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The map label for this gene is metC [H]

Identifier: 209694884

GI number: 209694884

Start: 1473236

End: 1474426

Strand: Reverse

Name: metC [H]

Synonym: VSAL_I1355

Alternate gene names: 209694884

Gene position: 1474426-1473236 (Counterclockwise)

Preceding gene: 209694889

Following gene: 209694878

Centisome position: 44.34

GC content: 44.08

Gene sequence:

>1191_bases
ATGTCAGATAAATTAGATACTAAATATGTTACGGCGGGTCGCAGTAAAAAATGGACAAAAGGCGTGGTTAATCCCCCCGT
TCAACGTGCTTCTACGGTGGTTTTTAACTCTGTGGCAGAAAAGAATCACGCGATGGTGAATCGTGCCAAACAAACTCTTT
TTTATGGTCGTCGTGGTACAGAAACTCACTTTGCCTTGCAAGATGCGATGGTTGAGCTAGAGGGCGGCGCAGGGTGTGCC
TTATACCCTTGTGGGACCGCTGCAATAGCGAATGCGATTTTGTGTTTTGTAAAAACGGGCGATCACATTTTAATGGTTGA
TGGCTGCTACGAACCAACCCGTGATTACTGTGACACGATGTTAAAGAAAATGGGGATTGAAACCACCTATTACGATCCAA
TGATTGGCGAAGGCATTCGTGATCTAATCAAACCCAATACCACGGTGCTATTCACTGAATCCCCTTGTTCTATCACGATG
GAAGTGCAAGATGTTCCGCTTCTTGCTCGTATTGCGCATGAATCCGATATTGTGGTGATGCTTGATAATACATGGGCAGC
GGGTGTGAATTTCTCTCCTTTTGACCATGGTGTTGATATCTCGATTCAAGCGGCGACCAAATACATTGTTGGACATTCCG
ATGTGATGCTTGGTACGGCGGTTGCGAATGAAAAACATTGGGACCAACTGCGTGAACAAAGCTATTTAATGGGCCAATGC
ATCTCTCCTGATGATGCTTACCTTGCCATGCGCGGTTTACGCACCATGGGCGTTCGTCTGAAGCAACATGAGAAAAGCAG
CATTAAAATCGCCAATTGGTTGGCTGAGCATCCGCTTGTTGATCACGTTCGTCATCCTGCCCTTGAAAGCTGTCTGGGTA
ATGACATTTACCAACGTGACTTTACAGGCTGTAACGGCTTGTTCTCTTTTGTATTAAAGCAATCAGATACCAAAGCAACA
ACGGCACTGCTTGATAGCATGACGCATTTTAATATGGGTTATTCTTGGGGTGGATTTGAAAGCTTGATCTTAGCGAATGA
ACCAAAGAGCTTTAATGCATTAAGAACAGTGGCTCATCCTAACTTTGAAGGCACATTGATACGTCTTCATATTGGACTAG
AAGACATTGATGATTTGATTGAAGATTTAGAAGAAGGGTTAGCTCTCTACCAAGAAACCTTGTCAGCTTAA

Upstream 100 bases:

>100_bases
AATAAAAATTTATTCGATAAGAATTCGTTTTAATCCTTGATATTTCTCCTTCACTTTGGCTTTATGGAGGTATTGCCTAC
TTATAATTGAATGGATTCAG

Downstream 100 bases:

>100_bases
CTTCTACTGACTAGTAAGAAGTTAGCGTAACTCACACGCTTGTTTAGCGAAAATACAAAAAATGGCGACTCTTATTTGAG
TCGCCATTTTTATATGTCTC

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSDKLDTKYVTAGRSKKWTKGVVNPPVQRASTVVFNSVAEKNHAMVNRAKQTLFYGRRGTETHFALQDAMVELEGGAGCA
LYPCGTAAIANAILCFVKTGDHILMVDGCYEPTRDYCDTMLKKMGIETTYYDPMIGEGIRDLIKPNTTVLFTESPCSITM
EVQDVPLLARIAHESDIVVMLDNTWAAGVNFSPFDHGVDISIQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
ISPDDAYLAMRGLRTMGVRLKQHEKSSIKIANWLAEHPLVDHVRHPALESCLGNDIYQRDFTGCNGLFSFVLKQSDTKAT
TALLDSMTHFNMGYSWGGFESLILANEPKSFNALRTVAHPNFEGTLIRLHIGLEDIDDLIEDLEEGLALYQETLSA

Sequences:

>Translated_396_residues
MSDKLDTKYVTAGRSKKWTKGVVNPPVQRASTVVFNSVAEKNHAMVNRAKQTLFYGRRGTETHFALQDAMVELEGGAGCA
LYPCGTAAIANAILCFVKTGDHILMVDGCYEPTRDYCDTMLKKMGIETTYYDPMIGEGIRDLIKPNTTVLFTESPCSITM
EVQDVPLLARIAHESDIVVMLDNTWAAGVNFSPFDHGVDISIQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
ISPDDAYLAMRGLRTMGVRLKQHEKSSIKIANWLAEHPLVDHVRHPALESCLGNDIYQRDFTGCNGLFSFVLKQSDTKAT
TALLDSMTHFNMGYSWGGFESLILANEPKSFNALRTVAHPNFEGTLIRLHIGLEDIDDLIEDLEEGLALYQETLSA
>Mature_395_residues
SDKLDTKYVTAGRSKKWTKGVVNPPVQRASTVVFNSVAEKNHAMVNRAKQTLFYGRRGTETHFALQDAMVELEGGAGCAL
YPCGTAAIANAILCFVKTGDHILMVDGCYEPTRDYCDTMLKKMGIETTYYDPMIGEGIRDLIKPNTTVLFTESPCSITME
VQDVPLLARIAHESDIVVMLDNTWAAGVNFSPFDHGVDISIQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQCI
SPDDAYLAMRGLRTMGVRLKQHEKSSIKIANWLAEHPLVDHVRHPALESCLGNDIYQRDFTGCNGLFSFVLKQSDTKATT
ALLDSMTHFNMGYSWGGFESLILANEPKSFNALRTVAHPNFEGTLIRLHIGLEDIDDLIEDLEEGLALYQETLSA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=329, Percent_Identity=32.2188449848024, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI299473759, Length=329, Percent_Identity=29.1793313069909, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI25453487, Length=328, Percent_Identity=28.3536585365854, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=57.9081632653061, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=30.8673469387755, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71980708, Length=392, Percent_Identity=29.8469387755102, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=367, Percent_Identity=30.7901907356948, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=371, Percent_Identity=29.1105121293801, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321170, Length=335, Percent_Identity=42.9850746268657, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319307, Length=397, Percent_Identity=29.9748110831234, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6321904, Length=382, Percent_Identity=22.7748691099476, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=352, Percent_Identity=23.5795454545455, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321254, Length=408, Percent_Identity=23.7745098039216, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922554, Length=391, Percent_Identity=32.2250639386189, Blast_Score=193, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43897; Mature: 43765

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKLDTKYVTAGRSKKWTKGVVNPPVQRASTVVFNSVAEKNHAMVNRAKQTLFYGRRGT
CCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ETHFALQDAMVELEGGAGCALYPCGTAAIANAILCFVKTGDHILMVDGCYEPTRDYCDTM
CHHHHHHHHHEEECCCCCEEEECCCHHHHHHHHEEEEECCCEEEEEECCCCCHHHHHHHH
LKKMGIETTYYDPMIGEGIRDLIKPNTTVLFTESPCSITMEVQDVPLLARIAHESDIVVM
HHHHCCCCEECCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHCCCCCEEEE
LDNTWAAGVNFSPFDHGVDISIQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
EECCEECCCCCCCCCCCCCEEEEEHEEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHCCC
ISPDDAYLAMRGLRTMGVRLKQHEKSSIKIANWLAEHPLVDHVRHPALESCLGNDIYQRD
CCCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHCCCHHHHC
FTGCNGLFSFVLKQSDTKATTALLDSMTHFNMGYSWGGFESLILANEPKSFNALRTVAHP
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHCCC
NFEGTLIRLHIGLEDIDDLIEDLEEGLALYQETLSA
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDKLDTKYVTAGRSKKWTKGVVNPPVQRASTVVFNSVAEKNHAMVNRAKQTLFYGRRGT
CCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ETHFALQDAMVELEGGAGCALYPCGTAAIANAILCFVKTGDHILMVDGCYEPTRDYCDTM
CHHHHHHHHHEEECCCCCEEEECCCHHHHHHHHEEEEECCCEEEEEECCCCCHHHHHHHH
LKKMGIETTYYDPMIGEGIRDLIKPNTTVLFTESPCSITMEVQDVPLLARIAHESDIVVM
HHHHCCCCEECCCHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCHHHHHCCCCCEEEE
LDNTWAAGVNFSPFDHGVDISIQAATKYIVGHSDVMLGTAVANEKHWDQLREQSYLMGQC
EECCEECCCCCCCCCCCCCEEEEEHEEEEECCCCEEEEHHHCCHHHHHHHHHHHHHHCCC
ISPDDAYLAMRGLRTMGVRLKQHEKSSIKIANWLAEHPLVDHVRHPALESCLGNDIYQRD
CCCCHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHCCCHHHHC
FTGCNGLFSFVLKQSDTKATTALLDSMTHFNMGYSWGGFESLILANEPKSFNALRTVAHP
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHCCC
NFEGTLIRLHIGLEDIDDLIEDLEEGLALYQETLSA
CCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]