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The map label for this gene is lon [H]

Identifier: 209694400

GI number: 209694400

Start: 912000

End: 914363

Strand: Direct

Name: lon [H]

Synonym: VSAL_I0821

Alternate gene names: 209694400

Gene position: 912000-914363 (Clockwise)

Preceding gene: 209694399

Following gene: 209694401

Centisome position: 27.43

GC content: 39.72

Gene sequence:

>2364_bases
ATGAACCTGGAGCGTTCCGAGCGCATTGAGATACCAGTTCTGCCATTACGAGATGTAGTGGTGTATCCGCATATGGTTAT
TCCACTATTTGTGGGCCGTGAAAAATCCATCCGTTGCTTAGAAGCTGCAATGGAGCAGAACAAACAAGTCTTGCTTGTGG
CACAAAAAGAAGCCGCTAAAGAAGAGCCGCAACTAGATGACCTGCACAGTGTTGGTACTATCGCGACTATTTTGCAACTA
TTGAAGTTGCCTGATGGTACTGTAAAGGTATTAGTTGAAGGTCAGCAGCGTGCAAAAATACATCAATTTTTAGAAGCAGA
TTTTTTTACTGCGGATGCCGAATTTTTAGTTACCCCTGAAATTGATGATGCTGAACAAGAAGTGATTATGCGTTCTGCAA
TTAATCAATTCGATGGTTTTATCAAACTGAATAAAAAGATCCCACCAGAAGTTCTGACTTCTTTGAGTGGTATTGAAGAT
GCCGCGCGTTTAGCCGATACCATTGCTGCTCATATGCCACTAAAGCTTGCTGATAAGCAAGAAGTGTTAGAGTTGATTGA
TGTGATCGCTCGTTTAGAGTTTTTGATGGGCATGATGGAGTCTGAAATAGACCTTCTGCAAATTGAAAAACGCATTCGTG
GCCGCGTTAAAAAACAAATGGAAAAGAGTCAGCGTGAGTACTATTTGAATGAGCAAATGAAAGCCATTCAAAAAGAACTG
GGCGACTTAGATGACGCTCCTGATGAATTTGAAGCTCTGCAAAAGAAAATTGCAGACGCTAAAATGCCAAAAGAAGCGCA
AGAAAAAGCGGAACAAGAATTACAGAAGCTAAAGATGATGTCTCCGATGTCAGCAGAAGCAACCGTGGTTCGTAGTTACA
TTGACTGTATGGTTGGTGTGCCTTGGTTTAAGCGCTCTAAAGTCAAAAAAGACTTAGCTAAAGCAGAAGATATCCTAAAC
GCTGACCACTATGGCTTAGAACGTGTTAAAGAACGTATTCTTGAGTATTTAGCGGTTCAAAGTCGAGTGACTAAACTTAA
AGGTCCGATTCTTTGTTTAGTTGGACCTCCTGGTGTTGGTAAAACATCATTAGGGCAATCTATTGCGAGAGCGACAGGGC
GTAAATATACACGAATGGCACTTGGTGGCGTTCGTGACGAAGCTGAGATTCGTGGTCATAGACGCACGTATATTGGTTCT
TTACCTGGTAAATTAATTCAAAAAATGTCAAAAGTTGAGGTTAAAAACCCACTTTTCTTATTAGATGAAATTGATAAAAT
GTCTTCTGATATGCGCGGTGATCCAGCCTCTGCACTTCTTGAGGTGTTGGATCCAGAGCAAAACAGCACATTTAGTGATC
ATTATTTAGAAGTTGATTACGATTTATCTGATGTCATGTTTGTTGCAACATCGAATTCTATGAATATTCCAGGTCCATTG
CTTGACCGTATGGAAGTGATTCGTTTATCTGGGTATACCGAAGACGAAAAGCTAAACATAGCTAAAAATCATTTATTGAT
GAAGCAAGTAAAGCGCAATGGTCTTAAAGAAGATGAAATTCAAATCGATGATTCAGCCATTATGGGAATTATCCGTTATT
ACACTAGAGAAGCTGGTGTACGTAGCTTAGAGAGAGAAATCTCTAAATTATGTCGTAAAGCAGTGAAGCAAATCTTACTT
GATAAATCGATTAAAAAAGTAACGATTAATCAAGATAATCTAAAAGATTTCTTAGGTGTTCAACGTTGTGATTACGGTAA
AGCAGACACTGAAAATCGAGTGGGTCAGGTTGTTGGTTTAGCATGGACTGAAGTCGGTGGTGATCTATTGACGATTGAAG
CGGAATCTATGATTGGTAAAGGCAAACTTGCTTATACTGGTTCTCTTGGTGACGTTATGAAAGAGTCAATTCAAGCGGCA
ATGACGGTGGTTCGTACTCGAGCTGAAAAATTAGGTATTAATCCTGATTTTTATGAGAAACGTGATATTCATGTTCACGT
ACCAGAAGGCGCTACACCAAAAGATGGTCCAAGTGCTGGTGTTGGTATGTGTACTGCACTTGTATCAAGCTTAACGGGTA
ATCCGGTTCGTTCTGATGTTGCAATGACAGGTGAAATTACATTACGTGGTGAAGTACTGCCAATTGGTGGTTTAAAAGAA
AAATTATTAGCTGCTCACCGTGGTGGTATTAAAACTGTCATTATTCCAAAAGATAATGAACGTGACTTAGAAGAAATCCC
AGCAAACGTAATTGCTGATCTTTCGGTTCATCCTGTGAAGTGGATTGACGAGGTATTAACACTTGCTTTACAAAATGATC
CTCAAGGCTTTAGTCTTGAATCGTCTCAAAAAAGTGATGTGTAG

Upstream 100 bases:

>100_bases
CATTGGCCTCCTTTTTTATTTTTTAATTTAAAATAATGTTGAATCTTAGCTACTTGCCCCCATATTATTTCTATAGATAC
TGACGGAGAGAGAGAAGAAT

Downstream 100 bases:

>100_bases
CAAAAAACGTTGATATAACAGGGCTGACAGGTCGAAAATACTTGTCAGCTTATAATGAGATAGCTAAGTTAGACACAGTG
TTGTGATTTGTTTTTCACAC

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 787; Mature: 787

Protein sequence:

>787_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAKEEPQLDDLHSVGTIATILQL
LKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLVTPEIDDAEQEVIMRSAINQFDGFIKLNKKIPPEVLTSLSGIED
AARLADTIAAHMPLKLADKQEVLELIDVIARLEFLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDDAPDEFEALQKKIADAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGVPWFKRSKVKKDLAKAEDILN
ADHYGLERVKERILEYLAVQSRVTKLKGPILCLVGPPGVGKTSLGQSIARATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMSKVEVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSTFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKNHLLMKQVKRNGLKEDEIQIDDSAIMGIIRYYTREAGVRSLEREISKLCRKAVKQILL
DKSIKKVTINQDNLKDFLGVQRCDYGKADTENRVGQVVGLAWTEVGGDLLTIEAESMIGKGKLAYTGSLGDVMKESIQAA
MTVVRTRAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGVGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVIIPKDNERDLEEIPANVIADLSVHPVKWIDEVLTLALQNDPQGFSLESSQKSDV

Sequences:

>Translated_787_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAKEEPQLDDLHSVGTIATILQL
LKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLVTPEIDDAEQEVIMRSAINQFDGFIKLNKKIPPEVLTSLSGIED
AARLADTIAAHMPLKLADKQEVLELIDVIARLEFLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDDAPDEFEALQKKIADAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGVPWFKRSKVKKDLAKAEDILN
ADHYGLERVKERILEYLAVQSRVTKLKGPILCLVGPPGVGKTSLGQSIARATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMSKVEVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSTFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKNHLLMKQVKRNGLKEDEIQIDDSAIMGIIRYYTREAGVRSLEREISKLCRKAVKQILL
DKSIKKVTINQDNLKDFLGVQRCDYGKADTENRVGQVVGLAWTEVGGDLLTIEAESMIGKGKLAYTGSLGDVMKESIQAA
MTVVRTRAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGVGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVIIPKDNERDLEEIPANVIADLSVHPVKWIDEVLTLALQNDPQGFSLESSQKSDV
>Mature_787_residues
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAKEEPQLDDLHSVGTIATILQL
LKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLVTPEIDDAEQEVIMRSAINQFDGFIKLNKKIPPEVLTSLSGIED
AARLADTIAAHMPLKLADKQEVLELIDVIARLEFLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
GDLDDAPDEFEALQKKIADAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGVPWFKRSKVKKDLAKAEDILN
ADHYGLERVKERILEYLAVQSRVTKLKGPILCLVGPPGVGKTSLGQSIARATGRKYTRMALGGVRDEAEIRGHRRTYIGS
LPGKLIQKMSKVEVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNSTFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKNHLLMKQVKRNGLKEDEIQIDDSAIMGIIRYYTREAGVRSLEREISKLCRKAVKQILL
DKSIKKVTINQDNLKDFLGVQRCDYGKADTENRVGQVVGLAWTEVGGDLLTIEAESMIGKGKLAYTGSLGDVMKESIQAA
MTVVRTRAEKLGINPDFYEKRDIHVHVPEGATPKDGPSAGVGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVIIPKDNERDLEEIPANVIADLSVHPVKWIDEVLTLALQNDPQGFSLESSQKSDV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=788, Percent_Identity=39.7208121827411, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI21396489, Length=675, Percent_Identity=39.2592592592593, Blast_Score=490, Evalue=1e-138,
Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=81.6326530612245, Blast_Score=1297, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=659, Percent_Identity=39.7572078907436, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=797, Percent_Identity=33.5006273525721, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=671, Percent_Identity=41.1326378539493, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24666867, Length=622, Percent_Identity=44.5337620578778, Blast_Score=520, Evalue=1e-147,
Organism=Drosophila melanogaster, GI221513036, Length=622, Percent_Identity=44.5337620578778, Blast_Score=519, Evalue=1e-147,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87754; Mature: 87754

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAK
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEHHHCC
EEPQLDDLHSVGTIATILQLLKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLVTPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHEECCCCEEECCC
IDDAEQEVIMRSAINQFDGFIKLNKKIPPEVLTSLSGIEDAARLADTIAAHMPLKLADKQ
CCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHH
EVLELIDVIARLEFLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLDDAPDEFEALQKKIADAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWFKRSKVKKDLAKAEDILNADHYGLERVKERILEYLAVQSRVTKLKGPILCLVGPPGVG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGQSIARATGRKYTRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKMSKVEVKNPLFL
HHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCHH
LDEIDKMSSDMRGDPASALLEVLDPEQNSTFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIAKNHLLMKQVKRNGLKEDEIQIDDSAIMGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHH
RSLEREISKLCRKAVKQILLDKSIKKVTINQDNLKDFLGVQRCDYGKADTENRVGQVVGL
HHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHCCHHCCCCCCCCHHHHHHHHHH
AWTEVGGDLLTIEAESMIGKGKLAYTGSLGDVMKESIQAAMTVVRTRAEKLGINPDFYEK
HHHHCCCCEEEEEHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDIHVHVPEGATPKDGPSAGVGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHHH
KLLAAHRGGIKTVIIPKDNERDLEEIPANVIADLSVHPVKWIDEVLTLALQNDPQGFSLE
HHHHHHCCCCEEEEECCCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
SSQKSDV
CCCCCCC
>Mature Secondary Structure
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMEQNKQVLLVAQKEAAK
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEHHHCC
EEPQLDDLHSVGTIATILQLLKLPDGTVKVLVEGQQRAKIHQFLEADFFTADAEFLVTPE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHEECCCCEEECCC
IDDAEQEVIMRSAINQFDGFIKLNKKIPPEVLTSLSGIEDAARLADTIAAHMPLKLADKQ
CCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHH
EVLELIDVIARLEFLMGMMESEIDLLQIEKRIRGRVKKQMEKSQREYYLNEQMKAIQKEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLDDAPDEFEALQKKIADAKMPKEAQEKAEQELQKLKMMSPMSAEATVVRSYIDCMVGV
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
PWFKRSKVKKDLAKAEDILNADHYGLERVKERILEYLAVQSRVTKLKGPILCLVGPPGVG
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KTSLGQSIARATGRKYTRMALGGVRDEAEIRGHRRTYIGSLPGKLIQKMSKVEVKNPLFL
HHHHHHHHHHHHCCHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCHH
LDEIDKMSSDMRGDPASALLEVLDPEQNSTFSDHYLEVDYDLSDVMFVATSNSMNIPGPL
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHHH
LDRMEVIRLSGYTEDEKLNIAKNHLLMKQVKRNGLKEDEIQIDDSAIMGIIRYYTREAGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHH
RSLEREISKLCRKAVKQILLDKSIKKVTINQDNLKDFLGVQRCDYGKADTENRVGQVVGL
HHHHHHHHHHHHHHHHHHHHHCCHHEEECCHHHHHHHHCCHHCCCCCCCCHHHHHHHHHH
AWTEVGGDLLTIEAESMIGKGKLAYTGSLGDVMKESIQAAMTVVRTRAEKLGINPDFYEK
HHHHCCCCEEEEEHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RDIHVHVPEGATPKDGPSAGVGMCTALVSSLTGNPVRSDVAMTGEITLRGEVLPIGGLKE
CCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEEECEEEECCCHHH
KLLAAHRGGIKTVIIPKDNERDLEEIPANVIADLSVHPVKWIDEVLTLALQNDPQGFSLE
HHHHHHCCCCEEEEECCCCCCCHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
SSQKSDV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]