Click here to switch to the map view.

The map label for this gene is sucD [H]

Identifier: 209694428

GI number: 209694428

Start: 945990

End: 946862

Strand: Direct

Name: sucD [H]

Synonym: VSAL_I0849

Alternate gene names: 209694428

Gene position: 945990-946862 (Clockwise)

Preceding gene: 209694427

Following gene: 209694431

Centisome position: 28.45

GC content: 42.38

Gene sequence:

>873_bases
ATGTCTGTACTAATTAATAAAGATACAAAAGTTATCTGCCAAGGTTTCACTGGTGGCCAAGGAACATTCCACTCAGAGCA
AGCAATTGATTACGGAACAAAAATGGTTGGTGGCGTATCACCAGGCAAAGGCGGTCAAGTTCATTTAGGTCTTCCTGTAT
TTAACACCGTTCGTGATGCAGTTGAAGCAACTGGCGCAACCGCTTCTGTTATTTATGTACCTGCACCTTTCTGTAAAGAT
GCGATTCTTGAAGCAATCGATGCGGGCATCAAATTAATCATAACGATTACAGAAGGTATTCCTACGCTTGATCTTCTTGA
CGTTAAAGTTCGTCTAGATGCTGAAGGTGTTGTGATGATCGGTCCTAACTGTCCGGGTGTAATTACTCCTGATGAATGTA
AGATTGGTATTATGCCAGGTCACATTCATAAAAAAGGTAAAGTAGGTATTGTCTCTCGTTCAGGTACATTGACTTATGAA
GCCGTAAAGCAAACAACGGATGAAGGTTTCGGCCAATCAACGTGCGTTGGTATCGGTGGTGATCCAATTCCTGGTTCAAA
CTTTATTGATATCTTAAAGTTATTCCAAGAAGATCCAGAGACTGAAGCAATTGTTATGATTGGTGAAATCGGTGGTACTG
CGGAAGAAGAAGCTGCTGAGTTTATTAAACACAATGTAACTAAGCCTGTTGTTTCTTACATTGCGGGTGTTACCGCGCCT
CCTGGTAAGCGTATGGGGCATGCTGGTGCAATCATCTCTGGTGGTAAAGGTACTGCTGAAGATAAGTTTGCAGCACTTGA
AGCCGCAGGCGTTAAAACAGTTAAGAGCCTTGCTGATATCGGTAAAGGATTGCGTGAAATCACTGGTTGGTAA

Upstream 100 bases:

>100_bases
TAGGGTCACAAAAACTGGCTGAAAGTGGCCTAAATATCATTGCGGCTACTTCATTAACTGAAGCAGCTGAAAAAGTTGTT
GCTGCTGCGGAGGGCAAATA

Downstream 100 bases:

>100_bases
TCAACTGCTGATATTCCCGTAAAAATAAACCCCGAGTTCTTGTGAGCTCGGGGTTTTTATTTACAGGTATTATCTAAAGC
TTATTATTATATTAAGACTG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSVLINKDTKVICQGFTGGQGTFHSEQAIDYGTKMVGGVSPGKGGQVHLGLPVFNTVRDAVEATGATASVIYVPAPFCKD
AILEAIDAGIKLIITITEGIPTLDLLDVKVRLDAEGVVMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKHNVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW

Sequences:

>Translated_290_residues
MSVLINKDTKVICQGFTGGQGTFHSEQAIDYGTKMVGGVSPGKGGQVHLGLPVFNTVRDAVEATGATASVIYVPAPFCKD
AILEAIDAGIKLIITITEGIPTLDLLDVKVRLDAEGVVMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKHNVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW
>Mature_289_residues
SVLINKDTKVICQGFTGGQGTFHSEQAIDYGTKMVGGVSPGKGGQVHLGLPVFNTVRDAVEATGATASVIYVPAPFCKDA
ILEAIDAGIKLIITITEGIPTLDLLDVKVRLDAEGVVMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEA
VKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKHNVTKPVVSYIAGVTAPP
GKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=67.2535211267606, Blast_Score=326, Evalue=1e-89,
Organism=Homo sapiens, GI38569423, Length=260, Percent_Identity=33.0769230769231, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI38569421, Length=260, Percent_Identity=33.0769230769231, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786949, Length=287, Percent_Identity=85.3658536585366, Blast_Score=493, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=64.2361111111111, Blast_Score=343, Evalue=7e-95,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=62.0689655172414, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17557344, Length=259, Percent_Identity=31.6602316602317, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=260, Percent_Identity=33.0769230769231, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=53.0821917808219, Blast_Score=284, Evalue=9e-78,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=59.6551724137931, Blast_Score=338, Evalue=2e-93,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=61.8055555555556, Blast_Score=323, Evalue=9e-89,
Organism=Drosophila melanogaster, GI281363477, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363475, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281363473, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30010; Mature: 29879

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKDTKVICQGFTGGQGTFHSEQAIDYGTKMVGGVSPGKGGQVHLGLPVFNTVRDA
CEEEEECCCEEEEECCCCCCCCCCCHHHHHHCHHHHCCCCCCCCCEEEECCCHHHHHHHH
VEATGATASVIYVPAPFCKDAILEAIDAGIKLIITITEGIPTLDLLDVKVRLDAEGVVMI
HHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEEEEEECCCCEEEE
GPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKHNVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVLINKDTKVICQGFTGGQGTFHSEQAIDYGTKMVGGVSPGKGGQVHLGLPVFNTVRDA
EEEEECCCEEEEECCCCCCCCCCCHHHHHHCHHHHCCCCCCCCCEEEECCCHHHHHHHH
VEATGATASVIYVPAPFCKDAILEAIDAGIKLIITITEGIPTLDLLDVKVRLDAEGVVMI
HHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEEEEEECCCCEEEE
GPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAEFIKHNVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEDKFAALEAAGVKTVKSLADIGKGLREITGW
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]