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The map label for this gene is sdhA [H]

Identifier: 209694423

GI number: 209694423

Start: 938005

End: 939774

Strand: Direct

Name: sdhA [H]

Synonym: VSAL_I0844

Alternate gene names: 209694423

Gene position: 938005-939774 (Clockwise)

Preceding gene: 209694422

Following gene: 209694424

Centisome position: 28.21

GC content: 44.97

Gene sequence:

>1770_bases
GTAGTGAGTATTGCTGTTAGAGAATTTGACGCTGTTGTAATCGGCGCTGGTGGTGCAGGAATGCGAGCTGCACTACAAAT
TTCAGAACAAGGCTTATCATGTGCTTTGTTATCAAAAGTGTTTCCAACTCGTTCTCATACTGTATCTGCTCAAGGTGGTA
TTACCGTTGCTCTCGGTAATGCGCATGAAGATCACTGGGAACAACATATGTACGATACCGTAAAAGGTTCCGATTATATT
GGTGACCAAGATGCAATCGAATACATGTGTAAGAATGGCCCTGAATCAGTTATCGAATTAGAGAAGATGGGATTGCCTTT
TTCTCGTTTTGATGACGGTACGATTTATCAGCGACCATTCGGTGGTCAATCTAAAAACTTCGGTGGTGAGCAAGCGGCAC
GTACTGCGGCGGCAGCTGACCGTACTGGGCACGCTTTGCTTCATACGTTATACCAACAAAATATTAAGCACAAAACGACC
ATTTTTTCTGAGTGGTACGCGCTTGACCTTGTTAAAAATGAAGACGGTGCCATTTTAGGCTGTACCGCGCTTTGCATGGA
AACAGGGGAGATTTGTTACTTTAAATCGAAAGCAACCATCCTTGCTACAGGTGGCGCTGGTCGTATTTATGCGTCAACAA
CGAATGCACACATTAATACCGGTGATGGTGTTGGTATGGCGATTCGTGCTGGCGTTCCAATGCAAGATATCGAAATGTGG
CAATTCCATCCGACGGGCATTGCCGGTGCGGGTGTTCTTGTTACTGAAGGTTGTCGTGGTGAAGGTGGTTATCTTCTAAA
TAAAGACGGTGAGCGCTTCATGGAGCGTTATGCTCCAAACGCGAAAGATCTTGCTGGTCGTGATGTTGTTGCTCGTTCAA
TGATGGTTGAAATTCGCGAAGGTCGTGGTTGTGATGGTCCTTGGGGTCCTCACCTTAAACTGAAGTTGGATCATTTAGGC
AAAGAAACGCTTGAATCTCGCCTACCTGGTGTGTGTGAGCTATCTCGTACCTTTGCTCATGTTGATCCAGTAAAAGAACC
AATCCCAGTGATTCCTACTTGTCATTACATGATGGGTGGCGTACCAACACAAGTGTCTGGTCAAGCAATTAAGCAAGACC
CAACGGGCGCAGATGTAGAAATTCAAGGTCTATTTGCTTGTGGTGAAATTGCGTCGGTATCGGTCCATGGTGCAAACCGC
CTAGGTGGTAATTCACTGCTTGATTTAGTCGTGTTTGGTCGTGCAACCGGTCTTCATTTAGGTGAAACACTGAAGAAACA
AGCAGAAGCTAAGCCGGCTACTGAAGCGGATATTGAAGCGTCTCTTGATCGTTACAATCGTTGGGAGAACAGTACGGGTG
GTGAAGACCCAGTTCAAATCCGCAAAGACTTACAACAATGTATGCAAAATAACTTCTCGGTATTCCGTGAAGGCGATGCA
ATGGCTAAAGGTCTTGAAGAGCTTAAAGCGATTCGTGAGCGTTTGAAAAATGCTTATCTTGCCGATAAATCAACAGAATT
TAACACTCAACGTATCGAATGTTTAGAGTTAGAAAACTTGATGGAAACGGCATTTGCGACGGCAGTTGCAGCAAACTATC
GTACAGAAAGTCGTGGAGCACATGCTCGTTTTGACTTCCCTGATCGTGATGATGTGAATTGGTTATGTCATTCAGTGTAT
AACCCTGAGACAGAATCGATGACTAAGCGTGGTGTGAACATGGAGCCTATCCATCGTGAAGCATTTCCACCTAAAGCACG
TACGTATTAA

Upstream 100 bases:

>100_bases
ATTATATTAAACCAGTATTGTTGCGTGCTCTGCTTCAACTAGGTTTGGTTGCTGTTTTGCTTGGGTATTTCTTCTCTGGT
TTAATTATTGTGTGGGGTGT

Downstream 100 bases:

