCHHCCHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCC
AMDGYVICGDDLERNSYTVVAEIMAGHSYDHPLQHGEAAKIMTGAPVPQNGNAVIMREQA
CCCCEEEECCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCC
TQEGNQVRFDTGKSGIRKGQNVRLAGEDLAINQVCVAKGTRITAPEVGMLASLGIASVSV
CCCCCEEEEECCCHHHCCCCCEEEECCCCEECEEEECCCCEECCCCHHHHHHCCHHHEEE
VTKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQKLGCEVIDFGIIEDNEAALE
EEEEEEEEEECCCCCCCCCCHHHHCHHHCCCCEEHHHHHHHHCCCEEEECEECCCHHHHH
STLSQASQQADMILSSGGVSVGDADYIKTILDKLGDINFWRINMRPGRPLAFGHIGDTPF
HHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCC
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETYTAIAKEFIRSRTGRTEYSRGVYSI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCEEEE
NQNGQMEVVTTGKQGSGILRSMSEANCLIEVQPEVESVNIGQKVTVIPLLSRI
CCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCEECCCCEEEEEHHHHCC
>Mature Secondary Structure 
SLTTASIPLLGFVAYSGTGKTTLLEKLLPKLNEMGLKVAVIKHAHHNFDIDQEGKDSYR
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHH
LRKAGASQMLISSRFRHALITETPDEETSCQQLINKLDQTQLDLILIEGFKQLPYTKIEL
HHHCCHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCHHHEEEEEEECHHHCCCEEEEE
HRDDVGKPWIFPEDNNIIAIAADSKAKSELPQMNINDTDAITAFIVEYVKQHQHKQQSDL
ECCCCCCCCEEECCCCEEEEEECCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SANCDELSPAFLSVSQGRAKILEAIKPLESNENVCLISSINALSAQDILSPINVPQHNNS
CCCCHHCCHHHHHHHCCHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHCCCCCCCCCCC
AMDGYVICGDDLERNSYTVVAEIMAGHSYDHPLQHGEAAKIMTGAPVPQNGNAVIMREQA
CCCCEEEECCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCC
TQEGNQVRFDTGKSGIRKGQNVRLAGEDLAINQVCVAKGTRITAPEVGMLASLGIASVSV
CCCCCEEEEECCCHHHCCCCCEEEECCCCEECEEEECCCCEECCCCHHHHHHCCHHHEEE
VTKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQKLGCEVIDFGIIEDNEAALE
EEEEEEEEEECCCCCCCCCCHHHHCHHHCCCCEEHHHHHHHHCCCEEEECEECCCHHHHH
STLSQASQQADMILSSGGVSVGDADYIKTILDKLGDINFWRINMRPGRPLAFGHIGDTPF
HHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCC
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETYTAIAKEFIRSRTGRTEYSRGVYSI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCEEEE
NQNGQMEVVTTGKQGSGILRSMSEANCLIEVQPEVESVNIGQKVTVIPLLSRI
CCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCEECCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]