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The map label for this gene is sdhB [H]

Identifier: 209694424

GI number: 209694424

Start: 939789

End: 940502

Strand: Direct

Name: sdhB [H]

Synonym: VSAL_I0845

Alternate gene names: 209694424

Gene position: 939789-940502 (Clockwise)

Preceding gene: 209694423

Following gene: 209694425

Centisome position: 28.26

GC content: 40.2

Gene sequence:

>714_bases
ATGAAATTAAATTTTTCAATCTATCGTTATAATCCGGATGTAGATAATGCTCCTCACATGAAGGCGTATACGTTAGAAGT
GGAAGAAGGCTCTGACATGATGGTGCTAGATGCACTTATCTTATTAAAAGAGCAAGATCCTACAATCTCATTCCGTCGCT
CATGCCGAGAAGGGGTATGTGGTTCTGATGGTTTAAATATGAATGGTAAAAATGGGCTGGCTTGTATCACACCGTTATCA
GAGTTAATTGGTAAAGGTGATCTTGTTATTCGTCCATTACCAGGCTTACCTGTCGTTCGAGATTTAATTGTCGATATGGC
GCAGTTCTATGAAAATTATGAGAAAGTGAAACCTTTCCTAATCAGTGATGGTGCTACACCGCCTTCAAGAGAAAACCTAC
AGTCTCCTGAAGAACGTGAACACTTAGATGGGTTGTATGAATGTATTATGTGCGCATGTTGTACGACATCATGCCCATCA
TTCTGGTGGAACCCTGATAAGTTCATTGGACCTGCTGGGCTTCTTGCTGCTTACCGTTGGTTAATTGATAGTCGTGATAC
CGCAACAAACGAACGTTTGTCTAATTTAGACGATGCATTCAGTGTTTTTCGTTGCCATGGCATAATGAATTGTGTAAGTG
TATGTCCTAAAGGGTTAAATCCGACAAAAGCGATTGGTCATATTAAGACCATGCTATTGAAGAAAGCGGTATAA

Upstream 100 bases:

>100_bases
CTGAGACAGAATCGATGACTAAGCGTGGTGTGAACATGGAGCCTATCCATCGTGAAGCATTTCCACCTAAAGCACGTACG
TATTAAGAGAGGGCAGAAAG

Downstream 100 bases:

>100_bases
CCATACTGCCTCAACTTACTCATTGGTTTTATGAATCTTATTAAGCGGTGAGTAAGTTGAAGTTTATAAGCCCGGTACAA
AAGACCGGGATAGACGTGAA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKLNFSIYRYNPDVDNAPHMKAYTLEVEEGSDMMVLDALILLKEQDPTISFRRSCREGVCGSDGLNMNGKNGLACITPLS
ELIGKGDLVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFLISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPS
FWWNPDKFIGPAGLLAAYRWLIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV

Sequences:

>Translated_237_residues
MKLNFSIYRYNPDVDNAPHMKAYTLEVEEGSDMMVLDALILLKEQDPTISFRRSCREGVCGSDGLNMNGKNGLACITPLS
ELIGKGDLVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFLISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPS
FWWNPDKFIGPAGLLAAYRWLIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV
>Mature_237_residues
MKLNFSIYRYNPDVDNAPHMKAYTLEVEEGSDMMVLDALILLKEQDPTISFRRSCREGVCGSDGLNMNGKNGLACITPLS
ELIGKGDLVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFLISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPS
FWWNPDKFIGPAGLLAAYRWLIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=53.448275862069, Blast_Score=259, Evalue=2e-69,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=77.5423728813559, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=37.5545851528384, Blast_Score=157, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=50.8620689655172, Blast_Score=246, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=51.0822510822511, Blast_Score=251, Evalue=9e-68,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=53.6480686695279, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=50.6437768240343, Blast_Score=242, Evalue=1e-64,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26412; Mature: 26412

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNFSIYRYNPDVDNAPHMKAYTLEVEEGSDMMVLDALILLKEQDPTISFRRSCREGVC
CCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
GSDGLNMNGKNGLACITPLSELIGKGDLVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFL
CCCCCCCCCCCCEEHHCCHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEE
ISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRW
EECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHH
LIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLNFSIYRYNPDVDNAPHMKAYTLEVEEGSDMMVLDALILLKEQDPTISFRRSCREGVC
CCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCC
GSDGLNMNGKNGLACITPLSELIGKGDLVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFL
CCCCCCCCCCCCEEHHCCHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEE
ISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRW
EECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHH
LIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]