>100_bases
GAGAGGGCAGAAAGATGAAATTAAATTTTTCAATCTATCGTTATAATCCGGATGTAGATAATGCTCCTCACATGAAGGCG
TATACGTTAGAAGTGGAAGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MVSIAVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDYI
GDQDAIEYMCKNGPESVIELEKMGLPFSRFDDGTIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTT
IFSEWYALDLVKNEDGAILGCTALCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMW
QFHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREGRGCDGPWGPHLKLKLDHLG
KETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQDPTGADVEIQGLFACGEIASVSVHGANR
LGGNSLLDLVVFGRATGLHLGETLKKQAEAKPATEADIEASLDRYNRWENSTGGEDPVQIRKDLQQCMQNNFSVFREGDA
MAKGLEELKAIRERLKNAYLADKSTEFNTQRIECLELENLMETAFATAVAANYRTESRGAHARFDFPDRDDVNWLCHSVY
NPETESMTKRGVNMEPIHREAFPPKARTY

Sequences:

>Translated_589_residues
VVSIAVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDYI
GDQDAIEYMCKNGPESVIELEKMGLPFSRFDDGTIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTT
IFSEWYALDLVKNEDGAILGCTALCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMW
QFHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREGRGCDGPWGPHLKLKLDHLG
KETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQDPTGADVEIQGLFACGEIASVSVHGANR
LGGNSLLDLVVFGRATGLHLGETLKKQAEAKPATEADIEASLDRYNRWENSTGGEDPVQIRKDLQQCMQNNFSVFREGDA
MAKGLEELKAIRERLKNAYLADKSTEFNTQRIECLELENLMETAFATAVAANYRTESRGAHARFDFPDRDDVNWLCHSVY
NPETESMTKRGVNMEPIHREAFPPKARTY
>Mature_589_residues
VVSIAVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDYI
GDQDAIEYMCKNGPESVIELEKMGLPFSRFDDGTIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTT
IFSEWYALDLVKNEDGAILGCTALCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMW
QFHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIREGRGCDGPWGPHLKLKLDHLG
KETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGGVPTQVSGQAIKQDPTGADVEIQGLFACGEIASVSVHGANR
LGGNSLLDLVVFGRATGLHLGETLKKQAEAKPATEADIEASLDRYNRWENSTGGEDPVQIRKDLQQCMQNNFSVFREGDA
MAKGLEELKAIRERLKNAYLADKSTEFNTQRIECLELENLMETAFATAVAANYRTESRGAHARFDFPDRDDVNWLCHSVY
NPETESMTKRGVNMEPIHREAFPPKARTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=545, Percent_Identity=54.4954128440367, Blast_Score=552, Evalue=1e-157,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=82.9931972789116, Blast_Score=982, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=573, Percent_Identity=39.9650959860384, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=29.0322580645161, Blast_Score=209, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=588, Percent_Identity=49.8299319727891, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17505833, Length=590, Percent_Identity=49.6610169491525, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=54.6931407942238, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6322701, Length=558, Percent_Identity=53.9426523297491, Blast_Score=582, Evalue=1e-167,
Organism=Drosophila melanogaster, GI17137288, Length=544, Percent_Identity=54.5955882352941, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655642, Length=544, Percent_Identity=54.5955882352941, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655647, Length=544, Percent_Identity=54.5955882352941, Blast_Score=563, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24663005, Length=552, Percent_Identity=48.3695652173913, Blast_Score=518, Evalue=1e-147,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64283; Mature: 64283

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
VVSIAVREFDAVVIGAGGAGMRAALQISEQGLSCALLSKVFPTRSHTVSAQGGITVALGN
CEEEEEEEEEEEEEECCCCCCEEEEEEHHCCCHHHHHHHHCCCCCCEEECCCCEEEEECC
AHEDHWEQHMYDTVKGSDYIGDQDAIEYMCKNGPESVIELEKMGLPFSRFDDGTIYQRPF
CCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCEEECCC
GGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNIKHKTTIFSEWYALDLVKNEDGAILG
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHCEEEEEEEECCCCCEEE
CTALCMETGEICYFKSKATILATGGAGRIYASTTNAHINTGDGVGMAIRAGVPMQDIEMW
HHHHHHCCCCEEEEECCEEEEEECCCCEEEEECCCCEEECCCCCCEEEECCCCHHHCCEE
QFHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLAGRDVVARSMMVEIRE
EECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHC
GRGCDGPWGPHLKLKLDHLGKETLESRLPGVCELSRTFAHVDPVKEPIPVIPTCHYMMGG
CCCCCCCCCCCEEEEHHHCCHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
VPTQVSGQAIKQDPTGADVEIQGLFACGEIASVSVHGANRLGGNSLLDLVVFGRATGLHL
CCCCCCCCHHCCCCCCCCEEEEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCHH
GETLKKQAEAKPATEADIEASLDRYNRWENSTGGEDPVQIRKDLQQCMQNNFSVFREGDA
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHH
MAKGLEELKAIRERLKNAYLADKSTEFNTQRIECLELENLMETAFATAVAANYRTESRGA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
HARFDFPDRDDVNWLCHSVYNPETESMTKRGVNMEPIHREAFPPKARTY
EEECCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]