Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 209693650

GI number: 209693650

Start: 17172

End: 18809

Strand: Reverse

Name: groEL [H]

Synonym: VSAL_I0017

Alternate gene names: 209693650

Gene position: 18809-17172 (Counterclockwise)

Preceding gene: 209693651

Following gene: 209693649

Centisome position: 0.57

GC content: 44.44

Gene sequence:

>1638_bases
ATGGCTGCTAAAGACGTTAAATTTGGTAATGACGCACGAATCAAAATGCTAGAAGGTGTAAATGTTCTGGCTGATGCGGT
TAAAGTAACTTTGGGTCCTAAGGGTCGTAACGTTGTTTTAGATAAATCATTTGGCGCACCAACGATCACTAAAGATGGTG
TTTCTGTTGCACGTGAAATCGAACTTGAAGATAAGTTCCAAAACATGGGCGCACAAATGGTTAAAGAAGTGGCTTCGCAA
GCGAATGACGCGGCGGGCGACGGAACAACAACGGCAACCGTTCTTGCTCAAGCTATCATTGCTGAAGGCCTAAAAGCCGT
TGCTGCGGGTATGAACCCAATGGATCTTAAACGTGGTATCGACAAAGCAGTTATTGCTGCTGTTGAAGCACTTAAAGATC
TATCTGTTCCATGTGCTGATACAAAAGCGATCGCGCAAGTAGGTACTATCTCTGCAAACTCTGATTATACTGTTGGTAAT
CTTATTGCTGAAGCAATGGAAAAAGTAGGTCGTGACGGTGTTATCACTGTTGAAGAAGGCCAATCTCTTCAAGACGAATT
AGACGTTGTTGAAGGTATGCAGTTTGATCGCGGTTACCTATCTCCATATTTCGTAAACAACCAAGAAGCCGGTTCTGTTG
ATCTAGACAGCCCATTCATCTTGCTTGTTGATAAAAAAGTATCAAACATCCGTGAATTGCTTCCAACTCTAGAAGCAGTA
GCGAAAGCATCTCGTCCTCTTCTTATCATCGCTGAAGATATTGAAGGCGAAGCGCTTGCTACTCTAGTTGTGAACAACAT
GCGTGGTATCGTTAAAGTTGCAGCGGTTAAAGCACCTGGTTTTGGTGACCGTCGTAAAGCAATGTTACAAGATATCGCGG
CATTAACTGCGGGCTCTGTAATTTCAGAAGAGATCGGTTTAGAACTTGAAAAAGTAGTTCTTGAAGATCTTGGTCAAGCG
AAGCGTGTAACTATTACAAAAGAAACAACAACTATCATCGATGGTGCTGGTGATGAGACTATTATCTCTGGCCGTGTTTC
TCAAATTCGTCAACAAATCGAAGATGCAACCTCTGACTACGATAAAGAAAAACTTCAAGAGCGTGTAGCTAAATTGGCTG
GCGGTGTTGCAGTGATCAAAGTGGGTGCGGCGACTGAAGTTGAGATGAAAGAGAAGAAAGACCGTGTTGAAGATGCACTT
CACGCGACTCGCGCAGCCGTTGAAGAAGGTGTTGTTGCTGGTGGTGGTGTTGCACTTATCCGTGCTGCGTCTAAAGTTGT
TAACCTTGAAGGTGACAATGAAGAGCAAACTGTGGGTATTCGTTTAGCACTTCGTGCTATGGAAGCACCACTTCGTCAAA
TCGTTAAAAACGCAGGTGAAGAAGATTCAGTTGTTGCTAACAACGTTCGCGCTGGTGAAGATAACTACGGTTACAACGCA
GCTACTGGCGTTTACGGCGACATGATCGAAATGGGTATTCTTGACCCAACTAAAGTAACGCGTTCTGCACTTCAGTTCGC
AGCATCGGTTGCGGGTCTTATGATCACAACAGAAGCGATGATCACTGATAAGCCACAAGATTCAAGTTCTTCTATGCCAG
ATATGGGCGGCATGGGCGGCATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
TTGAATAATAAGCACTCGTTGAGTAATTCGTTTTTCGAACTTTGCTATTTTCGATACTAATAAGCGATATTAAGAAAAGA
ATTTAAAAAGGAAATTAAAG

Downstream 100 bases:

>100_bases
TCATCGCCATAAACTGATTCGCTTTATAGTGTAATTTGTTTGAAAAGCCGAGGCAGAGATGTCTCGGCTTTTTTGTGCGT
AGGAAAGAGCACCCCCTCCC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQ
ANDAAGDGTTTATVLAQAIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVEALKDLSVPCADTKAIAQVGTISANSDYTVGN
LIAEAMEKVGRDGVITVEEGQSLQDELDVVEGMQFDRGYLSPYFVNNQEAGSVDLDSPFILLVDKKVSNIRELLPTLEAV
AKASRPLLIIAEDIEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAALTAGSVISEEIGLELEKVVLEDLGQA
KRVTITKETTTIIDGAGDETIISGRVSQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDAL
HATRAAVEEGVVAGGGVALIRAASKVVNLEGDNEEQTVGIRLALRAMEAPLRQIVKNAGEEDSVVANNVRAGEDNYGYNA
ATGVYGDMIEMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSSSSMPDMGGMGGMGGMM

Sequences:

>Translated_545_residues
MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQ
ANDAAGDGTTTATVLAQAIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVEALKDLSVPCADTKAIAQVGTISANSDYTVGN
LIAEAMEKVGRDGVITVEEGQSLQDELDVVEGMQFDRGYLSPYFVNNQEAGSVDLDSPFILLVDKKVSNIRELLPTLEAV
AKASRPLLIIAEDIEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAALTAGSVISEEIGLELEKVVLEDLGQA
KRVTITKETTTIIDGAGDETIISGRVSQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDAL
HATRAAVEEGVVAGGGVALIRAASKVVNLEGDNEEQTVGIRLALRAMEAPLRQIVKNAGEEDSVVANNVRAGEDNYGYNA
ATGVYGDMIEMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSSSSMPDMGGMGGMGGMM
>Mature_544_residues
AAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREIELEDKFQNMGAQMVKEVASQA
NDAAGDGTTTATVLAQAIIAEGLKAVAAGMNPMDLKRGIDKAVIAAVEALKDLSVPCADTKAIAQVGTISANSDYTVGNL
IAEAMEKVGRDGVITVEEGQSLQDELDVVEGMQFDRGYLSPYFVNNQEAGSVDLDSPFILLVDKKVSNIRELLPTLEAVA
KASRPLLIIAEDIEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAALTAGSVISEEIGLELEKVVLEDLGQAK
RVTITKETTTIIDGAGDETIISGRVSQIRQQIEDATSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALH
ATRAAVEEGVVAGGGVALIRAASKVVNLEGDNEEQTVGIRLALRAMEAPLRQIVKNAGEEDSVVANNVRAGEDNYGYNAA
TGVYGDMIEMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSSSSMPDMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=526, Percent_Identity=50.1901140684411, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI31542947, Length=526, Percent_Identity=50.1901140684411, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI38455427, Length=151, Percent_Identity=27.1523178807947, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=84.2105263157895, Blast_Score=893, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=50.8506616257089, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI193210679, Length=222, Percent_Identity=50.4504504504504, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17564182, Length=565, Percent_Identity=23.8938053097345, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.4714828897338, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322524, Length=140, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=53.041825095057, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=53.041825095057, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=50.5725190839695, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=50.5725190839695, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=50.5725190839695, Blast_Score=532, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=542, Percent_Identity=42.2509225092251, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=38.0228136882129, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=38.0228136882129, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24583944, Length=136, Percent_Identity=28.6764705882353, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57336; Mature: 57205

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00284 SERPIN ; PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCCCEEEECCHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFQNMGAQMVKEVASQANDAAGDGTTTATVLAQAIIAEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVEALKDLSVPCADTKAIAQVGTISANSDYTVGNLIAEAMEKVGRDGVITVEEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
QSLQDELDVVEGMQFDRGYLSPYFVNNQEAGSVDLDSPFILLVDKKVSNIRELLPTLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEECCCCEEEEECCHHHHHHHHHHHHHHH
AKASRPLLIIAEDIEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAALTAGSV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ISEEIGLELEKVVLEDLGQAKRVTITKETTTIIDGAGDETIISGRVSQIRQQIEDATSDY
HHHHHCCHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALI
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVVNLEGDNEEQTVGIRLALRAMEAPLRQIVKNAGEEDSVVANNVRAGEDNYGYNA
HHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCC
ATGVYGDMIEMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSSSSMPDMGGMGG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCC
MGGMM
CCCCC
>Mature Secondary Structure 
AAKDVKFGNDARIKMLEGVNVLADAVKVTLGPKGRNVVLDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCCEEEECCHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFQNMGAQMVKEVASQANDAAGDGTTTATVLAQAIIAEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVEALKDLSVPCADTKAIAQVGTISANSDYTVGNLIAEAMEKVGRDGVITVEEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
QSLQDELDVVEGMQFDRGYLSPYFVNNQEAGSVDLDSPFILLVDKKVSNIRELLPTLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEECCCCEEEEECCHHHHHHHHHHHHHHH
AKASRPLLIIAEDIEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAALTAGSV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ISEEIGLELEKVVLEDLGQAKRVTITKETTTIIDGAGDETIISGRVSQIRQQIEDATSDY
HHHHHCCHHHHHHHHHCCCCCEEEEEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVEDALHATRAAVEEGVVAGGGVALI
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVVNLEGDNEEQTVGIRLALRAMEAPLRQIVKNAGEEDSVVANNVRAGEDNYGYNA
HHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCC
ATGVYGDMIEMGILDPTKVTRSALQFAASVAGLMITTEAMITDKPQDSSSSMPDMGGMGG
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCCCCCCCC
MGGMM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA