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The map label for this gene is ilvC

Identifier: 209693711

GI number: 209693711

Start: 115825

End: 117309

Strand: Direct

Name: ilvC

Synonym: VSAL_I0087

Alternate gene names: 209693711

Gene position: 115825-117309 (Clockwise)

Preceding gene: 209693708

Following gene: 209693716

Centisome position: 3.48

GC content: 39.06

Gene sequence:

>1485_bases
ATGTCTAACTACTTTGATACGCTAAATTTACGTGAACAATTAGATCAACTAGGTCGTTGTCGTTTTATGGACCGCGAAGA
ATTTTCTACAGAAGCGGATTACCTTAAAGGTAAAAGGGTGGTTATTGTTGGCTGTGGAGCTCAAGGCCTAAATCAAGGTT
TAAATATGCGAGATTCAGGTTTGAATGTTGCTTATGCTTTACGTCAGGCTGCTATTGATGAGCAACGTCAATCATTTAAG
AATGCAAGCGAAAATGGTTTTGAAGTTGCTAGCTACGAAAAATTGATCCCTCAAGCCGATTTGGTTATTAACCTTACTCC
TGATAAACAGCATACGAATGTTGTTGAAACTGTTATGCCTTTAATGAAGGAAGGTGCAACGCTTGGTTACTCGCATGGCT
TTAATATCGTTGAAGAAGGTATGAAAATCCGTAAAGATTTAACGGTTGTTATGGTTGCTCCTAAATGTCCAGGTACAGAA
GTTCGAGAAGAATATAAGCGTGGTTTTGGTGTTCCTACTCTTATTGCTGTTCATCCTGAAAATGATCCTAAAGGCGAAGG
TTGGGATATAGCGAAAGCATGGGCGGCTGGGACTGGTGGTCATCGTGCCGGTTGTTTAGAGTCTTCATTCGTTGCTGAAG
TTAAATCTGACTTAATGGGTGAACAAACAATTCTTTGTGGAATGCTGCAAGCCGGCTCTATTGTTTGTTATGAAAAAATG
ATCGCTGATGGTATCGATGCTAGCTATGCAGGCAAACTTCTACAATTTGGCTGGGAAACAGTTACAGAAGCACTGAAGTT
TGGTGGTGTGACGCATATGATGGATCGTCTATCAAACCCAGCTAAAATTAAAGCCTTTGATTTATCTGAAGAATTAAAAG
ATCTAATGCGCCCACTTTATAATAAGCATATGGATGATATTATCTCGGGACATTTTTCAAGTACGATGATGGCTGACTGG
GCAAATGATGATGTTAACTTGCTAGGGTGGCGTGAAGAGACGGGTGAAACTGCTTTTGAAAACTACCCTGATTCTAGTCT
GGAAATTCCAGAACAAGAATATTTTGATAATGGTATTTTAATGGTTGCTATGGTTCGTGCTGGTGTTGAATTAGCATTTG
AAGCGATGACTGCTTCAGGTATTGTAGATGAATCTGCTTATTACGAATCATTGCATGAGCTACCATTAATCGCTAACACT
GTTGCACGTAAACGCTTATATGAAATGAATGTCGTTATTTCAGATACGGCTGAATATGGTAATTATCTATTCGCAAATGT
TGCAACACCATTGCTGCGTGAAAAATTCATGCCTTTAGTTGATACTGATGTTATTGGTCGTGGTTTAGGGGCAATATCTA
ATCAAGTGGATAATGCTAAATTGATCGAAGTGAATGAGACTATTCGTAATCACCCAGTTGAGTATATTGGTGAAGAACTA
CGCGGTTATATGACTGATATGAAAACAATTGCTGTTGGTGGTTAA

Upstream 100 bases:

>100_bases
ATTGTTAATATATCACTTCTTACAATGTTAATCTTTGGTTATTATCTTTGTATGCACAGAATTATCCTAATGGATTAAAT
GATATTTATGGAGTTTCACA

Downstream 100 bases:

>100_bases
CTTACATAATTAATAAAAAAGCCCGATATTATATCGGGCTTTTTTGTATCTAAAGGAATTGTTCTAATCTTAAGAACAAA
ATTATGTTTATTTTTCAGAT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSNYFDTLNLREQLDQLGRCRFMDREEFSTEADYLKGKRVVIVGCGAQGLNQGLNMRDSGLNVAYALRQAAIDEQRQSFK
NASENGFEVASYEKLIPQADLVINLTPDKQHTNVVETVMPLMKEGATLGYSHGFNIVEEGMKIRKDLTVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
IADGIDASYAGKLLQFGWETVTEALKFGGVTHMMDRLSNPAKIKAFDLSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDVNLLGWREETGETAFENYPDSSLEIPEQEYFDNGILMVAMVRAGVELAFEAMTASGIVDESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPLVDTDVIGRGLGAISNQVDNAKLIEVNETIRNHPVEYIGEEL
RGYMTDMKTIAVGG

Sequences:

>Translated_494_residues
MSNYFDTLNLREQLDQLGRCRFMDREEFSTEADYLKGKRVVIVGCGAQGLNQGLNMRDSGLNVAYALRQAAIDEQRQSFK
NASENGFEVASYEKLIPQADLVINLTPDKQHTNVVETVMPLMKEGATLGYSHGFNIVEEGMKIRKDLTVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
IADGIDASYAGKLLQFGWETVTEALKFGGVTHMMDRLSNPAKIKAFDLSEELKDLMRPLYNKHMDDIISGHFSSTMMADW
ANDDVNLLGWREETGETAFENYPDSSLEIPEQEYFDNGILMVAMVRAGVELAFEAMTASGIVDESAYYESLHELPLIANT
VARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPLVDTDVIGRGLGAISNQVDNAKLIEVNETIRNHPVEYIGEEL
RGYMTDMKTIAVGG
>Mature_493_residues
SNYFDTLNLREQLDQLGRCRFMDREEFSTEADYLKGKRVVIVGCGAQGLNQGLNMRDSGLNVAYALRQAAIDEQRQSFKN
ASENGFEVASYEKLIPQADLVINLTPDKQHTNVVETVMPLMKEGATLGYSHGFNIVEEGMKIRKDLTVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKMI
ADGIDASYAGKLLQFGWETVTEALKFGGVTHMMDRLSNPAKIKAFDLSEELKDLMRPLYNKHMDDIISGHFSSTMMADWA
NDDVNLLGWREETGETAFENYPDSSLEIPEQEYFDNGILMVAMVRAGVELAFEAMTASGIVDESAYYESLHELPLIANTV
ARKRLYEMNVVISDTAEYGNYLFANVATPLLREKFMPLVDTDVIGRGLGAISNQVDNAKLIEVNETIRNHPVEYIGEELR
GYMTDMKTIAVGG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=494, Percent_Identity=73.0769230769231, Blast_Score=745, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=292, Percent_Identity=31.5068493150685, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ALISL (B6EP33)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002261639.1
- GeneID:   6988713
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0087
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- ProtClustDB:   PRK05225
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 54781; Mature: 54650

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYFDTLNLREQLDQLGRCRFMDREEFSTEADYLKGKRVVIVGCGAQGLNQGLNMRDSG
CCCCHHHCHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LNVAYALRQAAIDEQRQSFKNASENGFEVASYEKLIPQADLVINLTPDKQHTNVVETVMP
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKEGATLGYSHGFNIVEEGMKIRKDLTVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
CCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
IADGIDASYAGKLLQFGWETVTEALKFGGVTHMMDRLSNPAKIKAFDLSEELKDLMRPLY
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDVNLLGWREETGETAFENYPDSSLEIPEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCCHHHCCCCCCCCCCHHHHHCCCHH
MVAMVRAGVELAFEAMTASGIVDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVATPLLREKFMPLVDTDVIGRGLGAISNQVDNAKLIEVNETIRNHPVEYIGEEL
CEEHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCHHHHHHHH
RGYMTDMKTIAVGG
HHHHHHHHHEECCC
>Mature Secondary Structure 
SNYFDTLNLREQLDQLGRCRFMDREEFSTEADYLKGKRVVIVGCGAQGLNQGLNMRDSG
CCCHHHCHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCEEEEEECCCHHHHCCCCCCCCC
LNVAYALRQAAIDEQRQSFKNASENGFEVASYEKLIPQADLVINLTPDKQHTNVVETVMP
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
LMKEGATLGYSHGFNIVEEGMKIRKDLTVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGWDIAKAWAAGTGGHRAGCLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYEKM
CCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHH
IADGIDASYAGKLLQFGWETVTEALKFGGVTHMMDRLSNPAKIKAFDLSEELKDLMRPLY
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECHHHHHHHHHHHHH
NKHMDDIISGHFSSTMMADWANDDVNLLGWREETGETAFENYPDSSLEIPEQEYFDNGIL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHCCCCHHHCCCCCCCCCCHHHHHCCCHH
MVAMVRAGVELAFEAMTASGIVDESAYYESLHELPLIANTVARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCHHHC
NYLFANVATPLLREKFMPLVDTDVIGRGLGAISNQVDNAKLIEVNETIRNHPVEYIGEEL
CEEHHHHHHHHHHHHCCCHHCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCHHHHHHHH
RGYMTDMKTIAVGG
HHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA