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The map label for this gene is clpP [H]

Identifier: 209694398

GI number: 209694398

Start: 908532

End: 909155

Strand: Direct

Name: clpP [H]

Synonym: VSAL_I0818

Alternate gene names: 209694398

Gene position: 908532-909155 (Clockwise)

Preceding gene: 209694397

Following gene: 209694399

Centisome position: 27.32

GC content: 40.06

Gene sequence:

>624_bases
ATGAGCTATCAAGAAAACAATGCAATGCCTTCTATTATGGATGCACTTGTTCCTATGGTTGTTGAACAAACTTCACGTGG
TGAGCGTTCGTATGATATTTATTCCCGTCTGTTAAAAGAGCGCGTTATCTTTTTAACAGGTCAAGTTGAAGATCACATGG
CCAACCTAGTTGTGGCACAGTTGCTTTTCCTTGAGTCTGAAAACCCTGATAAGGATATCTTCCTATATATTAACTCTCCA
GGCGGCTCAGTTACTGCAGGTATGTCTATCTATGACACCATGCAGTTTATTAAGCCAAATGTAAGTACGGTATGTATGGG
TCAAGCATGTTCTATGGGTGCTTTCTTACTTGCAGGTGGCGCACCAGGTAAACGTTATGTATTACCTAATTCTCGTGTGA
TGATTCACCAACCACTTGGTGGTTTCCAAGGCCAAGCATCTGATATTCAAATTCATGCGCAAGAAATCTTAACGATTAAA
AAGAAATTGAATACATTACTTGCTGAGCATACAGGCCAACCATTAGAAGTGATCGAAAAAGATACAGATCGTGATAACTT
CATGGCTGCAGATGATGCAGTGAAATATGGTCTTGTAGATGCTGTGCTAAATAAGCGTGACTAA

Upstream 100 bases:

>100_bases
TTTAAAATTAATTAAGTAGTTGACTTAGTTTCAAAAGATCTGCTAATAATGGTTCGAATGAAGCGTCATTCGGACCATTT
ATTTTATAAGGGATACGGTT

Downstream 100 bases:

>100_bases
TTAATAAAAAAGCAGTAACGTTTACAGTAAAGAAGGTAAGTTGGTATAGACTTACAGCATAAAGGCAACGTTTAAGAGGT
TAGCAAATGACAGACAAGCG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSP
GGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIK
KKLNTLLAEHTGQPLEVIEKDTDRDNFMAADDAVKYGLVDAVLNKRD

Sequences:

>Translated_207_residues
MSYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSP
GGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIK
KKLNTLLAEHTGQPLEVIEKDTDRDNFMAADDAVKYGLVDAVLNKRD
>Mature_206_residues
SYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSPG
GSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKK
KLNTLLAEHTGQPLEVIEKDTDRDNFMAADDAVKYGLVDAVLNKRD

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=57.9787234042553, Blast_Score=237, Evalue=5e-63,
Organism=Escherichia coli, GI1786641, Length=209, Percent_Identity=73.6842105263158, Blast_Score=330, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=60.1063829787234, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22860; Mature: 22728

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQ
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCHHHHHHHHHHHH
LLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGG
HHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECC
APGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKKKLNTLLAEHTGQPLEVIEK
CCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
DTDRDNFMAADDAVKYGLVDAVLNKRD
CCCCCCEEECHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SYQENNAMPSIMDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQ
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCHHHHHHHHHHHH
LLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGG
HHHHCCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHCCCCCEEECCCCCCCCEEEEECC
APGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKKKLNTLLAEHTGQPLEVIEK
CCCCEEECCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHC
DTDRDNFMAADDAVKYGLVDAVLNKRD
CCCCCCEEECHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA