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The map label for this gene is 209693873

Identifier: 209693873

GI number: 209693873

Start: 312237

End: 313691

Strand: Direct

Name: 209693873

Synonym: VSAL_I0265

Alternate gene names: NA

Gene position: 312237-313691 (Clockwise)

Preceding gene: 209693867

Following gene: 209693874

Centisome position: 9.39

GC content: 43.78

Gene sequence:

>1455_bases
ATGCCAACACCCCAAAAACACTCAACCCAAAGCACAAATTTTGAAATAAACCTAAAACACCACGGCGGAAAACTCGGCGT
CACCGGCTCTTGCCATGAACTCTGCATTAATAGCAACGGCAATAAGCACGGCATATTAATCGACTGCGGTTTATTTCAAG
GCAAAGACGCTAAAGATAAACATGGCAATGACAAAAAACTTGATATTGAATTTCCCATCTCACACCTCAAAGCATTAATC
CTCACCCATACCCACATAGACCATATCGGTCGCTTACCTTGGTTATTAACAAAAGGCTTCAAGCAACCCATATACTGCAC
ACCAGCAACCGCTGAGTTAGTACCACTCATGCTAGATGATGGCTTAAAACTGCAACTCGGGCTAAACAAAGGCCAAAGAG
AAAGAGTATTAGAATTAATAAGAAAACAGATAAAACCCATTCCATACAACCAATGGCACCGAATTAAACTCACCTCTACA
ATGGTACCTTCTCACTCTAAAAGTTCTTGTTCTTCCCTGAAAGCGAAGCGTCCTGAATCCTTAAACCTGCTCTTAAGATT
CCAACCCGCCGGCCACATCCTCGGCTCCGCTTACGTCGAAATCAAACTCCCCAACGATGAAATCGTCGTATTTTCAGGCG
ATCTTGGTCCATCCAATACCCCATTACTTCCCGATCCAATTTCACCAAAACGTGCCGACTTATTAGTAATAGAAAGCACT
TATGGCAACAAACTTCACGACAGTGTAGAAACCAGAGCAAAGCGACTGCAAGAGATAATAGAACGTTCACTACAAGATGG
TGGCGCAATCATTATTCCCGCATTCTCAGTCGGCAGAACCCAAGAGCTGTTGTTTGATATTGAGCACTTAATTCATCACA
ACAAAATAGACTCAAAAATTCCTATCATTTTAGATTCTCCATTAGCCAACAAAGTCACCAAACAATATCGCCGATTCAAA
AAACTCTGGAGTAAAGAAGCGAAAACCAAACTCAACAATCAACGGCATCCACTTAATTTCGAACAATGCATCACCATAGA
AAGTCACAAAGAACATATGCAAATCGTCAACCGCCTAAAAAGCACCGCAAAGCCCTGCATAATAGTCGCCGCCAGCGGCA
TGTGCGCTGGAGGCCGAGTGATGAATTATCTAGAAGCGTTATTACCAGATAAACGCACCGACATTATTCTTGCCGGTTAC
CAAGCCCACGGTACTCTAGGCCGAGATCTGCAAAACCAAAGATCAACGGTCTGGATAGATAATCAACCAGTAGATGTAAA
TGCTCAAATCCATACCATGTCAGGCTATTCAGCCCACGCCGATCAAGCAGATTTAATTAAGTTTGTTGATGGGATTGAGG
AGGGAAGGAAGGAGGTGGTTGTGGTGCATGGCGAGGATAACGTGCGCGAGGAGTTTGAGAGGGTACTGGAGGCTAGAAAC
TATACGCTGCGCTAG

Upstream 100 bases:

>100_bases
GTGATATATTTGATAAATCAGTATTACTGGCTTTTATAGTCTCTAGTCACGCAGTGAATATAGTTAGCAAAGCGTATAGT
TTATTTAAAATGGAGTTATC

Downstream 100 bases:

>100_bases
CTAGAGACTATAAGTGCGGGAGTGTTTATAGCTGATAGTTTATTTATGTATTTTACATAGCTAGAGATGTTTGGAGCGGC
TAGAAACTATACGCTTCGCT

Product: metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MPTPQKHSTQSTNFEINLKHHGGKLGVTGSCHELCINSNGNKHGILIDCGLFQGKDAKDKHGNDKKLDIEFPISHLKALI
LTHTHIDHIGRLPWLLTKGFKQPIYCTPATAELVPLMLDDGLKLQLGLNKGQRERVLELIRKQIKPIPYNQWHRIKLTST
MVPSHSKSSCSSLKAKRPESLNLLLRFQPAGHILGSAYVEIKLPNDEIVVFSGDLGPSNTPLLPDPISPKRADLLVIEST
YGNKLHDSVETRAKRLQEIIERSLQDGGAIIIPAFSVGRTQELLFDIEHLIHHNKIDSKIPIILDSPLANKVTKQYRRFK
KLWSKEAKTKLNNQRHPLNFEQCITIESHKEHMQIVNRLKSTAKPCIIVAASGMCAGGRVMNYLEALLPDKRTDIILAGY
QAHGTLGRDLQNQRSTVWIDNQPVDVNAQIHTMSGYSAHADQADLIKFVDGIEEGRKEVVVVHGEDNVREEFERVLEARN
YTLR

Sequences:

>Translated_484_residues
MPTPQKHSTQSTNFEINLKHHGGKLGVTGSCHELCINSNGNKHGILIDCGLFQGKDAKDKHGNDKKLDIEFPISHLKALI
LTHTHIDHIGRLPWLLTKGFKQPIYCTPATAELVPLMLDDGLKLQLGLNKGQRERVLELIRKQIKPIPYNQWHRIKLTST
MVPSHSKSSCSSLKAKRPESLNLLLRFQPAGHILGSAYVEIKLPNDEIVVFSGDLGPSNTPLLPDPISPKRADLLVIEST
YGNKLHDSVETRAKRLQEIIERSLQDGGAIIIPAFSVGRTQELLFDIEHLIHHNKIDSKIPIILDSPLANKVTKQYRRFK
KLWSKEAKTKLNNQRHPLNFEQCITIESHKEHMQIVNRLKSTAKPCIIVAASGMCAGGRVMNYLEALLPDKRTDIILAGY
QAHGTLGRDLQNQRSTVWIDNQPVDVNAQIHTMSGYSAHADQADLIKFVDGIEEGRKEVVVVHGEDNVREEFERVLEARN
YTLR
>Mature_483_residues
PTPQKHSTQSTNFEINLKHHGGKLGVTGSCHELCINSNGNKHGILIDCGLFQGKDAKDKHGNDKKLDIEFPISHLKALIL
THTHIDHIGRLPWLLTKGFKQPIYCTPATAELVPLMLDDGLKLQLGLNKGQRERVLELIRKQIKPIPYNQWHRIKLTSTM
VPSHSKSSCSSLKAKRPESLNLLLRFQPAGHILGSAYVEIKLPNDEIVVFSGDLGPSNTPLLPDPISPKRADLLVIESTY
GNKLHDSVETRAKRLQEIIERSLQDGGAIIIPAFSVGRTQELLFDIEHLIHHNKIDSKIPIILDSPLANKVTKQYRRFKK
LWSKEAKTKLNNQRHPLNFEQCITIESHKEHMQIVNRLKSTAKPCIIVAASGMCAGGRVMNYLEALLPDKRTDIILAGYQ
AHGTLGRDLQNQRSTVWIDNQPVDVNAQIHTMSGYSAHADQADLIKFVDGIEEGRKEVVVVHGEDNVREEFERVLEARNY
TLR

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=460, Percent_Identity=25.2173913043478, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI7706427, Length=446, Percent_Identity=25.1121076233184, Blast_Score=134, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32566029, Length=445, Percent_Identity=26.0674157303371, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI32564696, Length=456, Percent_Identity=25.4385964912281, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323307, Length=462, Percent_Identity=22.2943722943723, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24648013, Length=467, Percent_Identity=26.1241970021413, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI21358523, Length=461, Percent_Identity=27.3318872017354, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 54413; Mature: 54282

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPQKHSTQSTNFEINLKHHGGKLGVTGSCHELCINSNGNKHGILIDCGLFQGKDAKDK
CCCCCCCCCCCCCEEEEEEECCCEECCCCCHHHEEECCCCCCEEEEEEECCCCCCCCCCC
HGNDKKLDIEFPISHLKALILTHTHIDHIGRLPWLLTKGFKQPIYCTPATAELVPLMLDD
CCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECCCHHHHHHHEECC
GLKLQLGLNKGQRERVLELIRKQIKPIPYNQWHRIKLTSTMVPSHSKSSCSSLKAKRPES
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCC
LNLLLRFQPAGHILGSAYVEIKLPNDEIVVFSGDLGPSNTPLLPDPISPKRADLLVIEST
EEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECC
YGNKLHDSVETRAKRLQEIIERSLQDGGAIIIPAFSVGRTQELLFDIEHLIHHNKIDSKI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC
PIILDSPLANKVTKQYRRFKKLWSKEAKTKLNNQRHPLNFEQCITIESHKEHMQIVNRLK
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEHHHHHHHHHHHHHH
STAKPCIIVAASGMCAGGRVMNYLEALLPDKRTDIILAGYQAHGTLGRDLQNQRSTVWID
HCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHCCCCEEEEC
NQPVDVNAQIHTMSGYSAHADQADLIKFVDGIEEGRKEVVVVHGEDNVREEFERVLEARN
CCCEECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
YTLR
CCCC
>Mature Secondary Structure 
PTPQKHSTQSTNFEINLKHHGGKLGVTGSCHELCINSNGNKHGILIDCGLFQGKDAKDK
CCCCCCCCCCCCEEEEEEECCCEECCCCCHHHEEECCCCCCEEEEEEECCCCCCCCCCC
HGNDKKLDIEFPISHLKALILTHTHIDHIGRLPWLLTKGFKQPIYCTPATAELVPLMLDD
CCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEECCCHHHHHHHEECC
GLKLQLGLNKGQRERVLELIRKQIKPIPYNQWHRIKLTSTMVPSHSKSSCSSLKAKRPES
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCC
LNLLLRFQPAGHILGSAYVEIKLPNDEIVVFSGDLGPSNTPLLPDPISPKRADLLVIEST
EEEEEEECCCCCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECC
YGNKLHDSVETRAKRLQEIIERSLQDGGAIIIPAFSVGRTQELLFDIEHLIHHNKIDSKI
CCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCC
PIILDSPLANKVTKQYRRFKKLWSKEAKTKLNNQRHPLNFEQCITIESHKEHMQIVNRLK
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEHHHHHHHHHHHHHH
STAKPCIIVAASGMCAGGRVMNYLEALLPDKRTDIILAGYQAHGTLGRDLQNQRSTVWID
HCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHCCCCEEEEC
NQPVDVNAQIHTMSGYSAHADQADLIKFVDGIEEGRKEVVVVHGEDNVREEFERVLEARN
CCCEECCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCC
YTLR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA