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The map label for this gene is pepD [H]

Identifier: 209694536

GI number: 209694536

Start: 1074320

End: 1075774

Strand: Reverse

Name: pepD [H]

Synonym: VSAL_I0973

Alternate gene names: 209694536

Gene position: 1075774-1074320 (Counterclockwise)

Preceding gene: 209694542

Following gene: 209694535

Centisome position: 32.35

GC content: 42.47

Gene sequence:

>1455_bases
GTGTCTGAGATCAGTCAACTAACACCACAACCTATTTGGCAATTTTTCGATAAAATTTGTTCTATCCCCCACCCATCTAA
ACATGAAGATGCATTAGCTCAATATATTATTGATTGGGCAACAAGCGAAGGTCTTGATGTTCGCCGCGATCCTACGGGTA
ATGTATTCATCAAAAAAGCGGCAACGCCGGGAATGGAAGATCGCAAGGGTGTTGTACTTCAAGCCCATATTGATATGGTT
CCACAAAAAAATGAAGATACTGACCATGATTTTACTAACGATCCAATCCTTCCATATATAGATGGCGAGTGGGTTACAGC
AAAAGGCACAACACTGGGTGCCGACAATGGTATGGGCATGGCTTCATGTCTTGCTGTTTTAGCCTCAAAAGAATTGAAGC
ATGGCCCATTAGAAGTATTATTAACCATTGATGAAGAAGCAGGCATGACTGGTGCCTTTGGTCTAGAAGCCGGTTGGTTA
GAAGGTGATATTCTTCTTAATACCGATTCAGAACAAGAAGGGGAAATCTACATGGGTTGTGCTGGTGGTGCTGATGGTGC
TATCAAATTAATGATCGAACGTGAAGCACTGCCTGCTGGCTATGTTACTCGTCAAATCACACTAAAAGGCCTAAAAGGCG
GCCATTCTGGTTGTGACATTCATACTGGTCGTGGTAACGCGAACAAATTACTGGGTCGATTCCTTGCTGGCCACGCTGTT
GAACTGGATTTACGCCTTGTTGAATTCCGTGGTGGTAGCTTACGTAATGCTATTCCTCGTGAAGCATTCGCAACGGTTGC
CGTTCCTGCTGAGAATGAAGCAAAACTGGCTGAGCTATTTACTTTTTATACCGATCTATTGAAAGACGAATTAGGTCGAG
TAGAAACGAATATTGTAAGCATCAACGAGACAGCCTCTGCTGAAAATGTCTTGACACTAGCCACTCAAACTCCGTTCATT
GCGACACTAAATGCCTGTCCAAATGGTGTTATCCGCATGAGTGATGATATTGAGGGTGTGGTAGAAACGTCTTTAAATGT
GGGCGTTATTACTACTGAAGAAAGCACAATCACAATTCTATGCCTAATCCGTTCATTAATGGATTCTGGCCGTAGCATGG
TTGAAGGAATGCTTTCATCTGTGGCTGAATTAGCAGGAGCACAAGTCAGCTTCTCTGGTACATATCCAGGTTGGAAGCCA
GACGCAGATTCTGAAATCATGCATGTGTTCCGTGATGTCTACGAAGGCATTTACGGAAATAAGCCAAACATCATGGTAAT
TCATGCAGGTTTAGAGTGTGGTCTATTTAAAGAACCTTATCCTAAAATGGACATGATCTCATTTGGTCCAACCATCAAAT
TCCCTCATTCTCCAGATGAGAAAGTGAAAATTGATACGGTTGCTCTTTACTGGGAACAAATGGTTGCCATTTTAGAGAAC
ATTCCAAAAAAATAA

Upstream 100 bases:

>100_bases
ATTAGCTAATTTGAGGGGTATACTTATTTGTATTGGTAATCAATTACCCAAAAAGACAGCGCATTAATTTGCTATTTACT
GTTTTCAAAAGGAGATACTT

Downstream 100 bases:

>100_bases
TCCTTTAATATTAGGATTATAAAAAACGGTCAGCTTATGCTGACCGTTTTTATTTATAGTCAAATGACGTCAATCATTAA
AAATAAACTTTTGGGTTAGT

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSEISQLTPQPIWQFFDKICSIPHPSKHEDALAQYIIDWATSEGLDVRRDPTGNVFIKKAATPGMEDRKGVVLQAHIDMV
PQKNEDTDHDFTNDPILPYIDGEWVTAKGTTLGADNGMGMASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWL
EGDILLNTDSEQEGEIYMGCAGGADGAIKLMIEREALPAGYVTRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAV
ELDLRLVEFRGGSLRNAIPREAFATVAVPAENEAKLAELFTFYTDLLKDELGRVETNIVSINETASAENVLTLATQTPFI
ATLNACPNGVIRMSDDIEGVVETSLNVGVITTEESTITILCLIRSLMDSGRSMVEGMLSSVAELAGAQVSFSGTYPGWKP
DADSEIMHVFRDVYEGIYGNKPNIMVIHAGLECGLFKEPYPKMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
IPKK

Sequences:

>Translated_484_residues
MSEISQLTPQPIWQFFDKICSIPHPSKHEDALAQYIIDWATSEGLDVRRDPTGNVFIKKAATPGMEDRKGVVLQAHIDMV
PQKNEDTDHDFTNDPILPYIDGEWVTAKGTTLGADNGMGMASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWL
EGDILLNTDSEQEGEIYMGCAGGADGAIKLMIEREALPAGYVTRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAV
ELDLRLVEFRGGSLRNAIPREAFATVAVPAENEAKLAELFTFYTDLLKDELGRVETNIVSINETASAENVLTLATQTPFI
ATLNACPNGVIRMSDDIEGVVETSLNVGVITTEESTITILCLIRSLMDSGRSMVEGMLSSVAELAGAQVSFSGTYPGWKP
DADSEIMHVFRDVYEGIYGNKPNIMVIHAGLECGLFKEPYPKMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
IPKK
>Mature_483_residues
SEISQLTPQPIWQFFDKICSIPHPSKHEDALAQYIIDWATSEGLDVRRDPTGNVFIKKAATPGMEDRKGVVLQAHIDMVP
QKNEDTDHDFTNDPILPYIDGEWVTAKGTTLGADNGMGMASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWLE
GDILLNTDSEQEGEIYMGCAGGADGAIKLMIEREALPAGYVTRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAVE
LDLRLVEFRGGSLRNAIPREAFATVAVPAENEAKLAELFTFYTDLLKDELGRVETNIVSINETASAENVLTLATQTPFIA
TLNACPNGVIRMSDDIEGVVETSLNVGVITTEESTITILCLIRSLMDSGRSMVEGMLSSVAELAGAQVSFSGTYPGWKPD
ADSEIMHVFRDVYEGIYGNKPNIMVIHAGLECGLFKEPYPKMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILENI
PKK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=61.8556701030928, Blast_Score=632, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52604; Mature: 52472

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEISQLTPQPIWQFFDKICSIPHPSKHEDALAQYIIDWATSEGLDVRRDPTGNVFIKKA
CCCHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
ATPGMEDRKGVVLQAHIDMVPQKNEDTDHDFTNDPILPYIDGEWVTAKGTTLGADNGMGM
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEEECCCEECCCCCCCH
ASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWLEGDILLNTDSEQEGEIYMGC
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCEECCCCCCCCCCCEEEECCCCCCCCEEEEE
AGGADGAIKLMIEREALPAGYVTRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAV
CCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHCCCEE
ELDLRLVEFRGGSLRNAIPREAFATVAVPAENEAKLAELFTFYTDLLKDELGRVETNIVS
EEEEEEEEECCCCHHCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEE
INETASAENVLTLATQTPFIATLNACPNGVIRMSDDIEGVVETSLNVGVITTEESTITIL
ECCCCCCCCEEEEEECCCEEEEECCCCCCEEEECCCCCHHHHCCCCEEEEEECCCCCHHH
CLIRSLMDSGRSMVEGMLSSVAELAGAQVSFSGTYPGWKPDADSEIMHVFRDVYEGIYGN
HHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
KPNIMVIHAGLECGLFKEPYPKMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
CCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
IPKK
CCCC
>Mature Secondary Structure 
SEISQLTPQPIWQFFDKICSIPHPSKHEDALAQYIIDWATSEGLDVRRDPTGNVFIKKA
CCHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEC
ATPGMEDRKGVVLQAHIDMVPQKNEDTDHDFTNDPILPYIDGEWVTAKGTTLGADNGMGM
CCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEECCCEEEECCCEECCCCCCCH
ASCLAVLASKELKHGPLEVLLTIDEEAGMTGAFGLEAGWLEGDILLNTDSEQEGEIYMGC
HHHHHHHHHHHCCCCCEEEEEEECCCCCCCEECCCCCCCCCCCEEEECCCCCCCCEEEEE
AGGADGAIKLMIEREALPAGYVTRQITLKGLKGGHSGCDIHTGRGNANKLLGRFLAGHAV
CCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHCCCEE
ELDLRLVEFRGGSLRNAIPREAFATVAVPAENEAKLAELFTFYTDLLKDELGRVETNIVS
EEEEEEEEECCCCHHCCCCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEE
INETASAENVLTLATQTPFIATLNACPNGVIRMSDDIEGVVETSLNVGVITTEESTITIL
ECCCCCCCCEEEEEECCCEEEEECCCCCCEEEECCCCCHHHHCCCCEEEEEECCCCCHHH
CLIRSLMDSGRSMVEGMLSSVAELAGAQVSFSGTYPGWKPDADSEIMHVFRDVYEGIYGN
HHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
KPNIMVIHAGLECGLFKEPYPKMDMISFGPTIKFPHSPDEKVKIDTVALYWEQMVAILEN
CCCEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCCEEEHHHHHHHHHHHHHHHH
IPKK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]